Computational analysis of HIV drug resistance data:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Aachen
Shaker
2004
|
| Schriftenreihe: | Berichte aus der Informatik
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Saarbrücken, Univ., Diss., 2004 |
| Beschreibung: | 188 S. |
| ISBN: | 3832226397 |
Internformat
MARC
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
1 Introduction 1
2 HIV Biology and Treatment 5
2.1 HIV molecular biology 5
2.1.1 Structure 6
2.1.2 Genome 7
2.1.3 Replication 8
2.1.4 Pathogenesis 10
2.1.5 Epidemiology 13
2.2 Antiretroviral therapy 15
2.2.1 Protease inhibitors 15
2.2.2 Reverse transcriptase inhibitors 17
2.2.3 Fusion inhibitors 21
2.2.4 Combination therapy 21
2.3 Drug resistance 23
2.3.1 Resistance testing 27
2.3.2 Resistance-associated mutations 31
2.3.3 Mechanisms of resistance 32
2.4 Virus-host dynamics 37
2.4.1 The basic model of virus dynamics 37
2.4.2 Virus decline under drug therapy 38
2.4.3 Dynamics of resistance 40
2.5 Treatment strategies 42
3 The Arevir Database 45
v
vi CONTENTS
3.1 Data management 45
3.2 Related work 47
3.3 Database design 48
3.4 System architecture 51
3.5 Implementation 53
4 Evolution of Drug Resistance 55
4.1 Viral evolution 55
4.1.1 Random genetic drift 58
4.1.2 Mutation and selection 61
4.1.3 Accumulation of resistance-associated mutations 67
4.2 Learning mutational pathways 69
4.2.1 Mutagenetic trees 70
4.2.2 Mixture models 74
4.2.3 Model selection 76
4.2.4 Validation 79
4.2.5 Results 81
4.2.6 Discussion 88
5 Phenotype Prediction from Genotypes 91
5.1 Data mining 91
5.1.1 Related work 95
5.2 Mutual information profiles 97
5.2.1 Mutual information 97
5.2.2 Results and discussion 100
5.3 Decision trees 103
5.3.1 Decision tree building 104
5.3.2 Results and discussion 105
5.4 Support vector machines Ill
5.4.1 Statistical learning theory 112
5.4.2 Results and discussion 115
5.5 Clinical utility 116
6 Therapy Optimization 121
6.1 Related work 121
6.2 Interpretation of resistance factors 123
CONTENTS vii
6.2.1 Comparison to therapy-naive patients 125
6.2.2 The two-state model 126
6.3 Scoring function 129
6.3.1 Sequence space search 131
6.4 Model selection and evaluation on clinical data 135
6.5 Discussion 138
7 Conclusions 141
Summary 145
Zusammenfassung 149
Bibliography 152
|
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| institution | BVB |
| isbn | 3832226397 |
| language | English |
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| publishDate | 2004 |
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| publisher | Shaker |
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| series2 | Berichte aus der Informatik |
| spelling | Beerenwinkel, Niko Verfasser aut Computational analysis of HIV drug resistance data Niko Beerenwinkel Aachen Shaker 2004 188 S. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Informatik Zugl.: Saarbrücken, Univ., Diss., 2004 Arzneimittelresistenz (DE-588)4143180-7 gnd rswk-swf Stochastisches Modell (DE-588)4057633-4 gnd rswk-swf Relationale Datenbank (DE-588)4049358-1 gnd rswk-swf HIV-Infektion (DE-588)4203852-2 gnd rswk-swf Phänotyp (DE-588)4248244-6 gnd rswk-swf Data Mining (DE-588)4428654-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content HIV-Infektion (DE-588)4203852-2 s Arzneimittelresistenz (DE-588)4143180-7 s Phänotyp (DE-588)4248244-6 s Stochastisches Modell (DE-588)4057633-4 s Relationale Datenbank (DE-588)4049358-1 s Data Mining (DE-588)4428654-5 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012768905&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Beerenwinkel, Niko Computational analysis of HIV drug resistance data Arzneimittelresistenz (DE-588)4143180-7 gnd Stochastisches Modell (DE-588)4057633-4 gnd Relationale Datenbank (DE-588)4049358-1 gnd HIV-Infektion (DE-588)4203852-2 gnd Phänotyp (DE-588)4248244-6 gnd Data Mining (DE-588)4428654-5 gnd |
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| title | Computational analysis of HIV drug resistance data |
| title_auth | Computational analysis of HIV drug resistance data |
| title_exact_search | Computational analysis of HIV drug resistance data |
| title_full | Computational analysis of HIV drug resistance data Niko Beerenwinkel |
| title_fullStr | Computational analysis of HIV drug resistance data Niko Beerenwinkel |
| title_full_unstemmed | Computational analysis of HIV drug resistance data Niko Beerenwinkel |
| title_short | Computational analysis of HIV drug resistance data |
| title_sort | computational analysis of hiv drug resistance data |
| topic | Arzneimittelresistenz (DE-588)4143180-7 gnd Stochastisches Modell (DE-588)4057633-4 gnd Relationale Datenbank (DE-588)4049358-1 gnd HIV-Infektion (DE-588)4203852-2 gnd Phänotyp (DE-588)4248244-6 gnd Data Mining (DE-588)4428654-5 gnd |
| topic_facet | Arzneimittelresistenz Stochastisches Modell Relationale Datenbank HIV-Infektion Phänotyp Data Mining Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012768905&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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