Life - as a matter of fat: the emerging science of lipidomics
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u. a.]
Springer
2005
|
| Schriftenreihe: | The frontiers collection
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 276 S. Ill., graph. Darst. |
| ISBN: | 3540232486 9783540232483 |
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| adam_text | CONTENTS PROLOGUE: LIPIDOMICS * A SCIENCE BEYOND STAMP COLLECTION .. 1
PART I THE OVERLOOKED MOLECULES 1 LIFE FROM MOLECULES
....................................... 9 1.1 THE THREE KINGDOMS OF LIFE
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1.2 THE
MOLECULES OF LIFE . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 10 1.3 THE POST-GENOMIC ERA . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 16 1.4 A CALL FOR PHYSICS . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2 HEAD AND TAIL ............................................ 23 2.1 FAT
FAMILY: FATS AND FATTY ACIDS . . . . . . . . . . . . . . . . . . . . . .
. . . 23 2.2 THE POLAR LIPIDS * BOTH HEAD AND TAIL . . . . . . . . . . .
. . . . . . . . 26 2.3 CHOLESTEROL * A LIPID OF ITS OWN . . . . . . . .
. . . . . . . . . . . . . . . . . 28 2.4 STRANGE LIPIDS . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 2.5
LIPID COMPOSITION OF MEMBRANES . . . . . . . . . . . . . . . . . . . . .
. . . . 31 3 OIL AND WATER ............................................
33 3.1 WATER * THE BIOLOGICAL SOLVENT . . . . . . . . . . . . . . . . .
. . . . . . . . . . 33 3.2 THE HYDROPHOBIC EFFECT . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 34 3.3 MEDIATING OIL AND
WATER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
3.4 SELF-ASSEMBLY AND THE LIPID AGGREGATE FAMILY . . . . . . . . . . . .
. 37 3.5 PLUCKING LIPIDS . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 40 4 LIPIDS SPEAK THE LANGUAGE OF
CURVATURE .................. 43 4.1 HOW LARGE IS A LIPID MOLECULE? . . .
. . . . . . . . . . . . . . . . . . . . . . . 43 4.2 LIPID MOLECULES
HAVE SHAPE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46
4.3 LIPID STRUCTURES WITH CURVATURE . . . . . . . . . . . . . . . . . .
. . . . . . . . 46 4.4 MICROORGANISMS* SENSE OF CURVATURE . . . . . . .
. . . . . . . . . . . . . . . 51 5 A MATTER OF SOFTNESS
..................................... 53 5.1 SOFT MATTER . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
53 5.2 SOFT INTERFACES . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 53 5.3 FORCES BETWEEN SOFT INTERFACES .
. . . . . . . . . . . . . . . . . . . . . . . . . . 58 X CONTENTS 5.4
LIPID MEMBRANES ARE REALLY SOFT . . . . . . . . . . . . . . . . . . . .
. . . . . 59 6 SOFT SHELLS SHAPE UP
..................................... 63 6.1 BENDING INTERFACES . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
6.2 SPONTANEOUS CURVATURE . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 66 6.3 SHAPING MEMBRANES . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 67 6.4 RED BLOOD CELLS SHAPE
UP. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 7
BIOLOGICAL MEMBRANES * MODELS AND FASHION ............. 73 7.1 WHAT IS A
MODEL? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 73 7.2 BRIEF HISTORY OF MEMBRANE MODELS. . . . . . . . . . . .
. . . . . . . . . . . . 74 7.3 DO WE NEED A NEW MEMBRANE MODEL? . . . .
. . . . . . . . . . . . . . . . 76 7.4 THEORETICAL AND EXPERIMENTAL
MODEL SYSTEMS . . . . . . . . . . . . . . 78 PART II LIPIDS MAKE SENSE 8
LIPIDS IN BILAYERS * A STRESSFUL AND BUSY LIFE
............................................ 81 8.1 TRANS-BILAYER
STRUCTURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . 81 8.2 THE LATERAL PRESSURE PROFILE . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 83 8.3 HOW THICK ARE MEMBRANES? . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 85 8.4 LIVELY LIPIDS ON
THE MOVE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
86 9 THE MORE WE ARE TOGETHER .............................. 91 9.1
PHASE TRANSITIONS BETWEEN ORDER AND DISORDER . . . . . . . . . . . . .
