Basic & clinical endocrinology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Lange Medical Books/MacGraw-Hill
2004
|
| Ausgabe: | 7. ed. |
| Schriftenreihe: | A Lange medical book
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 976 S. Ill., graph. Darst. |
| ISBN: | 0071402977 |
Internformat
MARC
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| 245 | 1 | 0 | |a Basic & clinical endocrinology |c ed. by Francis S. Greenspan ... |
| 246 | 1 | 3 | |a Basic and clinical endocrinology |
| 250 | |a 7. ed. | ||
| 264 | 1 | |a New York [u.a.] |b Lange Medical Books/MacGraw-Hill |c 2004 | |
| 300 | |a XVI, 976 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804130486675570688 |
|---|---|
| adam_text | Cont
Authors Preface 1. Introduction to Endocrinology John D. Baxter, MD, RalffC.J. Ribeiro, MD, PhD, t
The Endocrine System 2
Hormones: Endocrine, Paracrine, Autocrine Actions 3
Chemical Composition of Hormones 3
Relationships between Hormones Other Signaling
Molecules 4
Neurotransmitters Hormones 4
Vitamins Hormones 5
Oncogenes Hormones 5
The Immune System Hormones 5
Eicosanoids: Prostaglandins Related Compounds 6
Mechanisms of Hormone Action 6
Hormone Receptors 6
Hormone Effects on Receptor Activity 8
Classes of Hormone Action 8
Classification of Hormone Action by Receptor Type 8
Classification of Hormone Action by Ligand Type 9
Mechanisms of Ligand Action 10
Regulation of Hormone Responsiveness 11
Hormone Responses Can Be Self Limiting 11
Different Signals Influence Hormone Responsiveness 11
Modulation of Hormone Levels 12
Hormone Synthesis 12
Regulation of Hormone Production 12
Hormone Transport in the Circulation 13
Transport of Hormones across the Membrane 14
Metabolism Elimination of Hormones 14
Recombinant DNA, Genomics, Proteomics,
Endocrinology 15
Sequencing of the Human Genome 16
Genomics Patterns of Transcription 16
Proteomics 16
Molecular Basis of Genetic Endocrine Disease 17
Evolution of the Endocrine System 17
The Origins of Regulatory Chemicals the Metabolic
Code 18
Evolution of Hormones Receptors 18
Evolution of Multiple Hormone Response Systems 19
2. Hormone Synthesis Release Vishwanath R. Lingappa, MD, PhD, Synthia H. l
Compartmentation of Eulcaryotic Cells in Relation to Hormone
Synthesis Release 38
Overview of Hormone Biosynthesis 39
Membrane Vesicle Mediated Hormone Export 40
:ents
xii
xvi
1
Paul Webb, PhD
Evolution of Endocrine Glands 19
Integrative Networks 19
Endocrine Nervous System Relationships:
Neuroendocrinology 19
Hypothalamic Pituitary Relationships 20
Endocrine Organs Hormone Production 21
Actions of Hormones 21
Hormone Release 21
Fetal Development 21
Cell Growth Cancer 21
Hormonal Effects on Intermediary Metabolism 22
Hormonal Effects on Mineral Water Metabolism 22
Hormonal Effects on Cardiovascular Renal
Function 22
Hormonal Effects on Skeletal Function 23
Hormonal Effects on Reproductive Function 23
Hormonal Effects on the Immune System 23
Hormonal Effects on the Central Nervous System 23
Selective Modulation 24
Disorders of the Endocrine System 24
Endocrine Hypofunction 25
Endocrine Hyperfunction 25
Defects in Sensitivity to Hormones 26
Syndromes of Hormone Excess Due to Administration of
Exogenous Hormone 27
Nonendocrine Problems Associated with Endocrine
Disease 28
Approach to the Patient with Endocrine Disease 28
Evidence Based Endocrinology 28
History Physical Examination 29
Laboratory Studies 29
Screening for Endocrine Diseases 33
Clinical Interpretation of Laboratory Tests 34
Treatment of Endocrine Diseases 34
Uses of Hormones Selective Modulators in Therapy
of Nonendocrine Disease 35
38
Mellon, PhD
Hormone Export Not Mediated by Membrane Vesicles 51
Metabolism, Transport, Elimination, Regulation of
Hormones 56
3. Mechanisms of Hormone Action David G. Gardner, MD, Robert A. Nissenson, Ph
Receptors 62
Neurotransmitter Peptide Hormone Receptors 63
G Protein Coupled Receptors 64
G Protein Transducers 65
G Protein Disorders 66
Effectors 67
G Protein Coupled Receptors Human Disease 68
Growth Factor Receptors 70
Cytokine Receptors 73
4. Endocrine Autoimmunity Juan Carlos Jaume, MD
Basic Immune Components Mechanisms 86
Immune Recognition Response 87
Tolerance 90
Autoimmunity Is Multifactorial 95
Genetic Factors in Autoimmunity 95
Environmental Factors in Autoimmunity 96
Single Gland Autoimmune Syndromes 96
Autoimmune Aspects of Thyroid Disease 97
5. Hypothalamus Pituitary Gland David C. Aron, MD, MS, James W. Findling, MD,
Hypothalamic Hormones 111
Anterior Pituitary Hormones 119
ACTH Related Peptides 119
Growth Hormone 120
Prolactin 125
Thyrotropin 126
Gonadotropins: Luteinizing Hormone, Follicle Stimulating
Hormone 128
Endocrinologic Evaluation of the Hypothalamic Pituitary
Axis 129
Evaluation of ACTH 129
Evaluation of Growth Hormone 131
Evaluation of Prolactin 132
Evaluation of TSH 132
Evaluation of LH FSH 132
Problems in Evaluation of the Hypothalamic Pituitary
Axis 133
6. Growth Dennis Styne, MD
Normal Growth 176
Intrauterine Growth 176
The Placenta 177
Classic Hormones of Growth Fetal Growth 177
Growth Factors Oncogenes in Fetal Growth 177
Insulin Like Growth Factors, Receptors, Binding
Proteins 177
Insulin 178
Epidermal Growth Factor 178
Fetal Origins of Adult Disease 179
7. The Thyroid Gland ,
Francis S. Greenspan, MD
Anatomy Histology 216
Physiology 216
Structure of Thyroid Hormones 216
61
D
Guanylyl Cyclase Linked Receptors 73
Nuclear Action of Peptide Hormones 74
Nuclear Receptors 75
Steroid Receptor Family 76
Thyroid Receptor Family 77
Nongenomic Effects of the Steroid Hormones 82
Steroid Thyroid Hormone Receptor Resistance
Syndromes 83
85
Autoimmune Aspects of Type 1 Diabetes 98
Autoimmune Aspects of Other Endocrinopathies 100
Autoimmune Polyglandular Syndromes 103
Autoimmune Polyglandular Syndrome I (APS I) 103
Autoimmune Polyglandular Syndrome II (APS II) 103
Management of Autoimmune Polyglandular Syndromes 104
106
]. Blake Tyrrell, MD
