Cells, aging, and human disease:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Oxford Univ. Press
2004
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIII, 489 S. |
| ISBN: | 0195140354 |
Internformat
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV019398235 | ||
| 003 | DE-604 | ||
| 005 | 20041013 | ||
| 007 | t | ||
| 008 | 040922s2004 xxu |||| 00||| eng d | ||
| 010 | |a 2003060938 | ||
| 020 | |a 0195140354 |9 0-19-514035-4 | ||
| 035 | |a (OCoLC)636253778 | ||
| 035 | |a (DE-599)BVBBV019398235 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 044 | |a xxu |c US | ||
| 049 | |a DE-12 | ||
| 050 | 0 | |a QP86 | |
| 082 | 0 | |a 612.6/7 | |
| 100 | 1 | |a Fossel, Michael |d 1950- |e Verfasser |0 (DE-588)12045811X |4 aut | |
| 245 | 1 | 0 | |a Cells, aging, and human disease |c Michael B. Fossel |
| 264 | 1 | |a New York [u.a.] |b Oxford Univ. Press |c 2004 | |
| 300 | |a XIII, 489 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Aging | |
| 650 | 4 | |a Cells |x Aging | |
| 650 | 0 | 7 | |a Alterskrankheit |0 (DE-588)4132293-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Altern |0 (DE-588)4068596-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Altern |0 (DE-588)4068596-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Alterskrankheit |0 (DE-588)4132293-9 |D s |
| 689 | 1 | |C b |5 DE-604 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012860619&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-012860619 | ||
Datensatz im Suchindex
| _version_ | 1804132850711134208 |
|---|---|
| adam_text | Contents
Part I The Aging Cell
1. The Context, 3
2. Cell Senescence, 16
Telomeres, Telomerase, and Cell Senescence, 16
The History of Cell Senescence, 24
Telomerase and Its Function, 28
Is Telomerase Good for Anything?, 33
3. Cell Senescence in Aging, 38
What Is Cell Senescence?, 38
The Limited Model: Cells Senesce, 45
The General Model: Cell Senescence Results in Organismal Aging, 56
FERTILIZATION RESETS TELOMERE EFFECTS, 59
CRITICISM GONE AWRY, 61
CELLS TO ORGANISMS, 63
4. The Aging Cascade, 66
The Jigsaw Puzzle of Aging, 66
Upstream from Cell Division, 71
Cell Turnover and Gene Expression, 71
Between Cells: Cells, Tissues, and Pathology, 73
5. Cancer, 75
Cancer in Its Cellular Context, 75
Cancer and Cell Senescence, 76
xii CONTENTS
Diagnosis, 79
DERMAL CANCER, 82
HEMATOPOETIC CANCER, 83
PULMONARY CANCER, 85
BREAST CANCER, 87
MALE GENITAL CANCER, 90
FEMALE GENITAL CANCER, 92
RENAL AND URINARY TRACT CANCER, 97
GASTROINTESTINAL CANCER, 99
CENTRAL NERVOUS SYSTEM CANCER, 104
OTHER CANCER, 107
Prognosis, 108
Therapy, 110
6. Parasitic Disease, 122
Pathology and Incidence, 122
Cell Senescence and Intervention, 124
Part II The Aging Organism
7. The Progerias, 129
What They Are, 129
Werner Syndrome, 130
Hutchinson Gilford Syndrome, 133
8. The Skin, 140
Structure and Overview, 140
Aging and Other Pathology, 143
The Role of Cell Senescence, 147
Intervention, 157
9. Cardiovascular System, 161
Structure and Overview, 161
Aging and Other Pathology, 162
The Role of Cell Senescence, 168
Intervention, 173
10. Orthopedic Systems, 179
Structure and Overview, 179
Aging and Other Pathology, 181
The Role of Cell Senescence, 184
Intervention, 187
11. Hematopoetic and Immune Systems, 191
Structure and Overview, 191
Aging and Other Pathology, 192
The Role of Cell Senescence, 195
REGULATION OF TELOMERASE EXPRESSION, 200
CONTENTS
CELL SENESCENCE IN OTHER HEMATOLOGIC DISEASE STATES, 202
Intervention, 205
12. Endocrine Systems, 208
Structure and Overview, 208
Aging and Other Pathology, 211
The Role of Cell Senescence, 217
Intervention, 220
13. Nervous System, 224
Structure and Overview, 224
Aging and Other Pathology, 227
The Role of Cell Senescence, 234
Intervention, 238
14. Kidneys, 245
Structure and Overview, 245
Aging and Other Pathology, 248
The Role of Cell Senescence, 249
Intervention, 250
15. Muscle, 252
Structure and Overview, 252
Aging and Other Pathology, 253
The Role of Cell Senescence, 256
Intervention, 258
16. Gastrointestinal System, 261
Structure and Overview, 261
Aging and Other Pathology, 263
The Role of Cell Senescence, 267
Intervention, 270
17. The Eye, 271
Structure and Overview, 271
Aging and Other Pathology, 273
The Role of Cell Senescence, 277
Intervention, 280
18. Towards Therapy, 283
Interventions, 283
TECHNIQUES, 284
CAVEATS, 288
OBSTACLES, 288
Implications, 289
References, 291
Index, 469
|
| any_adam_object | 1 |
| author | Fossel, Michael 1950- |
