Immunobiology of carbohydrates:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Georgetown, Tex.
Eurekah.com/Landes Bioscience
2003
New York, N.Y. Kluwer Academic/Plenum |
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 315 S. |
| ISBN: | 0306478447 |
Internformat
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| 245 | 1 | 0 | |a Immunobiology of carbohydrates |c [edited by] Simon Y.C. Wong |
| 264 | 1 | |a Georgetown, Tex. |b Eurekah.com/Landes Bioscience |c 2003 | |
| 264 | 1 | |a New York, N.Y. |b Kluwer Academic/Plenum | |
| 300 | |a 315 S. | ||
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| 490 | 0 | |a Molecular biology intelligence unit | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 2 | |a Glucides - immunologie | |
| 650 | 4 | |a Antigen-antibody reactions |x Physiological effect | |
| 650 | 4 | |a Carbohydrates |x Immunology | |
| 650 | 4 | |a Carbohydrates |x immunology | |
| 650 | 4 | |a Immunity, Cellular | |
| 650 | 4 | |a Receptors, Immunologic |x physiology | |
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| 700 | 1 | |a Wong, Simon Y. C. |e Sonstige |4 oth | |
| 700 | 1 | |a Arsequell, Gemma |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804130286566375424 |
|---|---|
| adam_text | I = CONTENTS 1
Preface xiv
1. Carbohydrate Blood Group Antigens and Tumor Antigens 1
Reiji Kannagi
Abstract 1
ABO(H) Blood Group Antigens 1
I and i Antigens 5
P Blood Group Antigens 9
Lewis Blood Group Antigens 12
Differentiation and Developmental Carbohydrate Determinants,
Lewisx, Lewisy, Sialyl Lewisx and Related Antigens 16
Heterophile Antigens 24
2. Structural Basis for Mannose Binding Protein Function
in Innate Immunity 34
Russell Wallis
Summary 34
Introduction 34
Structural Organization of MBP 35
Gene Organization of MBP 36
Sugar Recognition by MBP 37
MBP/MASP Complexes 38
Mechanism of Complement Activation by MBP 39
MBP Associated Immunodeficiency 40
Complement Activation and Disease 41
MBP and Opsonization 42
MBP As a Therapeutic Agent 42
3. C Reactive Protein: Structure, Synthesis and Function 46
Terry W. Du Clos and Carolyn Mold
Abstract 46
Introduction 46
History 46
Synthesis 47
Structure 48
Ligand Binding 48
Receptor Interactions 50
CRP and the Complement System 52
CRP and Infection 52
CRP and Autoimmunity 54
CRP and Cardiovascular Disease 55
CRP and Inflammation 56
CRP and Cytokine Production 57
Summary 57
4. Complement: A Major Humoral Effector System in Innate
and Acquired Immunity 62
Philippe Gasque and B. Paul Morgan
Abstract 62
Molecular Elements of the Innate Immune Response Involved
in the Recognition of Pathogens and Toxic Cell Debris:
A Common Ancestral Scavenging System 62
The Complement System and Complement Associated Proteins:
Routes of Activation against Pathogens 63
The C System and C Associated Proteins: Clearance
of Apoptotic Cells 65
The Proposed Clq Receptor Involved in Phagocytosis
and/or Signaling Events 67
Other Clq and Defense Collagen Receptors (CR1, Cclqr,
CD91,Gclqr) 67
C Receptors Involved in Phagocytosis and Cell Recruitment
(Chemotaxis) 67
CR2(CD21): The Link Between Innate and Acquired
Immune Responses 69
The Opsonic Ancestral Element 69
C and Other Innate Immune Signaling Pathways:
An Ancestral Innate Immune Signaling Pathway 69
Conclusion 70
5. Carbohydrate Recognition Receptors on Antigen Presenting Cells 74
Philip R. Taylor, Gordon D. Brown, Luisa Martinez Pomares
andSiamon Gordon
Abstract 74
Introduction 74
The Macrophage Mannose Receptor Family 75
Other Receptors with Mannose Specificity 78
