Aspirin and related drugs:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Taylor & Francis
2004
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 770 S. graph. Darst. 26 cm |
| ISBN: | 0748408851 |
Internformat
MARC
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| 245 | 1 | 0 | |a Aspirin and related drugs |c K. D. Rainsford |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London [u.a.] |b Taylor & Francis |c 2004 | |
| 300 | |a XXI, 770 S. |b graph. Darst. |c 26 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Acetylsalicylzuur |2 gtt | |
| 650 | 4 | |a Anti-inflammatoires non stéroïdiens | |
| 650 | 4 | |a Aspirine | |
| 650 | 7 | |a Salicylaten |2 gtt | |
| 650 | 4 | |a Salicylothérapie | |
| 650 | 4 | |a Aspirin | |
| 650 | 4 | |a Aspirin |x pharmacology | |
| 650 | 4 | |a Nonsteroidal anti-inflammatory agents | |
| 650 | 4 | |a Salicylates |x Therapeutic use | |
| 650 | 4 | |a Salicylates |x pharmacology | |
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Datensatz im Suchindex
| _version_ | 1804132752217341952 |
|---|---|
| adam_text | Contents
Contributors xiii
Preface xv
Abbreviations and nomenclature xix
1 HISTORY AND DEVELOPMENT OF THE SALICYLATES 1
K.D. Rainsford
Introduction 1
Early Use of Salicylate containing Plants 1
Chemical Development of Salicylates 6
Clinical Observations on the Use of Salicylates in the Nineteenth Century 7
Early Clinical Studies with Salicylates in the Treatment of Rheumatoid Arthritis 13
Chemical Development and Early Clinical Studies with Aspirin 14
Aspects of the Commercial Development of Aspirin 17
Other Salicylates 19
References 19
2 THE INDUSTRIAL HISTORY OF ANALGESICS: THE EVOLUTION OF
ANALGESICS AND ANTIPYRETICS 25
J.R. McTavish
Recognition of Pain 25
Therapeutic Nihilism and Fevers 26
The Organic Chemical Industry 26
The Salicylates 28
The Value of a Good Name 33
Conclusion 38
References 39
3 OCCURRENCE, PROPERTIES AND SYNTHETIC DEVELOPMENTS OF
THE SALICYLATES 45
K.D. Rainsford
Introduction 45
Naturally Occurring Salicylates 45
Chemical Properties 51
Commercial Synthesis and Properties of the Salicylates 57
Experimental Drugs 65
CONTENTS
Various Chemical Applications 78
Conclusions 79
References 79
4 PHARMACOKINETICS AND METABOLISM OF THE SALICYLATES 97
G.G. Graham, M.S. Roberts, R.O. Day andK.D. Rainsford
Introduction 97
Absorption of Aspirin and Salicylate 97
Distribution of Aspirin and Salicylate 101
Elimination of Aspirin 106
Elimination of Salicylate 109
Metabolic Pathways of Salicylate 112
Factors Controlling the Elimination of Aspirin and Salicylate 117
Kinetics of Elimination of Salicylate 121
Pro Drugs 123
Analytical Methods for the Salicylates 126
Salicylate Derivatives 130
Diflunisal 132
Salicylamide 134
References 137
5 METABOLISM AND PHARMACOKINETICS OF IBUPROFEN 157
G.G. Graham and KM. Williams
Introduction 157
Absorption 157
Distribution 159
Elimination 162
Half life and Clearance 166
Factors Affecting the Elimination of Ibuprofen 167
Pharmacokinetics, Plasma Concentrations and Clinical Response 170
Analytical Methods 171
References 172
6 PHARMACOKINETICS AND METABOLISM OF PARACETAMOL
(ACETAMINOPHEN) 181
G.G. Graham andM. Hicks
Introduction 181
Absorption 181
Distribution 183
CONTENTS
Elimination 186
Half life and Clearance 191
Factors Affecting the Elimination of Paracetamol 192
Metabolism of Pro drugs 199
Analytical Methods 200
References 200
7 PHARMACOLOGY AND BIOCHEMISTRY OF SALICYLATES AND
RELATED DRUGS 215
K.D. Rainsford
Introduction 215
Anti inflammatory Effects 220
Biochemical Effects of Salicylates in Relation to their Anti inflammatory Actions 244
Analgesic Activity 291
Antipyresis 307
References 309
Appendix to Chapter 7 355
8 SIDE EFFECTS AND TOXICOLOGY OF THE SALICYLATES 367
K.D. Rainsford
Introduction 367
Occurrence of Adverse Events from NSAIDs, including Aspirin 369
Gastrointestinal Side Effects 370
Hepatotoxicity 448
Nephropathy 452
Hypersensitivity Reactions and Asthma 465
Teratogenesis and Pregnancy 472
Miscellaneous Side Effects 476
Acute Salicylate Poisoning 478
Conclusions 485
References 486
9 REYE S SYNDROME AND ASPIRIN 555
J.F.T. Glasgow andS.M. Hall
Introduction 555
Background 556
Definition 556
Clinical Features 557
Investigations 558
CONTENTS
Differential Diagnosis 560
Aetiology and Pathogenesis 561
Management Principles 575
The Future 577
Conclusion 579
Acknowledgements 579
References 579
10 SALICYLATES IN THE TREATMENT OF ACUTE PAIN 587
K.D. Rainsford
Introduction 587
