Physics of bio-molecules and cells: = Physique de biomolécules et des cellules
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| Format: | Conference Proceeding Book |
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| Language: | English French |
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Berlin ; Heidelberg ; New York ; Barcelona ; Hong Kong ; London
Springer
2002
Les Ulis ; Paris ; Cambridge EDP Sciences |
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| Item Description: | Literaturangaben |
| Physical Description: | XXXIV, 580 S. Ill., graph. Darst. : 23 cm |
| ISBN: | 3540441328 2868836186 |
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| 245 | 1 | 0 | |a Physics of bio-molecules and cells |b = Physique de biomolécules et des cellules |c École de Physique des Houches - UJF & INPG-Grenoble, a NATO Advanced Study Institute, LesHouches, Session LXXV, 2 - 7 July 2001. Ed. by H. Flyvbjerg ... Publ. in cooperation with the NATO Scientific Affair Division |
| 246 | 1 | 1 | |a Physique de biomolécules et des cellules |
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| _version_ | 1804129807457320960 |
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| adam_text | CONTENTS LECTURERS XI PARTICIPANTS XIII PR´ EFACE XVII PREFACE XXI
CONTENTS XXV COURSE 1. PHYSICS OF PROTEIN-DNA INTERACTION BY R.F.
BRUINSMA 1 1 INTRODUCTION 3 1.1 THE CENTRAL DOGMA AND BACTERIAL GENE
EXPRESSION . . . . . . . . . . 3 1.1.1 TWO FAMILIES . . . . . . . . . .
. . . . . . . . . . . . . . . . 3 1.1.2 PROKARYOTE GENE EXPRESSION . . .
. . . . . . . . . . . . . . . 5 1.2 MOLECULAR STRUCTURE . . . . . . . .
. . . . . . . . . . . . . . . . . . 8 1.2.1 CHEMICAL STRUCTURE OF DNA .
. . . . . . . . . . . . . . . . . 8 1.2.2 PHYSICAL STRUCTURE OF DNA . .
. . . . . . . . . . . . . . . . . 10 1.2.3 CHEMICAL STRUCTURE OF
PROTEINS . . . . . . . . . . . . . . . . 12 1.2.4 PHYSICAL STRUCTURE OF
PROTEINS . . . . . . . . . . . . . . . . . 14 2 THERMODYNAMICS AND
KINETICS OF REPRESSOR-DNA INTERACTION 16 2.1 THERMODYNAMICS AND THE LAC
REPRESSOR . . . . . . . . . . . . . . . . 16 2.1.1 THE LAW OF MASS
ACTION . . . . . . . . . . . . . . . . . . . . 16 2.1.2 STATISTICAL
MECHANICS AND OPERATOR OCCUPANCY . . . . . . . . 19 2.1.3 ENTROPY,
ENTHALPY, AND DIRECT READ-OUT . . . . . . . . . . . . 20 2.1.4 THE LAC
REPRESSOR COMPLEX: A MOLECULAR MACHINE . . . . . . 23 2.2 KINETICS OF
REPRESSOR-DNA INTERACTION . . . . . . . . . . . . . . . . 26 2.2.1
REACTION KINETICS . . . . . . . . . . . . . . . . . . . . . . . . 26
2.2.2 DEBYE*SMOLUCHOWSKI THEORY . . . . . . . . . . . . . . . . . . 28
2.2.3 BWH THEORY . . . . . . . . . . . . . . . . . . . . . . . . . . 30
2.2.4 INDIRECT READ-OUT AND INDUCED FIT . . . . . . . . . . . . . . . 32
XXVI 3 DNA DEFORMABILITY AND PROTEIN-DNA INTERACTION 34 3.1 INTRODUCTION
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3.1.1
EUKARYOTIC GENE EXPRESSION AND CHROMATIN CONDENSATION . . 34 3.1.2 A
MATHEMATICAL EXPERIMENT AND WHITE*S THEOREM . . . . . . 37 3.2 THE
WORM-LIKE CHAIN . . . . . . . . . . . . . . . . . . . . . . . . . . 40
3.2.1 CIRCULAR DNA AND THE PERSISTENCE LENGTH . . . . . . . . . . 42
3.2.2 NUCLEOSOMES AND THE MARKY*MANNING TRANSITION . . . . . . 42 3.2.3
PROTEIN-DNA INTERACTION UNDER TENSION . . . . . . . . . . . 45 3.2.4
FORCE-EXTENSION CURVES . . . . . . . . . . . . . . . . . . . . 47 3.3
THE RST MODEL . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
50 3.3.1 STRUCTURAL SEQUENCE SENSITIVITY . . . . . . . . . . . . . . . .
