Cell motility: from molecules to organisms
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2004
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 342 S.: Ill., graph. Darst. |
| ISBN: | 0470848723 |
Internformat
MARC
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| 245 | 1 | 0 | |a Cell motility |b from molecules to organisms |c ed. by Anne Ridley ... |
| 264 | 1 | |a Chichester |b Wiley |c 2004 | |
| 300 | |a XXII, 342 S.: Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cell Movement | |
| 650 | 4 | |a Cells |x Motility | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-010556662 | ||
Datensatz im Suchindex
| _version_ | 1804130314693378048 |
|---|---|
| adam_text | Contents
Preface
xv
List of Contributors
xix
1
Molecular Mechanisms Regulating Actin Filament Dynamics
at the Leading Edge of Motile Cells
Thomas D. Pollard
1
Inventory of components
2
The ground state of the system
5
Signalling pathways
6
Activation of the Arp2/3 complex
8
Growth of the branched actin filament network
10
Filament ageing, remodelling and disassembly
10
Recycling ADP-actin subunits
12
Reaction to a chemoattractant
12
Reaction to the withdrawal of a chemoattractant
12
Acknowledgements
13
References
13
2
The Role of Talin and Myosin
VII
in Adhesion
-
A FERM
Connection
Margaret A. Titus
19
Adhesion receptors in Dictyostelium
22
Links between the Dictyostelium cytoskeleton and adhesion
24
A link between M7 and talin?
28
The relationship of DdM7 to another
FERM
myosin,
MIO
31
Conclusions
32
Acknowledgements
32
References
32
3
Do Class I Myosins exert their Functions through Regulation
of Actin Dynamics?
Thierry
Soldati
and Claudia Kistler
39
Introduction
40
Structure function analysis of Class I myosins
44
viii
CONTENTS
Phenotypes
resulting from manipulation of class I myosins
48
Class I myosins and the actin dynamics connection
Conclusions and outlook
54
Acknowledgements
References
4
Ephrin-regulated Contact Repulsion of Growth Cones
Lene K.
Harbott, Daniel
J. Mar ston
and Catherine D. Nobes
61
Introduction 62
Eph receptor and ephrin families
62
Eph receptor/ephrin regulation of axon guidance
62
Eph receptor/ephrin mediated control of cell segregation
63
Eph receptor/ephrin signalling
64
Eph receptor activation by soluble ephrins rapidly stimulates
the assembly of filamentous actin structures in
fibroblast
cells
65
EphB2 and EphA7 induced lamellipodial protrusion is
mediated by the small GTPase
Rac
65
Role of Rho GTPases in ephrin induced growth cone collapse
67
Conclusions
71
References
72
5
Interplay between the Actin Cytoskeleton, Focal Adhesions
and Microtubules
Christoph Ballestrem,
Natalia Magid, Julia Zonis,
Michael Shtutman and Alexander Bershadsky
75
Introduction
76
Actin, microtubules and cell-matrix adhesions in crawling cell
locomotion
78
Mechanosensory function of focal adhesions and its modulation
by microtubules
81
mDial as a possible coordinator of actin, focal adhesions and
microtubule assembly
84
Conclusion and perspectives
91
References
93
6
Initial Steps from Cell Migration to Cell-cell Adhesion
Jason S.
Ehrlich,
W.
James Nelson and Marc D. H.
Hansen 101
Introduction
201
Epithelial cell-cell adhesion complexes
102
Molecular interactions and functions of classical cadherins
103
CONTENTS ix
Examining E-cadherin distribution during cell-cell adhesion
in live cells
104
Mechanistic insights into E-cadherin function during cell-cell
adhesion
106
The role of Rho family small GTPases and membrane dynamics
in cell-cell adhesion
106
Rac
1
-containing lamellipodia drive cell-cell contact formation
between MDCK cells
107
Cell-cell contact induces changes in Racl complexes
108
Effects of Racl mutant expression on endogenous Racl
complexes and cell behaviour
108
Linking Racl complexes back to mechanisms of cell-cell
adhesion
111
Acknowledgements
112
References
112
Using
Bioprobes
to follow Protein Dynamics in Living Cells
Mark R. Holt,
Daniel Y. H.