Concepts of the Mode of Action in Acute Pain 588
Early Observations in Various Pain States 588
Efficacy in Various Pain Conditions 589
Comparative Effects in Acute Pain States 592
References 607
11 ACETYLSALICYLIC ACID FOR THE PREVENTION AND TREATMENT
OF THROMBOEMBOLIC DISEASES 619
K.E. WebertandJ.G.Kelton
The Role of Platelets in Haemostasis and Thrombosis 619
The Role of Platelets in Acute and Chronic Vascular Injury 622
Effects of Acetylsalicylic Acid on Platelet Function 622
Pharmacokinetics of ASA 624
Dose Effect Relationships of ASA 625
The Effects of ASA on Coagulation Factors, other than Platelets 626
ASA for the Prevention of Vascular Thromboembolic Disease: Epidemiological Studies 626
ASA for the Treatment of Acute Vascular Thromboembolic Events 629
Novel Analogues of Salicylates and Further Developments 631
References 631
12 USE OF SALICYLATES IN RHEUMATIC AND RELATED CONDITIONS 635
W. W. Buchanan, W.F. Kean and K.D. Rainsford
Introduction 635
History 636
Rheumatoid Arthritis 637
Osteoarthritis 646
Miscellaneous musculoskeletal disorders 648
Drug Kinetics and Monitoring 649
CONTENTS
Adverse Events in Rheumatic Patients 651
Factors Affecting Side Effects and Therapeutic Effects 664
Toxicity 666
Conclusions 666
References 667
13 ASPIRIN AND NSAIDs IN THE PREVENTION OF CANCER, ALZHEIMER S
DISEASE AND OTHER NOVEL THERAPEUTIC ACTIONS 707
K.D. Rainsford
Introduction 707
Prevention of Colorectal and Other Cancers 707
Alzheimer s Disease and Related Dementias 717
Copper Salicylates in the Treatment of Inflammatory Diseases and Cancer 720
Therapeutic Uses of Aspirin in Pregnancy 723
Kawasaki Disease 726
Perturbed Metabolic States 727
Immunological Effects 732
Other Possible Uses 733
Miscellaneous 735
References 736
Index 759
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| id | DE-604.BV019332127 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:57:49Z |
| institution | BVB |
| isbn | 0748408851 |
| language | English |
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| physical | XXI, 770 S. graph. Darst. 26 cm |
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| spelling | Aspirin and related drugs K. D. Rainsford 1. publ. London [u.a.] Taylor & Francis 2004 XXI, 770 S. graph. Darst. 26 cm txt rdacontent n rdamedia nc rdacarrier Acetylsalicylzuur gtt Anti-inflammatoires non stéroïdiens Aspirine Salicylaten gtt Salicylothérapie Aspirin Aspirin pharmacology Nonsteroidal anti-inflammatory agents Salicylates Therapeutic use Salicylates pharmacology Acetylsalicylsäure (DE-588)4000351-6 gnd rswk-swf Nichtsteroidales Antiphlogistikum (DE-588)4209813-0 gnd rswk-swf Nichtsteroidales Antiphlogistikum (DE-588)4209813-0 s DE-604 Acetylsalicylsäure (DE-588)4000351-6 s Rainsford, Kim D. 1941- Sonstige (DE-588)130488917 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012797090&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Aspirin and related drugs Acetylsalicylzuur gtt Anti-inflammatoires non stéroïdiens Aspirine Salicylaten gtt Salicylothérapie Aspirin Aspirin pharmacology Nonsteroidal anti-inflammatory agents Salicylates Therapeutic use Salicylates pharmacology Acetylsalicylsäure (DE-588)4000351-6 gnd Nichtsteroidales Antiphlogistikum (DE-588)4209813-0 gnd |
| subject_GND | (DE-588)4000351-6 (DE-588)4209813-0 |
| title | Aspirin and related drugs |
| title_auth | Aspirin and related drugs |
| title_exact_search | Aspirin and related drugs |
| title_full | Aspirin and related drugs K. D. Rainsford |
| title_fullStr | Aspirin and related drugs K. D. Rainsford |
| title_full_unstemmed | Aspirin and related drugs K. D. Rainsford |
| title_short | Aspirin and related drugs |
| title_sort | aspirin and related drugs |
| topic | Acetylsalicylzuur gtt Anti-inflammatoires non stéroïdiens Aspirine Salicylaten gtt Salicylothérapie Aspirin Aspirin pharmacology Nonsteroidal anti-inflammatory agents Salicylates Therapeutic use Salicylates pharmacology Acetylsalicylsäure (DE-588)4000351-6 gnd Nichtsteroidales Antiphlogistikum (DE-588)4209813-0 gnd |
| topic_facet | Acetylsalicylzuur Anti-inflammatoires non stéroïdiens Aspirine Salicylaten Salicylothérapie Aspirin Aspirin pharmacology Nonsteroidal anti-inflammatory agents Salicylates Therapeutic use Salicylates pharmacology Acetylsalicylsäure Nichtsteroidales Antiphlogistikum |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012797090&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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