Free radicals and inhalation pathology: respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2004
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XXI, 773 S. Ill., graph. Darst. 1 CD-ROM |
| ISBN: | 3540002014 |
Internformat
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| 100 | 1 | |a Schiller, Erich |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Free radicals and inhalation pathology |b respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer |c Erich Schiller |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2004 | |
| 300 | |a XXI, 773 S. |b Ill., graph. Darst. |e 1 CD-ROM | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Azote actif - Physiopathologie | |
| 650 | 4 | |a Granulome | |
| 650 | 4 | |a Oxygène actif - Physiopathologie | |
| 650 | 7 | |a Pneumopatias (etiologia) |2 larpcal | |
| 650 | 4 | |a Poumons - Physiopathologie | |
| 650 | 7 | |a Radicais livres (efeitos adversos) |2 larpcal | |
| 650 | 4 | |a Radicaux libres (Chimie) - Physiopathologie | |
| 650 | 4 | |a Active nitrogen |x Pathophysiology | |
| 650 | 4 | |a Active oxygen |x Pathophysiology | |
| 650 | 4 | |a Free Radicals |x adverse effects | |
| 650 | 4 | |a Free radicals (Chemistry) |x Pathophysiology | |
| 650 | 4 | |a Granuloma | |
| 650 | 4 | |a Lung Diseases |x etiology | |
| 650 | 4 | |a Lung |x physiology | |
| 650 | 4 | |a Lungs |x Pathophysiology | |
| 650 | 0 | 7 | |a Atemwegskrankheit |0 (DE-588)4003360-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pathogenese |0 (DE-588)4115512-9 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Pathogenese |0 (DE-588)4115512-9 |D s |
| 689 | 0 | 2 | |a Freies Radikal |0 (DE-588)4137149-5 |D s |
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| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010306343&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-010306343 | ||
Datensatz im Suchindex
| _version_ | 1804129970228822016 |
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| adam_text | Part I History and Scientific Background l
1 Introduction 3
2 Protagonists of Industrial Medicine 15
2.1 The Neolithic Period 17
2.2 Slaves as Miners in Antiquity 17
2.3 Treatment of Consumptive Miners in the Middle Ages
and the Renaissance 19
2.4 Professional Lung Diseases in the Baroque Period (ca. 1600 to 1740) .. 22
2.5 Occupational Lung Diseases in the Age of Enlightenment
(ca. 1740 1830) 30
2.6 Professional Lung Diseases in the Age of Industry 33
2.7 Treatment of Hypoxaemia and Hypercapnia 35
2.8 Environmental Protection 35
2.9 Contamination of the Soil 36
3 Aetiopathogenesis of Pulmonary Fibrosis and Malignancy 37
4 Formulation of the Problems 43
4.1 Tumour Defence 43
4.2 Aetiopathogenesis of Silicosis 44
4.3 Silicosis and Carcinoma 48
4.3.1 Epidemiology 48
4.3.2 In Vitro Studies and Bioassay 50
4.4 Fibrous Dusts and Malignancy 50
5 Material and Methods 57
5.1 Freund s Adjuvant 57
5.2 Implants 57
5.3 Dusts 57
5.3.1 Preparation of Dusts for Animal Experiments 61
5.3.2 Dust Feed Mechanisms 62
5.3.3 Intratracheal Application 63
5.3.3.1 Intratracheal Instillation 63
5.3.3.2 Intratracheal Inhalation 64
5.4 Pharmaca 64
5.5 Animals 65
5.6 Tissue Culture 65
5.7 Detection of Reactive Species 66
5.7.1 Electron Spin Resonance (ESR) 66
5.7.2 Chemiluminescence 68
5.7.3 Tetrazolium Compounds 71
5.7.4 Fluorescent Probes 72
X Contents
5.8 Light Microscope Techniques 73
5.9 Electron Microscope Techniques 74
