Immunology of type 1 diabetes:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Kluwer Acad. / Plenum Publ. [u.a.]
2004
|
| Ausgabe: | 2. ed. |
| Schriftenreihe: | Advances in experimental medicine and biology
552 |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | 1. Aufl. u.d.T.: Type 1 diabetes |
| Beschreibung: | XVI, 335 S. Ill., graph. Darst. |
| ISBN: | 0306478714 |
Internformat
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| 245 | 1 | 0 | |a Immunology of type 1 diabetes |c ed. by George S. Eisenbarth |
| 246 | 1 | 3 | |a Type I diabetes |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a New York [u.a.] |b Kluwer Acad. / Plenum Publ. [u.a.] |c 2004 | |
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| 490 | 1 | |a Advances in experimental medicine and biology |v 552 | |
| 500 | |a 1. Aufl. u.d.T.: Type 1 diabetes | ||
| 650 | 4 | |a Diabète insulinodépendant - Aspect immunologique | |
| 650 | 4 | |a Diabetes Mellitus, Type 1 |x immunology | |
| 650 | 4 | |a Diabetes |x Immunological aspects | |
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Datensatz im Suchindex
| _version_ | 1804133013538209792 |
|---|---|
| adam_text | CONTENTS
1. PRIMER: IMMUNOLOGY/AUTOIMMUNITY 1
Stephanie C. Eisenbarth and George S. Eisenbarth
Normal Immune Response 1
Genetics of Autoimmunity 5
Triggering of Autoimmunity 6
Target Antigens 7
Effector Mechanisms 9
Therapy of Autoimmunity 9
2A. CELL THERAPY OF DIABETES 16
Jan Nygaard Jensen and Jan Jensen
Islet Cell Transplantation The Beginning of a New Era
in Diabetes Treatment 16
The Cell Type in Demand: The Highly Specialized P Cell 17
The Beta Cell: A Specialized Team Player Packing a Punch
but with a Poor Constitution 19
Overview of Possible P Cell Sources 21
P Cells from P Cells: Controlling Replication 22
Xenotransplantation 22
Embryonic Stem Cells A Holy Grail or the Epitome of Man s
Reduction of Life Through Science? 23
Differentiation of Embryonic Stem Cells into Insulin Producing Cells 23
The Active Selection Approach 23
The Culture Refinement Approach 25
Promises and Pitfalls on the Path to a Cure for Diabetes Using ES Cells 25
Therapeutic Cloning Taking Advantage of Person Specific Stem Cells 26
Adult Stem Cells a Resource for Tissue Homeostasis
and Regeneration And Perhaps Conversion 27
Plasticity of Adult Stem Cells 27
Liver 27
Modified GIP Cells: Intestinal Rescue of a Pancreatic Problem 28
Endocrine Tumor Cells 29
xi
xii Contents
Regeneration of f5 Cells from Pancreatic Tissue 30
Reprogamming Cells Where Do We Get a Grip? 33
What Technology Is Acceptable And What Does the Patient
with Diabetes Wish? 34
Perspectives 35
2B. PROPROTEIN PROCESSING AND PANCREATIC
ISLET FUNCTION 39
John Hutton, Christina Wasmeier, Rodabe Amaria, Nicholas Bright
and John Creemers
Overview and Introduction 39
Perspective 41
The Islet as a Neuroendocrine Organ 41
The Regulated Pathway of Polypeptide Secretion 42
The Enzymology of Pancreatic Hormone Proteolysis 44
Pathways of Prohormone Processing in the Endocrine Pancreas 46
Regulation of Prohormone Processing Activity
within the Secretory Pathway 50
The Structure of PCI, PC2 and CPE and Their Post Translational
Processing 51
Antiproteases and Chaperones 53
Inherited Defects in Prohormone Processing in the Islet 53
Proprotein Processing Peturbations of Nongenetic Origin 56
Processing of Islet Autoantigens and Type 1A Diabetes 58
2C. STIMULUS SECRETION COUPLING
IN THE PANCREATIC BETA CELL 66
Kirstine Juhl and John Hutton
Introduction 66
Physiology of the Islet of Langerhans 66
The Biosynthesis of Insulin 67
Physiological Regulation of Islet Hormone Secretion 68
Islet Pathophysiology in Type 1 Diabetes 69
The Stimulus Secretion Coupling of the Pancreatic P Cell 71
Concluding Remarks 82
3. ANIMAL MODELS OF TYPE 1 DIABETES: GENETICS
AND IMMUNOLOGICAL FUNCTION 91
Julie Lang and Donald Bellgrau
The Nonobese Diabetic Mouse 91
Genetics of Diabetogenesis in the NOD Mouse 92
Immunology of the NOD Mouse 96
Contents xiii
TCR Tg Mouse Models of Type 1 Diabetes 99
