Classics in total synthesis II: more targets, strategies, methods
Nicolaou and Snyder present top experts from the field of total synthesis to include figures and diagrams, and all the essential details, such as elegant reaction chains or asymmetric process steps.
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2003
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Zusammenfassung: | Nicolaou and Snyder present top experts from the field of total synthesis to include figures and diagrams, and all the essential details, such as elegant reaction chains or asymmetric process steps. |
| Beschreibung: | Forts. von: Nicolaou, Kyriacos C.: Classics in total synthesis |
| Beschreibung: | XIX, 639 S. Ill. 1 CD-ROM (12 cm) |
| ISBN: | 3527306854 3527306846 |
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| 245 | 1 | 0 | |a Classics in total synthesis II |b more targets, strategies, methods |c K. C. Nicolaou and S. A. Snyder |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2003 | |
| 300 | |a XIX, 639 S. |b Ill. |e 1 CD-ROM (12 cm) | ||
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| 500 | |a Forts. von: Nicolaou, Kyriacos C.: Classics in total synthesis | ||
| 520 | 3 | |a Nicolaou and Snyder present top experts from the field of total synthesis to include figures and diagrams, and all the essential details, such as elegant reaction chains or asymmetric process steps. | |
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Datensatz im Suchindex
| _version_ | 1826287665144659968 |
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| adam_text |
Table
of Contents
Chapter
1
Introduction:
Perspectives in Total Synthesis
1.1
Targets
. 2
1.2
Strategies
. 5
1.3
Methods
. 8
1.4
Classics in Total Synthesis II
. 12
Chapter
2
Isochrysohermidin
D. L.
Boger (1993)
2.1
Introduction
. 15
2.1.1
Azadiene-Based Inverse-Electron-Demand
Diels—Alder Reactions
. 17
2.2
Retrosynthetic Analysis and Strategy
. 22
2.3
Total Synthesis
. 25
2.4
Conclusion
. 29
Chapter
3
Swinholide A
I. Paterson
(1994)
3.1
Introduction
. 31
3.1.1
Boron-Mediated Asymmetric Aldol Reactions
. 33
3.2
Retrosynthetic Analysis and Strategy
. 46
3.3
Total Synthesis
. 50
3.4
Conclusion
. 67
3.5
Nicolaou's Total Synthesis of Swinholide A
. 67
XIV Table of
Contents
Chapter
4
Dynemicin A
A. G.
Myers
(1995);
S.
J.
Danishefsky
(1995)
4.1
Introduction
. 75
4.2
Retrosynthetic Analysis and Strategy
. 78
4.2.1
Myers'Synthetic Approach to Dynemicin A
. 78
4.2.2
Danishefsky's Synthetic Approach to Dynemicin A
. 82
4.3
Total Synthesis
. 86
4.3.1
Myers'Total Synthesis of Dynemicin A
. 86
4.3.2
Danishefsky's Total Synthesis of Dynemicin A
. 96
4.4
Conclusion
. 104
4.5
Schreiber's Synthesis of
Tri-0-Methyl
Dynemicin A
Methyl Ester
. 105
Chapter
5
Ecteinascidin
743
E. J.
Corey
(1996)
5.1
Introduction
. 109
5.2
Retrosynthetic Analysis and Strategy
. 113
5.3
Total Synthesis
. 120
5.4
Conclusion
. 132
5.5
Fukuyama's Total Synthesis of Ecteinascidin
743 . . 133
Chapter
6
Resiniferatoxin
P. A.
Wender (1997)
6.1
Introduction
. 137
6.2
Retrosynthetic Analysis and Strategy
. 139
6.3
Total Synthesis
. 146
6.4
Conclusion
. 157
Table
of
Contents
XV
Chapter
7
Epothilones A
and B
К. С.
Nicolaou
(1997)
7.1
Introduction
.161
7.1.1
Olefin
Metathesis: A Brief History.
163
7.1.2
Olefin
Metathesis: Case Studies
. 172
7.2
Retrosynthetic Analysis and Strategy
. 188
7.3
Total Synthesis
. 191
7.3.1
Solution-Phase Synthesis of Epothilone A
.191
7.3.2
Solid-Phase Synthesis of Epothilone A
.196
7.3.3
Alternative Metathesis Approaches to the
Epothilones
.203
7.4
Conclusion
.206
Chapter
8
Manzamìne A
J. D.
Winkler (1998);