6 Reactive Oxygen and Nitrogen Species 75
6.1 The Respiratory Burst 75
6.1.1 Reactive Oxygen Intermediates 76
6.1.1.1 Singlet Oxygen 78
6.1.2 Oxygen Activating Enzymes 82
6.1.2.1 Aldehyde Oxidase 82
6.1.2.2 Cytochrome Oxidase 82
6.1.2.3 NADH Dehydrogenase 88
6.1.2.4 NADPH Dehydrogenase 88
6.1.2.5 Galactose Oxidase 89
6.1.2.6 Xanthine Oxidase 89
6.1.2.7 L 4,5 Dihydroorotate:Oxygen Oxidoreductase 92
6.1.2.8 Cucumber Monodehydroascorbate Reductase 92
6.1.2.9 Prostaglandin H Synthase 92
6.1.3 Modulation of the Respiratory Burst 93
6.1.3.1 Activation 93
6.1.3.2 Inhibition 98
6.1.3.3 Influences of ATP, ADP, and Cyclic Nucleotides on the Formation
of Reactive Oxygen Intermediates 100
6.1.4 Radical Scavengers 100
6.1.4.1 Ascorbic Acid 100
6.1.4.2 Tocopherols 102
6.1.4.3 Dihydrolipoate Lipoate 103
6.1.4.4 l,2 Diselenolane 3 pentanoic Acid 104
6.1.4.5 Melatonin 104
6.1.4.6 5,6 Dihydroxyindoles 106
6.1.4.7 4b,5,9b,10 Tetrahydroindeno[l,26]indole 107
6.1.4.8 Pinoline 107
6.1.4.9 Indolinonic Aminoxyls 107
6.1.4.10 Fluvastain and its Metabolites 107
6.1.4.11 Benzylisoquinolines 107
6.1.4.12 Bilirubin 107
6.1.4.13 Trimethyluric Acid and its Analogues 108
6.1.4.14 Curcumin 108
6.1.4.15 Amidothionophosphates 109
6.1.4.16 Poly 2 vinylpyridine 7V oxide and Other Nitroxides 109
6.1.4.17 3 Methyl l phenyl 2 pyrazolin 5 one 110
6.1.4.18 Chlorpromazine 110
6.1.4.19 Ebselen 110
6.1.4.20 Thiols Ill
6.1.4.21 Carvedilol 113
6.1.4.22 Angiotensin Converting Enzyme Inhibitors 114
6.1.4.23 Propofol 115
6.1.4.24 Marchantin H 115
6.1.4.25 Salen Manganese Complexes 115
6.1.4.26 Schizandrins 115
6.1.5 Antioxidants 116
6.2 The L Arginine Nitric Oxide Pathway 118
6.2.1 Nitric Oxide Synthase (NOS) 119
6.2.1.1 Nitric Oxide Synthase Inhibitors 125
6.2.2 Activation of Guanylate Cyclase by Nitric Oxide 127
6.2.3 Indirect Inhibition of Mitochondrial Dihydroorotate
Dehydrogenase Activity 128
Contents XI
6.2.4 Nitric Oxide and Iron Proteins 129
6.2.4.1 Iron Regulatory Protein 1 RNA Binding Activity 129
6.2.5 Modulation of *NO Production in the Respiratory Tract 130
6.2.6 Modulation of Endocrine Feedback Control Systems 130
6.2.7 Modulation of DNA Repair Proteins 131
6.2.8 Nitric Oxide and Apoptosis 131
6.2.9 Nitric Oxide and Lipid Peroxidation 131
6.2.10 Peroxynitrite 132
6.2.11 N2O3: Nitrosative Stress 138
6.2.12 Nitric Oxide/Nucleophile Complexes 138
6.2.13 5 Nitrosothiols as Intermediates in the Metabolism or Bioactivity
of NO 139
6.2.14 Cell Protection Against NO* 140
Part II Respiratory System: Orthology and Pathology 143
7 Tracheo bronchial Epithelium 145
7.1 Cell Types 145
7.1.1 Ciliated Cells 145
7.1.1.1 Kinocilia 145
7.1.1.2 Microvilli 146
7.1.1.3 Zonula Occludens 146
7.1.1.4 Mitochondria 146
7.1.1.5 Golgi Apparatus 146
7.1.1.6 Histochemistry 146
7.1.2 Serous Cells 147
7.1.3 Clara Cells 148
7.1.3.1 Ultrastructure 149
7.1.3.2 Histochemistry 153
7.1.3.3 Comparative Anatomy and Biochemistry 156
7.1.4 Goblet Cells 157
7.1.4.1 Ultrastructure 157
7.1.4.2 Histochemistry 158
7.1.5 Intermediate Cells 158
7.1.6 Brush Cells 158
7.1.6.1 Ultrastructure 158
7.1.6.2 Histochemistry 158
7.1.7 Basal Cells 158
7.1.7.1 Ultrastructure 159
7.1.7.2 Histochemistry 159
7.1.8 APUD Cells 160
7.2 Pharmacology 160
7.2.1 Adrenergic Activators 161
7.2.1.1 Superoxide Oxidises Catecholamines 162
7.2.1.2 P2 Agonists Have Antioxidant Function 163
7.2.1.3 Link Between Catecholamine and Nitric Oxide Metabolism 163
