Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [.u.a.]
Lippincott Williams & Wilkins
2004
|
| Ausgabe: | 11. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 991 S. Ill. |
| ISBN: | 0781734819 |
Internformat
MARC
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| 245 | 1 | 0 | |a Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry |c ed. by John H. Block ... |
| 246 | 1 | 3 | |a Organic medicinal and pharmaceutical chemistry |
| 246 | 1 | 3 | |a Textbook of organic medicinal and pharmaceutical chemistry |
| 250 | |a 11. ed. | ||
| 264 | 1 | |a Philadelphia [.u.a.] |b Lippincott Williams & Wilkins |c 2004 | |
| 300 | |a XIV, 991 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Chemistry, Organic | |
| 650 | 4 | |a Chemistry, Pharmaceutical | |
| 650 | 4 | |a Pharmaceutical chemistry | |
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| 700 | 1 | |a Block, John H. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804132766978146304 |
|---|---|
| adam_text | m mm
%m m
¦Bl CONTENTS
Preface vii
Contributors ix
CHAPTER 1
Introduction 1
John H. Block and John M. Beale, Jr.
CHAPTER 2
Physicochemical Properties in Relation to
Biological Action 3
John H. Block
Overview 3
Drug Distribution 3
Acid Base Properties 9
Statistical Prediction of Pharmacological Activity . . 17
Combinatorial Chemistry 26
Molecular Modeling (Computer Aided Drug
Design) 27
Selected Web Pages 41
CHAPTER 3
Combinatorial Chemistry 43
Douglas R. Henry
How It Began: Peptides and Other Linear
Structures 43
Drug Like Molecules 46
Supports and Linkers 48
Solution Phase Combinatorial Chemistry 49
Pooling Strategies 50
Detection, Purification, and Analysis 51
Encoding Combinatorial Libraries 52
High Throughput Screening (HTS) 53
Virtual (in Silico) Screening 54
Chemical Diversity and Library Design 55
Report Card on Combinatorial Chemistry: Has It
Worked? 58
Resources for Combinatorial Chemistry 60
Combinatorial Chemistry Terminology 60
CHAPTER 4
Metabolic Changes of Drugs and Related
Organic Compounds 65
Stephen J. Culler and John H. Block
General Pathways of Drug Metabolism 65
Sites of Drug Biotransformation 66
Role of Cytochrome P 450 Monooxygenases in
Oxidative Biotransformations 67
Oxidative Reactions 69
Reductive Reactions 103
Hydrolytic Reactions 109
Phase II or Conjugation Reactions 111
Factors Affecting Drug Metabolism 126
CHAPTER 5
Prodrugs and Drug Latentiation 142
Forrest T. Smith and C. Randall Clark
History 142
Basic Concepts 142
Prodrugs of Functional Groups 144
Bioprecursor Prodrugs 152
Chemical Delivery Systems 155
CHAPTER 6
Biotechnology and Drug Discovery 160
John M. Beak, Jr.
Biotechnology: An Overview 160
Biotechnology and Pharmaceutical Care 160
Literature of Biotechnology 160
Biotechnology and New Drug Development 160
The Biotechnology of Recombinant DNA (rDNA) . . 162
Some Types of Cloning 166
Expression of Cloned DNA 167
Manipulation of DNA Sequence Information .... 168
New Biological Targets for Drug Development ... 169
Novel Drug Screening Strategies 170
Processing of the Recombinant Protein 172
Pharmaceutics of Recombinant DNA (rDNA)
Produced Agents 173
Delivery and Pharmacokinetics of Biotechnology
Products 175
Recombinant Drug Products 175
The Interleukins 182
Enzymes 183
Vaccines 186
Preparation of Antibodies 187
Genomics 191
Antisense Technology 193
Gene Therapy 194
Afterword 194
CHAPTER 7
Immunobiologicals 197
John M. Beale, Jr.
Cells of the Immune System 197
Immunity 200
Acquisition of Immunity 206
XI
X/7 Contents
CHAPTER 8
Anti infective Agents 217
John M. Beale, Jr.
Evaluation of the Effectiveness of a Sterilant 219
Alcohols and Related Compounds 219
Phenols and Their Derivatives 221
Oxidizing Agents 223
Halogen Containing Compounds 223
Cationic Surfactants 224
Dyes 226
Mercury Compounds (Mercurials) 228
Preservatives 228
Antifungal Agents 230
Synthetic Antibacterial Agents 247
Antiprotozoal Agents 259
Anthelmintics 264
Antiscabious and Antipedicular Agents 268
Antibacterial Sulfonamides 268
Dihydrofolate Reductase Inhibitors 279
Sulfones 279
CHAPTER 9
Antimalarials 282
John H. Block
Stimulation of Antimalarial Research by War .... 283
Drug Therapy 285
Cinchona Alkaloids 286
CHAPTER 10
Antibacterial Antibiotics 299
John M. Beale, Jr.