Effects of Pharmacologic Agents on Hypothalamic Pituitary
Function 133
Endocrine Tests of Hypothalamic Pituitary Function 133
Neuroradiologic Evaluation 136
Pituitary Hypothalamic Disorders 136
Empty Sella Syndrome 138
Hypothalamic Dysfunction 139
Hypopituitarism 140
Pituitary Adenomas 147
Posterior Pituitary 163
Antidiuretic Hormone (ADH; Vasopressin) 163
Oxytocin 164
Control of Water Balance 164
Diabetes Insipidus 167
Syndrome of Inappropriate Secretion of Antidiuretic
Hormone (SIADH) 170
176
Postnatal Growth 179
Measurement of Growth 187
Skeletal (Bone) Age 191
Disorders of Growth 194
Short Stature Due to Nonendocrine Causes 194
Short Stature Due to Endocrine Disorders 198
The Diagnosis of Short Stature 210
Tall Stature Due to Nonendocrine Causes 211
Beckwith Wiedemann Syndrome 212
Tall Stature Due to Endocrine Disorders 212
215
Iodine Metabolism 216
Thyroid Hormone Synthesis Secretion 219
Abnormalities in Thyroid Hormone Synthesis Release 224
Thyroid Hormone Transport 225
Metabolism of Thyroid Hormones 227
Control of Thyroid Function 232
The Action of Thyroid Hormones 238
Physiologic Changes in Thyroid Function 241
Thyroid Autoimmunity 243
Tests of Thyroid Function 244
Tests of Thyroid Hormones in Blood 244
Evaluation of the Hypothalarnic Pituitary Thyroid Axis 245
Iodine Metabolism Biosynthetic Activity 245
Thyroid Imaging 247
Thyroid Ultrasonography or Magnetic Resonance Imaging 248
8. Metabolic Bone Disease Dolores Shoback, MD, Robert Marcus, MD, Daniei
Cellular Extracellular Calcium Metabolism 295
Parathyroid Hormone 296
Calcitonin 302
Vitamin D 304
Integrated Control of Mineral Homeostasis 311
Medullary Thyroid Carcinoma 311
Hypercalcemia 313
Disorders Causing Hypercalcemia 314
Treatment of Hypercalcemia 323
Hypocalcemia 324
Causes of Hypocalcemia 325
Treatment of Hypocalcemia 329
Bone Anatomy Remodeling 330
Functions of Bone 330
Structure of Bone 330
Bone Remodeling 332
9. Glucocorticoids Adrenal Androgens David C. Ann, MD, MS, James W. Findling, MD, 6
Embryology Anatomy 363
Biosynthesis of Cortisol Adrenal Androgens 364
Circulation of Cortisol Adrenal Androgens 371
Metabolism of Cortisol Adrenal Androgens 371
Biologic Effects of Adrenal Steroids 372
Glucocorticoids 372
Adrenal Androgens 380
Laboratory Evaluation 380
Disorders of Adrenocortical Insufficiency 384
Primary Adrenocortical Insufficiency
(Addison s Disease) 384
10. Endocrine Hypertension BurlR. Don, MD, Morris Schambelan, MD, Joan I
Hypertension of Adrenal Origin 414
Synthesis, Metabolism, Action of
Mineralocorticoid Hormones 414
Pathogenesis of Mineralocorticoid Hypertension 416
Aldosterone the Heart 417
Primary Aldosteronism 417
Syndromes Due to Excess Deoxycorticosterone
Production 422
Cushing s Syndrome 424
Pseudohyperaldosteronism 425
Type II Pseudohypoaldosteronism (Arnold Healy Gordon
Syndrome) 427
CONTENTS / vii
Thyroid Biopsy 249
Effects of Thyroid Hormones on Peripheral Tissues 249
Measurement of Thyroid Autoantibodies 250
Summary: Clinical Use of Thyroid Function Tests 250
Disorders of the Thyroid 251
Hypothyroidism 251
Hyperthyroidism Thyrotoxicosis 260
Thyroid Hormone Resistance Syndromes 272
Nontoxic Goiter 273
Thyroiditis 275
Effects of Ionizing Radiation on the Thyroid Gland 278
Thyroid Nodules Thyroid Cancer 279
295
I Bikle, MD, PhD
Osteoporosis 335
Treatment of Osteoporosis 338
Nonpharmacologic Aspects of Osteoporosis
Management 343
Glucocorticoid Induced Osteoporosis 343