7.2.1.4 a Adrenergica 163
7.2.1.5 P Adrenergica 164
7.2.2 Adrenolytic Drugs 167
7.2.2.1 Propranolol 167
7.2.2.2 Nifenalol 167
7.2.2.3 4 (2 Hydroxy 3 isopropylaminopropoxy) acetanilide 168
7.2.2.4 Pindolol 168
7.2.2.5 Carvedilol 168
7.2.3 Cholinergic Activators 168
XII Contents 7.2.3.1 Acetylcholine 169
7.2.3.2 Carbamylcholine 169
7.2.3.3 Pilocarpine 169
7.2.3.4 Nicotine 169
7.2.4 Anticholinergic Drugs 169
7.2.4.1 Atropine 169
7.2.4.2 Benztropine 170
7.2.5 Vitamins 170
7.2.5.1 Retinoids 170
7.2.5.2 Tocopherols 171
7.2.5.3 Pantothenic Acid 173
7.2.6 Bradykinin 174
7.2.7 Expectorants 175
7.2.7.1 Bromhexine 175
7.2.7.2 Cistinexine 175
7.2.7.3 Ozothin 175
7.2.8 Carbocromene 176
7.2.9 Isoniazid 176
7.2.10 Streptozotocin Induced Diabetes 177
7.3 Toxicology 177
7.3.1 Ciliated Cells 177
7.3.2 Serous Cells 181
7.3.3 Clara Cells 181
7.3.4 Goblet Cells 186
7.3.5 Brush Cells 187
7.3.6 Neuroendocrine (APUD) Cells 187
7.4 Dust Clearance 188
7.4.1 Aluminium 190
7.4.2 Clayey Shale 191
7.4.3 Amosite 191
7.4.4 Crocidolite 192
7.4.5 Chrysotile 192
7.4.6 Quartz 192
7.4.7 Coal Dust 193
7.4.8 Magnetite 194
7.4.9 Manganese Dioxide 194
7.4.10 Tantalum Oxide 194
7.4.11 Titanium Dioxide 194
7.4.12 Vanadium 194
7.4.13 Cotton Dust 195
7.4.14 Diesel Exhaust 195
7.4.15 Trimethylolmelamine (Madurit) 195
7.5 Submucosal Glands 195
8 Pneumocytes 197
8.1 Type I Pneumocytes 197
8.1.1 Ultrastructure 197
8.1.2 Histochemistry 198
8.1.3 Pharmacology 198
8.1.4 Toxicology 198
8.1.4.1 Aluminium 198
8.1.4.2 Ammonia 198
8.1.4.3 Asbestos 198
8.1.4.4 Cadmium 199
8.1.4.5 Cobalt 199
8.1.4.6 Nickel Compounds 199
Contents XIII
8.1.4.7 Ozone 200
8.1.4.8 Plutonium 200
8.1.4.9 Zinc 200
8.1.4.10 Butylated Hydroxytoluene 200
8.2 Type II Pneumocytes 200
8.2.1 infrastructure 201
8.2.2 Histochemistry 202
8.2.2.1 Glutathione 202
8.2.2.2 Glycoproteins 203
8.2.2.3 Enzymes 203
8.2.2.4 Endothelin 208
8.2.2.5 Tenascin Immunoreactivity in Cryptogenic Fibrosing Alveolitis 208
8.2.2.6 Fas 208
8.2.3 Surfactant 208
8.2.4 Pharmacology 213
8.2.4.1 Hormones 214
8.2.4.2 P Adrenergic Agonists 215
8.2.4.3 Cholinergic Agonists 216
8.2.4.4 Serotonin 217
8.2.4.5 Vitamins 218
8.2.4.6 Benzodiazepine Receptor Agonists 219
8.2.4.7 Protein Synthesis Inhibitors 219
8.2.4.8 Hyperlipidemic Agents 219
8.2.4.9 Expectorants 220
8.2.4.10 Pentoxifylline 220
8.2.4.11 Cytokines 221
8.2.4.12 Poly 2 vinylpyridine l oxide 221
8.2.4.13 Sydnonimines 221
8.2.4.14 Ferritin 221
8.2.5 Toxicology 222
8.2.5.1 Inorganic Agents 222
8.2.5.2 Organic Agents 231
8.3 Type III Pneumocytes 234
8.3.1 Ultrastructure 234
8.3.2 Histochemistry 235
8.3.3 Pharmacology 235
8.3.4 Toxicology 235
8.3.4.1 Pyridinium Compounds 235
9 Alveolar Macrophages 237
9.1 Electron Microscopy 237
9.1.1 Lysosomes 238
9.1.1.1 Primary Lysosomes 238
9.1.1.2 Secondary Lysosomes 239
9.1.1.3 Autophagous Vacuoles 240
9.1.2 Peroxisomes 241
9.1.3 Cytoskeleton 241
9.1.3.1 Actin and Microfilaments 243
9.1.3.2 Tubulin and Microtubuli 248
9.1.3.3 Intermediate Filaments 250
9.2 Histochemistry 251
9.2.1 Glutathione 251
9.2.2 Immunophenotypes 251
9.2.3 Enzymes 251
9.2.3.1 Oxidoreductases 251
9.2.3.2 Transferases 256
XIV Contents
9.2.3.3 Hydrolases 257
9.2.3.4 Lyases 260
9.2.4 Lipids 260
9.2.5 Ascorbic Acid 260
9.2.6 Pantothenol 261
9.2.7 Retinoids 262
9.2.8 Tocopherol 263
9.3 Origin of Alveolar Macrophages 263
9.4 Secretion 263
9.4.1 Polypeptide Hormones 264
9.4.1.1 Interleukin 1 264
