Genomics, proteomics and vaccines:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2004
|
| Ausgabe: | Reprint. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 313 S. Ill., graph. Darst. |
| ISBN: | 0470856165 |
Internformat
MARC
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| 245 | 1 | 0 | |a Genomics, proteomics and vaccines |c Ed.: Guido Grandi |
| 250 | |a Reprint. | ||
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 2004 | |
| 300 | |a XXI, 313 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Genómica | |
| 650 | 4 | |a Proteómica | |
| 650 | 4 | |a Vacunas - Biotecnología | |
| 650 | 4 | |a Genomics | |
| 650 | 4 | |a Genomics |x methods | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Proteomics |x methods | |
| 650 | 4 | |a Vaccines |x Biotechnology | |
| 650 | 4 | |a Vaccines |x chemical synthesis | |
| 650 | 0 | 7 | |a Impfstoff |0 (DE-588)4026655-2 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804132775257702400 |
|---|---|
| adam_text | Contents
Preface xi
List of contributors xix
PART 1: INTRODUCTION
1 Vaccination: Past, Present and Future 3
Maria Lattanzi and Rino Rappuoli
1.1 Introduction 3
1.2 Vaccination: the past 4
1.3 Vaccination: the present 6
1.4 Vaccination: the future 12
1.5 Conclusion: the intangible value of vaccination 14
References 15
2 Bioinformatics, DNA Microarrays and Proteomics in Vaccine
Discovery: Competing or Complementary Technologies? 23
Guido Grandi
2.1 Introduction 23
2.2 From genome sequence to vaccine discovery 25
2.3 A case study: the anti meningococcus B vaccine 28
2.4 Comparison of the three approaches 34
2.5 Conclusions: a nomics approach to vaccine discovery 37
References 40
Genomics, Proteomics and Vaccines edited by Guido Grandi
© 2004 John Wiley Sons, Ltd ISBN 0 470 85616 5
vi CONTENTS
PART 2: TECHNOLOGIES
3 Genome Sequencing and Analysis 45
Herve Tettelin and Tamara Feldblyum
3.1 Introduction 45
3.2 Genome sequencing 46
3.3 Genome analysis 60
3.4 Conclusion 65
References 65
4 Understanding DNA Microarrays: Sources and Magnitudes
of Variances in DNA Microarray Data Sets 75
She pin Hung, Suman Sundaresh, Pierre F. Baldi and
G Wesley Hatfield
4.1 Introduction 75
4.2 DNA array formats 76
4.3 Data analysis methods 79
4.4 Sources and magnitudes of noise in DNA microarray experiments 84
4.5 Conclusions 97
Acknowledgements 100
References 100
5 The Proteome, Anno Domini Two Zero Zero Three 103
Pier Giorgio Righetti, Mahmoud Hamdan, Frederic Reymond
and Joel S. Rossier
5.1 Introduction 103
5.2 Some definitions 105
5.3 What methods exist to tackle the proteome complexity? 107
5.4 Quantitative proteomics 112
5.5 Pre fractionation in proteome analysis 117
5.6 Multi dimensional chromatography 120
5.7 Protein chip arrays 123
5.8 Imaging mass spectrometry 126
Acknowledgements 127
References 127
CONTENTS vii
6 Mass Spectrometry in Proteomics 135
Pierre Alain Binz
6.1 Introduction 135
6.2 MS technology 136
6.3 Principle of protein identification based on MS data 147
6.4 Proteomics workflows 155
References 155
7 High Throughput Cloning, Expression and Purification
Technologies 171
Andreas Kreusch and Scott A. Lesley
7.1 Introduction 171
7.2 Gene cloning 172
7.3 Protein expression 174
7.4 High throughput protein purification 175
7.5 Validation of the pipeline and outlook 178
7.6 Conclusion 179
References 180
PART 3: APPLICATIONS
8 Meningococcus B: from Genome to Vaccine 185
Davide Serruto, Rino Rappuoli and Mariagrazia Pizza
8.1 Meningococcus, a major cause of bacterial meningitis 185
8.2 Group B meningococcus as an example of reverse vaccinology 190
8.3 Conclusions 200
References 201
9 Vaccines Against Pathogenic Streptococci 205
John L. Telford, Immaculada Margarit y Ros, Domenico Maione,
Vega Masignani, Herve Tettelin, Giuliano Bensi and Guido Grandi
9.1 Introduction 205
9.2 Comparative genomics of streptococci 206
9.3 A vaccine against group B streptococcus 208
9.4 A vaccine against group A streptococcus 215
