The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2002
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | München, Techn. Univ., Diss., 2002 (Nicht für den Austausch) |
| Beschreibung: | IV, 108 Bl. Ill., graph. Darst. : 30 cm |
Internformat
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| 245 | 1 | 0 | |a The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo |c Stephan W. Grill |
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Datensatz im Suchindex
| _version_ | 1816445024440680448 |
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CONTENTS
1 INTRODUCTION 1
1.1 CELL DIVISION. 2
1.1.1 BIOLOGICAL FEATURES OF CELL DIVISION. 2
1.1.2 PROPERTIES OF MICROTUBULES AND MOTOR PROTEINS. 8
1.1.3 MECHANISMS OF SPINDLE POSITIONING. 12
1.2 ASYMMETRIC CELL DIVISION IN CAENORHABDITIS ELEGANS .19
1.3 BIOPHYSICAL TECHNIQUES.26
1.3.1 MATERIAL PROPERTIES.27
1.3.2 ACTIVE FORCES AND TENSILE STRASS.29
1.3.3 EXPERIMENTAL SETUP.31
2 EXPERIMENTS 34
2.1 ANALYSIS OF YOLK GRANULE DIFFUSION.34
2.1.1 THEORETICAL BASIS OF THE MSD ANALYSIS.34
2.1.2 APPLICATION TO YOLK GRANULES.37
2.2 SPINDLE SEVERING EXPERIMENTS.39
2.2.1 SEVERING AT ANAPHASE IN THE WILD-TYPE EMBRYO.39
2.2.2 SEVERING AT METAPHASE IN THE WILD-TYPE EMBRYO . 45
2.2.3 PAR-2 AR^D PAR-3 MUTANT BACKGROUNDS.45
2.2.4 DISINTEGRATION OF CENTROSOMES.50
2.3 OPTICALLY INDUCED CENTROSOME DISINTEGRATION.53
2.3.1 CENTROSOME DISINTEGRATION IN THE WILD-TYPE EMBRYO . . 53
2.3.2 CENTROSOME DISINTEGRATION IN PAR-2 AND AGS-3 (RNAI) . 64
3 MODEL OF SPINDLE POLE BEHAVIOR DURING ANAPHASE 67
3.1 SET OF DIFFERENTIAL EQUATIONS . 70
3.1.1 CIRCULAR GEOMETRY.72
3.1.2 REMOVING THE SPINDLE MIDZONE.73
3.1.3 ANAPHASE IN THE UNPERTURBED EMBRYO.74
78
III
4 DISCUSSION
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/966041046
5 SUMMARY
87
6 APPENDIX 89
6.1 METHODS. 89
6.2 ABBREVIATIONS.,.92
BIBLIOGRAPHY 93
PUBLICATIONS 107
ACKNOWLEDGMENTS 108
IV |
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| physical | IV, 108 Bl. Ill., graph. Darst. : 30 cm |
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| spelling | Grill, Stephan W. 1974- Verfasser (DE-588)123807786 aut The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo Stephan W. Grill 2002 IV, 108 Bl. Ill., graph. Darst. : 30 cm txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2002 (Nicht für den Austausch) Biomechanik (DE-588)4006880-8 gnd rswk-swf Mitose (DE-588)4170185-9 gnd rswk-swf Asymmetrie (DE-588)4136656-6 gnd rswk-swf Zygote (DE-588)4328479-6 gnd rswk-swf Kernspindel (DE-588)4206805-8 gnd rswk-swf Caenorhabditis elegans (DE-588)4147127-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Caenorhabditis elegans (DE-588)4147127-1 s Mitose (DE-588)4170185-9 s Kernspindel (DE-588)4206805-8 s Asymmetrie (DE-588)4136656-6 s DE-604 Zygote (DE-588)4328479-6 s Biomechanik (DE-588)4006880-8 s 1\p DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010225847&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Grill, Stephan W. 1974- The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo Biomechanik (DE-588)4006880-8 gnd Mitose (DE-588)4170185-9 gnd Asymmetrie (DE-588)4136656-6 gnd Zygote (DE-588)4328479-6 gnd Kernspindel (DE-588)4206805-8 gnd Caenorhabditis elegans (DE-588)4147127-1 gnd |
| subject_GND | (DE-588)4006880-8 (DE-588)4170185-9 (DE-588)4136656-6 (DE-588)4328479-6 (DE-588)4206805-8 (DE-588)4147127-1 (DE-588)4113937-9 |
| title | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo |
| title_auth | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo |
| title_exact_search | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo |
| title_full | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo Stephan W. Grill |
| title_fullStr | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo Stephan W. Grill |
| title_full_unstemmed | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo Stephan W. Grill |
| title_short | The mechanics of asymmetric spindle positioning in the Caenorhabditis elegans embryo |
| title_sort | the mechanics of asymmetric spindle positioning in the caenorhabditis elegans embryo |
| topic | Biomechanik (DE-588)4006880-8 gnd Mitose (DE-588)4170185-9 gnd Asymmetrie (DE-588)4136656-6 gnd Zygote (DE-588)4328479-6 gnd Kernspindel (DE-588)4206805-8 gnd Caenorhabditis elegans (DE-588)4147127-1 gnd |
| topic_facet | Biomechanik Mitose Asymmetrie Zygote Kernspindel Caenorhabditis elegans Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010225847&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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