9.4.1.2 Interleukin 4 264
9.4.1.3 Interleukin 6 265
9.4.1.4 Interleukin 8 266
9.4.1.5 Interleukin 10 266
9.4.1.6 Interleukin 12 267
9.4.1.7 Interleukin 13 267
9.4.1.8 Interleukin 18 268
9.4.1.9 Tumour Necrosis Factor a 268
9.4.1.10 Interferons 270
9.4.1.11 Fibroblast Growth Factors (FGFs) 270
9.4.1.12 Colony Stimulating Factor (CSF) 270
9.4.2 Complement Components 271
9.4.3 Platelet Activating Factor 271
9.4.4 Proteolytic Enzymes 271
9.4.4.1 Metalloproteinases 271
9.4.4.2 Serine Proteinases 273
9.4.4.3 Aspartyl Proteinases 273
9.4.4.4 Cysteine Proteinases (EC 3.4.22) 273
9.4.5 Other Enzymes 274
9.4.5.1 Lipases 274
9.4.5.2 Glucosaminidase: Lysozyme 274
9.4.5.3 Lysosomal Acid Hydrolases 274
9.4.5.4 Deaminase: Arginase 275
9.4.6 Inhibitors of Enzymes 275
9.4.7 Proteins of Extracellular Matrix or Cell Adhesion 275
9.4.7.1 Fibronectin 275
9.4.7.2 Gelatin Binding Protein/95 kDa Gelatinase 276
9.4.7.3 Thrombospondin 276
9.4.7.4 Chondroitin Sulphate Proteoglycans 276
9.4.7.5 Heparin Sulphate Proteoglycans 276
9.4.8 Bioactive Oligopeptides 276
9.4.8.1 Glutathione 276
9.4.9 Arachidonic Acid and Prostaglandins 277
9.4.9.1 Arachidonic Acid Release from Membrane Phospholipids 277
9.4.9.2 Inhibition of Arachidonic Acid Metabolism by Radical Scavengers .. 278
9.4.10 Cyclic Nucleotides 278
9.4.11 Cytotoxic Substances 278
9.5 Pharmacology 278
9.5.1 Receptors 278
9.5.1.1 Cell Surface Receptors 279
9.5.1.2 Thyrotropin Receptors 280
9.5.2 Serotonin 281
9.5.3 Histamine 281
9.5.4 Dexamethasone 281
9.5.5 Dehydroepiandrosterone 282
Contents XV
9.5.6 Phosphodiesterase Inhibitors 282
9.5.7 H+ Transport Inhibitors 282
9.5.8 Phenylbutazone 282
9.5.9 Phenothiazines 283
9.5.9.1 Promethazine 283
9.5.9.2 Thiazinamium Chloride 283
9.5.9.3 Chlorpromazine 283
9.5.10 Thiosemicarbazones 283
9.5.11 Isoniazid 284
9.5.12 Histamine Liberator 48/80 284
9.5.13 Dinitrophenol 284
9.5.14 Chlorophyllin 284
9.5.15 Chloroquine 284
9.5.16 Azaspiranes 285
9.5.17 Poly 2 vinylpyridine l oxide 285
9.5.18 Coumarins 287
9.5.18.1 Carbocromene 287
9.5.18.2 Cloricromene 287
9.5.19 Benzhydryl Piperazines 287
9.5.19.1 N Benzhydryl AT p hydroxybenzylpiperazine 288
9.5.20 Lazaroids 288
9.5.21 Biphosphonates 289
9.5.22 Ginkgo biloba Extract 289
9.6 Toxicology 289
9.6.1 Physical Hazards 289
9.6.2 Chemical Agents 289
9.6.2.1 Inorganic Agents 289
9.6.2.2 Organic Agents 351
9.7 Transformation of Macrophages to Epithelioid Cells 364
9.7.1 Epithelioid Cells in Resorption Granulomas 364
9.8 Stimulation, Priming and Activation of Macrophages 366
9.8.1 Non immunological Stimulation 366
9.8.1.1 Immunostimulators 367
9.8.2 Immunologically Specific Activation 382
9.8.2.1 Activation of the Mononuclear Phagocyte System by Complete
Freund s Adjuvant 383
9.8.3 Prospective Pulmonary Fibrosis Inducing Potency of Macrophages .. 389
10 Interstice 391
10.1 Alveolar Septa 391
10.1.1 Matrix 391
10.1.2 Alveolar Myofibroblasts (Contractile Interstitial Cells) 392
10.1.3 Histiocytes 400
10.1.4 Lymphoid Cells 400
10.1.5 Plasma Cells 401
10.1.6 Mast Cells 402
10.1.7 Neutrophil Granulocytes 403
10.1.8 Eosinophils 404
10.1.9 Pericytes 404
10.2 Interalveolar Pores 404
10.3 Peribronchium 405
11 Pulmonary Blood Vessels 407
11.1 Arteria Pulmonalis 407
11.1.1 Truncus 407
11.1.2 Muscular Branches 407
XVI Contents
11.2 Capillaries 407
11.3 Pulmonary Veins 409
11.3.1 Intrapulmonary Veins 409
11.3.2 Extrapulmonary Veins 410
