Genetics of apoptosis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford
Bios
2003
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 309 S. graph. Darst. |
| ISBN: | 1859960642 |
Internformat
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| 245 | 1 | 0 | |a Genetics of apoptosis |c ed. by Stefan Grimm |
| 264 | 1 | |a Oxford |b Bios |c 2003 | |
| 300 | |a XVII, 309 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Apoptosis |2 swd | |
| 650 | 7 | |a Cytologie |2 swd | |
| 650 | 7 | |a Molekulargenetik |2 swd | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Apoptosis |x genetics | |
| 650 | 4 | |a Genetics | |
| 700 | 1 | |a Grimm, Stefan |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010289108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1804129945165758464 |
|---|---|
| adam_text | Genetics ofApoptosis
Edited by
Stefan Grimm
! Max-Planck Institute for Biochemistry,
Martinsried,
Germany
Contents
Abbreviations ix
Contributors xii
Preface xiii
Introduction xv
Section I: Molecular Biology of Apoptosis
Chapter 1 Death receptors in apoptosis 1
Rajani Ravi and Atul Bedi
Introduction
Death receptors and ligands
Induction of apoptosis by death receptors
Regulation of death receptor-induced apoptosis
Role of death receptor-induced apoptosis in the immune
system
Role of death receptor-induced apoptosis in development
Death receptor-induced apoptosis of tumor cells
Conclusion
Chapter 2 The role of caspases in apoptosis 31
Sharad Kumar and Dimitrios Cakouros
1 What are caspases? 31
2 Types of caspases 31
3 Caspase structure 33
4 Substrate specificity of caspases 33
5 Caspase activation 34
6 Regulation of caspase activation 38
7 Caspase targets 41
8 Function of individual caspases 42
vi Genetics of Apoptosis
Chapter 3 Making sense of the Bcl-2 family of
apoptosis regulators 47
Loralee Haughn and David Hockenbery
1 Introduction
2 Internecine warfare or private agendas
3 Location, location, location
4 A finger in every pot
5 Specialists or generalists?
6 Summary
Chapter 4 Functional domains in apoptosis proteins 67
Kay Hofmann
1 Introduction 67
2 Death ligands and receptors 70
3 Adapter domains 73
4 Caspases and inhibitors 83
5 Other important domains 86
6 A domain-centric view of apoptosis 89
Section II: Cell Biology of Apoptosis
Chapter 5 The role of the endoplasmic reticulum
in apoptosis 93
David G Breckenridge and Gordon C Shore
1 Introduction 93
2 ER stress-induced apoptosis 94
3 Regulation of mitochondrial apoptosis by ER Ca2+ signals 101
4 Other ER regulators of apoptosis 108
5 Concluding remarks 112
Chapter 6 Mitochondria in apoptosis induction 115
Bruno Antonsson
1 Introduction 115
2 The mitochondria 115
3 Apoptosis pathways 116
4 The Bcl-2 protein family 118
5 Structure and channel-forming activity 120
6 Activation of the multidomain Bcl-2 proteins 122
7 BH3-domain-only proteins as multidomain protein
activators 124
8 How do the multidomain Bcl-2 proteins trigger the release
of proteins from the intermembrane space of the
mitochondria? 124
9 Activities of the mitochondrial proteins released 130
10 Bax and mitochondrial respiration 131
11 Conclusion 132
Contents vii
Section III: Cell Death in Model Systems
Chapter 7 Regulators and applications of yeast
apoptosis 135
Kai-Uwe Frohlich and Frank Madeo
1 Introduction 135
2 Expression of metazoan apoptotic genes induces cell
death in yeast 135
3 Mutations leading to apoptosis in yeast 137
4 ROS are central regulators of yeast apoptosis 138
5 DNA damage induces yeast apoptosis 140
6 Speculations about the origin of apoptosis 140
7 Apoptosis and aging in yeast 141
8 Applications of yeast apoptosis to plant research 142
9 Applications of yeast apoptosis for medical research 142
10 Perspectives 143
Chapter 8 Evolution of cell death: caspase-medialed
mechanisms in early metazoans; noncaspase
mechanisms in single-celled eukaryotes 145
Angelika B6ttgerf and Charles N David
1 Introduction 145
2 Cell death in Cnidaria and Porifera 146