Osteomalacia Rickets 345
Nephrotic Syndrome 348
Hepatic Osteodystrophy 349
Drug Induced Osteomalacia 349
Hypophosphatemic Disorders 349
Calcium Deficiency 351
Primary Disorders of the Bone Matrix 351
Inhibitors of Mineralization 352
Paget s Disease of Bone (Osteitis Deformans) 352
Renal Osteodystrophy 357
362
•/. Blake Tyrrell, MD
Secondary Adrenocortical Insufficiency 389
Diagnosis of Adrenocortical Insufficiency 390
Treatment of Adrenocortical Insufficiency 393
Prognosis of Adrenocortical Insufficiency 395
Cushing s Syndrome 395
Hirsutism Virilism 408
Incidental Adrenal Mass 408
Glucocorticoid Therapy for Nonendocrine Disorders 410
414
C. Lo, MD
Hypertension of Renal Origin 428
The Renin Angiotensin System 428
The Renin Angiotensin System Hypertension 431
Other Hormone Systems Hypertension 435
Insulin 435
Natriuretic Peptides 436
Endothelium Derived Relaxing Factor 436
Endothelin 436
Kallikrein Kinin System 437
Other Hormones Autacoids 437
Sympathetic Nervous System 437
viii / CONTENTS
11. Adrenal Medulla Paul A. Fitzgerald, MD, Alan Goldfien, MD
History 439
Anatomy 440
Hormones of the Adrenal Medulla 441
Catecholamines 441
Other Hormones 451
12. Testes Glenn D. Braunstein, MD
Anatomy Structure Function Relationships 478
Testes 478
Accessory Structures 480
Physiology of the Male Reproductive System 480
Gonadal Steroids 480
Control of Testicular Function 483
Evaluation of Male Gonadal Function 484
Clinical Evaluation 484
Laboratory Tests of Testicular Function 486
Pharmacology of Drugs Used to Treat Male Gonadal
Disorders 488
Androgens 489
Gonadotropins 490
Gonadotropin Releasing Hormone 490
13. Female Reproductive Endocrinology Infertility
Mitchell Rosen, MD Marcelle I. Cedars, MD
Embryology Anatomy 511
Ovarian Steroidogenesis 514
Physiology of the Menstrual Cycle 514
Menstrual Disturbances 522
Hypothalamic Amenorrhea 522
Pituitary Amenorrhea 525
Ovarian Amenorrhea 528
Adrenal Causes of Amenorrhea 535
Outflow Tract Disorders 538
Menopause 539
14. Abnormalities of Sexual Determination Differs
Felix A. Conte, MD, MelvinM. Grumbach, MD
Normal Sex Differentiation 564
Testicular Ovarian Differentiation 569
Psychosexual Differentiation 576
Abnormal Sex Differentiation 576
Seminiferous Tubule Dysgenesis: Chromatin Positive
Klinefelter s Syndrome Its Variants 576
Syndrome of Gonadal Dysgenesis: Turner s Syndrome
Its Variants 579
True Hermaphroditism 583
15. Puberty Dennis Styne, MD
Physiology of Puberty 608
Delayed Puberty or Absent Puberty (Sexual Infantilism) 617
439
Disorders of Adrenal Medullary Function 451
Adrenal Medullary Hypofunction 451
Adrenal Medullary Hyperfunction 453
Pheochromocytoma 453
478
Clinical Male Gonadal Disorders 490
Klinefelter s Syndrome (XXY Seminiferous Tubule
Dysgenesis) 491
Bilateral Anorchia (Vanishing Testes Syndrome) 493
Cryptorchidism 494
Noonan s Syndrome (Male Turner s Syndrome) 496
Myotonic Dystrophy 497
Adult Leydig Cell Failure (Andropause) 499
Male Infertility 500
Erectile Dysfunction (Impotence) 502
Gynecomastia 505
Testicular Tumors 508
511
Oocyte Depletion 540
Endocrine System Changes with Aging 541
Menopausal Consequences 542
Infertility 544
Diagnosis of Infertility 545
Management of the Infertile Couple 546
Contraception 547
Oral Contraceptives 548
Contraception: Long Acting Contraceptives 555
Emergency Contraception 561
ntiation 564
Female Pseudohermaphroditism 584
P450 Aromatase Deficiency 589
Maternal Androgens Progestogens 589