50 3.3.2 THERMAL FLUCTUATIONS . . . . . . . . . . . . . . . . . . . . .
. 52 4 ELECTROSTATICS IN WATER AND PROTEIN-DNA INTERACTION 53 4.1
MACRO-IONS AND AQUEOUS ELECTROSTATICS . . . . . . . . . . . . . . . . 54
4.2 THE PRIMITIVE MODEL . . . . . . . . . . . . . . . . . . . . . . . .
. . 56 4.2.1 THE PRIMITIVE MODEL: ION-FREE . . . . . . . . . . . . . . .
. . 57 4.2.2 THE PRIMITIVE MODEL: DH REGIME . . . . . . . . . . . . . .
. 57 4.3 MANNING CONDENSATION . . . . . . . . . . . . . . . . . . . . .
. . . . 58 4.3.1 CHARGE RENORMALIZATION . . . . . . . . . . . . . . . .
. . . . 58 4.3.2 PRIMITIVE MODEL: OOSAWA THEORY . . . . . . . . . . . .
. . . 59 4.3.3 PRIMITIVE MODEL: FREE ENERGY . . . . . . . . . . . . . .
. . . 61 4.4 COUNTER-ION RELEASE AND NON-SPECIFIC PROTEIN-DNA
INTERACTION . . . 63 4.4.1 COUNTER-ION RELEASE . . . . . . . . . . . . .
. . . . . . . . . . 63 4.4.2 NUCLEOSOME FORMATION AND THE ISOELECTRIC
INSTABILITY . . . . 64 COURSE 2. MECHANICS OF MOTOR PROTEINS BY J.
HOWARD 69 1 INTRODUCTION 71 2 CELL MOTILITY AND MOTOR PROTEINS 72 3
MOTILITY ASSAYS 73 4 SINGLE-MOLECULES ASSAYS 75 5 ATOMIC STRUCTURES 77 6
PROTEINS AS MACHINES 78 7 CHEMICAL FORCES 80 8 EFFECT OF FORCE ON
CHEMICAL EQUILIBRIA 81 9 EFFECT OF FORCE ON THE RATES OF CHEMICAL
REACTIONS 82 XXVII 10 ABSOLUTE RATE THEORIES 85 11 ROLE OF THERMAL
FLUCTUATIONS IN MOTOR REACTIONS 87 12 A MECHANOCHEMICAL MODEL FOR
KINESIN 89 13 CONCLUSIONS AND OUTLOOK 92 COURSE 3. MODELLING MOTOR
PROTEIN SYSTEMS BY T. DUKE 95 1 MAKING A MOVE: PRINCIPLES OF ENERGY
TRANSDUCTION 98 1.1 MOTOR PROTEINS AND CARNOT ENGINES . . . . . . . . .
. . . . . . . . . 98 1.2 SIMPLE BROWNIAN RATCHET . . . . . . . . . . . .
. . . . . . . . . . . . 99 1.3 POLYMERIZATION RATCHET . . . . . . . . .
. . . . . . . . . . . . . . . . 100 1.4 ISOTHERMAL RATCHETS . . . . . .
. . . . . . . . . . . . . . . . . . . . . 103 1.5 MOTOR PROTEINS AS
ISOTHERMAL RATCHETS . . . . . . . . . . . . . . . . 104 1.6 DESIGN
PRINCIPLES FOR EFFECTIVE MOTORS . . . . . . . . . . . . . . . . . 105 2
PULLING TOGETHER: MECHANO-CHEMICAL MODEL OF ACTOMYOSIN 108 2.1 SWINGING
LEVER-ARM MODEL . . . . . . . . . . . . . . . . . . . . . . . 108 2.2
MECHANO-CHEMICAL COUPLING . . . . . . . . . . . . . . . . . . . . . .
110 2.3 EQUIVALENT ISOTHERMAL RATCHET . . . . . . . . . . . . . . . . .
. . . . 111 2.4 MANY MOTORS WORKING TOGETHER . . . . . . . . . . . . . .
. . . . . . 112 2.5 DESIGNED TO WORK . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 115 2.6 FORCE-VELOCITY RELATION . . . . . . . . . .