11.4 Bronchial Arteries 410
11.5 Experimental Pharmacology of Pulmonary Endothelial Cells 410
11.5.1 Vasoactive Amines 411
11.5.1.1 Serotonin 411
11.5.1.2 Norepinephrine 411
11.5.1.3 Isoprenaline 412
11.5.1.4 P Adrenergic Antagonists 412
11.5.2 Polypeptides 412
11.5.2.1 Angiotensin I 412
11.5.2.2 Angiotensin II 412
11.5.2.3 Angiotensin IV 413
11.5.2.4 Bradykinin 413
11.5.2.5 Endothelin 413
11.5.2.6 Tumour Necrosis Factor a 413
11.5.3 Fatty Peroxides and Lung Prostaglandins 414
11.5.3.1 Arachidonic Acid Metabolites 414
11.5.4 Xanthine Oxidase 415
11.5.5 Reactive Oxygen Species 415
11.5.6 Nitric Oxide and Peroxynitrite 416
11.5.7 S Nitroso N acetyl D penicillamine 418
11.6 Experimental Pathology of Pulmonary Endothelial Cells 418
11.6.1 Arsenite 418
11.6.2 Carbon Monoxide 418
11.6.3 Silica 419 j
11.6.4 Diperoxovanadate 419 {
11.6.5 Bleomycin 419
11.6.6 Paraquat 419 1
11.6.7 Pyrrolizidine Alkaloids 420
11.6.8 Tobacco Smoke 420
11.6.9 Diesel Exhaust 420
12 Pulmonary Lymphatic Vessels 421
12.1 Lymph Capillaries 421
12.2 Pulmonary Lymph Nodes 421
12.2.1 Topography 421
12.2.2 Free Cells 421
12.2.3 Postcapillary Venules 422
12.3 Lymphoid Tissue: BALT 424
12.4 Lymphatic Clearance 424
12.4.1 Lymphotropism of Quartz Dust 425
12.4.2 Conveyance of Quartz Dust to Other Organs 425
12.4.2.1 Liver 425
12.4.2.2 Spleen 425
12.4.2.3 Bone Marrow 425
13 Pulmonary Nerves 427
13.1 Plexus Bronchiales 427
13.2 Peribronchial Microparaganglia 428
13.2.1 Neuronal Nitric Oxide Synthase in Peribronchial Microparaganglia .. 428
13.3 Pulmonary Neuropharmacology 428
14 Radical Mediated Pulmonary Lesions 431
14.1 Reperfusion Injury 431
Contents XVII
14.2 Hyperoxia 433
14.3 Haemorrhagic Shock 437
( 14.4 Granulomatous Epithelioid Cell Reactions 438
14.4.1 The Tuberculous Granuloma 441
14.4.1.1 Polymorphonuclear Initial Stage 441
14.4.1.2 The Monocyte in Tuberculosis 441
14.4.1.3 The Epithelioid Cell in Tuberculosis 442
14.4.1.4 The Giant Cell in Tuberculosis 442
IAA.2 Morphological Manifestations of Leprosy 442
14.4.3 Sarcoidosis 443
I 14.4.3.1 The Monocyte in Sarcoidosis 443
I 14.4.3.2 The Macrophage in Sarcoidosis 444
14.4.3.3 Epithelioid and Giant Cells in Sarcoidosis 445
14.4.4 Sarcoidosis like Granulomas 445
14.4.4.1 Granulomatous Dermal Reactions 445
14.4.4.2 Selenium Granulomas 445
14.4.4.3 Zirconium Granulomas 446
; 14.4.4.4 Hodgkin s Disease Type VI 446
! 14.4.4.5 Granulomas in Brucellosis 446
! 14.4.4.6 Granulomas in Tularaemia 446
i 14.4.4.7 Lymphogranuloma Venereum = Lymphopathia Venerea 447
I 14.4.4.8 Syphilitic Granulomas 447
14.4.4.9 Granulomas in Benign Lymphoreticulosis (Cat Scratch Disease) .... 447
14.4.4.10 Granuloma Inguinale 448
14.4.4.11 Toxoplasmosis 448
14.4.5 Granulomas Without Epithelioid Cell Formation 448
14.4.5.1 Granulomas in Salmonelloses 448
14.4.5.2 Granulomas in Listeriosis 448
14.4.6 Granulomas in Mycoses 449
14.4.6.1 Blastomycosis 449
14.4.6.3 Coccidioidomycosis 449
14.4.6.4 Torulosis (Cryptococcosis) 450
14.4.6.5 Histoplasmosis 450
14.4.7 Granulomas in Helminthiasis 450
14.4.7.1 Nematode Infections 450
14.4.7.2 Platyhelminth Infections 452
14.4.8 Granulomas Induced by Products of Plants and Animals 453
14.5 Pneumoconioses 454
14.5.1 Berylliosis 458
14.5.2 Silicosis 459
14.5.3 Asbestosis 464
14.5.4 Pneumoconiosis from Glass Fibres 468
14.5.5 Silicon Carbide Pneumoconiosis 469
14.5.6 Siderosis 469
14.5.7 Stannosis 469
14.5.8 Hard Metal Pneumoconiosis 469
