Cytokines and chemokines in autoimmune disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Georgetown [u.a.]
Landes Bioscience [u.a.]
2003
|
| Schriftenreihe: | Advances in experimental medicine and biology
520 |
| Schlagworte: | |
| Online-Zugang: | Table of Contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 295 S. graph. Darst. |
| ISBN: | 0306476932 |
Internformat
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| 650 | 4 | |a Chimiokines | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Maladies auto-immunes | |
| 650 | 4 | |a Autoimmune Diseases |x immunology | |
| 650 | 4 | |a Autoimmune diseases | |
| 650 | 4 | |a Autoimmunity | |
| 650 | 4 | |a Chemokines | |
| 650 | 4 | |a Chemokines |x immunology | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Cytokines |x immunology | |
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Datensatz im Suchindex
| _version_ | 1804129944502009856 |
|---|---|
| adam_text | I CONTENTS |
Preface xiii
Part I: Autoimmune Diseases, Cytokines and Chemokines
1. Cytokines and Chemokines in Autoimmune Disease: An Overview 1
Pert Santamaria
Introduction 1
Pro Inflammatory Cytokines 1
Chemokines 4
Regulatory Cytokines 5
Concluding Remarks 6
2. Cytokines and Chemokines—Their Receptors and Their Genes:
An Overview 8
Mark]. Cameron and David]. Kelvin
Introduction 8
Cytokines—Their Receptors and Their Genes 9
Chemokines—Their Receptors and Their Genes 21
Concluding Remarks 24
Part II: Genetics and Mechanisms
3. Cytokine and Cytokine Receptor Genes in the Susceptibility
and Resistance to Organ Specific Autoimmune Diseases 33
Hdline Coppin, Marie Paule Roth and Roland S. Liblau
Introduction 33
Cytokine and Cytokine Receptor Genes in the Susceptibility
to Multiple Sclerosis (MS) 33
Pro Inflammatory Cytokine and Cytokine Receptor Genes
and Susceptibility to MS 34
Anti Inflammatory Cytokine and Cytokine Receptor Genes
and Susceptibility to MS 39
Chemokine and Chemokine Receptor Genes and Susceptibility to MS 42
Conclusions 43
Cytokine and Cytokine Receptor Genes in the Susceptibility
to Rheumatoid Arthritis (RA) 44
Pro Inflammatory Cytokines and Cytokines Receptor Genes
and Susceptibility to RA 44
Anti Inflammatory Cytokines and Susceptibility to RA 47
Chemokine and Chemokine Receptor Genes and Susceptibility to RA 49
Cytokine and Cytokine Receptor Genes in the Susceptibility
to Insulin Dependent Diabetes Mellitus (IDDM) 50
Pro Inflammatory Cytokine and Cytokine Receptor Genes
and Susceptibility to IDDM 51
Anti Inflammatory Cytokine and Cytokine Receptor Genes
and Susceptibility to IDDM 54
Chemokine and Chemokine Receptor Genes and Susceptibility
to IDDM 54
4. Cytokines, Lymphocyte Homeostasis and Self Tolerance 66
Yiguang Chen and Youhai Chen
Introduction 66
Self Tolerance and Lymphocyte Homeostasis 66
TGF P and IL 10 68
IL 2 and IFN y 70
The TNF Superfamily 70
5. The Role of Cytokines as Effectors of Tissue Destruction
in Autoimmunity 73
Thomas W.H. Kay, Rima Darwiche, Windy Irawaty,
Mark M. W. Chong, Helen L. Pennington and Helen E. Thomas
Introduction 73
Interleukin 1 75
Interferon gamma 76
TNF and TNF Family Members 80
Fas Ligand 81
TRAIL 82
A Blueprint for Protection 82
6. Cytokines in the Treatment and Prevention of Autoimmune
Responses—A Role of IL 15 87
Xin Xiao Zheng, Wlodzmierz Maslinski, Sylvie Ferrari Lacraz
and Terry B. Strom
Introduction 87
IL 15 and IL 15Ra 88
IL 15/IL 15R System Is Critical for NK Cell Development
and Function 88
