Genetic recombination in cancer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Academic Press
2003
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 245 S. graph. Darst. |
| ISBN: | 012639881X |
Internformat
MARC
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| 245 | 1 | 0 | |a Genetic recombination in cancer |c Gajanan V. Sherbet |
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| 650 | 4 | |a Cancer |x Genetic aspects | |
| 650 | 4 | |a Genetic recombination | |
| 650 | 4 | |a Neoplasms Metastasis | |
| 650 | 4 | |a Neoplasms |x genetics | |
| 650 | 4 | |a Recombination, Genitic | |
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Datensatz im Suchindex
| _version_ | 1804130543595421696 |
|---|---|
| adam_text | Contents
Preface tx
Abbreviations xi
1 Introduction 1
2 Genetic integrity, DNA repair and recombination 3
Base excision and nucleotide excision repair system 5
RAD genes and their operation in DNA replication checkpoint 5
DNA recombination repair pathway 8
VDJ recombination, the immune system and haematological
malignancy 9
SET domain proteins in genetic transcription, growth regulation
and myeloma 12
Control of cell proliferation by SET domain proteins 12
The generation of chimeric transcripts of NSD family genes in
multiple myeloma and Wolf Hirschhorn syndrome 14
Ku protein in cell function 15
Regulation of transcription by Ku protein 17
Ku protein and DNA repair 18
Ku protein in the maintenance of chromosomal integrity 19
Ku protein in cell cycle progression and differentiation 19
Ku protein in cancer 21
3 Replication error (HER) and genetic instability 24
Microsatellite instability and cancer progression 25
Effects of microsatellite instability on p53 and growth factor gene
expression 28
Influence of microsatellite instability on invasive behaviour of
tumours 31
Microsatellite instability and metastasis suppressor nm23 gene
abnormalities 33
Chromosomal fragile sites and the RER phenotype 34
Sister chromatid recombination and fragile sites 35
Microsatellite instability and sister chromatid recombination 39
Genomic stability and chromosome structural dynamics 39
4 DNA repeats, genetic recombination and the pathogenesis of
genetic disorders 41
CAG repeat expansion and genetic instability 42
Microsatellite dinucleotide repeats in insulin dependent diabetes
mellitus and autoimmune thyroid disease 49
Alu repeats in genetic recombination 50
Intrachromosomal recombination in muscular dystrophy and
Alzheimer s disease mediated by Alu repeats 51
Intrachromosomal recombination in tumour suppressor genes in
cancer 52
Alu mediated alterations of cell cycle regulator genes 55
Alu mediated interchromosomal recombination in leukaemias 55
Alu mediated interchromosomal recombination in Ewing sarcoma 56
Alu repeats, DNA mismatch repair gene mutation and genomic
instability 57
Alu elements in genetic transcription 57
Mode of Alu function in recombination 58
Functional involvement of Alu with signal recognition particles 61
LINE repeats in genetic rearrangement 62
Cognate elements associated with recombination 64
Translin binding elements 64
Chi sequences in DNA repair and recombination 65
5 Chromosomal recombination in cancer 67
Karyotypic abnormalities in cancer 67
DNA aneuploidy and cancer progression 68
DNA ploidy, cell proliferation and growth factor expression 70
Association of DNA ploidy with p53 abnormalities 75
6 Chromosomal translocation and its phenotypic effects 76
Chromosomal translocation and signal transduction 76
Deregulation of notch signalling by chromosomal translocation 77
Loss of integrity of notch signalling in leukaemia and lymphoma
cells 83
Genetic abnormalities downstream of notch signal activation 85
Fibulins, notch signalling and cancer invasion 87
Chromosomal translocation and the dynamics of cell population
expansion in cancer 89
The modulation of cell proliferation related gene expression by
chromosomal rearrangement 90
Genetic rearrangement and the regulation of apoptosis by bcl2
gene family 91
Bcl2 in p53 induced apoptosis 92
T cell leukaemia/lymphoma (JCLT) gene in apoptosis 95
The PI 3 kinase/Akt pathway of signal transduction in cell
proliferation, apoptosis and differentiation 96
Akt in PTEN tumour suppressor function 97
Akt signalling in cancer growth and invasion 97
Akt in TCL1 function 100
Fusion oncoprotein signalling by PI 3 kinase/Akt pathway 100
Mechanism of transduction of signals by Akt 103
Chromosomal translocation and genetic transcription 104
Chromosomal translocation in synovial sarcomas 105
AML1 fusion proteins in haematopoietic neoplasms 106
Modulation of retinoic acid receptor function by chromosomal
translocation 108
TEL transcription related gene rearrangement in leukaemia and
lymphoma 109