14.6 Experimental Granulomatous Inflammation 470
14.6.1 Scanning Electron Microscopy in Peritoneal Exudate Macrophages .. 470
14.6.2 Cotton Pellet Test 470
14.6.3 Resorptive Inflammation of Implanted Gelatine Sponges 471
14.6.3.1 Giant Cells in Resorption Granulomas 472
14.7 Ionising Radiation 473
14.7.1 Does Ionising Radiation Promote Pneumoconiotic Fibrosis? 476
XVIII Contents Part III Extrapulmonary Targets 477
15 Radical Damage in Nonrespiratory Organ Systems 479
15.1 Reperfusion Damage 481
15.1.1 Nervous System 481
15.1.1.1 Hippocampus 496
15.1.1.2 Rhinencephalon 513
15.1.1.3 Nucleus Accumbens 514
15.1.1.4 Corpus Striatum 514
15.1.1.8 Pineal Body 525
15.1.1.9 Substantia Nigra 536
15.1.1.10 Cerebellum 537
15.1.1.11 Vestibular Nucleus 547
15.1.1.12 Nucleus Tractus Solitarii 548
15.1.1.13 Spinal Cord 548
15.1.1.14 Ependyma 548
15.1.1.15 Choroid Plexus 549
15.1.1.16 Retina 550
15.1.1.17 Olfactory Mucosa 551
15.1.1.18 Trigeminal Ganglion 551
15.1.1.19 Spiral Ganglion 551
15.1.1.20 Spinal Ganglia 551
5.1.1.21 Neuromuscular Junction 551
15.1.2 Pituitary 551
15.1.2.1 Pars Nervosa 551
15.1.2.2 Pars Intermedia 555
15.1.2.3 Pars Tuberalis 558
15.1.2.4 Pars Distalis 559
15.1.3 Thyroid 567
15.1.4 Adrenal 570
15.1.5 Carotid Body 574
15.1.6 Testis 574
15.1.7 Islands of Langerhans 575
15.1.8 Heart 578
15.1.8.1 Never Hypoxic Myocardial Cells 580
15.1.8.2 Hypoxic Myocardium 588
15.1.8.3 Intermittently Hypoxic Myocardium 590
15.1.8.4 Endothelium of the Myocardial Capillaries 603
15.1.8.5 Immigration of Inflammatory Cells 608
15.1.8.6 Fibrocytes 610
15.1.8.7 Mast Cells 611
15.1.9 Kidney 611
15.1.9.1 Reperfusion Injury 613
15.1.9.2 Diabetic Glomerulopathy 617
15.1.9.3 Steroid Sensitive Nephrotic Syndrome 617
15.1.9.4 Cadmium Provoked Oxidative Stress 617
15.1.9.5 Nickel Induced Crystalline Inclusions in Mitochondria
of the Ascending Limb 618
15.1.9.6 Halogenated Hydrocarbon Induced Nephrotoxicity
and Carcinogenicity 618
15.1.9.7 Doxorubicin Induced Glomerular Toxicity 620
15.1.9.8 Di 2 ethylhexyl Phthalate Induced Renal Microsomal P450 and b5
Induction 620
15.1.9.9 Paraquat Induced Lesions of Tubular Brush Border in Man 620
15.1.9.10 Styrene Induced Tubular Brush Border Villin Urinary Excretion 620
15.1.9.11 Nitric Oxide and Tubular Brush Border 620
Contents XIX
15.1.9.12 Nitric Oxide and the Juxtaglomerular Apparatus 621
15.1.9.13 Nitric Oxide and Reactive Oxygen Species in Wegener s
Granulomatosis 622
15.1.9.14 Experimental Hyperlipaemia Hyperglycaemia in the Hamster 623
15.1.9.15 Oxalate Mediated Oxidative Stress 623
15.1.10 Intestine 623
15.1.11 Liver 624
15.1.11.1 Hepatocytes 625
15.1.11.2 Ductular Progenitor Cells 650
15.1.11.3 Endothelial Cells 650
15.1.11.4 Kupffer Cells 650
15.1.11.5 Perisinusoidal Ito Cells 653
15.2 Manganese Induced Neuronal Cell Injury 654
15.3 Immobilization and Hypothermia Induced Myocardial Damage .... 655
15.4 Norcocaine Nitroxide Induced Hepatotoxicity 657
Part IV Ageing 659
16 Molecular Ageing 661
16.1 Oxidatively Damaged DNA Accumulates in Senescence 662
16.2 Decline of Mitochondrial Oxidative Phosphorylation 663
16.3 Biorheusis of Transition Metals 664
17 Ageing of Organs 667
17.1 Brain 667
17.2 Spinal Cord 673
17.3 Autonomous Nervous System 673
17.4 Pineal Gland 673
17.5 Neurosecretory System 673
17.6 Pituitary Pars Intermedia 674
17.7 Pituitary Pars Distalis 675
17.8 Thyroid 676
17.9 Parathyroid 678
17.10 Adrenal Cortex 679