Male Pseudohermaphroditism 589
Unclassified Forms of Abnormal Sexual Development
in Males 599
Unclassified Forms of Abnormal Sexual Development
in Females 601
Management of Patients with Intersex Problems 601
608
Precocious Puberty (Sexual Precocity) 628
16. The Endocrinology of Pregnancy Robert N. Taylor, MD, PhD, Dan I. Lebovic, Mi
Conception Implantation 637
Fetal Placental Decidual Unit 638
Polypeptide Hormones 641
Steroid Hormones 642
Maternal Adaptation to Pregnancy 643
Fetal Endocrinology 647
Endocrine Control of Parturition 649
17. Pancreatic Hormones Diabetes Mellitus....
Umesh Masharani, MRCP(UK), John H. Karam, A
The Endocrine Pancreas 658
Anatomy Histology 658
Hormones of the Endocrine Pancreas 660
Diabetes Mellitus 669
Classification 669
Type 1 Diabetes Mellitus 669
Type 2 Diabetes 672
Other Specific Types of Diabetes 675
Clinical Features of Diabetes Mellitus 678
Type 1 Diabetes 678
Type 2 Diabetes 679
Urinalysis 679
Blood Glucose Testing 681
Serum Ketone Determinations 682
Glycated Hemoglobin Assays 682
Lipoproteins in Diabetes 683
Diagnosis of Diabetes Mellitus 683
Oral Glucose Tolerance Test 684
Insulin Levels 684
Intravenous Glucose Tolerance Test 685
18. Hypoglycemic Disorders John H. Karam, MD, Umesh Masharani, MRCP
Pathophysiology of the Counterregulatory Response
to Neuroglycopenia 747
Classification of Hypoglycemic Disorders 752
Clinical Presentation of Hypoglycemia 753
Specific Hypoglycemic Disorders 754
Symptomatic Fasting Hypoglycemia with
Hyperinsulinism 754
19. Disorders of Lipoprotein Metabolism Mary]. Malloy, MD, John P. Kane, MD, PhD
Atherosclerosis 766
Overview of Lipid Transport 767
Differentiation of Disorders of Lipoprotein
Metabolism 771
Clinical Descriptions of Primary Secondary Disorders
of Lipoprotein Metabolism 774
The Hypertriglyceridemias 774
Primary Hypertriglyceridemia 774
Secondary Hypertriglyceridemia 778
The Primary Hypercholesterolemias 780
Familial Hypercholesterolemia 780
Familial Combined Hyperlipidemia 781
LP(a) Hyperlipoproteinemia 781
CONTENTS / ix
637
D,MA
Endocrinology of the Puerperium 650
Endocrine Disorders Pregnancy 652
Pituitary Disorders 652
Pregnancy Breast Cancer 653
Hypertensive Disorders of Pregnancy 654
Hyperthyroidism in Pregnancy 655
Hypothyroidism in Pregnancy 656
658
ID, MichaelS. German, MD
Treatment of Diabetes Mellitus 689
Diet 689
Oral Agents for the Treatment of Hyperglycemia 690
Insulin 698
Steps in the Management of the Diabetic Patient 704
Acute Complications of Diabetes Mellitus 711
Hypoglycemia 711
Coma 714
Chronic Complications of Diabetes Mellitus 723
Specific Chronic Complications of Diabetes Mellitus 725
Surgery in the Diabetic Patient 732
Diabetics Regulated by Diet Alone 732
Diabetics Taking Oral Hypoglycemic Agents 732
Diabetics Taking Insulin 732
Diabetes Mellitus Pregnancy (by John L. Kitzmiller,
MD) 733
Prognosis for Patients with Diabetes Mellitus 741
747
(UK)
Symptomatic Fasting Hypoglycemia without
Hyperinsulinism 762
Nonfasting Hypoglycemia (Reactive Hypoglycemia) 763
766
Familial Ligand Defective APO B 781
Cholesterol 7 X Hydroxylase Deficiency 781
Secondary Hypercholesterolemia 782
Hypothyroidism 782
Nephrosis 782
Immunoglobulin Disorders 782
Anorexia Nervosa 782
Cholestasis 782
The Primary Hypolipidemias 783
Primary Hypolipidemia Due to Deficiency of High Density
Lipoproteins 783
Primary Hypolipidemia Due to Deficiency of APO B
Containing Lipoproteins 784
x / CONTENTS
