Recent advances in epilepsy research:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Kluwer Acad. / Plenum Publ. [u.a.]
2004
|
| Schriftenreihe: | Advances in experimental medicine and biology
548 |
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XVII, 253 S. Ill., graph. Darst. |
| ISBN: | 0306478609 |
Internformat
MARC
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| 245 | 1 | 0 | |a Recent advances in epilepsy research |c ed. by Devin K. Binder ... |
| 264 | 1 | |a New York [u.a.] |b Kluwer Acad. / Plenum Publ. [u.a.] |c 2004 | |
| 300 | |a XVII, 253 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in experimental medicine and biology |v 548 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Maladies neuromusculaires - Recherche | |
| 650 | 4 | |a Épilepsie - Aspect génétique | |
| 650 | 4 | |a Épilepsie - Physiopathologie | |
| 650 | 4 | |a Épilepsie - Recherche | |
| 650 | 4 | |a Epilepsy |x Genetic aspects | |
| 650 | 4 | |a Epilepsy |x Research | |
| 650 | 4 | |a Epilepsy |x genetics | |
| 650 | 4 | |a Epilepsy |x physiopathology | |
| 650 | 4 | |a Neuromuscular diseases |x Research | |
| 650 | 0 | 7 | |a Pathophysiologie |0 (DE-588)4044898-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Neurochemie |0 (DE-588)4041872-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Epilepsie |0 (DE-588)4015035-5 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
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| 689 | 0 | 1 | |a Pathophysiologie |0 (DE-588)4044898-8 |D s |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-012813107 | ||
Datensatz im Suchindex
| _version_ | 1804132777515286528 |
|---|---|
| adam_text | CONTENTS
1. GENETIC APPROACHES TO STUDYING MOUSE MODELS
OF HUMAN SEIZURE DISORDERS 1
Yan Yang and Wayne N. Frankel
Introduction 1
The Knock In Technique 2
Choosing a Target 2
Phenotypic Characterization of Epileptic Mutant Mice 3
Genetic Background on Seizure Phenotyping 6
Summary 8
2. INTEGRINS, SYNAPTIC PLASTICITY
AND EPILEPTOGENESIS 12
Christine M. Gall and Gary Lynch
Abstract 12
Introduction 12
Integrins: Cell Matrix and Cell Cell Adhesion Receptors 13
Integrin Expression in the Adult CNS 15
Adhesion Proteins Contribute to the Consolidation of Long Term Potentiation 17
Seizures Activate Changes in Adhesion Chemistries: Evidence for Turnover
in Adhesive Contacts 21
Significance of Seizure Induced Proteolysis and Adhesion Protein Expression
to Epileptogenesis 24
Concluding Comments 26
3. THE ROLE OF BDNF IN EPILEPSY AND OTHER DISEASES
OF THE MATURE NERVOUS SYSTEM 34
Devin K. Binder
Abstract 34
BDNF: Introduction 34
BDNF Structure 34
BDNF Signaling 35
Localization, Transport and Release of BDNF 35
BDNF Effects in Development 36
BDNF Gene Regulation 36
xiii
xiv Contents
BDNF, Synaptic Plasticity, and Learning 37
BDNF and Disease 37
BDNF and Epilepsy 37
Effects of Inhibition of BDNF/trkB in Seizure Models 38
Activation of trk Receptors after Seizures 42
BDNF Induced Hyperexcitability of the Mossy Fiber CA3 Synapse 44
Cellular Model of BDNF trkB Interaction 45
Other Effects of BDNF 46
BDNF and Human Epilepsy 46
BDNF and Other Diseases of the Adult Nervous System 47
Summary 48
4. VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)
IN SEIZURES: A DOUBLE EDGED SWORD 57
Susan D. Croll, Jeffrey H. Goodman and Helen E. Scharfman
Abstract 57
Introduction 57
Vascular Endothelial Growth Factor (VEGF) 58
VEGF Regulation after Seizures 60
VEGF As a Neurotrophic Factor 62
Potential Effects of VEGF on Seizures and Their Sequelae 62
5. PLASTICITY MECHANISMS UNDERLYING mGLUR INDUCED
EPILEPTOGENESIS 69
Robert K.S. Wong, Shih Chieh Chuang and Riccardo Bianchi
Abstract 69
Introduction 69
Cellular Mechanisms for Group I mGluR Induced Excitation
in Hippocampal Neurons 70
Role of ImCluR(v) in the Neuronal Activities of Single Pyramidal Cells 70
Role of ImClu in the Generation of Network Activity 71
Plasticity Mechanisms Underlying Group I mGluR Induced Network
Burst Discharges 73
Conclusion 74
6. ROLE OF THE GABA TRANSPORTER IN EPILEPSY 76