17.11 Thymus 679
17.12 Lymphoid Tissues 680
17.13 Myocardium 680
17.14 Lung 682
17.15 Liver 683
17.16 Kidney 685
17.17 Blood Vessel Atherogenesis 686
18 Possible Strategies to Prevent and Reverse Manifestations
of Ageing 693
Part V Cancer 697
19 Carcinogenesis 699
19.1 Reactive Species 699
19.1.1 Reactive Oxygen Species 699
19.1.2 Reactive Nitrogen Species 699
19.1.3 Simultaneous Generation of Nitric Oxide and Superoxide 701
19.1.4 DNA Sugar Radicals 701
XX Contents 19.2 Carcinogenicity of Paniculate Air Pollutants 701
19.2.1 Silica 701
19.2.2 Asbestos 702
19.2.3 Automobile Exhaust Particulates 708
19.2.4 Beryllium 708
19.2.5 Styrene 708
19.3 Oxidation Reactions of DNA 708
19.4 Fenton Reactions and Other Metal Mediated Oxidation Reactions ... 711
19.4.1 Copper 711
19.4.2 Chromium 716
19.4.3 Cobalt 718
19.4.4 Nickel(II) 718
19.4.5 Iron 720
19.4.6 Vanadium 721
19.5 Tumour Induction with Chemicals 721
19.5.1 Arsenics 721
19.5.2 Nitrosamines 721
19.5.3 AT Methyl 1 naphthylcarbamate 722
19.5.4 Vinyl Chloride 722
19.5.5 Acrylamide 723
19.5.6 Acrylonitrile 723
19.5.7 Trichloroethylene 723
19.5.8 Pentachlorophenol Metabolites 724
19.5.9 Polychlorinated Biphenyls 724
19.5.10 4 Aminobiphenyl 725
19.5.11 Hydrazines 725
19.6 Tumour Induction with Natural Products 726
19.6.1 Betel 726
19.6.2 Opium 726
19.6.3 Tobacco 726
19.6.4 Aflatoxin Bj 727
19.6.5 Methylazoxymethanol 727
19.6.6 Azoxymethane 727
19.7 Peroxisome Proliferators 727
19.8 Tumour Promoters 728
19.9 Epoxide Formation 729
19.10 Inhibitory Effect of Melatonin 729
19.11 Indole 3 carbinol 731
19.12 Antioxidants 731
19.13 Nitroxides 733
19.14 Selenium 733
19.15 13 Methyltetradecanoic Acid 734
20 Tumour Proliferation and Metastasis 735
20.1 Macrophage Mediated Tumour Cell Proliferation and Migration 735
20.2 Tumour Cell Invasion 736
20.2.1 Angiogenesis Enhanced by Hypoxia 736
20.2.2 Invasive Pericytes in Tumour Angiogenesis Assay 737
20.2.3 Inhibitors of Angiogenesis 737
20.2.4 Tumour Cell Adhesion to Postcapillary Venules 738
20.2.5 Lymphatic Vessels of Tumours 738
21 Antitumour Drug Therapy 739
21.1 Free Radicals Forming Drugs 739
21.1.1 Anthracyclines 739
21.1.2 Further Intercalating Agents 744
Contents XXI
21.1.3 Bleomycin 744
21.1.4 Further Antibiotics 745
21.1.5 Cisplatin 746
21.1.6 Folk Acid Antagonists 748
21.1.7 Oracin 748
21.1.8 Thiosemicarbazones 749
21.1.9 Tirapazamine 749
21.1.10 Paclitaxel 749
21.2 Anticancer Drug Resistance 750
Epilogue 753
Subject Index 755
References, see accompanying CD Rom
|
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| dewey-search | 616.2/407 |
| dewey-sort | 3616.2 3407 |
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| discipline | Medizin |
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| id | DE-604.BV017087518 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:13:36Z |
| institution | BVB |
| isbn | 3540002014 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010306343 |