Soong, James Monypenny,
Ian M. Dobbie, Daniel
Zicha
and Graham A. Dunn
117
Fluorescence resonance energy transfer (FRET)
118
Fluorescence lifetime imaging microscopy (FLIM)
120
Total internal reflection fluorescence (TIRF)/evanescent
wave microscopy
122
Fluorescence speckle microscopy (FSM)
125
Fluorescence localization after photobleaching (FLAP)
127
FLAP: Image acquisition and image processing
128
FLAP: Some points to consider
131
Concluding remarks
132
Acknowledgements
132
References
132
Actin Filament Assembly: The Search for a Barbed End
Craig F. Stovold, Stewart J. Sharp and Laura M. Macheshy
135
The Arp2/3 complex
137
WASp family proteins
138
The WASp-Arp2/3 pathway
139
The role of
Ena/
VASP
proteins
144
Conclusions
146
References
147
CONTENTS
Role of WASp Family Proteins in Cytoskeletal Reorganization
and Cell Motility
Tadaomi Takenawa and Shiro Suetsugu
Introduction
WASp and WAVE family proteins 154
WASp and WAVE activate the Arp2/3 complex through the
VCA region 155
Mechanism of activation of N-WASp, WAVE1
,
and WAVE2
157
N-WASp is involved in podosome formation and tubulogenesis
159
Conclusions
161
References
10
Regulation and Function of the Small GTP-binding
Protein ARF6 in Membrane Dynamics
Thierry
Dubois,
Emma Colucci-Guyon, Florence
Niedergang,
Magali Prigent
and Philippe Chavrier
165
Intracellular localization of ARF6
166
Regulation of ARF6 activation
167
Function of ARF6 in polarized membrane delivery at the
plasma membrane
168
Events downstream of ARF6 activation
170
Acknowledgements
171
References
171
11
Chemotaxis of Cancer Cells during Invasion and Metastasis
John Condeelis, Xiaoyan Song, Jonathan M. Backer,
Jeffrey Wyckoff and Jeffrey
Segali
17 5
Chemotaxis to EGF
175
Events that define the leading edge during chemotaxis
179
Is actin polymerization the initial asymmetry generating event?
180
Do the early and late actin polymerization transients result
from different mechanisms?
182
Conclusions
184
References
186
12
Dynamin and Cytoskeletal-dependent Membrane Processes
James D. Orth, Noah W. Gray, Heather M. Thompson
and Mark A. McNiven
189
Introduction
189
Participation of dynamin in actin-based membrane dynamics
193
Conclusions and perspectives
198
References
CONTENTS xi
13 Regulation
of Microtubule
Dynamics in
Migrating Cells:
a New Role for Rho GTPases
Torsten Wittmann
and Clare M. Waterman-Storer
203
Introduction
203
Centrosome
reorientation
downstream of Cdc42
207
Microtubule stabilization downstream of RhoA
209
Regulation of microtubule dynamic instability downstream
ofRacl
210
Conclusion
213
References
213
14
Calpain Regulation of Cell Migration
Anna Huttenlocher
219
Basic steps of cell movement
220
External factors that regulate cell migration
220
Integrin
receptors and focal adhesions
222
Calpain
222
Mechanisms of cell detachment and focal adhesion
disassembly: a role for calpain
225
Calpain during adhesion formation and directional migration
227
Conclusions
229
References
230
15
Role of
Villin in
the Dynamics of Actin
Microfilaments
Rafika
Athman,
Sylvie Robině
and Daniel
Louvar d
235
Introduction
236
Villin,
a structural actin-binding protein
236
Viliin
as a regulator of actin dynamics
240
Perspectives
242
References
244
16
Scar, WASp and the Arpl/3 Complex in Dictyostelium
Migration
Simone Blagg
and Robert
Insali
247
Introduction
247
The Arp2/3 complex and WASp family proteins
248
Control of actin dynamics in Dictyostelium
252
Evolutionary implications
254
Coupling signalling pathways to Arp2/3 dependent actin
polymerization
255
References
257
XÍi
CONTENTS
17
Directional Sensing: Subcellular Targeting of GPCR
Downstream Effectors During Chemotaxis
Šatoru Funamoto
and Richard A. Firtel
261
Introduction 262
GPCR-mediated
lipid
signalling in chemotaxis of
amoeboid cells 262
Mechanisms controlling PH domain localization and
the role of PI3K in chemotaxis
263
PI3K translocates upon stimulation with a chemoattractant
265
PTEN as a negative regulator of the D3-PI signalling pathway
in chemotaxis
267
Chemotaxis regulated by
MEK kinase
signalling
269
The initial asymmetric signal and downstream asymmetric
signals
271
References
272
18
Cell Crawling, Cell Behaviour and Biomechanics during
Convergence and Extension
Ray Keller and Lance Davidson
277
Introduction
277
The diversity and complexity of convergence and extension
283
Extension by shape change, orientated division and growth
286
Bipolar traction
286
Do the intercalating cells actually migrate on one another?