George B. Richerson and Yuanming Wu
Abstract 76
Introduction 76
Diversity of GABA Transporters 76
Role of the GABA Transporter in GABA Reuptake 77
Reversal of the GABA Transporter 77
Functional Significance of GABA Transporter Reversal 79
The GABA Transporter As a Target of Anticonvulsants 83
Contribution of the GABA Transporter to Tonic GABAergic Inhibition 84
Role of GABA Transporters in Epilepsy 87
Contents xv
7. GABA AND ITS RECEPTORS IN EPILEPSY 92
Giinther Sperk, Sabine Furtinger, Christoph Schwarzer and Susanne Pirker
Abstract 92
Changes in the Function of GABA Neurons 93
Enhanced Expression of GABA in Dentate Granule Cells 94
Altered Expression of GABAA Receptor and Its Subunits in TLE 95
GABAB Receptors 98
8. ROLE OF THE DEPOLARIZING GABA RESPONSE
IN EPILEPSY 104
Kevin J. Staley
9. GAP JUNCTIONS, FAST OSCILLATIONS AND THE
INITIATION OF SEIZURES 110
Roger D. Traub, Hillary Michelson Law, Andrea E.J. Bibbig, Eberhard H. Buhl
and Miles A. Whittington
In Vitro Population Activities Paroxysmal to Greater or Lesser Extent
Which Depend on Gap Junctions 110
What Is the Evidence That Principal Cell Gap Junctions Exist? 116
How Do Axonal Gap Junctions Lead to Very Fast Oscillations? 116
Gap Junctions and Epileptogenesis in Vivo 117
Summary and Unifying Hypotheses 117
10. FUNCTIONAL ROLE OF PROINFLAMMATORY AND
ANTI INFLAMMATORY CYTOKINES IN SEIZURES 123
Annamaria Vezzani, Daniela Moneta, Cristina Richichi, Carlo Perego
and Maria G. De Simoni
Abstract 123
Introduction 123
Cytokine Induction by Seizures 124
Pharmacological Effects: The Focus on IL 1 127
Proinflammatory Cytokines and Nerve Cell Injury 129
Human Epileptic Tissue 130
Mechanism of Action 130
11. USING THE IMMUNE SYSTEM TO TARGET EPILEPSY 134
Deborah Young and Matthew J. During
Introduction 134
Using the Immune System to Treat Neurological Disease—The Relationship
between the Brain and the Immune System 134
Using the Immune System to Treat Neurological Disease—Therapeutic
Agents for Neurological Disease 136
xvi Contents
Developing a Vaccine Strategy for Epilepsy 136
A Novel Genetic Vaccine for Stroke and Epilepsy 137
Concluding Remarks 141
12. CORTICAL DYSPLASIA AND EPILEPSY: ANIMAL MODELS 145
Philip A. Schwartzkroin, Steven N. Roper and H. Jurgen Wenzel
Abstract 145
What Is Cortical Dysplasia? 145
What Are the Processes that Lead to Dysplasia? 149
What Makes a Dysplastic Brain (or Brain Region) Epileptic? 154
Seizure Variability in Dysplastic Brain—What Makes a Given Dysplastic
Lesion Epileptogenic? 161
What Do Animal Models of Cortical Dysplasia Tell Us
about Human Epilepsies? 163
Concluding Comments 168
13. MALFORMATIONS OF CORTICAL DEVELOPMENT:
MOLECULAR PATHOGENESIS AND EXPERIMENTAL
STRATEGIES 175
Peter B. Crino
Abstract 175
Introduction 175
Important Clinical Issues in Patients with MCD 176
Developmental Contextual Background for MCD 176
Molecular Neurobiology of MCD 178
Epileptogenesis and MCD: How Does Cortical Maldevelopment Lead
to Epilepsy? 183
Experimental Strategies for Studying Epilepsy in MCD 185
Conclusions 187
Summary and New Directions: Targeted Therapy for Epilepsy in MCD 187
14. FUNCTIONAL IMPLICATIONS OF SEIZURE INDUCED
NEUROGENESIS 192
Helen E. Scharfman
Abstract 192
Introduction 192
Proving That Granule Like Cells in the Hilus after Seizures Were Newly Born
Granule Cells 194
Do All the New Granule Neurons Become Functional? Do They Behave
the Same? 198
Is Increased Neurogenesis Beneficial, or Might It Actually Increase
Seizure Susceptibility? 200
How Do the New Cells Interact with the Host Brain? 204
Is Neurogenesis Increased after Seizures in Man? 207
Summary 207
Contents xvjj
15. FEBRILE SEIZURES AND MECHANISMS
OF EPILEPTOGENESIS: INSIGHTS FROM
AN ANIMAL MODEL 213
Roland A. Bender, Celine Dube and Tallie Z. Baram
Abstract 213
Introduction: The Human Problem 213
The Optimal Animal Model 214
The Immature Rat Model 217
Do Prolonged Experimental Febrile Seizures Increase Seizure Susceptibility? 219
Do Prolonged Experimental Febrile Seizures Cause Neuronal Death
and/or Synaptic Reorganization? 220