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| spelling | Schiller, Erich Verfasser aut Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer Erich Schiller Berlin [u.a.] Springer 2004 XXI, 773 S. Ill., graph. Darst. 1 CD-ROM txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Azote actif - Physiopathologie Granulome Oxygène actif - Physiopathologie Pneumopatias (etiologia) larpcal Poumons - Physiopathologie Radicais livres (efeitos adversos) larpcal Radicaux libres (Chimie) - Physiopathologie Active nitrogen Pathophysiology Active oxygen Pathophysiology Free Radicals adverse effects Free radicals (Chemistry) Pathophysiology Granuloma Lung Diseases etiology Lung physiology Lungs Pathophysiology Atemwegskrankheit (DE-588)4003360-0 gnd rswk-swf Pathogenese (DE-588)4115512-9 gnd rswk-swf Freies Radikal (DE-588)4137149-5 gnd rswk-swf Atemwegskrankheit (DE-588)4003360-0 s Pathogenese (DE-588)4115512-9 s Freies Radikal (DE-588)4137149-5 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010306343&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schiller, Erich Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer Azote actif - Physiopathologie Granulome Oxygène actif - Physiopathologie Pneumopatias (etiologia) larpcal Poumons - Physiopathologie Radicais livres (efeitos adversos) larpcal Radicaux libres (Chimie) - Physiopathologie Active nitrogen Pathophysiology Active oxygen Pathophysiology Free Radicals adverse effects Free radicals (Chemistry) Pathophysiology Granuloma Lung Diseases etiology Lung physiology Lungs Pathophysiology Atemwegskrankheit (DE-588)4003360-0 gnd Pathogenese (DE-588)4115512-9 gnd Freies Radikal (DE-588)4137149-5 gnd |
| subject_GND | (DE-588)4003360-0 (DE-588)4115512-9 (DE-588)4137149-5 |
| title | Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer |
| title_auth | Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer |
| title_exact_search | Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer |
| title_full | Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer Erich Schiller |
| title_fullStr | Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer Erich Schiller |
| title_full_unstemmed | Free radicals and inhalation pathology respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer Erich Schiller |
| title_short | Free radicals and inhalation pathology |
| title_sort | free radicals and inhalation pathology respiratory system mononuclear phagocyte system hypoxia and reoxygenation pneumoconioses and other granulomatoses cancer |
| title_sub | respiratory system, mononuclear phagocyte system, hypoxia and reoxygenation, pneumoconioses and other granulomatoses, cancer |
| topic | Azote actif - Physiopathologie Granulome Oxygène actif - Physiopathologie Pneumopatias (etiologia) larpcal Poumons - Physiopathologie Radicais livres (efeitos adversos) larpcal Radicaux libres (Chimie) - Physiopathologie Active nitrogen Pathophysiology Active oxygen Pathophysiology Free Radicals adverse effects Free radicals (Chemistry) Pathophysiology Granuloma Lung Diseases etiology Lung physiology Lungs Pathophysiology Atemwegskrankheit (DE-588)4003360-0 gnd Pathogenese (DE-588)4115512-9 gnd Freies Radikal (DE-588)4137149-5 gnd |
| topic_facet | Azote actif - Physiopathologie Granulome Oxygène actif - Physiopathologie Pneumopatias (etiologia) Poumons - Physiopathologie Radicais livres (efeitos adversos) Radicaux libres (Chimie) - Physiopathologie Active nitrogen Pathophysiology Active oxygen Pathophysiology Free Radicals adverse effects Free radicals (Chemistry) Pathophysiology Granuloma Lung Diseases etiology Lung physiology Lungs Pathophysiology Atemwegskrankheit Pathogenese Freies Radikal |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010306343&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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