Molecular comparisons of humans and chimpanzees:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2003
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Leipzig, Univ., Diss., 2003 |
| Beschreibung: | 85 S. Ill., graph. Darst. : 21 cm |
Internformat
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| 100 | 1 | |a Enard, Wolfgang |d 1970- |e Verfasser |0 (DE-588)128582766 |4 aut | |
| 245 | 1 | 0 | |a Molecular comparisons of humans and chimpanzees |c vorgelegt von Wolfgang Enard |
| 264 | 1 | |c 2003 | |
| 300 | |a 85 S. |b Ill., graph. Darst. : 21 cm | ||
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| 500 | |a Leipzig, Univ., Diss., 2003 | ||
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Datensatz im Suchindex
| _version_ | 1807772289071054848 |
|---|---|
| adam_text |
CONTENTS
1.
INTRODUCTION
.
1
1.1.
BACKGROUND
AND
AIM
OF
THIS
THESIS
.
1
1.2.
THE
TWO
SPECIES
OF
CHIMPANZEE
ARE
THE
CLOSEST
LIVING
RELATIVES
OF
HUMANS
.
2
1.2.1.
THE
DISCOVERY
OF
THE
CHIMPANZEE
.
2
1.2.2.
MOLECULAR
PHYLOGENY
.
4
1.2.3.
ANCESTRAL
POLYMORPHISMS
AND
THE CHOICE
OF
AN
OUTGROUP
5
1.2.4.
GENETIC
DISTANCE
AND
REAL
TIME
.
5
1.3.
HUMANS
AND
CHIMPANZEES
TWO
PHENOTYPES
.
6
1.4.
HUMANS
AND
CHIMPANZEES:
TWO
GENOTYPES
.
7
1.4.1.
NUCLEOTIDE
SUBSTITUTIONS
.
7
1.4.2.
INDELS
.
8
1.4.3.
CYTOGENETIC
DIFFERENCES
.
8
1.4
4.
DUPLICATIONS
AND
DELETIONS
.
8
1.4.5.
REPETITIVE
ELEMENTS
.
9
1.4.6.
DIFFERENCES
IN
GENES
WITH
A
POSSIBLE
EFFECT
ON
THE PHENOTYPE
.
9
1.5.
GENOTYPE
-
PHENOTYPE
RELATIONSHIPS
.
10
2.
INTRA
AND
INTERSPECIFIC
VARIATION
IN
PRIMATE
GENE
EXPRESSION
PATTERNS
.
11
2.1.
MICROARRAYS
FOR
STUDYING
GENE
EXPRESSION
.
11
2.1.1.
THE
PRINCIPLE
OF
MICROARRAYS
.
11
21.2.
GENECHIPS
.
12
2.1.3.
GENEFILTERS
.
13
2.2.
DATA
COLLECTED
.
14
2.3.
IDENTIFYING
GENES
DIFFERENTLY
EXPRESSED
BETWEEN
HUMANS
AND
CHIMPANZEES
.
15
2.3.1.
EXPERIMENTAL
VARIANCE
.
15
2.3.2.
BIOLOGICAL
VARIANCE
.
17
2.3.3.
EXPRESSION
DIFFERENCES
BETWEEN
MUS
MUSCULUS
AND
MUS
SPRETUS
.
19
2.3.4.
EXPRESSION
DIFFERENCES
FOUND
WITH
THE
GENEFILTER
SYSTEM
20
2.4.
EVOLUTION
OF
GENE
EXPRESSION
PATTERNS
.
21
2.5.
GENOTYPE-PHENOTYPE
RELATIONSHIP
OF
EXPRESSION
DIFFERENCES.
23
2.5.1
SEQUENCE
DIFFERENCES
IN
THE
TARGET
SEQUENCE
.
23
2.5.2.
OTHER
POSSIBLE
GENETIC
CAUSES
.
24
2.6.
PHENOTYPE
-
PHENOTYPE
RELATIONSHIP
FOR
EXPRESSION
CHANGES.
.
24
2.7.
SUMMARY
.
25
3.
MOLECULAR
EVOLUTION
OF
FOXP2,
A
GENE
INVOLVED
IN
SPEECH
AND
LANGUAGE
.
27
3.1.
INTRODUCTION
. .
27
3.1.1.
TWO
INTACT
COPIES
OFFOXP2
ARE
NEEDED
FOR
THE
NORMAL
DEVELOPMENT
OF
SPEECH
AND
LANGUAGE
.
27
3.1.2.
MOLECULAR
EVOLUTION
AND
THE
DETECTION
OF
POSITIVE
SELECTION
28
3
1.2.1.