Historical Background 299
Current Status 299
Commercial Production 300
Spectrum of Activity 300
Mechanisms of Action 300
Chemical Classification 301
Microbial Resistance 301
p Lactam Antibiotics 301
The Penicillins 302
p Lactamase Inhibitors 314
Cephalosporins 318
Monobactams 334
Aminoglycosides 334
Tetracyclines 341
Macrolides 349
Lincomycins 353
Polypeptides 355
Unclassified Antibiotics 360
CHAPTER 1 1
Antiviral Agents 367
John M. Beale, Jr.
Classification of Viruses 367
Targets for the Prevention of Viral
Infections—Chemoprophylaxis 367
The Infectious Process for a Virus 370
Nucleoside Antimetabolites 375
Newer Agents for the Treatment of HIV Infection 382
CHAPTER 12
Antineoplastic Agents 390
William A. Renters
Tumor Cell Properties 390
Alkylating Agents 394
Antimetabolites 402
Antibiotics 414
Plant Products 424
Miscellaneous Compounds 428
Hormones 433
Signal Transduction Inhibitors 438
Immunotherapy 440
Monoclonal Antibodies 442
Radiotherapeutic Agents 444
Cytoprotective Agents 445
Future Antineoplastic Agents 446
Potential Future Developments 448
CHAPTER 13
Agents for Diagnostic Imaging 454
Tim B. Hunter, T. Kent Walsh, Jack N. Hall
Introduction to Radiation 454
Characteristics of Decay 456
Biological Effects of Radiation 457
Radionuclides and Radiopharmaceuticals for
Organ Imaging 458
Radionuclide Production 461
Technetium Radiochemistry 463
Fluorine Radiochemistry 468
Gallium Radiochemistry 468
Iodine Radiochemistry 468
Indium Radiochemistry 469
Thallium Radiochemistry 472
Xenon Radiochemistry 472
Radiological Contrast Agents 472
Paramagnetic Compounds 475
Ultrasound Contrast Agents 477
Radiological Procedures 478
CHAPTER 14
Central Nervous System Depressants 485
Eugene I. Isaacson
General Anesthetics 485
Anxiolytic, Sedative, and Hypnotic Agents 488
Antipsychotics 496
Anticonvulsant or Antiepileptic Drugs 503
CHAPTER 15
Central Nervous System Stimulants 510
Eugene I. Isaacson
Analeptics 510
Methylxanthines 511
Central Sympathomimetic Agents (Psychomotor
Stimulants) 512
Antidepressants 514
Miscellaneous CNS Acting Drugs 520
CHAPTER 16
Adrenergic Agents 524
Rodney L. Johnson
Adrenergic Neurotransmitters 524
Adrenergic Receptors 527
Drugs Affecting Adrenergic Neurotransmission . . . 528
Sympathomimetic Agents 530
Adrenergic Receptor Antagonists 539
CHAPTER 17
Cholinergic Drugs and Related Agents ... 548
George H. Cocolas and Stephen J. Cutler
Cholinergic Receptors 548
Cholinergic Neurochemistry 553
Cholinergic Agonists 553
Cholinergic Receptor Antagonists 558
Cholinergic Blocking Agents 572
Parasympathetic Postganglionic Blocking Agents . . 573
Solanaceous Alkaloids and Analogues 574
Synthetic Cholinergic Blocking Agents 579
Ganglionic Blocking Agents 586
Neuromuscular Blocking Agents 589
CHAPTER 18
Diuretics 596
Daniel A. Koechel
Anatomy and Physiology of the Nephron 596
Function 596
Introduction to the Diuretics 601
Site 1 Diuretics: Carbonic Anhydrase Inhibitors . . . 603
Site 3 Diuretics: Thiazide and Thiazide Like
Diuretics 605
Site 2 Diuretics: High Ceiling or Loop Diuretics ... 610
Site 4 Diuretics: Potassium Sparing Diuretics 616
Miscellaneous Diuretics 618
Emerging Developments in the Use of Diuretics
to Treat Hypertension and Congestive Heart
Failure 618
Summary 619
Diuretic Preparations 619
CHAPTER 19
Cardiovascular Agents 622
Stephen J. Cutler and George H. Cocolas
Antianginal Agents and Vasodilators 622
Antiarrhythmic Drugs 634
Antihypertensive Agents 642
Antihyperlipidemic Agents 657
Anticoagulants 663
Synthetic Hypoglycemic Agents 668
Thyroid Hormones 673
Antithyroid Drugs 673
CHAPTER 20
Local Anesthetic Agents 676
Gareth Thomas
Historical Development 676
The Nervous System 679
Mechanism of Action 685
Administration 687
Factors Influencing the Effectiveness of the
Anesthetic Action 687
Rate of Onset and Duration of Anesthesia 688
Secondary Pharmacological Action 689
Structure Action 690
CHAPTER 21
Histamine and Antihistaminic Agents .... 696
Thomas N. Riley and Jack DeRuiter
Histamine 696
Histamine Life Cycle 696
Histamine H , Antagonists (Antihistaminic Agents) 700
Contents xiii
Inhibition of Histamine Release: Mast Cell
Stabilizers 715
Recent Antihistamine Developments: The Dual
Acting Antihistamines 717
Histamine H2 Antagonists 718
Histamine H3 Receptor Ligands 727
CHAPTER 2 2
Analgesic Agents 731
Robert E. Willette
Pain 731
Morphine and Related Compounds 732
Antitussive Agents 752
Anti inflammatory Analgesics 753
CHAPTER 23
Steroids and Therapeutically Related
Compounds 767
Philip J. Proteau
Steroid Nomenclature, Stereochemistry, and
Numbering 767
Steroid Biosynthesis 768
Chemical and Physical Properties of Steroids 770
Changes to Modify Pharmacokinetic Properties of
Steroids 770
Steroid Hormone Receptors 770
GnRH and Gonadotropins 773
Sex Hormones 775
Chemical Contraceptive Agents 789
Androgens 797
Adrenal Cortex Hormones 803
CHAPTER 24
Prostaglandins, Leukotrienes, and Other
Eicosanoids 818
Thomas J. Holmes, Jr.