Secondary Hypolipidemia 785
Other Disorders of Lipoprotein Metabolism 785
The Lipodystrophies 785
Rare Disorders 786
Treatment of Hyperlipidemia 787
Dietary Factors in the Management of Lipoprotein
Disorders 787
Drugs Used in Treatment of Hyperlipoproteinemia 789
Bile Acid Sequestrants 789
20. Obesity Overweight MarcK. Hellerstein, MD, PhD, Elizabeth J. Parks,
Controversies Uncertainties Regarding the
Pathogenesis of Obesity 804
Survey of Treatment Approaches Their Efficacy 806
Dietary Therapies 806
Surgical Treatment of Obesity 807
Pharmacologic Therapies 807
Other Conditions Affected by Treatment of Obesity or
Overweight 810
21. Humoral Manifestations of Malignancy Dolores Shoback, MD, Janet Funk, MD
Ectopic Hormone Receptor Syndromes 814
Hypercalcemia of Malignancy 815
Ectopic Cushing s Syndrome 819
Syndrome of Inappropriate ADH (SIADH) Secretion 822
22. Multiple Endocrine Neoplasia David G. Gardner, MD
Multiple Endocrine Neoplasia Type 1 (MEN 1) 829
Multiple Endocrine Neoplasia Type 2 (MEN 2) 834
23 Geriatric Endocrinology Susan L. Greenspan, MD, NeilM. Resnick, MD
Thyroid Function Disease 842
Disorders of the Thyroid Gland 843
Carbohydrate Intolerance Diabetes Mellitus 847
Aging the Physiology of Carbohydrate Intolerance 847
Diabetes Mellitus 847
Nonketotic Hyperosmolar Coma 849
Osteoporosis Calcium Homeostasis 850
Osteoporosis 850
Hyperparathyroidism 858
24. Endocrine Emergencies David G. Gardner, MD, Francis S. Greenspan, Ml
MyxedemaComa 867
Thyroid Storm 869
Thyrotoxic Periodic Paralysis 870
Amiodarone Induced Thyrotoxicosis 871
Acute Adrenal Insufficiency 872
Pituitary Apoplexy 873
25. AIDS Endocrinopathies Grace Lee, MD, Carl Grunfeld, MD, PhD
Thyroid Disorders 893
Adrenal Disorders 895
Bone Mineral Disorders 897
Gonadal Disorders 897
Niacin (Nicotinic Acid) 789
Fibric Acid Derivatives 790
HMG CoA Reductase Inhibitors 790
Combined Drug Therapy 791
Possible Untoward Consequences of Lipid Lowering
Therapy 792
794
PhD
Type 2 Diabetes Mellitus 810
Hyperlipidemia 812
Polycystic Ovarian Syndrome 812
Hypertension 812
Gallstones 812
Osteoarthritis Other Weight Sensitive States 812
A Systematic Approach to the Treatment ofObesity 813
814
Non Islet Cell Tumors Hypoglycemia 823
Other Hormones Secreted by Tumors 824
Oncogenic Osteomalacia 825
Gut Hormones 826
829
Other Disorders Characterized by Multiple Endocrine
Organ Involvement 840
842
Changes in Water Balance 858
Hypernatremia 859
Hyponatremia 859
Hyporeninemic Hypoaldosteronism 859
Glucocorticoids Stress 859
Disorders of the Hypothalamic Pituitary Adrenal Axis 860
Changes in Reproductive Function in Men 861
Benign Prostatic Hyperplasia 862
867
Diabetic Ketoacidosis 873
Nonketotic Hyperosmolar Coma 878
Hypercalcemic Crisis 880
Acute Hypocalcemia 882
Hyponatremia 885
Diabetes Insipidus 888
893
Pituitary Disorders 898
Pancreatic Disorders 898
Lipid Disorders 899
Conclusion 900
26. Endocrine Surgery Geeta Lai, MD, Orlo H. Clark, MD
Introduction 902
The Thyroid Gland 902
Developmental Thyroid Abnormalities 902
Hyperthyroidism 903
Thyroiditis 904
Nodular Goiter 904
Thyroid Nodules 904
Thyroid Cancer 904
Conduct of Thyroidectomy 906
The Parathyroid Gland 908
Primary Hyperparathyroidism 908
Persistent Recurrent Primary Hyperparathyroidism 910
Secondary Hyperparathyroidism 911
Special Consideration: Familial Hyperparathyroidism 911
Complications of Parathyroid Surgery 911
Appendix: Normal Hormone Reference Ranges. .. .