S. F.
Martin
(1999)
8.1
Introduction
.211
8.2
Retrosynthetic Analysis and Strategy
.214
8.2.1
Winkler's Synthetic Approach to Manzamine A
. 214
8.2.2
Martin's Synthetic Approach to Manzamine A
. 218
8.3
Total Synthesis
.222
8.3.1
Winkler's Total Synthesis of Manzamine A
.222
8.3.2
Martin's Total Synthesis of Manzamine A
.229
8.4
Conclusion
.236
Chapter
9
Vancomycin
К. С
Nicolaou
(1998);
D.A. Evans
(1998)
9.1
Introduction
.239
9.2
Retrosynthetic Analysis and Strategy
.244
9.2.1
Nicolaou's Synthetic Approach to Vancomycin
and the Vancomycin Aglycon
.244
9.2.2
Evans' Synthetic Approach
to the Vancomycin Aglycon
.255
XVI Table of
Contents
9.3
Total
Synthesis
.259
9.3.1
Nicolaou's Total
Synthesis of the
Vancomycin Aglycon
259
9.3.2
Nicolaou's Total
Synthesis of
Vancomycin
.274
9.3.3
Evans' Total
Synthesis of the
Vancomycin Aglycon
. 279
9.4
Conclusion
.293
9.5 Boger'
s
Total
Synthesis of the Vancomycin Aglycon
. 293
Chapter
10
Everninomicin
13,384-1
К. С
Nicolaou
(1999)
10.1
Introduction
. 301
10.1.1
Glycosidation Methods in Carbohydrate Synthesis
. . 302
10.2
Retrosynthetic Analysis and Strategy
. 314
10.3
Total Synthesis
. 322
10.3.1
Synthesis of the A'B(A)C Fragment
. 322
10.3.2
Synthesis of the FGHA2 Fragment
. 331
10.3.3
Synthesis of the
DE
Fragment
. 340
10.3.4
Final Stages and Completion of the
Total Synthesis of Everninomicin
13,384-1. 344
10.4
Conclusion
. 348
Chapter
11
Bisorbicillinoids
К. С
Nicolaou
(1999)
11.1
Introduction
. 351
11.2
Retrosynthetic Analysis and Strategy
. 356
11.3
Total Synthesis
. 358
11.4
Conclusion
. 363
Chapter
12
Aspidophytine
E.J. Corey
(1999)
12.1
Introduction
. 365
12.2
Retrosynthetic Analysis and Strategy
. 366
12.3
Total Synthesis
. 370
12.4
Conclusion
. 378
Table
of
Contents
XVII
Chapter
13
CP
-Molecules
К. С.
Nicolaou
(1999)
13.1
Introduction
. 381
13.2
Retrosynthetic Analysis and Strategy
. 384
13.3
Total Synthesis
. 388
13.4
Conclusion
. 410
13.5
Fukuyama'
s
Total Synthesis of the CP-Molecules
. . 411
13.6
Shair'
s
Total Synthesis of the CP-Molecules
. 413
13.7
Danishefsky's Total Synthesis of the CP-Molecules
.416
Chapter
14
Colombiasin A
К. С
Nicolaou
(2001)
14.1
Introduction
. 423
14.2
Retrosynthetic Analysis and Strategy
. 425
14.3
Total Synthesis
. 430
14.4
Conclusion
. 440
Chapter
15
Quinine
G. Stork
(2001)
15.1
Introduction
.443
15.1.1
Initial Synthetic Forays
.444
15.1.2
The Woodward/Doering Formal Total Synthesis
. 448
15.1.3
The Hoffmann-La Roche Total Synthesis
.452
15.2
Retrosynthetic Analysis and Strategy
.456
15.3
Total Synthesis
.458
15.4
Conclusion
.462
Chapter
16
Longithorone A
M. D.
Shair
(2002)
16.1
Introduction
. 465
16.2
Retrosynthetic Analysis and Strategy
. 467
16.3
Total Synthesis
. 474
16.4
Conclusion
. 481
XVIII
Table of Contents
Chapter
17
(-)-FR182877
E. J. Sorensen
(2002)
17.1
Introduction
.483
17.2
Retrosynthetic Analysis and Strategy
.489
17.3
Total Synthesis
.493
17.4
Conclusion
.499
17.5
Evans' Total Synthesis of (-)-FRl
82877.500
Chapter
18
Vinblastine
T. Fukuyama
(2002)
18.1
Introduction
. 505
18.2
Retrosynthetic Analysis and Strategy
. 509
18.3
Total Synthesis
. 518
18.4
Conclusion
. 530
Chapter
19
Quadrigemine
С
and Psycholeine
L. E. Overman
(2002)
19.1
Introduction
.533
19.2
Retrosynthetic Analysis and Strategy
.535
19.3
Total Synthesis
.539
19.4
Conclusion
.547
Chapter
20
Diazonamide A
К. С
Nicolaou
(2002; 2003)
