Tacrolimus ointment: a topical immunomodulator for atopic dermatitis
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| Format: | Elektronisch Software E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2004
|
| Ausgabe: | [CD-ROM-Ausg.] |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 279 S. Ill., graph. Darst. |
| ISBN: | 3540435131 |
Internformat
MARC
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| 245 | 1 | 0 | |a Tacrolimus ointment |b a topical immunomodulator for atopic dermatitis |c T. Ruzicka ... (eds.) |
| 250 | |a [CD-ROM-Ausg.] | ||
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2004 | |
| 300 | |a XX, 279 S. |b Ill., graph. Darst. | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cd |2 rdacarrier | ||
| 533 | |a CD-ROM-Ausgabe |n CD-ROM-Ausg.: |e 1 CD-ROM ; 12 cm | ||
| 650 | 0 | 7 | |a Tacrolimus |0 (DE-588)4396700-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a CD-ROM |0 (DE-588)4139307-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Salbe |0 (DE-588)4178942-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Endogenes Ekzem |0 (DE-588)4223208-9 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Endogenes Ekzem |0 (DE-588)4223208-9 |D s |
| 689 | 0 | 1 | |a Tacrolimus |0 (DE-588)4396700-0 |D s |
| 689 | 0 | 2 | |a Salbe |0 (DE-588)4178942-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Endogenes Ekzem |0 (DE-588)4223208-9 |D s |
| 689 | 1 | 1 | |a Tacrolimus |0 (DE-588)4396700-0 |D s |
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| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Ruzicka, Thomas |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Reproduktion von |t Tacrolimus ointment |d 2004 |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010608386&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-010608386 | |
Datensatz im Suchindex
| _version_ | 1808225666832793600 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
ATOPIC
DERMATITIS
1
EPIDEMIOLOGY
OF
ATOPIC
DERMATITIS
.
3
T.L.
D
IEPGEN
INTRODUCTION
.
3
THE
PREVALENCE
OF
AD
YESTERDAY
AND
TODAY
.
4
DEFINITION
AND
VALIDATION
OF
AD
.
.
.
7
AGE
OF
ONSET
AND
CONCOMITANT
ATOPY
.
10
GENETIC
SUSCEPTIBILITY
.
.
11
EAST/WEST
DIFFERENCES
AND
MIGRATION
STUDIES
.
13
ENVIRONMENTAL
FACTORS
AND
LIFESTYLE
.
14
IMMUNOLOGY
AND
INFECTIONS
.
.
16
FUTURE
PUBLIC
HEALTH
IMPLICATIONS
OF
INCREASING
ATOPIC
DERMATITIS
.
18
REFERENCES
.
19
2
THE
PATHOGENESIS
OF
THE
ATOPIC
ECZEMA/DERMATITIS
SYNDROME
.
.
23
N.
N
OVAK
,
T.
B
IEBER
INTRODUCTION
.
.
23
GENETIC
FACTORS
.
24
CANDIDATE
GENES
RELATED
TO
IGE
SYNTHESIS
.
26
CANDIDATE
GENES
RELATED
TO
THE
HIGH
AFFINITY
RECEPTOR
FOR
IGE
F
CE
RI
.
26
CHEMOKINES
AND
OTHER
CANDIDATE
GENES
.
27
IMMUNOLOGICAL
MECHANISMS
INVOLVED
IN
AEDS
.
27
THE
SKIN
IMMUNE
SYSTEM
.
27
EVIDENCE
FOR
A
PATHOPHYSIOLOGICAL
ROLE
OF
KERATINOCYTES
IN
AEDS
.
28
THE
ROLE
OF
INFECTIOUS
AGENTS
.
.
.
.
.
29
AUTOALLERGENS
.
.
30
NEUROIMMUNOLOGICAL
FACTORS
INFLUENCING
THE
SKIN
.
30
PHOSPHODIESTERASE
ACTIVITY
.