91 9.2 LIPIDS HAVE PHASE TRANSITIONS . . . . . . . . . . . . . . . . . .
. . . . . . . . . 94 9.3 MIXING DIFFERENT LIPIDS. . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 98 9.4 CHOLESTEROL BRINGS
LIPIDS TO ORDER . . . . . . . . . . . . . . . . . . . . . . . . 100 10
LIPIDS IN FLATLAND ......................................... 105 10.1
GASES, LIQUIDS, AND SOLIDS IN TWO DIMENSIONS. . . . . . . . . . . . . .
105 10.2 LANGMUIR AND LANGMUIR-BLODGETT FILMS . . . . . . . . . . . . .
. . . . . . 107 10.3 PATTERN FORMATION IN LIPID MONOLAYERS . . . . . . .
. . . . . . . . . . . . 110 10.4 LIPIDS MAKE THE LUNG WORK . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 112 11 SOCIAL LIPIDS
.............................................. 117 11.1 LATERAL MEMBRANE
STRUCTURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
11.2 IMAGING LIPID DOMAINS . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 121 11.3 LIPID RAFTING . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 124 11.4 DOMAINS
AND RAFTS CARRY FUNCTION . . . . . . . . . . . . . . . . . . . . . . .
127 CONTENTS XI 12 LIVELY LIPIDS PROVIDE FOR FUNCTION
........................ 129 12.1 LEAKY AND THIRSTY MEMBRANES . . . . .
. . . . . . . . . . . . . . . . . . . . . . 129 12.2 REPELLING MEMBRANES
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
131 12.3 ENZYMES CAN SENSE MEMBRANE TRANSITIONS . . . . . . . . . . . .
. . . . 133 12.4 LIPID THERMOMETER IN LIZARDS . . . . . . . . . . . . .
. . . . . . . . . . . . . . 135 13 PROTEINS AT LIPID MATTRESSES
.............................. 137 13.1 COMING TO TERMS WITH LIPIDS . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 137 13.2 ANCHORING
AT MEMBRANES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 139 13.3 SPANNING THE MEMBRANE. . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 142 PART III LIPIDS IN ACTION 14 CHOLESTEROL
ON THE SCENE ................................. 149 14.1 MOLECULE OF THE
CENTURY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 149 14.2 EVOLUTIONARY PERFECTION OF A SMALL MOLECULE . . . . . . . . .
. . . . . . 150 14.3 CHOLESTEROL FIT FOR LIFE . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 152 14.4 CHOLESTEROL AS A
KILLER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 156 15 LIPIDS IN CHARGE .......................................... 159
15.1 LIPIDS AND PROTEINS MATCH UP . . . . . . . . . . . . . . . . . . .
. . . . . . . . 159 15.2 STRESSING PROTEINS TO FUNCTION . . . . . . . .
. . . . . . . . . . . . . . . . . . . 165 15.3 LIPIDS OPENING CHANNELS .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169 15.4
LIPIDS MEDIATE FUSION. . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 170 16 BEING SMART * A FISHY MATTER OF FAT
..................... 173 16.1 THE ESSENTIAL FATTY ACIDS . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 173 16.2 EVOLUTION OF THE
HUMAN BRAIN . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
16.3 LIPIDS AT THE BORDER OF MADNESS . . . . . . . . . . . . . . . . . .
. . . . . . . . 177 17 LIQUOR AND DRUGS * AS A MATTER OF FAT
................... 181 17.1 LIPIDS ARE TARGETS FOR DRUGS . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 181 17.2 ALCOHOL AND
ANESTHESIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 182 17.3 POKING HOLES IN MEMBRANES. . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 184 17.4 GRAMICIDIN * THE PORTABLE HOLE . . .