9.5 Conclusions 218
References 219
viii CONTENTS
10 Identification of the Antigenome a Novel Tool for Design
and Development of Subunit Vaccines Against Bacterial
Pathogens 223
Eszter Nagy, Tamds Henics, Alexander von Gabain
and Andreas Meinke
10.1 Introduction 223
10.2 Small DNA insert libraries a tool to cover a pathogen s antigenome 227
10.3 Proper display platforms 230
10.4 Selected human sera to provide imprints of pathogen encounters 231
10.5 Cognate antibodies reveal the antigenome of a pathogen 234
10.6 How to retrieve from the antigenome the candidate antigens for vaccine
development 235
10.7 Summary and discussion 237
References 239
11 Searching the Chlamydia Genomes for New Vaccine
Candidates 245
Giulio Ratti, Oretta Finco and Guido Grandi
11.1 Old problems and new perspectives for chlamydial vaccines 245
11.2 Post genomic approaches 250
11.3 Genomic screening results 251
11.4 Concluding considerations 262
References 263
12 Proteomics and Anti Chlamydia Vaccine Discovery 267
Gunna Christiansen, Svend Birkelund, Brian B. Vandahl
and Allan C Shaw
12.1 Introduction 267
12.2 Proteome analysis 269
12.3 Proteomics as a complement for genomics 277
12.4 Benefits that proteomics provide for vaccine development 279
References 280
13 Proteome Analysis of Outer Membrane and Extracellular
Proteins from Pseudomonas aeruginosa for Vaccine Discovery 285
Stuart J. Cordwell and Amanda S. Nouwens
13.1 Introduction 285
CONTENTS ix
13.2 Membrane proteins in P. aeruginosa 286
13.3 Extracellular proteins in P. aeruginosa 292
13.4 Immunogenic proteins and vaccine discovery 296
13.5 Conclusions 298
References 299
Index 305
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:58:11Z |
| institution | BVB |
| isbn | 0470856165 |
| language | English |
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| spelling | Genomics, proteomics and vaccines Ed.: Guido Grandi Reprint. Chichester [u.a.] Wiley 2004 XXI, 313 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genómica Proteómica Vacunas - Biotecnología Genomics Genomics methods Proteomics Proteomics methods Vaccines Biotechnology Vaccines chemical synthesis Impfstoff (DE-588)4026655-2 gnd rswk-swf Proteomanalyse (DE-588)4596545-6 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Impfstoff (DE-588)4026655-2 s Genanalyse (DE-588)4200230-8 s Proteomanalyse (DE-588)4596545-6 s DE-604 Grandi, Guido Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012811661&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genomics, proteomics and vaccines Genómica Proteómica Vacunas - Biotecnología Genomics Genomics methods Proteomics Proteomics methods Vaccines Biotechnology Vaccines chemical synthesis Impfstoff (DE-588)4026655-2 gnd Proteomanalyse (DE-588)4596545-6 gnd Genanalyse (DE-588)4200230-8 gnd |
| subject_GND | (DE-588)4026655-2 (DE-588)4596545-6 (DE-588)4200230-8 |
| title | Genomics, proteomics and vaccines |
| title_auth | Genomics, proteomics and vaccines |
| title_exact_search | Genomics, proteomics and vaccines |
| title_full | Genomics, proteomics and vaccines Ed.: Guido Grandi |
| title_fullStr | Genomics, proteomics and vaccines Ed.: Guido Grandi |
| title_full_unstemmed | Genomics, proteomics and vaccines Ed.: Guido Grandi |
| title_short | Genomics, proteomics and vaccines |
| title_sort | genomics proteomics and vaccines |
| topic | Genómica Proteómica Vacunas - Biotecnología Genomics Genomics methods Proteomics Proteomics methods Vaccines Biotechnology Vaccines chemical synthesis Impfstoff (DE-588)4026655-2 gnd Proteomanalyse (DE-588)4596545-6 gnd Genanalyse (DE-588)4200230-8 gnd |
| topic_facet | Genómica Proteómica Vacunas - Biotecnología Genomics Genomics methods Proteomics Proteomics methods Vaccines Biotechnology Vaccines chemical synthesis Impfstoff Proteomanalyse Genanalyse |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012811661&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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