31
OMEGA-6
FATTY
ACIDS
.
31
F
TABLE
OF
CONTENTS
CELLULAR
MECHANISMS
.
32
IGE-MEDIATED
TYPE
IV
REACTIONS
OF
THE
SKIN
.
32
ATOPIC
DERMATITIS
.
35
THE
ROLE
OF
IGE
-
THE
ALLERGIC
AND
NON-ALLERGIC
FORMS
OF
AEDS
.
36
THE
ATOPY
PATCH
TEST
AS
A
NEW
DIAGNOSTIC
TOOL
.
38
CONCLUSION
AND
FUTURE
PERSPECTIVES
.
39
REFERENCES
.
39
3
DETECTING,
DIAGNOSING
AND
GRADING
ATOPIC
DERMATITIS
.
47
J.M.
H
ANIFIN
INTRODUCTION
.
47
CRITERIA
FOR
RESEARCH
POPULATIONS
.
.
47
SCREENING
TOOLS
FOR
ATOPIC
DERMATITIS
.
50
SCREENING
WITH
QUESTIONNAIRES
.
51
CLINICAL
EXAMINATION
.
.
53
SEEKING
OPTIMAL
DIAGNOSTIC
CRITERIA
.
.
54
QUANTITATING
ECZEMATOUS
DISEASE
.
56
REFERENCES
.
59
4
CURRENT
TREATMENT
OF
ATOPIC
DERMATITIS
.
63
J.D.
BOS
INTRODUCTION
.
.
.
63
DIAGNOSIS
OF
ATOPIC
DERMATITIS:
KNOWING
WHETHER
IT
IS
ATOPY
(ATOPIC
DERMATITIS)
OR
NOT
(ATOPIFORM
DERMATITIS)
IS
ESSENTIAL
FOR
ITS
MANAGEMENT
.
.
65
ATOPIC
DERMATITIS:
A
COMMON
DISEASE
WITH
A
SERIOUS
IMPACT
ON
THE
QUALITY
OF
LIFE
.
65
GENETICS
OF
ATOPY
AND
ITS
ROLE
IN
THE
MANAGEMENT
OF
ATOPIC
DERMATITIS
.
66
GENERAL
MEASURES
IN
THE
MANAGEMENT
OF
ATOPIC
DERMATITIS
.
67
PREVENTION
.
68
ALLERGEN
AVOIDANCE
AND
ELIMINATION
OF
TRIGGERING
FACTORS
.
68
EMOLLIENTS
.
69
TOPICAL
ANTIMICROBIALS
AND
ANTISEPTICS
.
69
TREATMENT
FAILURE
.
69
SPECIFIC
THERAPIES
IN
THE
MANAGEMENT
OF
ATOPIC
DERMATITIS
.
70
TOPICAL
THERAPIES
INCLUDING
CORTICOSTEROIDS
.
70
SYSTEMIC
ANTIHISTAMINES
.
.
.
71
SYSTEMIC
ANTIBIOTICS
.
72
SYSTEMIC
IMMUNOMODULATORS
.
72
VIII
TABLE
OF
CONTENTS
|
PHOTOTHERAPY
AND
PHOTOCHEMOTHERAPY
.
HOSPITALISATION
AND
DAY-CARE
CENTRES
.
.
TREATMENT
OF
COMPLICATIONS
.
.
.
ALTERNATIVE
TREATMENTS
IN
THE
MANAGEMENT
OF
ATOPIC
DERMATITIS
.
NEW
APPROACHES
NEEDED
IN
ATOPIC
DERMATITIS
MANAGEMENT
.
.
IMPENDING
INNOVATIVE THERAPIES
IN
THE
MANAGEMENT
OF
ATOPIC
DERMATITIS
.,
72
73
73
74
75
75
76
DEVELOPMENT
OF
TACROLIMUS
OINTMENT
5
DEVELOPMENT
OF
TACROLIMUS
OINTMENT
.
