Metal ions and their complexes in medication:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Dekker
2004
|
| Ausgabe: | 1. print. |
| Schriftenreihe: | Metal ions in biological systems
41 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | LIII, 519 S. Ill., graph. Darst. |
| ISBN: | 0824753518 |
Internformat
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Datensatz im Suchindex
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Contents
PREFACE TO THE SERIES iii
PREFACE TO VOLUME 41 v
CONTRIBUTORS xv
CONTENTS OF PREVIOUS VOLUMES xix
HANDBOOK ON TOXICITY OF INORGANIC COMPOUNDS liii
HANDBOOK ON METALS IN CLINICAL AND
ANALYTICAL CHEMISTRY liii
HANDBOOK ON METALLOPROTEINS liii
Chapter 1
SPECIATION DEPENDENT INTAKE AND UPTAKE OF
ESSENTIAL ELEMENTS 1
Janette Davidge and David R. Williams
1. Introduction 2
2. Elements in Humans 5
3. Speciation 13
4. Optimizing Intakes and Uptakes 21
5. Commercial Element Supplementation 24
6. Conclusions 32
Acknowledgments 34
Abbreviations and Definitions 34
References 35
Chapter 2
MAGNESIUM IN HUMAN THERAPY 41
Hans Georg Classen, Heimo Franz Schimatschek, and Konrad Wink
1. Early Roots 42
ix
X CONTENTS
2. Magnesium Therapy 43
3. Magnesium in Obstetrics and Gynecology 45
4. Magnesium in Pediatrics 50
5. Magnesium in Neurology and Psychiatry 51
6. Magnesium in Cardiovascular Disorders and Hypertension 54
7. Renal Magnesium Wasting 58
8. Magnesium and Allergic Reactions, Acute Asthma 59
9. Safety Aspects 60
Abbreviations 61
References 61
Chapter 3
CALCIUM STATUS AND SUPPLEMENTATION 71
Lasse Larsson and Per Magnusson
1. Introduction: General Importance of Calcium 72
2. Calcium Homeostasis 73
3. Disturbances in Calcium Absorption 80
4. Renal Regulation of Calcium 84
5. Bone and Mineral Metabolism 87
6. Genetics in Calcium Homeostasis 94
7. Calcium Intake and Supplementation 96
3. General Conclusions 98
Abbreviations 100
References 100
Chapter 4
ZINC DEFICIENCY: ITS CHARACTERIZATION
AND TREATMENT 103
Ananda S. Prasad
1. Brief History of the Discovery of Zinc as an Essential
Element for Human Health 104
2. Clinical Effects of Zinc Deficiency 109
3. Major Effects of Zinc Deficiency in Humans 115
4. Diagnostic Criteria for Zinc Deficiency 123
5. Therapeutic Uses of Zinc 126
6. Toxicity of Zinc 132
CONTENTS Xi
7. Conclusion 133
Abbreviations 133
References 134
Chapter 5
THE USE AND ROLE OF ZINC AND ITS COMPOUNDS
IN WOUND HEALING 139
Paul W. Jones and David R. Williams
1. Introduction 140
2. The Anatomy and Functions of the Skin 143
3. The Physiology of Wound Healing 145
4. Zinc and Wound Healing 147
5. Wound Management Products and Treatments Containing Zinc 154
6. Innovations in Trace Element Based Wound Management 159
7. Conclusions 174
Abbreviations 178
References 178
Chapter 6
IRON CHELATORS AND THEIR THERAPEUTIC POTENTIAL 185
Robert R. Crichton and Roberta J. Ward
1. Introduction: The Importance of Iron in Biology and Medicine 186
2. Iron Metabolism and Its Disorders 188
3. Classes of Molecules with Potential for Iron Chelation Therapy 199
4. Potential Chelation Sites 208
5. Potential Applications of Chelation Therapy 209
Acknowledgment 212
Abbreviations 212
References 213
Chapter 7
VANADIUM COMPOUNDS IN THE TREATMENT
OF DIABETES 221
Katherine H. Thompson and Chris Orvig
1. Introduction 222
2. Insulin Resistance 223
xii CONTENTS
3. Vanadium Compounds as Insulin Mimetic Agents 226
4. Pharmacokinetics and Biodistribution of
Vanadium Containing Compounds 238
5. Conclusions 242
Acknowledgments 242
Abbreviations and Definitions 243
References 245
Chapter 8
COPPER AND ZINC COMPLEXES AS
ANTIINFLAMMATORY DRUGS 253
Carolyn T. Dillon, Trevor W. Hambley, Brendan J. Kennedy,
Peter A. Lay, Jane E. Weder, and Qingdi Zhou
1. Introduction 254
2. Definition of Non Steroidal Antiinflammatory Drugs 254
3. Structures of Copper and Zinc Antiinflammatory
Carboxylato Complexes 256
4. Spectroscopic and Magnetic Properties of Cu(II) NSAIDs
and Zn(II) NSAIDs 262
5. Chemical Stabilities and Formation Constants of
Cu(II) and Zn(II) NSAIDs 265
6. The Influence of Stability and Structure of Cu(II) and
Zn(II) NSAIDs on Their Biological Activities 267
7. Conclusions 270
Acknowledgments 271
Abbreviations and Definitions 271
References 273
Chapter 9
GOLD COMPLEXES IN THE TREATMENT OF
RHEUMATOID ARTHRITIS 279
Luigi Messori and Giordano Marcon