287
Dynamics and stiffness: how does a dynamic tissue push?
289
Cell-cell and cell-matrix adhesion in convergent extension
291
Extracellular matrix and cell intercalation
292
The special function of bipolarity
293
References
293
19
Regulation of Cell Migration In Vitro and In Vivo
Donna
J
Webb, Karen
Donais, Shin-ichi
Murase,
Hannelore Asmussen and Alan F. Horwitz 299
Introduction
300
Adhesion dynamics in migrating cells
301
Adhesion disassembly at the cell rear
304
Intracellular trafficking of adhesion molecules
306
Migration in vivo
309
Conclusions
References
CONTENTS xiii
20 Genes
that Control Cell Migration during Mouse Development
Carmen Birchmeier
317
Introduction
317
Migration of neural crest cells
318
ErbB receptors and their ligand, Nrgl
318
Nrgl, the
ErbBŽ/ErbBS
receptors and migration of neural
crest cells
320
Sox
10
controls the expression of
ЕгЬВЗ
during development
of neural crest cells
321
с
-Ret
and Eph tyrosine kinase receptors and the development
of neural crest cells
322
Development of migrating muscle precursor cells
324
с
-Met,
its ligand SF/HGF and the
Gabi
adaptor
324
с
-Met,
SF/HGF and
Gabi
control delamination of migrating
muscle precursors from the dermomyotome
325
The homeobox gene Lbxl is essential for correct target
finding of migrating muscle precursor cells
327
Eph receptor signals during migration of muscle precursor
cells to the limbs
328
Conclusions
328
References
328
Index
331
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| id | DE-604.BV017524984 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T19:19:04Z |
| institution | BVB |
| isbn | 0470848723 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010556662 |
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| physical | XXII, 342 S.: Ill., graph. Darst. |
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| spelling | Cell motility from molecules to organisms ed. by Anne Ridley ... Chichester Wiley 2004 XXII, 342 S.: Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell Movement Cells Motility Zelle (DE-588)4067537-3 gnd rswk-swf Motilität (DE-588)4114638-4 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2003 Oxford gnd-content Zelle (DE-588)4067537-3 s Motilität (DE-588)4114638-4 s DE-604 Ridley, Anne Sonstige oth Digitalisierung TU Muenchen application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010556662&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cell motility from molecules to organisms Cell Movement Cells Motility Zelle (DE-588)4067537-3 gnd Motilität (DE-588)4114638-4 gnd |
| subject_GND | (DE-588)4067537-3 (DE-588)4114638-4 (DE-588)1071861417 |
| title | Cell motility from molecules to organisms |
| title_auth | Cell motility from molecules to organisms |
| title_exact_search | Cell motility from molecules to organisms |
| title_full | Cell motility from molecules to organisms ed. by Anne Ridley ... |
| title_fullStr | Cell motility from molecules to organisms ed. by Anne Ridley ... |
| title_full_unstemmed | Cell motility from molecules to organisms ed. by Anne Ridley ... |
| title_short | Cell motility |
| title_sort | cell motility from molecules to organisms |
| title_sub | from molecules to organisms |
| topic | Cell Movement Cells Motility Zelle (DE-588)4067537-3 gnd Motilität (DE-588)4114638-4 gnd |
| topic_facet | Cell Movement Cells Motility Zelle Motilität Konferenzschrift 2003 Oxford |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010556662&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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