History of Discovery 818
Eicosanoid Biosynthesis 818
Drug Action Mediated by Eicosanoids 822
COX 2 Inhibitors 822
Design of Eicosanoid Drugs 823
Development of Prostacyclin Derived Products . . . 823
Eicosanoid Receptors 825
Eicosanoids Approved for Human Clinical Use . . . 827
Prostaglandins for Ophthalmic Use 828
Veterinary Uses of Prostanoids 828
Eicosanoids in Clinical Development for Human
Treatment 829
CHAPTER 25
Proteins, Enzymes, and Peptide
Hormones 830
Stephen J. Cutler and Horace G. Cutler
Protein Hydrolysates 830
Amino Acid Solutions 830
Proteins and Protein Like Compounds 831
Enzymes 835
Hormones 840
Blood Proteins 857
Impact of Biotechnology on the Development
XIV Contents
and Commercial Production of Proteins and
Peptides as Pharmaceutical Products 858
Biotechnology Derived Pharmaceutical Products . . 860
CHAPTER 2 6
Vitamins and Related Compounds 866
Gustavo R. Ortega, Michael J. Deimling, and Jaime N.
Delgado
Lipid Soluble Vitamins 867
Water Soluble Vitamins 885
Miscellaneous Considerations 900
CHAPTER 27
An Introduction to the Medicinal
Chemistry of Herbs 904
John M. Beale, Jr.
What is an Herb? 905
Herbal Purity and Standardization 905
An Herb Is a Drug 905
Types of Herbs 906
CHAPTER 28
Computational Chemistry and Computer
Assisted Drug Design 919
J. Phillip Bowen
Computer Graphics and Molecular Visualization . . 920
Computational Chemistry Overview 922
Force Field Methods 923
Geometry Optimization 929
Conformational Searching 930
Molecular Dynamics Simulations 933
Quantum Mechanics 935
Structure Based Drug Design and Pharmacophore
Perception 939
Predictive ADME 944
Appendix
Calculated Log P, Log D, and pKa 948
Index 957
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| language | English |
| lccn | 2003048849 |
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| physical | XIV, 991 S. Ill. |
| publishDate | 2004 |
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| publisher | Lippincott Williams & Wilkins |
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| spelling | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry ed. by John H. Block ... Organic medicinal and pharmaceutical chemistry Textbook of organic medicinal and pharmaceutical chemistry 11. ed. Philadelphia [.u.a.] Lippincott Williams & Wilkins 2004 XIV, 991 S. Ill. txt rdacontent n rdamedia nc rdacarrier Chemistry, Organic Chemistry, Pharmaceutical Pharmaceutical chemistry Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Pharmazeutische Chemie (DE-588)4132158-3 s DE-604 Wilson, Charles O. Sonstige oth Block, John H. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012806703&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry Chemistry, Organic Chemistry, Pharmaceutical Pharmaceutical chemistry Pharmazeutische Chemie (DE-588)4132158-3 gnd |
| subject_GND | (DE-588)4132158-3 (DE-588)4123623-3 |
| title | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry |
| title_alt | Organic medicinal and pharmaceutical chemistry Textbook of organic medicinal and pharmaceutical chemistry |
| title_auth | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry |
| title_exact_search | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry |
| title_full | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry ed. by John H. Block ... |
| title_fullStr | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry ed. by John H. Block ... |
| title_full_unstemmed | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry ed. by John H. Block ... |
| title_short | Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry |
| title_sort | wilson and gisvold s textbook of organic medicinal and pharmaceutical chemistry |
| topic | Chemistry, Organic Chemistry, Pharmaceutical Pharmaceutical chemistry Pharmazeutische Chemie (DE-588)4132158-3 gnd |
| topic_facet | Chemistry, Organic Chemistry, Pharmaceutical Pharmaceutical chemistry Pharmazeutische Chemie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012806703&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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