Tumor suppressor genes: 2 Regulation, function, and medicinal applications
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Totowa, N.J.
Humana Press
2003
|
| Schriftenreihe: | Methods in molecular biology
223 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | e-book: 1-59259-328-3 |
| Beschreibung: | XIX, 657 S. Ill., graph. Darst. |
| ISBN: | 0896039870 1592593283 |
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Datensatz im Suchindex
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| adam_text | Contents
Preface v
Contents of Companion Volume xi
Contributors xiii
Part I. Understanding the Function and Regulation
of Tumor Suppressor Genes
1 Utilizing NMR to Study the Structure of Growth Inhibitory Proteins
Franceses M. Marassi 3
2 Generation and Application of Phospho Specific Antibodies
for p53 and pRB
Yoichi Taya, Kiichiro Nakajima, Kumiko Yoshizawa Kumagaye,
and Katsuyuki Tamai 17
3 Stability and Ubiquitination of the Tumor Suppressor Protein p53
Lesley J. Jardine and Carl G. Maki 27
4 Role of Tumor Suppressors in DNA Damage Response
Bin Bing S. Zhou, Michael R. Mattern, and Kum Kum Khanna 39
5 In Situ Hybridization in Cancer and Normal Tissue
Shrihari Kadkol, Jeremy Juang, and Tzyy choou Wu 51
6 Genetic Strategies in Saccharomyces cerevisiae
to Study Human Tumor Suppressor Genes
Takahlko Kobayashi, Ting Wang, Hua Qian,
and Rainer K. Brachmann 73
7 Electrophoretic Mobility Shift Analysis of the DNA Binding
of Tumor Suppressor Gene Products
Edward C. Thornborrow, Matthew Maurer, and James J. Manfredi 87
8 Analysis of Gene Promoter Regulation by Tumor Suppressor Genes
Kumaravel Somasundaram, Sanjeev Das, Smita Lakhotia,
and Narendra Wajapeyee 101
9 DNA Footprinting
M. Stacey Ricci and Wafik S. El Deiry 117
10 Identification of DNA Binding of Tumor Suppressor Genes
by Chromatin Immunoprecipitation
Timothy K. MacLachlan and Wafik S. El Deiry 129
11 Co immunoprecipitation of Tumor Suppressor
Protein Interacting Proteins
Li KuoSu 135
vii
viii Contents
12 Microarray Approaches for Analysis
of Tumor Suppressor Gene Function
Sally A. Amundson and Albert J. Fornace, Jr. 141
13 Analysis of Tumor Suppressor Gene Induced Senescence
Judith Campisi 155
14 Yeast Two Hybrid Screening as a Means
of Deciphering Tumor Suppressor Pathways
E. Robert McDonald III and Wafik S. El Deiry 173
15 Somatic Cell Knockouts of Tumor Suppressor Genes
Ruth Hemmer, Wenyl Wei, Annie Dutriaux, and John M. Sedivy 187
16 Colony Growth Suppression by Tumor Suppressor Genes
Gen Sheng Wu 207
17 Flow Cytometric Analysis of Cell Cycle Control
by Tumor Suppressor Genes
David T. Dicker and Wafik S. El Deiry 211
18 Analysis of Cyclin Dependent Kinase Activity
Timothy K. MacLachlan and Wafik S. El Deiry 277
19 Tumor Suppressor Gene lnducible Cell Lines
Michael Dohn, Susan Nozell, Amy Willis, and Xinbin Chen 221
20 In Vitro Models of Early Neoplastic Transformation
of Human Mammary Epithelial Cells
VimlaBand 237
21 Tumor Suppression Through Angiogenesis Inhibition
Andrew M. Arsham and M. Celeste Simon 249
22 Flow Cytometric Analysis of Tumor Suppressor
Gene Induced Apoptosis
David T. Dicker and Wafik S. El Deiry 271
23 Functional Analysis of Tumor Suppressor Genes in Mice
Stephen N. Jones and Lawrence A. Donehower 283
24 The Tissue Microenvironment as an Epigenetic Tumor Modifier
Meredith Unger and Valerie M. Weaver 315
25 Analyzing the Function of Tumor Suppressor Genes
Using a Drosophila Model
Raymond A. Pagliarini, Ana T. Quinones, and Tian Xu 349
26 Assembling a Tumor Progression Model
MarkRedston 383
27 Conformation Sensitive Gel Electrophoresis
for Detecting BRCA1 Mutations
Smita Lakhotia and Kumaravel Somasundaram 403
Part II. Medicinal Applications of Tumor Suppressors
28 Conversion Technology and Cancer Predispositions
Nickolas Papadopoulos 415
Contents ix
29 Discovering Novel Anticancer Drugs:
Practical Aspects and Recent Advances
Cristina T. Lewis and Patrick M. O Connor 425