. . . . . . . . . . . . . . . . . . . . . . . 186 18 LIPID EATERS
.............................................. 189 18.1 ENZYMES THAT
BREAK DOWN LIPIDS IN CROWDS . . . . . . . . . . . . . . 189 18.2
WATCHING ENZYMES AT WORK . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 192 18.3 LIPIDS GOING RANCID . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . 193 XII CONTENTS 19 POWERFUL AND
STRANGE LIPIDS AT WORK ..................... 197 19.1 THE IMPERMEABLE
BARRIER * LIPIDS IN THE SKIN . . . . . . . . . . . . . . 197 19.2
SURVIVING AT DEEP SEA AND IN HOT SPRINGS . . . . . . . . . . . . . . . .
. 200 19.3 LIPIDS AS MESSENGERS . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 203 19.4 LIPIDS AS A MATTER OF DEATH . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 205 20 SURVIVAL BY
LIPIDS ........................................ 209 20.1 LIPIDS FOR
SMART NANOTECHNOLOGY . . . . . . . . . . . . . . . . . . . . . . . . .
209 20.2 LIPIDS DELIVER DRUGS . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 214 20.3 LIPOSOMES AS MAGIC BULLETS . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 216 20.4 LIPIDS
FIGHTING CANCER . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . 219 EPILOGUE: FAT FOR FUTURE
...................................... 225 BIBLIOGRAPHY
.................................................. 227 SOURCES FOR
FIGURES ........................................... 249 INDEX
......................................................... 255
|
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| isbn | 3540232486 9783540232483 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012957834 |
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| spelling | Mouritsen, Ole G. 1950- Verfasser (DE-588)110651057 aut Life - as a matter of fat the emerging science of lipidomics Ole G. Mouritsen Berlin [u. a.] Springer 2005 XII, 276 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The frontiers collection Lipide Fatty acids Lipid membranes Lipides Lipids Lipids Metabolism Lipids Physiological effect Physikalisch-chemische Eigenschaft (DE-588)4369521-8 gnd rswk-swf Lipide (DE-588)4035873-2 gnd rswk-swf Lipide (DE-588)4035873-2 s Physikalisch-chemische Eigenschaft (DE-588)4369521-8 s DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012957834&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mouritsen, Ole G. 1950- Life - as a matter of fat the emerging science of lipidomics Lipide Fatty acids Lipid membranes Lipides Lipids Lipids Metabolism Lipids Physiological effect Physikalisch-chemische Eigenschaft (DE-588)4369521-8 gnd Lipide (DE-588)4035873-2 gnd |
| subject_GND | (DE-588)4369521-8 (DE-588)4035873-2 |
| title | Life - as a matter of fat the emerging science of lipidomics |
| title_auth | Life - as a matter of fat the emerging science of lipidomics |
| title_exact_search | Life - as a matter of fat the emerging science of lipidomics |
| title_full | Life - as a matter of fat the emerging science of lipidomics Ole G. Mouritsen |
| title_fullStr | Life - as a matter of fat the emerging science of lipidomics Ole G. Mouritsen |
| title_full_unstemmed | Life - as a matter of fat the emerging science of lipidomics Ole G. Mouritsen |
| title_short | Life - as a matter of fat |
| title_sort | life as a matter of fat the emerging science of lipidomics |
| title_sub | the emerging science of lipidomics |
| topic | Lipide Fatty acids Lipid membranes Lipides Lipids Lipids Metabolism Lipids Physiological effect Physikalisch-chemische Eigenschaft (DE-588)4369521-8 gnd Lipide (DE-588)4035873-2 gnd |
| topic_facet | Lipide Fatty acids Lipid membranes Lipides Lipids Lipids Metabolism Lipids Physiological effect Physikalisch-chemische Eigenschaft |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012957834&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mouritsenoleg lifeasamatteroffattheemergingscienceoflipidomics |