Modulation of developmental and transcription factor PAX genes
by translocation 111
The role of HOX genes in development, differentiation and
neoplasia 113
Chromosomal translocation, fusion proteins and tumour
vascularisation 117
Chromosomal translocations, fusion proteins and immunity 119
The association of chromosomal translocation with fragile sites 120
Chromosomal fragility, genetic loss and tumour suppressor genes 121
Fragile histidine triad (FHIT) gene abnormalities in cancer 122
Tumour suppressor function of von Hippel lindau gene 124
The ras association domain family RASSF1 gene in tumour
suppression 126
Gene amplification and its relationship to genetic instability 126
Chromosomal fragility and micronuclei 128
DNA damage and the generation of micronuclei 128
The involvement of p53 in the formation of micronuclei 129
Centromeric instability, DNA methylation and micronuclei in ICF
syndrome 130
The nature and constitution of micronuclei 131
7 DNA methylation and genetic instability 133
DNA methylation in normal and neoplastic development 133
Abnormal DNA methylation in ICF and Rett syndromes 134
DNA methylation and genetic instability 135
The CpG Island Methylator Phenotype (CIMP) 136
Influence of DNA methylation on recombination 139
Methylation associated chromosomal recombination and genetic
transcription in childhood leukaemias 140
The dynamics of histone acetylation in cell differentiation, cell
proliferation and neoplasia 140
Histone acetylation dynamics in development and differentiation 141
Cell proliferation, apoptosis and histone acetylation dynamics 143
Histone acetylation dynamics and the neoplastic process 144
Synergistic effects of DNA methylation and histone acetylation
dynamics on epigenetic gene silencing 147
HDAC inhibitors in the treatment of cancer 148
The effects of p53 methylation on chromosome stability 149
DNA methylation in fragile X syndrome 151
FMR1 gene function in the pathogenesis of fragile X syndrome 151
Epigenetic silencing of FMR1 in fragile X syndrome 152
8 Telomeric DNA and genetic instability 154
Telomeres and cell proliferation, apoptosis and cell senescence 154
Telomeres in DNA repair 158
Telomere function and ATM kinase 158
Telomeric association 159
The incidence of telomeric association in cancer 159
Telomeric association and gene expression 161
Telomere position effect 162
Epilogue 164
References 170
Index 237
|
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| id | DE-604.BV017870667 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:22:42Z |
| institution | BVB |
| isbn | 012639881X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010721457 |
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| physical | XIV, 245 S. graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Academic Press |
| record_format | marc |
| spelling | Sherbet, Gajanan V. 1935- Verfasser (DE-588)118160281 aut Genetic recombination in cancer Gajanan V. Sherbet Amsterdam [u.a.] Academic Press 2003 XIV, 245 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer Genetic aspects Genetic recombination Neoplasms Metastasis Neoplasms genetics Recombination, Genitic Rekombination (DE-588)4049338-6 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Rekombination (DE-588)4049338-6 s Genetik (DE-588)4071711-2 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010721457&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sherbet, Gajanan V. 1935- Genetic recombination in cancer Cancer Genetic aspects Genetic recombination Neoplasms Metastasis Neoplasms genetics Recombination, Genitic Rekombination (DE-588)4049338-6 gnd Genetik (DE-588)4071711-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4049338-6 (DE-588)4071711-2 (DE-588)4073781-0 |
| title | Genetic recombination in cancer |
| title_auth | Genetic recombination in cancer |
| title_exact_search | Genetic recombination in cancer |
| title_full | Genetic recombination in cancer Gajanan V. Sherbet |
| title_fullStr | Genetic recombination in cancer Gajanan V. Sherbet |
| title_full_unstemmed | Genetic recombination in cancer Gajanan V. Sherbet |
| title_short | Genetic recombination in cancer |
| title_sort | genetic recombination in cancer |
| topic | Cancer Genetic aspects Genetic recombination Neoplasms Metastasis Neoplasms genetics Recombination, Genitic Rekombination (DE-588)4049338-6 gnd Genetik (DE-588)4071711-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Cancer Genetic aspects Genetic recombination Neoplasms Metastasis Neoplasms genetics Recombination, Genitic Rekombination Genetik Krebs Medizin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010721457&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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