81
T.
G
OTO
,
H.
N
AKAGAWA
DISCOVERY
AND
ISOLATION
OF
TACROLIMUS
.
.
.
.
PRECLINICAL
STUDIES
.
.
.
81
86
IN
VITRO
IMMUNOMODULATORY
EFFECTS
.
.
ANTIMICROBIAL
ACTIVITY
.
.
IN
VIVO
IMMUNOMODULATORY
EFFECTS
.
.
.
MOLECULAR
IMMUNOLOGY
.
.
.
.
.
.
.
CLINICAL
APPLICATIONS
.
.
.
.
TRANSPLANTATION
MEDICINE
.
.
TREATMENT
OF
DERMATOLOGICAL
DISEASES
.
.
EXPERIMENTAL
APPROACHES
.
.
.
.
.
.
ATOPIC
DERMATITIS
.
REFERENCES
86
87
87
89
90
90
91
92
95
98
6
PHARMACOKINETICS
OF
TACROLIMUS
OINTMENT:
CLINICAL
RELEVANCE
.
99
N.A.
U
NDRE
INTRODUCTION
99
PHARMACOKINETICS
.
100
PHYSICOCHEMICAL
PROPERTIES
.
101
SYSTEMIC
PHARMACOKINETICS
.
.101
DERMAL
PHARMACOKINETICS
-
IN
VITRO
MODELS
.
103
IN
VITRO
METABOLISM
OF
TACROLIMUS
BY
HUMAN
SKIN
.
105
PHARMACOKINETICS
OF
TACROLIMUS
-
TOPICAL
APPLICATION
.
105
PHARMACOKINETICS
-
HEALTHY
ADULT
SUBJECTS
.
105
PHARMACOKINETICS
-
PATIENTS
WITH
ATOPIC
DERMATITIS
.
.
106
POTENTIAL
FOR
INTERACTION
WITH
OTHER
MEDICATIONS
.
110
IX
TABLE
OF
CONTENTS
7
TACROLIMUS
AS
AN
IMMUNOMODULATOR
111
T.
A
SSMANN
,
B.
H
OMEY
,
T.
R
UZICKA
MODE
OF
ACTION
OF
TACROLIMUS
OINTMENT
.
112
BIOCHEMICAL
MECHANISMS
OF
ACTION
STUDIED
IN
T
CELLS
.
112
FURTHER
IN
VITRO
AND
EX
VIVO
FINDINGS
.
.
.
113
IN
VIVO
STUDIES
IN
ANIMALS
.
.
.
118
DIFFERENTIATION
OF
TOPICAL
TACROLIMUS
FROM
TOPICAL
GLUCOCORTICOSTEROIDS
.
120
GENERAL MODE
OF
ACTION
OF
GLUCOCORTICOSTEROIDS
IN
SKIN
.
120
COMPARISON
OF
IN
VIVO
EFFECTS
OF
TACROLIMUS
AND
GLUCOCORTICOSTEROIDS
.
121
EFFECTS
ON
COLLAGEN
SYNTHESIS
AND
SKIN
ATROPHY
.
.
.
122
CONCLUSION
.
123
REFERENCES
125
III
CLINICAL
EXPERIENCE
WITH
TACROLIMUS
OINTMENT
IN
ATOPIC
DERMATITIS
8
CLINICAL
EXPERIENCE
IN
ADULTS
.
.129
S.
R
EITAMO
INTRODUCTION
.
.
.
.
129
EARLY
CLINICAL
DEVELOPMENT
.
131
DRUG
CONCENTRATION
STUDIES
.
131
PHARMACOKINETICS
.
132
THE
TACROLIMUS
OINTMENT
CLINICAL
TRIALS
PROGRAMME
.
133
CLINICAL
EFFICACY
OF
TOPICAL
TACROLIMUS
.
.