COMPARING
VARIATION
BETWEEN
TWO
CATEGORIES
OF
SITES
29
3.1.2.2.
ADAPTIVE
HITCHHIKING
EFFECTS
ON
VARIATION
WITHIN
A
POPULATION
.
30
3.2.
EVOLUTION
OF
THE
FOXP2
PROTEIN
.
31
3.3.
EVOLUTION
OF
THE
FOXP2
LOCUS
IN
HUMANS
.
34
3.4.
FOXP2
AND
ITS
RELEVANCE
FOR
THE
EVOLUTION
OF
SPEECH AND
LANGUAGE
37
3.5.
PROPOSED
ADAPTATIONS
FOR
SPEECH
.
38
3.6.
THE
TIMEFRAME
OF
LANGUAGE
EVOLUTION
.
39
3.7.
PERSPECTIVES
ON
STUDYING
THE
FUNCTIONS
OF
FOXP2
IN
HUMANS.
40
3.7.1.
NATURAL
MUTATIONS
.
40
3.7.2.
MODEL
SYSTEMS
.
41
3.8.
SUMMARY
.
41
4.
OUTLOOK
.
43
4.1.
LIMITATIONS
AND
ADVANTAGES
OF
MOLECULAR
COMPARISONS
BETWEEN
HUMANS
AND
CHIMPANZEES
.
43
4.2.
PERSPECTIVES
FOR
FURTHER
MOLECULAR
COMPARISONS
OF
HUMANS
AND
CHIMPANZEES
.
44
4.3.
MOLECULAR
BIODIVERSITY
.
45
5.
SUMMARY
.
6.
BIBLIOGRAPHY
.
49
7.
ABBREVIATIONS
.
57
8.
APPENDIX
.
58
8.1.
TABLE
AL:
PHENOTYPIC
DIFFERENCES
BETWEEN
HUMANS
AND
CHIMPANZEES
58
8.2.
TABLE
A2:
GENOTYPIC
DIFFERENCES
BETWEEN
HUMANS
AND
CHIMPANZEES
66
8.3.
ENARD
ET
AL.,
(2002A)
INTRA
AND
INTERSPECIFIC
VARIATION
IN
PRIMATE
GENE
EXPRESSION
PATTERNS.
SCIENCE
246,340-343
.
69
8.3.1.
SUPPLEMENTARY
MATERIAL
.
73
8.4.
ENARD
ET
AL
,
(2002B)
MOLECULAR
EVOLUTION
OF
FOXP2,
A
GENE
INVOLVED
IN
SPEECH
AND
LANGUAGE
NATURE
418,
869-872
.
77
8.4.1.
SUPPLEMENTARY
MATERIAL
.
81
9.
ACKNOWLEDGMENTS
.
85 |
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| indexdate | 2024-08-19T00:06:40Z |
| institution | BVB |
| language | English |
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| physical | 85 S. Ill., graph. Darst. : 21 cm |
| publishDate | 2003 |
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| spelling | Enard, Wolfgang 1970- Verfasser (DE-588)128582766 aut Molecular comparisons of humans and chimpanzees vorgelegt von Wolfgang Enard 2003 85 S. Ill., graph. Darst. : 21 cm txt rdacontent n rdamedia nc rdacarrier Leipzig, Univ., Diss., 2003 Schimpanse (DE-588)4179632-9 gnd rswk-swf Mensch (DE-588)4038639-9 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Mensch (DE-588)4038639-9 s Molekularbiologie (DE-588)4039983-7 s Schimpanse (DE-588)4179632-9 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010696525&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Enard, Wolfgang 1970- Molecular comparisons of humans and chimpanzees Schimpanse (DE-588)4179632-9 gnd Mensch (DE-588)4038639-9 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4179632-9 (DE-588)4038639-9 (DE-588)4039983-7 (DE-588)4113937-9 |
| title | Molecular comparisons of humans and chimpanzees |
| title_auth | Molecular comparisons of humans and chimpanzees |
| title_exact_search | Molecular comparisons of humans and chimpanzees |
| title_full | Molecular comparisons of humans and chimpanzees vorgelegt von Wolfgang Enard |
| title_fullStr | Molecular comparisons of humans and chimpanzees vorgelegt von Wolfgang Enard |
| title_full_unstemmed | Molecular comparisons of humans and chimpanzees vorgelegt von Wolfgang Enard |
| title_short | Molecular comparisons of humans and chimpanzees |
| title_sort | molecular comparisons of humans and chimpanzees |
| topic | Schimpanse (DE-588)4179632-9 gnd Mensch (DE-588)4038639-9 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Schimpanse Mensch Molekularbiologie Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010696525&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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