20.1
Introduction
. 551
20.2
Retrosynthetic Analysis
. 556
20.3
Total Synthesis
. 565
20.3.1
The First Total Synthesis of Diazonamide A
. 565
20.3.2
The Second Total Synthesis of Diazonamide A
. 572
20.4
Conclusion
. 585
Table
of
Contents
XIX
Chapter
21
PUcamine
S. V.
Ley
(2002)
21.1
Introduction
. 589
21.1.1
Solid-Supported Reagents
. 590
21.2
Retrosynthetic Analysis and Strategy
. 595
21.3
Total Synthesis
. 597
21.4
Conclusion
. 602
Chapter
22
Okaramine
N
E. J. Corey
(2003)
22.1
Introduction
. 605
22.2
Retrosynthetic Analysis and Strategy
. 606
22.3
Total Synthesis
. 612
22.4
Conclusion
. 618
Author Index
. 621
Subject Index
. 623
Classics in Total Synthesis II is the long awaited
sequel to Classics in Total Synthesis, a book that has
made its mark as a superb tool for educating
students and practitioners alike in the art of organic
synthesis since its introduction in
1996.
In this
highly welcomed new volume,
К. С
Nicolaou and
Scott A. Snyder discuss in detail the most impressive
accomplishments in natural product total synthesis
during the
1990s
and the first years of the 21st
century. While all of the features that made the first
volume of Classics so popular and unique as a
teaching tool have been maintained, in this new
treatise the authors seek to present the latest
techniques and advances in organic synthesis as they
beautifully describe the works of some of the most
renowned synthetic organic chemists of our time.
•
domino reactions, cascade sequences, biomimetic
strategies, and asymmetric catalysis are system¬
atically developed through the chosen synthesis
•
cutting edge synthetic technologies are discussed
in terms of mechanism and scope
•
new reactions, such as
olefin
metathesis, are
presented in mini-review style
•
abundant references are given for further reading
•
a CD with useful teaching material for lecturers
Graduate students, educators, and researchers in the
fields of synthetic and medicinal chemistry will wish
to have a copy of this book in their collection as an
indispensable companion that both augments and
supplements the original Classics in Total Synthesis. |
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| id | DE-604.BV017159895 |
| illustrated | Illustrated |
| indexdate | 2025-03-11T09:00:40Z |
| institution | BVB |
| isbn | 3527306854 3527306846 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010344331 |
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| publishDate | 2003 |
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| spelling | Classics in total synthesis II more targets, strategies, methods K. C. Nicolaou and S. A. Snyder Weinheim Wiley-VCH 2003 XIX, 639 S. Ill. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Forts. von: Nicolaou, Kyriacos C.: Classics in total synthesis Nicolaou and Snyder present top experts from the field of total synthesis to include figures and diagrams, and all the essential details, such as elegant reaction chains or asymmetric process steps. Síntese orgânica larpcal Organic compounds Synthesis Organische Synthese (DE-588)4075695-6 gnd rswk-swf Naturstoff (DE-588)4041418-8 gnd rswk-swf Retrosynthese (DE-588)4330854-5 gnd rswk-swf Organische Synthese (DE-588)4075695-6 s DE-604 Naturstoff (DE-588)4041418-8 s Retrosynthese (DE-588)4330854-5 s Nicolaou, K. C. 1946- Sonstige (DE-588)11391041X oth Snyder, Scott A. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010344331&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010344331&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Classics in total synthesis II more targets, strategies, methods Síntese orgânica larpcal Organic compounds Synthesis Organische Synthese (DE-588)4075695-6 gnd Naturstoff (DE-588)4041418-8 gnd Retrosynthese (DE-588)4330854-5 gnd |
| subject_GND | (DE-588)4075695-6 (DE-588)4041418-8 (DE-588)4330854-5 |
| title | Classics in total synthesis II more targets, strategies, methods |
| title_auth | Classics in total synthesis II more targets, strategies, methods |
| title_exact_search | Classics in total synthesis II more targets, strategies, methods |
| title_full | Classics in total synthesis II more targets, strategies, methods K. C. Nicolaou and S. A. Snyder |
| title_fullStr | Classics in total synthesis II more targets, strategies, methods K. C. Nicolaou and S. A. Snyder |
| title_full_unstemmed | Classics in total synthesis II more targets, strategies, methods K. C. Nicolaou and S. A. Snyder |
| title_short | Classics in total synthesis II |
| title_sort | classics in total synthesis ii more targets strategies methods |
| title_sub | more targets, strategies, methods |
| topic | Síntese orgânica larpcal Organic compounds Synthesis Organische Synthese (DE-588)4075695-6 gnd Naturstoff (DE-588)4041418-8 gnd Retrosynthese (DE-588)4330854-5 gnd |
| topic_facet | Síntese orgânica Organic compounds Synthesis Organische Synthese Naturstoff Retrosynthese |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010344331&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010344331&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nicolaoukc classicsintotalsynthesisiimoretargetsstrategiesmethods AT snyderscotta classicsintotalsynthesisiimoretargetsstrategiesmethods |