135
EFFICACY
ASSESSMENTS
.
.
.
135
COMPARISON
WITH
VEHICLE
.
137
EFFICACY
IN
PATIENTS
WITH
LIMITED
DISEASE
.
141
COMPARISON
WITH
CORTICOSTEROIDS
.
141
LONG-TERM
COMPARISON
OF
TACROLIMUS
OINTMENT
AND
CORTICOSTEROIDS
.
144
SELECTION
OF
DRUG
CONCENTRATION
AND
ADMINISTRATION
.
144
LONG-TERM
EFFICACY
.
145
SAFETY
AND
TOLERABILITY
.
147
GENERAL
TOLERABILITY
AND
TREATMENT
DISCONTINUATIONS
.
148
LOCAL
ADVERSE
EVENTS
.
.
148
NON-APPLICATION-SITE
ADVERSE
EVENTS
.
150
EFFECTS
OF
TACROLIMUS
OINTMENT
ON
LABORATORY
VALUES
.
151
COMPARISON
WITH
TOPICAL
CORTICOSTEROIDS
.
151
LONG-TERM
SAFETY
AND
TOLERABILITY
.
.
154
QUALITY
OF
LIFE
AND
COST-EFFECTIVENESS
.
.157
SUMMARY
.
158
REFERENCES
.
159
X
TABLE
OF
CONTENTS
J
9
CLINICAL
EXPERIENCE
IN
CHILDREN
.
.
.
161
Y.
DE
P
ROST
EARLY
CLINICAL
DEVELOPMENT
.
.
162
MAJOR
CLINICAL
STUDIES
.
164
EFFICACY
OF
TACROLIMUS
OINTMENT
IN
CHILDREN
.
164
EFFICACY
ASSESSMENTS
.
165
COMPARISON
WITH
VEHICLE
.
166
COMPARISON
WITH
CORTICOSTEROIDS
.
170
SELECTION
OF
0.03%
TACROLIMUS
OINTMENT
FOR
STANDARD
USE
.
173
LONG-TERM
EFFICACY
.
.
.
173
SAFETY
AND
TOLERABILITY
.
175
LONG-TERM
SAFETY
AND
TOLERABILITY
.
177
RECENT
LONG-TERM
SAFETY
DATA
.
178
SKIN
ATROPHY
.
179
IMMUNOMODULATION
.
.
.
179
SUMMARY
.
180
IMPACT
OF
TACROLIMUS
OINTMENT
ON
QUALITY
OF
LIFE
.
180
CONCLUSIONS
.
182
REFERENCES
.
182
10
THE
ROLE
OF
TACROLIMUS
OINTMENT
IN
ATOPIC
DERMATITIS
.
185
S.
R
EITAMO
INTRODUCTION
185
THE
CURRENT
MANAGEMENT
MODEL
FOR
ATOPIC
DERMATITIS
AND
ITS
LIMITATIONS
.
.
.
185
THE
INTRODUCTION
OF
TACROLIMUS
OINTMENT
.
.
189
EFFICACY
OF
TACROLIMUS
OINTMENT
MONOTHERAPY
.
.
192
THE
ISSUE
OF
SAFETY
.
.
.
.
195
USING
TACROLIMUS
OINTMENT
IN
EVERYDAY
PRACTICE
.
199
SELECTION
OF
OINTMENT
STRENGTH
AND
DOSING
.
199
FREQUENCY
OF
ADMINISTRATION
.
200
CAUTIONS
AND
CONTRAINDICATIONS
.
201
TOWARDS
A
NEW
TREATMENT
PARADIGM
FOR
ATOPIC
DERMATITIS
.
.
201
MODIFICATIONS
TO
THE
TRADITIONAL
MODEL
.
.
203
MANAGEMENT
OF
MILD
ATOPIC
DERMATITIS
.
.
206
DIFFERENT
PATIENT
GROUPS
.
.
208
REFERENCES
.