3 Cell death in single-celled eukaryotes 150
4 Conclusions 153
Chapter 9 Programmed cell death in C elegans 155
Anton Gartner, Arno Alpi and Bjorn Schumacher
1 Introduction 155
2 Identity and origin of cells undergoing programmed cell
death during the somatic development of C elegans 155
3 Identity and origin of cells undergoing programmed cell
death in the C elegans germ line 156
4 Identification and quantification of programmed cell death
in C elegans 157
5 Mutants define four distinct steps in the core apoptotic
pathway 159
6 Four genes, egl-1, ced-3, ced-4, and ced-9, define a
genetic pathway needed for (almost) all programmed
cell deaths 160
7 egl-1, ced-3, ced-4, and ced-9 are functionally conserved
throughout evolution 161
8 EGL-1, CED-3, CED-4, and CED-9 are part of a molecular
framework regulating programmed cell death 162
9 Modulators and downstream components of the
cell-death pathway 164
10 The regulation of programmed cell death in specific cell
types 165
viii Genet ics of Apop tos i s
11 Germ-line cell death 166
12 Genes required for the engulfment of dying cells 170
13 Potential functions of programmed cell death in C elegans 174
14 Conclusion 175
Chapter 10 Apoptosis in Drosophila 177
Kristin White
1 Introduction 177
2 Genetic screens uncover genes important in developmental
apoptosis 177
3 How Rpr, Hid, Grim, and Ski initiate apoptosis 178
4 Caspases are required for Rpr-, Grim-, Hid-, and
Ski-induced apoptosis 180
5 Modifiers of caspase activation: the mitochondrial pathway 182
6 How is the mitochondrial pathway activated? 183
7 Moving upstream: regulation of Rpr, Hid, Grim, and Ski
activity 184
8 What is the role of apoptosis in Drosophila development? 186
9 Conclusions 188
Chapter 11 Cell-culture systems in apoptosis • 189
Stefan Grimm
1 Introduction: advantages of cell culture to investigate
apoptosis 189
2 Cell-culture approaches to isolate genes in apoptosis 190
3 Conclusions 199
Chapter 12 Caspase-independent cell death 203
Marcel Leist and Marja Jaattela
1 Introduction
2 Four patterns of death: from apoptosis to necrosis
3 Death programs beyond caspases
4 Signaling in caspase-independent PCD
5 The significance of the program: removal of corpses
6 Complex control of tumor cell death
7 Alternative cell death in the nervous system
8 Evolution of cell-death principles
9 Conclusion
References
Index
|
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| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:13:12Z |
| institution | BVB |
| isbn | 1859960642 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010289108 |
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| physical | XVII, 309 S. graph. Darst. |
| publishDate | 2003 |
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| spelling | Genetics of apoptosis ed. by Stefan Grimm Oxford Bios 2003 XVII, 309 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Apoptosis swd Cytologie swd Molekulargenetik swd Apoptosis Apoptosis genetics Genetics Grimm, Stefan Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010289108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genetics of apoptosis Apoptosis swd Cytologie swd Molekulargenetik swd Apoptosis Apoptosis genetics Genetics |
| title | Genetics of apoptosis |
| title_auth | Genetics of apoptosis |
| title_exact_search | Genetics of apoptosis |
| title_full | Genetics of apoptosis ed. by Stefan Grimm |
| title_fullStr | Genetics of apoptosis ed. by Stefan Grimm |
| title_full_unstemmed | Genetics of apoptosis ed. by Stefan Grimm |
| title_short | Genetics of apoptosis |
| title_sort | genetics of apoptosis |
| topic | Apoptosis swd Cytologie swd Molekulargenetik swd Apoptosis Apoptosis genetics Genetics |
| topic_facet | Apoptosis Cytologie Molekulargenetik Apoptosis genetics Genetics |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010289108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT grimmstefan geneticsofapoptosis |