Function of IL 15 on TCRT Cells 89
Role of IL 15 in Autoimmune and Inflammatory Disease 90
Part III: Cytokines and Chemokines in Autoimmune Diseases
7. Cytokines in the Pathogenesis and Therapy of Autoimmune
Encephalomyelitis and Multiple Sclerosis 96
David O. Willenborg and Maria A. Staykova
Introduction 96
Multiple Sclerosis 96
Experimental Autoimmune Encephalomyelitis 97
Interleukin 1 97
Tumor Necrosis Factor alpha and Lymphotoxin alpha 98
Interleukin 6 101
Interferon Y 101
Interleukin 18 103
Transforming Growth Factor B 104
Interleukin 4 105
Interleukin 10 107
Interleukin 12 108
Concluding Observations 109
A Ready Reckoner to Cytokine Function in Relation
to CNS Inflammation 110
8. Chemokines in Experimental Autoimmune Encephalomyelitis
and Multiple Sclerosis 120
Alicia Babcock and Trevor Owens
Introduction 120
Chemokines 120
Immunology of Multiple Sclerosis (MS) 121
Immunology of Experimental Autoimmune Encephalomyelitis (EAE) 121
The Blood Brain Barrier (BBB) 122
Chemokines in EAE 123
Chemokines in MS 126
Chemokine Genetics and CNS Disease 128
Neural Roles for Chemokines 128
Conclusions 129
9. Cytokines and Chemokines in the Pathogenesis of Murine
Type 1 Diabetes 133
C. Meagher, S. Sharif, S. Htissain, M. J. Cameron, G. A. Arreaza
and T. L. Delovitch
Introduction 133
Immune Deviation and the NOD Mouse 133
Anti Inflammatory Cytokines and Autoimmune Diabetes 134
Proinflammatory Cytokines and Autoimmune Diabetes 141
Conclusions 148
10. Immunoregulation by Cytokines in Autoimmune Diabetes 159
Alex Rabinovitch
Introduction 159
Type 1 Diabetes Viewed as a Disorder of Immunoregulation 159
Immune Responses: Roles of Cytokines 160
Approaches Used to Study Roles of Cytokines in Type 1 Diabetes 163
Cytokines in Human Type 1 Diabetes 170
Autoimmune Diabetes: A Dominance of Thl Over Th2 Cells? 171
Antigen Specific and Nonspecific Mechanisms of Islet
P Cell Destruction 174
Immunosnmulatory Procedures to Prevent Type 1 Diabetes 176
Future Prospects: Clinical Considerations 179
11. Cytokines in the Pathogenesis of Rheumatoid Arthritis
and Collagen Induced Arthritis 194
Erik Lubberts and Wim B. van den Berg
Introduction 194
Pathways in the Pathogenesis of RA 194
Proinflammatoiy Cytokines IL 1 andTNF 195
Role of T Cell Cytokines in Pathology of RA 196
IL 15 196
IL 17 197
RANKL 197
IL 12/IL 18 198
Regulation by IL 4/IL 10 199
12. Cytokines and Chemokines in Virus Induced Autoimmunity 203
Urs Christen and Matthias G. von Herrath
Introduction 203
Cytokines and Chemokines as Conductors of the Immune Response 203
Cytokines and Chemokines in Autoimmune Type 1 Diabetes 204
The Role of Cytokines and Chemokines in the RIP LCMV
Transgenic Mouse Model for Autoimmune Diabetes 205
The Role of Cytokines and Chemokines in Viral Infections
and Their Potential Interference with Autoimmunity 213
Conclusions 215
13. Cytokines and Chemokines in Human Autoimmune
Skin Disorders 221
Dorothh Nashan and Thomas Schwarz
Introduction 221
Lupus Erythematosus 222
Systemic Sclerosis (SSc) 224
Dermatomyositis 225
Autoimmune Bullous Diseases 226
Pemphigus 226
Dermatitis Herpetiformis 229
Therapeutic Perspectives 229
Conclusions 230
14. Involvement of Cytokines in the Pathogenesis of Systemic
Lupus Erythematosus 237
B.R. Lauwerys andF A. Houssiau
Introduction 237
Dysregulation of B , T and APC Function in SLE 237
Role of IL 10 in the Pathogenesis of SLE 239
Role of IL 12 in the Pathogenesis of SLE 240
Other Cytokines 242
Conclusions 244