209
XI
TABLE
OF
CONTENTS
11
OTHER
POTENTIAL
DERMATOLOGICAL
INDICATIONS
FOR
TACROLIMUS
.
.213
T.
A
SSMANN
,
T.
R
UZICKA
PSORIASIS
.
214
ACRODERMATITIS
CONTINUA
.
217
LICHEN
PLANUS
.
219
LICHEN
SCLEROSUS
.
.
221
PYODERMA
GANGRENOSUM
.
223
LEG
ULCERS
IN
RHEUMATOID
ARTHRITIS/RHEUMATOID
ULCERS
.
224
STEROID
ROSACEA
.
226
CHRONIC
GRAFT-VERSUS-HOST
DISEASE
.
227
ALOPECIA
AREATA
.
.
229
REFERENCES
.
231
IV
SOCIAL
IMPACT
OF
ATOPIC
DERMATITIS
12
QUALITY
OF
LIFE
MEASUREMENTS
IN
ATOPIC
DERMATITIS
.
237
A.Y.
F
INLAY
,
W.H.C.
B
URGDORF
INTRODUCTION
.
.
.
.
.
TYPES
OF
QOL
MEASUREMENT
.
GENERAL
HEALTH
INDEX
.
.
.
UTILITY
MEASURES
.
.
DERMATOLOGY-SPECIFIC
MEASURES
.
SKIN
DISEASE-SPECIFIC
MEASURES
.
QOL
MEASUREMENT
IN
CHILDREN
AND
INFANTS
.
QOL
INDICES
DEVELOPED
BY
OUR
GROUP
.
DERMATOLOGY
LIFE
QUALITY
INDEX
.
CHILDREN
'
S
DERMATOLOGY
LIFE
QUALITY
INDEX
.
DERMATITIS
FAMILY
IMPACT
QUESTIONNAIRE
.
.
.
INFANTS
'
DERMATITIS
QOL
INDEX
.
QOL
IN
ATOPIC
DERMATITIS
.
CLINICAL
FEATURES
.
.
.
USE
OF
QOL
MEASURES
IN
ATOPIC
DERMATITIS
.
CHILDREN
.
FAMILIES
AND
INFANTS
.
.
QOL
ASSESSMENT
IN
PATIENTS
TREATED
WITH
TACROLIMUS
OINTMENT
.
237
238
238
239
240
240
240
241
241
244
245
247
248
249
250
250
251
251
252
253
XII
TABLE
OF
CONTENTS
13
PHARMACOECONOMICS
IN
ATOPIC
DERMATITIS
M.
A
UGUSTIN
255
INTRODUCTION:
SOCIOECONOMIC
IMPACT
OF
ATOPIC
DERMATITIS
.
255
PHARMACOECONOMICS:
DEFINITION
AND
AIMS
.
.
.
255
DEFINITION
AND
EVALUATION
OF
COSTS
.
256
DEFINITION
AND
EVALUATION
OF
QUALITY
OF
LIFE
.
257
PHARMACOECONOMIC
ANALYSES
.
.
259
PHARMACOECONOMIC
ASPECTS
IN
ATOPIC
DERMATITIS
.
260
COST
FACTORS
IN
ATOPIC
DERMATITIS
.
.
.
.
260
QUALITY
OF
LIFE
IN
ATOPIC
DERMATITIS
.
.
.
262
PHARMACOECONOMICS
OF
TACROLIMUS
OINTMENT
(PROTOPIC)
.
263
COSTS
OF
TACROLIMUS
OINTMENT
IN
CLINICAL
STUDIES
.
264
POTENTIAL
COSTS
DUE
TO
SIDE
EFFECTS
.
.
.
264
SKIN
ATROPHY
.
264
SKIN
INFECTIONS
.
265
SYSTEMIC
EFFECTS
.
265
CARCINOGENIC
AND
MUTAGENIC
EFFECTS
.