Do Prolonged Experimental Febrile Seizures Alter the Rate of Granule
Cell Neurogenesis? 220
Molecular Plasticity after Experimental Prolonged Febrile Seizures 221
Summary 221
16. THE TETANUS TOXIN MODEL OF CHRONIC EPILEPSY 226
Timothy A. Benke and John Swann
Introduction 226
Mechanisms of Tetanus Toxin 226
Experimental Implementation 230
Chronic Epilepsy in Adult Animals 230
Chronic Epilepsy in Young Animals 233
Comparisons to Other Models of Chronic Epilepsy 235
17. BRAIN STIMULATION AS A THERAPY FOR EPILEPSY 239
Jeffrey H. Goodman 239
Abstract 239
Introduction 239
Vagus Nerve Stimulation 240
DBS As a Therapy for Epilepsy 241
Activation of Seizure Gating Networks—Animal Studies 241
Activation of Seizure Gating Networks—Clinical Studies 242
Focal Stimulation 242
Selection of Stimulation Parameters 242
Safety 243
The Future Is Now: Seizure Prediction Combined with Pre Emptive
Stimulation 243
Conclusion 244
INDEX 249
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| indexdate | 2024-07-09T19:58:13Z |
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| isbn | 0306478609 |
| language | English |
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| physical | XVII, 253 S. Ill., graph. Darst. |
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| spelling | Recent advances in epilepsy research ed. by Devin K. Binder ... New York [u.a.] Kluwer Acad. / Plenum Publ. [u.a.] 2004 XVII, 253 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 548 Includes bibliographical references and index Maladies neuromusculaires - Recherche Épilepsie - Aspect génétique Épilepsie - Physiopathologie Épilepsie - Recherche Epilepsy Genetic aspects Epilepsy Research Epilepsy genetics Epilepsy physiopathology Neuromuscular diseases Research Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Neurochemie (DE-588)4041872-8 gnd rswk-swf Epilepsie (DE-588)4015035-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Epilepsie (DE-588)4015035-5 s Pathophysiologie (DE-588)4044898-8 s DE-604 Neurochemie (DE-588)4041872-8 s b DE-604 Binder, Devin K. Sonstige oth Advances in experimental medicine and biology 548 (DE-604)BV000003102 548 http://www.loc.gov/catdir/toc/ecip0410/2003022445.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012813107&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Recent advances in epilepsy research Advances in experimental medicine and biology Maladies neuromusculaires - Recherche Épilepsie - Aspect génétique Épilepsie - Physiopathologie Épilepsie - Recherche Epilepsy Genetic aspects Epilepsy Research Epilepsy genetics Epilepsy physiopathology Neuromuscular diseases Research Pathophysiologie (DE-588)4044898-8 gnd Neurochemie (DE-588)4041872-8 gnd Epilepsie (DE-588)4015035-5 gnd |
| subject_GND | (DE-588)4044898-8 (DE-588)4041872-8 (DE-588)4015035-5 (DE-588)4143413-4 |
| title | Recent advances in epilepsy research |
| title_auth | Recent advances in epilepsy research |
| title_exact_search | Recent advances in epilepsy research |
| title_full | Recent advances in epilepsy research ed. by Devin K. Binder ... |
| title_fullStr | Recent advances in epilepsy research ed. by Devin K. Binder ... |
| title_full_unstemmed | Recent advances in epilepsy research ed. by Devin K. Binder ... |
| title_short | Recent advances in epilepsy research |
| title_sort | recent advances in epilepsy research |
| topic | Maladies neuromusculaires - Recherche Épilepsie - Aspect génétique Épilepsie - Physiopathologie Épilepsie - Recherche Epilepsy Genetic aspects Epilepsy Research Epilepsy genetics Epilepsy physiopathology Neuromuscular diseases Research Pathophysiologie (DE-588)4044898-8 gnd Neurochemie (DE-588)4041872-8 gnd Epilepsie (DE-588)4015035-5 gnd |
| topic_facet | Maladies neuromusculaires - Recherche Épilepsie - Aspect génétique Épilepsie - Physiopathologie Épilepsie - Recherche Epilepsy Genetic aspects Epilepsy Research Epilepsy genetics Epilepsy physiopathology Neuromuscular diseases Research Pathophysiologie Neurochemie Epilepsie Aufsatzsammlung |
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