15. Cytokines, Chemokines and Growth Factors in the Pathogenesis
and Treatment of Inflammatory Bowel Disease 252
Deborah O NeilandLothar Steidler
Introduction 252
Soluble Regulators of Immunity 253
Cytokines in the Normal versus the Inflammatory State 253
A Balancing Act 253
When the Balance Tips: Chronic Inflammation 254
Tumor Necrosis Factor alpha (TNF a) 255
Interleukin 6 (IL 6) 261
Interleukin 12(IL 12) 262
Interleukin 15(IL 15) 264
Interleukin 16 (IL 16) 265
Interleukin 18(IL 18) 265
Chemokines 267
Regulatory Cytokines and Growth Factors 269
Conclusion 275
Index 287
|
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| spelling | Cytokines and chemokines in autoimmune disease Ed. by Pere Santamaria Georgetown [u.a.] Landes Bioscience [u.a.] 2003 295 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 520 Includes bibliographical references and index Auto-immunité Chimiokines Cytokines Maladies auto-immunes Autoimmune Diseases immunology Autoimmune diseases Autoimmunity Chemokines Chemokines immunology Cytokines immunology Chemokine (DE-588)4429989-8 gnd rswk-swf Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf Cytokine (DE-588)4205701-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Autoaggressionskrankheit (DE-588)4003935-3 s Cytokine (DE-588)4205701-2 s DE-604 Chemokine (DE-588)4429989-8 s Santamaria, Pere Sonstige oth Advances in experimental medicine and biology 520 (DE-604)BV000003102 520 Table of Contents http://www.loc.gov/catdir/toc/ecip02/2001004698.html HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010288593&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cytokines and chemokines in autoimmune disease Advances in experimental medicine and biology Auto-immunité Chimiokines Cytokines Maladies auto-immunes Autoimmune Diseases immunology Autoimmune diseases Autoimmunity Chemokines Chemokines immunology Cytokines immunology Chemokine (DE-588)4429989-8 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd Cytokine (DE-588)4205701-2 gnd |
| subject_GND | (DE-588)4429989-8 (DE-588)4003935-3 (DE-588)4205701-2 (DE-588)4143413-4 |
| title | Cytokines and chemokines in autoimmune disease |
| title_auth | Cytokines and chemokines in autoimmune disease |
| title_exact_search | Cytokines and chemokines in autoimmune disease |
| title_full | Cytokines and chemokines in autoimmune disease Ed. by Pere Santamaria |
| title_fullStr | Cytokines and chemokines in autoimmune disease Ed. by Pere Santamaria |
| title_full_unstemmed | Cytokines and chemokines in autoimmune disease Ed. by Pere Santamaria |
| title_short | Cytokines and chemokines in autoimmune disease |
| title_sort | cytokines and chemokines in autoimmune disease |
| topic | Auto-immunité Chimiokines Cytokines Maladies auto-immunes Autoimmune Diseases immunology Autoimmune diseases Autoimmunity Chemokines Chemokines immunology Cytokines immunology Chemokine (DE-588)4429989-8 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd Cytokine (DE-588)4205701-2 gnd |
| topic_facet | Auto-immunité Chimiokines Cytokines Maladies auto-immunes Autoimmune Diseases immunology Autoimmune diseases Autoimmunity Chemokines Chemokines immunology Cytokines immunology Chemokine Autoaggressionskrankheit Cytokine Aufsatzsammlung |
| url | Table of Contents http://www.loc.gov/catdir/toc/ecip02/2001004698.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010288593&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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