266
REBOUND
.
,
.
266
COSTS
DUE
TO
NON-COMPLIANCE
.
266
BENEFITS
AND
COST-BENEFIT
RATIOS
.
267
CLINICAL
IMPROVEMENT
.
267
QUALITY
OF
LIFE
.
267
COSTS
.
267
COST
-
BENEFIT
RATIO
.J.
267
PHARMACOECONOMICS
IN
A
MARKOV
MODEL
ANALYSIS
.
268
PERSPECTIVES
.
268
REFERENCES
.
269
APPENDIX
INDEX
.
273
V
XIII |
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV017638148 |
| classification_rvk | YF 3715 |
| ctrlnum | (OCoLC)634856427 (DE-599)BVBBV017638148 |
| discipline | Medizin |
| edition | [CD-ROM-Ausg.] |
| format | Electronic Software eBook |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV017638148 |
| illustrated | Illustrated |
| indexdate | 2024-08-24T00:12:54Z |
| institution | BVB |
| isbn | 3540435131 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010608386 |
| oclc_num | 634856427 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XX, 279 S. Ill., graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Springer |
| record_format | marc |
| spelling | Tacrolimus ointment a topical immunomodulator for atopic dermatitis T. Ruzicka ... (eds.) [CD-ROM-Ausg.] Berlin [u.a.] Springer 2004 XX, 279 S. Ill., graph. Darst. c rdamedia cd rdacarrier CD-ROM-Ausgabe CD-ROM-Ausg.: 1 CD-ROM ; 12 cm Tacrolimus (DE-588)4396700-0 gnd rswk-swf CD-ROM (DE-588)4139307-7 gnd rswk-swf Salbe (DE-588)4178942-8 gnd rswk-swf Endogenes Ekzem (DE-588)4223208-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Endogenes Ekzem (DE-588)4223208-9 s Tacrolimus (DE-588)4396700-0 s Salbe (DE-588)4178942-8 s DE-604 CD-ROM (DE-588)4139307-7 s Ruzicka, Thomas Sonstige oth Reproduktion von Tacrolimus ointment 2004 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010608386&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tacrolimus ointment a topical immunomodulator for atopic dermatitis Tacrolimus (DE-588)4396700-0 gnd CD-ROM (DE-588)4139307-7 gnd Salbe (DE-588)4178942-8 gnd Endogenes Ekzem (DE-588)4223208-9 gnd |
| subject_GND | (DE-588)4396700-0 (DE-588)4139307-7 (DE-588)4178942-8 (DE-588)4223208-9 (DE-588)4143413-4 |
| title | Tacrolimus ointment a topical immunomodulator for atopic dermatitis |
| title_auth | Tacrolimus ointment a topical immunomodulator for atopic dermatitis |
| title_exact_search | Tacrolimus ointment a topical immunomodulator for atopic dermatitis |
| title_full | Tacrolimus ointment a topical immunomodulator for atopic dermatitis T. Ruzicka ... (eds.) |
| title_fullStr | Tacrolimus ointment a topical immunomodulator for atopic dermatitis T. Ruzicka ... (eds.) |
| title_full_unstemmed | Tacrolimus ointment a topical immunomodulator for atopic dermatitis T. Ruzicka ... (eds.) |
| title_short | Tacrolimus ointment |
| title_sort | tacrolimus ointment a topical immunomodulator for atopic dermatitis |
| title_sub | a topical immunomodulator for atopic dermatitis |
| topic | Tacrolimus (DE-588)4396700-0 gnd CD-ROM (DE-588)4139307-7 gnd Salbe (DE-588)4178942-8 gnd Endogenes Ekzem (DE-588)4223208-9 gnd |
| topic_facet | Tacrolimus CD-ROM Salbe Endogenes Ekzem Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010608386&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ruzickathomas tacrolimusointmentatopicalimmunomodulatorforatopicdermatitis |