Expression of recombinant human androgen receptor and its use for screening methods:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2002
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | München, Techn. Univ., Diss., 2002 |
| Beschreibung: | 93 Bl. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
| _version_ | 1816445103915401216 |
|---|---|
| adam_text |
INTRODUCTION
CONTENT
1.
INTRODUCTION.5
1.1. ENDOCRINE DISRUPTERS 5
1.2. ANDROGENS AND ANTIANDROGENS 7
1.2.1. DEFINITIONS 7
1.2.2. MODE OF ACTION 8
1.3. STRUCTURES OF ENDOCRINE DISRUPTERS 10
1.4. STRATEGIES FOR MONITORING ANDROGEN ACTIVE SUBSTANCES 13
1
.
4
.
1
.
IN VIVO METHODS 13
1
.
4
.
2
.
IN VITRO METHODS -- 15
1.5.
OBJEKTIVE OF THE STUDIES 18
2.
MATERIALS AND METHODS.19
2.1.
PREPARATION OF RECEPTORS 19
2.2. ASSAY SYSTEMS 19
2.2.1.
IN SOLUTION
AR
ASSAY
19
2.2.2.
IMMUNO-IMMOBILISED RECEPTOR ASSAY
(IRA) 20
2.2.3.
PR
AND
SHBG
ASSAYS
21
2.2.4. DATA EVALUATION 21
2.3.
ANALYTES 22
3. RESULTS AND DISCUSSION.23
3.1.
DEVELOPMENT OF NEW ASSAY SYSTEMS 23
3.1.1. BAR
ASSAY
' 23
3.1.2. CLONING OF THE HUMAN AR AND PRODUCTION OF FUNCTIONAL PROTEIN 24
3.1.3.
DEVELOPMENT OF A SCREENING ASSAY ON MICROTITRE PLATES (IRA) 25
3.2.
APPLICATION 26
3.2.1. BINDING AFFINITIES OF PESTICIDES 26
3.2.2. EVALUATION OF PHENYLUREA HERBICIDES 29
3.2.3. STUDIES OF BINDING AFFINITIES OF GROWTH PROMOTORS 30
3.3.
LIGANDS OF THE AR 31
3.3.1. THE IRA IN COMPARISON WITH OTHER TEST SYSTEMS 31
3.3.2. PROSPECTS 33
2
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/967532426
INTRODUCTION
4.
ABSTRACT.
34
5
REFERENCES.38
6 CURRICULUM VITAE. 50
7 LIST OF PUBLICATIONS.
51
\
8 APPENDIX.54
8.1
DEVELOPMENT OF AN IMMUNO-IMMOBILIZED ANDROGEN RECEPTOR ASSAY
(IRA)
AND ITS
APPLICATION FOR THE CHARACTERIZATION OF THE RECEPTOR BINDING AFFINITY OF
DIFFERENT
PESTICIDES. CHEMOSPHERE
2002,46:1107-15 54
8.2 APPLICATION OF AN ANDROGEN RECEPTOR ASSAY FOR THE CHARACTERISATION
OF THE
ANDROGENIC OR ANHANDROGENIC ACTIVITY OF VARIOUS PHENYLUREA HERBICIDES
AND THEIR
DERIVATIVES. ANALYST 1998,123:2485-7 ~ 70
8.3 CHARACTERISATION OF THE AFFINITY OF DIFFERENT ANABOLICS AND
SYNTHETIC HORMONES TO
THE HUMAN ANDROGEN RECEPTOR, HUMAN SEX HORMONE BINDING GLOBULIN AND TO
THE
BOVINE PROGESTIN RECEPTOR.
APMIS 2000,108: 838-46 78
3 |
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| indexdate | 2024-11-22T17:37:22Z |
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| language | English |
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| spelling | Bauer, Ellinor Rose Sigrid 1971- Verfasser (DE-588)124622291 aut Expression of recombinant human androgen receptor and its use for screening methods Ellinor Rose Sigrid Bauer 2002 93 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2002 Umweltindikator (DE-588)4201889-4 gnd rswk-swf Androgen-Rezeptor (DE-588)4619850-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Androgen-Rezeptor (DE-588)4619850-7 s Umweltindikator (DE-588)4201889-4 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010363115&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bauer, Ellinor Rose Sigrid 1971- Expression of recombinant human androgen receptor and its use for screening methods Umweltindikator (DE-588)4201889-4 gnd Androgen-Rezeptor (DE-588)4619850-7 gnd |
| subject_GND | (DE-588)4201889-4 (DE-588)4619850-7 (DE-588)4113937-9 |
| title | Expression of recombinant human androgen receptor and its use for screening methods |
| title_auth | Expression of recombinant human androgen receptor and its use for screening methods |
| title_exact_search | Expression of recombinant human androgen receptor and its use for screening methods |
| title_full | Expression of recombinant human androgen receptor and its use for screening methods Ellinor Rose Sigrid Bauer |
| title_fullStr | Expression of recombinant human androgen receptor and its use for screening methods Ellinor Rose Sigrid Bauer |
| title_full_unstemmed | Expression of recombinant human androgen receptor and its use for screening methods Ellinor Rose Sigrid Bauer |
| title_short | Expression of recombinant human androgen receptor and its use for screening methods |
| title_sort | expression of recombinant human androgen receptor and its use for screening methods |
| topic | Umweltindikator (DE-588)4201889-4 gnd Androgen-Rezeptor (DE-588)4619850-7 gnd |
| topic_facet | Umweltindikator Androgen-Rezeptor Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010363115&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bauerellinorrosesigrid expressionofrecombinanthumanandrogenreceptoranditsuseforscreeningmethods |