| author_GND | (DE-588)12045811X |
| author_facet | Fossel, Michael 1950- |
| author_role | aut |
| author_sort | Fossel, Michael 1950- |
| author_variant | m f mf |
| building | Verbundindex |
| bvnumber | BV019398235 |
| callnumber-first | Q - Science |
| callnumber-label | QP86 |
| callnumber-raw | QP86 |
| callnumber-search | QP86 |
| callnumber-sort | QP 286 |
| callnumber-subject | QP - Physiology |
| ctrlnum | (OCoLC)636253778 (DE-599)BVBBV019398235 |
| dewey-full | 612.6/7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.6/7 |
| dewey-search | 612.6/7 |
| dewey-sort | 3612.6 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01452nam a2200421zc 4500</leader><controlfield tag="001">BV019398235</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20041013 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">040922s2004 xxu |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2003060938</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0195140354</subfield><subfield code="9">0-19-514035-4</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)636253778</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV019398235</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">xxu</subfield><subfield code="c">US</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP86</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612.6/7</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Fossel, Michael</subfield><subfield code="d">1950-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)12045811X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cells, aging, and human disease</subfield><subfield code="c">Michael B. Fossel</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York [u.a.]</subfield><subfield code="b">Oxford Univ. Press</subfield><subfield code="c">2004</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIII, 489 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aging</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cells</subfield><subfield code="x">Aging</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Alterskrankheit</subfield><subfield code="0">(DE-588)4132293-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Altern</subfield><subfield code="0">(DE-588)4068596-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Altern</subfield><subfield code="0">(DE-588)4068596-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Alterskrankheit</subfield><subfield code="0">(DE-588)4132293-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012860619&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-012860619</subfield></datafield></record></collection> |
| id | DE-604.BV019398235 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T19:59:23Z |
| institution | BVB |
| isbn | 0195140354 |
| language | English |
| lccn | 2003060938 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012860619 |
| oclc_num | 636253778 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XIII, 489 S. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | Fossel, Michael 1950- Verfasser (DE-588)12045811X aut Cells, aging, and human disease Michael B. Fossel New York [u.a.] Oxford Univ. Press 2004 XIII, 489 S. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Aging Cells Aging Alterskrankheit (DE-588)4132293-9 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf Altern (DE-588)4068596-2 s DE-604 Alterskrankheit (DE-588)4132293-9 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012860619&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fossel, Michael 1950- Cells, aging, and human disease Aging Cells Aging Alterskrankheit (DE-588)4132293-9 gnd Altern (DE-588)4068596-2 gnd |
| subject_GND | (DE-588)4132293-9 (DE-588)4068596-2 |
| title | Cells, aging, and human disease |
| title_auth | Cells, aging, and human disease |
| title_exact_search | Cells, aging, and human disease |
| title_full | Cells, aging, and human disease Michael B. Fossel |
| title_fullStr | Cells, aging, and human disease Michael B. Fossel |
| title_full_unstemmed | Cells, aging, and human disease Michael B. Fossel |
| title_short | Cells, aging, and human disease |
| title_sort | cells aging and human disease |
| topic | Aging Cells Aging Alterskrankheit (DE-588)4132293-9 gnd Altern (DE-588)4068596-2 gnd |
| topic_facet | Aging Cells Aging Alterskrankheit Altern |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012860619&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT fosselmichael cellsagingandhumandisease |