NKCL/Dectin 2 78
P Glucan Recognition by APCs 80
Galactose Receptors 82
L Selectin (CD62L) 82
Summary 82
6. Toll Like Receptor: Specificity and Signaling 87
Osamu Takeuchi, Tsuneyasu Kaisho and Shizuo Akira
Abstract 87
Introduction 87
Toll Like Receptor Family and Relatives 88
TLR Signaling Pathway 93
Essential Role of MyD88 in TLR/IL 1 Signaling 94
TLR4 Specific Signaling Pathway 95
Perspectives 96
7. C Type Lectin and Lectin Like Receptors
in the Immune System 101
Sally Rogers and Simon Y.C. Wong
Abstract 101
Introduction 101
CTLDs in the Immune Response—Ligand Binding,
Specificity and Function 102
Group II of CTLD Containing Proteins in the Immune
System—Endocytic Type II Transmembrane Proteins 102
Group III of CTLD Containing Proteins in the Immune
System—Pathogen Recognition 105
Group IV of CTLD Containing Proteins in the Immune
System—Leukocyte Adhesion Events 107
Group V CTLD Containing Proteins in the Immune
System—NKC Encoded Receptors 109
Ly49 Receptor Family 111
NKG2 Receptor Family 112
CD69 and NKR P1 Receptors 113
Group VI CTLD Containing Proteins in the Immune
System—Phagocytosis and Antigen Uptake and Processing 115
Conclusions 115
8. The Sialic Acid Binding Siglec Family 119
Lars Nitschke and Paul R. Crocker
Abstract 119
Introduction to the Siglec Family 119
CD22: An Example of a Siglec on B Cells with Inhibitory
and Adhesion Functions 124
Conclusions 125
9. Antibody Responses to Polysaccharides 128
Carola G. Vinuesa and Ian CM. MacLennan
Abstract 128
Introduction 128
B Cell Activation and Signaling Pathways Triggered
by Polysaccharide Antigens 129
The Three Main Sources of Antibodies 130
MZ B Cells and Their Specialized Response
to Polysaccharide Antigens 138
Other TI Responses: Critical Costimulation
by Toll Like Receptors 141
Conclusions 142
10. CD 1 Restricted T Cell Responses against Microbial Glycolipids 148
Steven A. Porcelli, Lynn G. Dover and Gurdyal S. Besra
Introduction 148
CD1 Genes and the Evolution of the CD 1 Family 148
CD1 Protein Structure 150
Cellular Expression and Tissue Distribution of CD1 Proteins 150
TCell Recognition ofCDl and CD 1 Presented Antigens 151
CDl Presented Antigens 153
Cellular and Molecular Mechanisms of Antigen Presentation
byCDl 162
Molecular Basis of Lipid Antigen Interactions with CD1
andTCRs 165
Potential Role of CD1 in Microbial Immunity 165
11. Processing and Presentation of Glycoproteins in the MHC
Class I and II Antigen Presentation Pathways 173
Denise Golgber, Tim Elliott and Mark Howarth
Abstract 173
Introduction 173
Where Does Giycosylation Occur? 174
The MHC Class I Processing Pathway 174
Outline of the Class I Processing Pathway 174
How Does Giycosylation of the Protein Antigen Affect
MHC Class I Processing? 174
The MHC Class II Processing Pathway 177
How Does Giycosylation Affect Class II Processing? 178
Glycopeptides As T Cell Epitopes 180
Naturally Processed Glycopeptide Epitopes 182
Crystal Structures of MHC Glycopeptide Complexes 183
How Does the T Cell Receptor Interact
with MHC Glycopeptide Complexes? 184
Giycosylation in Autoimmune and Anti Tumor
T Cell Responses 185
Conclusions and Perspectives 186
12. Chemical Synthesis of Bacterial Carbohydrates 192
Vince Pozsgay
Introduction 192
Synthesis of Bacterial Oligosaccharides 194
13. Challenges and Opportunities in the Development
of New Conjugate Vaccines against Infectious Diseases 274
P. Moingeon, M. Moreau andA.A. Lindberg
Abstract 274
The Success of Vaccines Based on Glycoconjugates 274
Conjugate Vaccines in Development 277