30 Targets in Apoptosis Signaling:
Promise of Selective Anticancer Therapy
Ramadevi Nimmanapalli and Kapil Bhalla 465
31 Tumor Deprivation of Oxygen and Tumor Suppressor Gene Function
Zhong Yun and Amato J. Giaccia 485
32 Hormonal and Differentiation Agents in Cancer Growth Suppression
Mikhail V. Blagosklonny 505
33 Regulation of NF kB by Oncoproteins and Tumor Suppressor Proteins
Lee V. Madrid and Albert S. Baldwin, Jr. 523
34 Blocking Survivin to Kill Cancer Cells
Dario C. Altieri 533
35 Targeting the Mitochondria to Enhance Tumor Suppression
Eyal Gottlieb and Craig B. Thompson 543
36 Novel Approaches to Screen for Anticancer Drugs
Using Saccharomyces cerevisiae
Julian A. Simon and Timothy J. Yen 555
37 Tumor Suppressor Gene Therapy
Jack A. Roth and Susan F. Grammer 577
38 Therapeutic Strategies Using Inhibitors of Angiogenesis
Michael S. O Reilly 599
39 Isolation of p53 Inhibitors by Screening Chemical Libraries
in Cell Based Readout System
Andrei Gudkov and Elena Komarova 635
Index 649
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| language | English |
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| series | Methods in molecular biology |
| series2 | Methods in molecular biology |
| spelling | Tumor suppressor genes 2 Regulation, function, and medicinal applications edited by Wafik S. El-Deiry Totowa, N.J. Humana Press 2003 XIX, 657 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 223 Methods in molecular biology ... e-book: 1-59259-328-3 Antioncogenes Laboratory manuals Genes, Tumor Suppressor physiology Laboratory Manuals Neoplasms genetics Laboratory Manuals Neoplasms therapy Laboratory Manuals Signal Transduction physiology Laboratory Manuals Tumor Suppressor Proteins physiology Laboratory Manuals Labortechnik (DE-588)4123602-6 gnd rswk-swf Tumorsuppressor-Gen (DE-588)4326903-5 gnd rswk-swf Tumorsuppressor-Gen (DE-588)4326903-5 s Labortechnik (DE-588)4123602-6 s DE-604 El-Deiry, Wafik S. Sonstige oth (DE-604)BV014668841 2 Methods in molecular biology 223 (DE-604)BV035362695 223 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010560214&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tumor suppressor genes Methods in molecular biology Antioncogenes Laboratory manuals Genes, Tumor Suppressor physiology Laboratory Manuals Neoplasms genetics Laboratory Manuals Neoplasms therapy Laboratory Manuals Signal Transduction physiology Laboratory Manuals Tumor Suppressor Proteins physiology Laboratory Manuals Labortechnik (DE-588)4123602-6 gnd Tumorsuppressor-Gen (DE-588)4326903-5 gnd |
| subject_GND | (DE-588)4123602-6 (DE-588)4326903-5 |
| title | Tumor suppressor genes |
| title_auth | Tumor suppressor genes |
| title_exact_search | Tumor suppressor genes |
| title_full | Tumor suppressor genes 2 Regulation, function, and medicinal applications edited by Wafik S. El-Deiry |
| title_fullStr | Tumor suppressor genes 2 Regulation, function, and medicinal applications edited by Wafik S. El-Deiry |
| title_full_unstemmed | Tumor suppressor genes 2 Regulation, function, and medicinal applications edited by Wafik S. El-Deiry |
| title_short | Tumor suppressor genes |
| title_sort | tumor suppressor genes regulation function and medicinal applications |
| topic | Antioncogenes Laboratory manuals Genes, Tumor Suppressor physiology Laboratory Manuals Neoplasms genetics Laboratory Manuals Neoplasms therapy Laboratory Manuals Signal Transduction physiology Laboratory Manuals Tumor Suppressor Proteins physiology Laboratory Manuals Labortechnik (DE-588)4123602-6 gnd Tumorsuppressor-Gen (DE-588)4326903-5 gnd |
| topic_facet | Antioncogenes Laboratory manuals Genes, Tumor Suppressor physiology Laboratory Manuals Neoplasms genetics Laboratory Manuals Neoplasms therapy Laboratory Manuals Signal Transduction physiology Laboratory Manuals Tumor Suppressor Proteins physiology Laboratory Manuals Labortechnik Tumorsuppressor-Gen |
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