Transgenic Expression of NeoSelf Antigens in Pancreas
and Diabetes Incidence 101
Human Autoimmunity Genes Expressed as Transgenes in Mice 103
BioBreeding Diabetes Prone (BB DP) Rat Model of Spontaneous
Type 1 Diabetes 103
Derivation of BB Rats 104
Genetics of BB Rats 104
Immune Dysfunction in the BB DP Rat and Its Relationship
to Lym phopenia 104
Activation and Death of T Cells Homozygous for lyp Mutation 106
The lyp Paradox 107
Disease Prevention in the BB DP Rat 107
Concluding Remarks 107
Long Evans Tokushima Lean (LETL) Rat Model 108
4. THE ROLE OF T CELLS IN BETA CELL DAMAGE
IN NOD MICE AND HUMANS 117
Katalin Kelemen
The NOD Mouse 117
Adoptive Transfer of Diabetes by T Cells 117
Checkpoints in the Development of Autoimmune Diabetes 118
T Cell Subsets in Type 1A Diabetes 118
Mechanism and Mediators of Beta Cell Death 119
The Autoantigens 120
Results from Investigations of Human Subjects 122
Histological Investigations 122
Demonstration of in Vitro T Cell Reactivity to Islet Cell Antigens 122
Problems Associated with the Detection of T Cell Reactivity in Diabetes
Conclusions from the First International T Cell Workshop 123
Summary 123
5. TYPE 1 DATABASE MELLITUS: AN INFLAMMATORY
DISEASE OF THE ISLET 129
Regine Bergholdt, Peter Heding, Karin Nielsen, Runa Nolsoe, Thomas Sparre,
Joachim Storling, Jotti Nerup, Flemming Pociot
and Thomas Mandrup Poulsen
Genetic Aspects of the Inflammatory Model for the Pathogenesis
of Type 1 Diabetes 131
Expression Profiling Studies of Genes and Proteins Regulated
by Inflammatory Mediators 136
Signal Transduction of Cytokine Mediated 0 Cell Death 140
The MAPK Pathways 141
Effector Mechanisms of Cytokine Mediated p Cell Destruction 144
Conclusions and Perspectives 146
xiv Contents
6. THE IMMUNOBIOLOGY OF PANCREATIC ISLET
TRANSPLANTATION 154
Marilyne Coulombe and Ronald G. Gill
Pancreatic Islet Allografting: The Allograft Paradox 155
Antigenicity Versus Immunogenicity of MHC Alloantigens 157
Pancreatic Islet Xenografting: The Xenograft Paradox 158
Role of T Cell Subsets in Islet Graft Rejection:
A Central Role for CD4 T Cells 160
The Role of Donor APCs in Allograft Versus Xenograft Immunity 162
Islet Xenografting in Autoimmune Diabetes 162
Future Direction: Donor Specific Tolerance Induction 162
7. TYPE 1 DIABETES MELLITUS OF MAN:
GENETIC SUSCEPTIBILITY AND RESISTANCE 170
Alberto Pugliese and George S. Eisenbarth
Introduction 170
Inherited Susceptibility Loci 171
The Major Susceptibility Locus IDDM1 171
The Insulin Gene VNTR Locus IDDM2 177
Other Susceptibility Loci 187
Parental Effects on Inherited Genes Expression 187
Other Nonmendelian Regulatory Mechanisms 188
Acquired Genetic Polymorphisms 190
Concluding Remarks 190
8. AUTOIMMUNE POLYENDOCRINE SYNDROMES 204
George S. Eisenbarth
Autoimmune Polyendocrine Syndrome Type II
(APS II, Schmidt s Syndrome) 204
Therapy 209
Autoimmune Polyendocrine Syndrome Type I (APS I) 210
XPID (X Linked Polyendocrinopathy Immune Dysfunction)
and Diarrhea 210
Anti Insulin Receptor Antibodies 210
Thymic Tumors 210
POEMS Syndrome 211
Insulin Autoimmune Syndrome (Hirata Syndrome) 211
Other Disorders 211
Conclusions 211
9. EPIDEMIOLOGY OF TYPE 1 DIABETES MELLITUS 219
Marian Rewers, Jill Norris and Dana Dabelea
Type 1 Diabetes 219
Natural History of Type 1A Diabetes 219
Contents xv
Clinical Onset of type 1 Diabetes 221
Incidence of Type 1 Diabetes 222
Remission ( Honeymoon Period ) 229
Established Diabetes 229
Mortality 230
Coronary Artery Disease 233
Summary 233
10. HUMORAL AUTOIMMUNITY 247
Liping Yu and George S. Eisenbarth
Islet Cell Autoantibodies (ICAs) 248
Sequenced Autoantigens 249
Partially Characterized Autoantigens 257
Other Autoantigens 258
T Cell Reactivity 259
Conclusions 260
11. PREDICTION OF TYPE 1 DIABETES: THE NATURAL
HISTORY OF THE PREDIABETIC PERIOD 268
George S. Eisenbarth
Predictive Factors in Relatives 268
Prediction in the General Population 271
Prediction/Diagnosis in Adults 272
At What Stage in Life Is Beta Cell Autoimmunity Initiated?