Index
CONTENTS / xi
902
The Adrenal (Suprarenal) Gland 911
Primary Hyperaldosteronism 911
Hypercortisolism 912
Sex Steroid Excess 912
Pheochromocytoma 913
Adrenal Cortical Carcinoma 913
Adrenal Incidentaloma 913
Technique of Adrenalectomy 914
The Endocrine Pancreas 914
Insulinoma 915
Gastrinoma (Zollinger Ellison Syndrome) 916
Vipoma (Verner Morrison) Syndrome 917
Glucagonoma 917
Somatostatinoma 917
Nonfunctioning Pancreatic Tumors 917
920
939
|
| any_adam_object | 1 |
| author_GND | (DE-588)172104742 |
| building | Verbundindex |
| bvnumber | BV017786423 |
| classification_rvk | YC 3100 |
| ctrlnum | (OCoLC)249301440 (DE-599)BVBBV017786423 |
| dewey-full | 616.4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.4 |
| dewey-search | 616.4 |
| dewey-sort | 3616.4 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 7. ed. |
| format | Book |
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| genre | (DE-588)4151278-9 Einführung gnd-content |
| genre_facet | Einführung |
| id | DE-604.BV017786423 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:21:48Z |
| institution | BVB |
| isbn | 0071402977 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010680194 |
| oclc_num | 249301440 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XVI, 976 S. Ill., graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Lange Medical Books/MacGraw-Hill |
| record_format | marc |
| series2 | A Lange medical book |
| spelling | Basic & clinical endocrinology ed. by Francis S. Greenspan ... Basic and clinical endocrinology 7. ed. New York [u.a.] Lange Medical Books/MacGraw-Hill 2004 XVI, 976 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier A Lange medical book Endokrinologie (DE-588)4014663-7 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Endokrinologie (DE-588)4014663-7 s DE-604 Greenspan, Francis S. 1920-2016 Sonstige (DE-588)172104742 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010680194&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Basic & clinical endocrinology Endokrinologie (DE-588)4014663-7 gnd |
| subject_GND | (DE-588)4014663-7 (DE-588)4151278-9 |
| title | Basic & clinical endocrinology |
| title_alt | Basic and clinical endocrinology |
| title_auth | Basic & clinical endocrinology |
| title_exact_search | Basic & clinical endocrinology |
| title_full | Basic & clinical endocrinology ed. by Francis S. Greenspan ... |
| title_fullStr | Basic & clinical endocrinology ed. by Francis S. Greenspan ... |
| title_full_unstemmed | Basic & clinical endocrinology ed. by Francis S. Greenspan ... |
| title_short | Basic & clinical endocrinology |
| title_sort | basic clinical endocrinology |
| topic | Endokrinologie (DE-588)4014663-7 gnd |
| topic_facet | Endokrinologie Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010680194&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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