New Directions 279
Specific Challenges in the Development of Conjugate Vaccines 282
Conclusions 287
14. Carbohydrate Based Targets and Vehicles for Cancer
and Infectious Diseases Vaccines 292
Vasso Apostolopoulos, Magdalena Plebanski and Ian McKenzie
Abstract 292
Bacterial Carbohydrates As Danger Signals 292
Bacterial Carbohydrates As Human Vaccines 293
Bacterial Carbohydrates As the Basis of Novel Vaccine Approaches... 294
Parasite Carbohydrates As Targets of Protective Immunity 294
Parasite Carbohydrates As Immunomodulators 295
Targeting the Mannose Receptor for Vaccine Development 296
Targeting the Mannose Receptor for Drug Therapy 296
Targeting the Mannose Receptor for Antigen Delivery 297
Targeting the Scavenger Receptor for Vaccine Development 298
Future Prospects 298
15. The Interaction between Anti Gal and the a Gal Epitope
As an Immunologic Barrier to Xenotransplantation 302
Uri Galili
Abstract 302
Introduction 302
Elimination of a Gal Epitopes 307
Prevention of Anti Gal Response in Xenograft Recipients 308
Index 313
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| id | DE-604.BV017487319 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T19:18:37Z |
| institution | BVB |
| isbn | 0306478447 |
| language | English |
| lccn | 2003018772 |
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| spelling | Immunobiology of carbohydrates [edited by] Simon Y.C. Wong Georgetown, Tex. Eurekah.com/Landes Bioscience 2003 New York, N.Y. Kluwer Academic/Plenum 315 S. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Includes bibliographical references and index Glucides - immunologie Antigen-antibody reactions Physiological effect Carbohydrates Immunology Carbohydrates immunology Immunity, Cellular Receptors, Immunologic physiology Kohlenhydrate (DE-588)4164517-0 gnd rswk-swf Immunbiologie (DE-588)4072743-9 gnd rswk-swf Kohlenhydrate (DE-588)4164517-0 s Immunbiologie (DE-588)4072743-9 s DE-604 Wong, Simon Y. C. Sonstige oth Arsequell, Gemma Sonstige oth http://www.loc.gov/catdir/toc/ecip048/2003018772.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010535018&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunobiology of carbohydrates Glucides - immunologie Antigen-antibody reactions Physiological effect Carbohydrates Immunology Carbohydrates immunology Immunity, Cellular Receptors, Immunologic physiology Kohlenhydrate (DE-588)4164517-0 gnd Immunbiologie (DE-588)4072743-9 gnd |
| subject_GND | (DE-588)4164517-0 (DE-588)4072743-9 |
| title | Immunobiology of carbohydrates |
| title_auth | Immunobiology of carbohydrates |
| title_exact_search | Immunobiology of carbohydrates |
| title_full | Immunobiology of carbohydrates [edited by] Simon Y.C. Wong |
| title_fullStr | Immunobiology of carbohydrates [edited by] Simon Y.C. Wong |
| title_full_unstemmed | Immunobiology of carbohydrates [edited by] Simon Y.C. Wong |
| title_short | Immunobiology of carbohydrates |
| title_sort | immunobiology of carbohydrates |
| topic | Glucides - immunologie Antigen-antibody reactions Physiological effect Carbohydrates Immunology Carbohydrates immunology Immunity, Cellular Receptors, Immunologic physiology Kohlenhydrate (DE-588)4164517-0 gnd Immunbiologie (DE-588)4072743-9 gnd |
| topic_facet | Glucides - immunologie Antigen-antibody reactions Physiological effect Carbohydrates Immunology Carbohydrates immunology Immunity, Cellular Receptors, Immunologic physiology Kohlenhydrate Immunbiologie |
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