What Is the Initial Target Antigen, and in What Sequence
Do Different Autoantibodies Appear? 272
Are Environmental Factors Important Either in the Initiation
of Beta Cell Autoimmunity or in Modulating the Process Once
it Has Begun? 274
Once Autoimmunity Is Initiated Are Beta Cells Destroyed in a Progressive
Linear Fashion or Are There Spontaneous Remissions? 276
Conclusions 281
12. CLINICAL TRIALS FOR THE PREVENTION
OF TYPE 1 DIABETES 291
H. Peter Chase, Anthony R. Hayward and George S. Eisenbarth
Animal Models for Type 1 Diabetes Prevention 291
Clinical Trials for the Prevention of Type 1 Diabetes 292
Trials in Newly Diagnosed Subjects 293
Other Immunosuppressive Agents (Rapamycin, Mycophenolate Mofetil,
Anti IL 2 Antibodies, Methotrexate) 293
Anti CD3 Therapy 294
High Dose Intravenous Insulin 294
Immunostimulation 294
Identification of Subjects with PreType 1 Diabetes 294
Genetics 295
xvi Contents
Immunological 296
Metabolic Testing 297
Trials Using Subjects with PreType 1 Diabetes 298
Nicotinamide 298
Additional Clinical Trials of Antigen Based Therapies 301
Conclusions 301
THEORETICAL ESSAY A.
TYPE 1 DIABETES: MOLECULAR, CELLULAR
AND CLINICAL IMMUNOLOGY 306
George S. Eisenbarth
THEORETICAL ESSAY B.
CAN GETTING EXCITED OVER NOTHING
PROVOKE AUTOIMMUNITY? 311
Donald Bellgrau
THEORETICAL ESSAY C.
PATHOGENESIS OF TYPE 1 DIABETES:
A VIEWPOINT 317
Matthias G. von Herrath
THEORETICAL ESSAY D.
WAS THERE TYPE 1 DIABETES
IN THE OLDUVAI GORGE? 322
David V. Serreze and Deny C. Roopenian
INDEX 327
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| indexdate | 2024-07-09T20:01:58Z |
| institution | BVB |
| isbn | 0306478714 |
| language | English |
| lccn | 2003021860 |
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| physical | XVI, 335 S. Ill., graph. Darst. |
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| spelling | Immunology of type 1 diabetes ed. by George S. Eisenbarth Type I diabetes 2. ed. New York [u.a.] Kluwer Acad. / Plenum Publ. [u.a.] 2004 XVI, 335 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 552 1. Aufl. u.d.T.: Type 1 diabetes Diabète insulinodépendant - Aspect immunologique Diabetes Mellitus, Type 1 immunology Diabetes Immunological aspects Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf Diabetes mellitus Typ 1 (DE-588)1194595685 gnd rswk-swf Immunologie (DE-588)4026637-0 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Diabetes mellitus Typ 1 (DE-588)1194595685 s Immunologie (DE-588)4026637-0 s DE-604 Molekularpathologie (DE-588)4170396-0 s Autoaggressionskrankheit (DE-588)4003935-3 s b DE-604 Eisenbarth, George S. Sonstige oth Advances in experimental medicine and biology 552 (DE-604)BV000003102 552 http://www.loc.gov/catdir/toc/ecip049/2003021860.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012970315&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunology of type 1 diabetes Advances in experimental medicine and biology Diabète insulinodépendant - Aspect immunologique Diabetes Mellitus, Type 1 immunology Diabetes Immunological aspects Autoaggressionskrankheit (DE-588)4003935-3 gnd Diabetes mellitus Typ 1 (DE-588)1194595685 gnd Immunologie (DE-588)4026637-0 gnd Molekularpathologie (DE-588)4170396-0 gnd |
| subject_GND | (DE-588)4003935-3 (DE-588)1194595685 (DE-588)4026637-0 (DE-588)4170396-0 (DE-588)4143413-4 |
| title | Immunology of type 1 diabetes |
| title_alt | Type I diabetes |
| title_auth | Immunology of type 1 diabetes |
| title_exact_search | Immunology of type 1 diabetes |
| title_full | Immunology of type 1 diabetes ed. by George S. Eisenbarth |
| title_fullStr | Immunology of type 1 diabetes ed. by George S. Eisenbarth |
| title_full_unstemmed | Immunology of type 1 diabetes ed. by George S. Eisenbarth |
| title_short | Immunology of type 1 diabetes |
| title_sort | immunology of type 1 diabetes |
| topic | Diabète insulinodépendant - Aspect immunologique Diabetes Mellitus, Type 1 immunology Diabetes Immunological aspects Autoaggressionskrankheit (DE-588)4003935-3 gnd Diabetes mellitus Typ 1 (DE-588)1194595685 gnd Immunologie (DE-588)4026637-0 gnd Molekularpathologie (DE-588)4170396-0 gnd |
| topic_facet | Diabète insulinodépendant - Aspect immunologique Diabetes Mellitus, Type 1 immunology Diabetes Immunological aspects Autoaggressionskrankheit Diabetes mellitus Typ 1 Immunologie Molekularpathologie Aufsatzsammlung |
| url | http://www.loc.gov/catdir/toc/ecip049/2003021860.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012970315&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT eisenbarthgeorges immunologyoftype1diabetes AT eisenbarthgeorges typeidiabetes |