1. Introduction 280
2. Main Structural Features of Antiarthritic Gold(I) Complexes 282
3. Solution Chemistry of Antiarthritic Gold(I) Complexes:
Reactions with Low Molecular Weight Biomolecules 285
CONTENTS Xiii
4. Reactions of Antiarthritic Gold(I) Complexes with Proteins 287
5. Metabolism, Biodistribution, and Pharmacokinetics 296
6. Hypotheses for the Mechanism of Action: Gold(I) Compounds
Primarily Depress the Immune Response 298
7. Conclusions and Perspectives 300
Abbreviations 300
References 301
Chapter 10
THE MEDICAL USE OF LITHIUM 305
Nicholas J. Birch
1. Introduction 307
2. Methods for the Determination of Lithium and Its Isotopes 308
3. Distribution of Lithium 309
4. Biochemistry and Pharmacology of Lithium 310
5. Use of Lithium in Medicine 314
6. Therapeutic Uses of Lithium 316
7. Conclusions 322
Abbreviations 323
References 324
Chapter 11
BISMUTH IN MEDICINE 333
Hongzhe Sun, Li Zhang, andKa Yee Szeto
1. Introduction 334
2. The Chemistry of Bismuth 335
3. Bismuth in Medicine and Biological Relevance 337
4. Bismuth Salicylate and Citrate Complexes 344
5. Interactions of Bismuth Compounds with Biomolecules 349
6. Pharmacology of Bismuth Compounds 361
7. Conclusions 365
Acknowledgments 366
Abbreviations 366
References 368
Xiv CONTENTS
Chapter 12
METAL COMPLEXES AS CHEMOTHERAPEUTIC
AGENTS AGAINST TROPICAL DISEASES: MALARIA,
TRYPANOSOMIASIS, AND LEISHMANIASIS 379
Roberto A. Sdnchez Delgado, Atilio Anzellotti, andLiliana Sudrez
1. Introduction 380
2. Metal Complexes as Possible Chemotherapeutic Agents
Against Malaria 382
3. Metal Complexes as Possible Chemotherapeutic Agents
Against Trypanosomiasis 395
4. Metal Complexes as Possible Chemotherapeutic Agents
Against Leishmaniasis 405
5. Final Comment 411
Acknowledgments 412
Abbreviations 412
References 413
Chapter 13
METAL COMPLEXES AS THERAPEUTIC AGENTS
IN NITROGEN MONOXIDE MODULATION 421
Simon P. Fricker
1. Introduction 422
2. Biology of Nitrogen Monoxide 423
3. Metal Complexes as Nitrogen Monoxide Donors 434
4. Scavengers of Nitrogen Monoxide 438
5. Ruthenium Complexes as Nitrogen Monoxide
Scavengers An Example of Inorganic Drug Design 448
6. Conclusion 463
Acknowledgments 464
Abbreviations 464
References 467
SUBJECT INDEX 481 |
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| spelling | Metal ions and their complexes in medication Ed. by Astrid Sigel ... 1. print. New York [u.a.] Dekker 2004 LIII, 519 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Metal ions in biological systems 41 Ions pharmacology Metal ions Metals in medicine Metals pharmacology Krankheit (DE-588)4032844-2 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Metallkomplexe (DE-588)4038898-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Metallkomplexe (DE-588)4038898-0 s Krankheit (DE-588)4032844-2 s Therapie (DE-588)4059798-2 s b DE-604 Sigel, Astrid Sonstige (DE-588)103367866X oth Metal ions in biological systems 41 (DE-604)BV000028701 41 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012033517&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metal ions and their complexes in medication Metal ions in biological systems Ions pharmacology Metal ions Metals in medicine Metals pharmacology Krankheit (DE-588)4032844-2 gnd Therapie (DE-588)4059798-2 gnd Metallkomplexe (DE-588)4038898-0 gnd |
| subject_GND | (DE-588)4032844-2 (DE-588)4059798-2 (DE-588)4038898-0 (DE-588)4143413-4 |
| title | Metal ions and their complexes in medication |
| title_auth | Metal ions and their complexes in medication |
| title_exact_search | Metal ions and their complexes in medication |
| title_full | Metal ions and their complexes in medication Ed. by Astrid Sigel ... |
| title_fullStr | Metal ions and their complexes in medication Ed. by Astrid Sigel ... |
| title_full_unstemmed | Metal ions and their complexes in medication Ed. by Astrid Sigel ... |
| title_short | Metal ions and their complexes in medication |
| title_sort | metal ions and their complexes in medication |
| topic | Ions pharmacology Metal ions Metals in medicine Metals pharmacology Krankheit (DE-588)4032844-2 gnd Therapie (DE-588)4059798-2 gnd Metallkomplexe (DE-588)4038898-0 gnd |
| topic_facet | Ions pharmacology Metal ions Metals in medicine Metals pharmacology Krankheit Therapie Metallkomplexe Aufsatzsammlung |
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