. . . . . . . . . . . . . . . 116 2.7 DYNAMICAL INSTABILITY AND
BIOCHEMICAL SYNCHRONIZATION . . . . . . . 118 2.8 TRANSIENT RESPONSE OF
MUSCLE . . . . . . . . . . . . . . . . . . . . . 119 3 MOTORS AT WORK:
COLLECTIVE PROPERTIES OF MOTOR PROTEINS 119 3.1 DYNAMICAL INSTABILITIES
. . . . . . . . . . . . . . . . . . . . . . . . . 119 3.2 BIDIRECTIONAL
MOVEMENT . . . . . . . . . . . . . . . . . . . . . . . . 120 3.3
CRITICAL BEHAVIOUR . . . . . . . . . . . . . . . . . . . . . . . . . . .
121 3.4 OSCILLATIONS . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 124 3.5 DYNAMIC BUCKLING INSTABILITY . . . . . . . . . . . . .
. . . . . . . . 125 3.6 UNDULATION OF FLAGELLA . . . . . . . . . . . . .
. . . . . . . . . . . . 127 4 SENSE AND SENSITIVITY: MECHANO-SENSATION
IN HEARING 129 4.1 SYSTEM PERFORMANCE . . . . . . . . . . . . . . . . .
. . . . . . . . . 129 4.2 MECHANO-SENSORS: HAIR BUNDLES . . . . . . . .
. . . . . . . . . . . . 130 4.3 ACTIVE AMPLIFICATION . . . . . . . . . .
. . . . . . . . . . . . . . . . 131 4.4 SELF-TUNED CRITICALITY . . . . .
. . . . . . . . . . . . . . . . . . . . . 133 4.5 MOTOR-DRIVEN
OSCILLATIONS . . . . . . . . . . . . . . . . . . . . . . . . 134 4.6
CHANNEL COMPLIANCE AND RELAXATION OSCILLATIONS . . . . . . . . . . . 136
XXVIII 4.7 CHANNEL-DRIVEN OSCILLATIONS . . . . . . . . . . . . . . . . .
. . . . . 138 4.8 HEARING AT THE NOISE LIMIT . . . . . . . . . . . . . .
. . . . . . . . . 139 COURSE 4. DYNAMIC FORCE SPECTROSCOPY BY E. EVANS
AND P. WILLIAMS 145 PART 1: E. EVANS AND P. WILLIAMS 147 1 DYNAMIC FORCE
SPECTROSCOPY. I. SINGLE BONDS 147 1.1 INTRODUCTION . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 147 1.1.1 INTRINSIC DEPENDENCE
OF BOND STRENGTH ON TIME FRAME FOR BREAKAGE . . . . . . . . . . . . . .
. . . . . . . . . . . . . 148 1.1.2 BIOMOLECULAR COMPLEXITY AND ROLE FOR
DYNAMIC FORCE SPECTROSCOPY . . . . . . . . . . . . . . . . . . . . . . .
. . . 148 1.1.3 BIOCHEMICAL AND MECHANICAL PERSPECTIVES OF BOND STRENGTH
. 150 1.1.4 RELEVANT SCALES FOR LENGTH, FORCE, ENERGY, AND TIME . . . .
. . 153 1.2 BROWNIAN KINETICS IN CONDENSED LIQUIDS: OLD-TIME PHYSICS . .
. . . 154 1.2.1 TWO-STATE TRANSITIONS IN A LIQUID . . . . . . . . . . .
. . . . 155 1.2.2 KINETICS OF FIRST-ORDER REACTIONS IN SOLUTION . . . .
. . . . . . 156 1.3 LINK BETWEEN FORCE * TIME * AND BOND CHEMISTRY . . .
. . . . . . . 158 1.3.1 DISSOCIATION OF A SIMPLE BOND UNDER FORCE . . .
. . . . . . . 158 1.3.2 DISSOCIATION OF A COMPLEX BOND UNDER FORCE:
STATIONARY RATE APPROXIMATION . . . . . . . . . . . . . . . . 159 1.3.3
EVOLUTION OF STATES IN COMPLEX BONDS . . . . . . . . . . . . . 163 1.4
TESTING BOND STRENGTH AND THE METHOD OF DYNAMIC FORCE SPECTROSCOPY . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 164 1.4.1 PROBE
MECHANICS AND BOND LOADING DYNAMICS . . . . . . . . 165 1.4.2 STOCHASTIC
PROCESS OF BOND FAILURE UNDER RISING FORCE . . . . 168 1.4.3
DISTRIBUTIONS OF BOND LIFETIME AND RUPTURE FORCE . . . . . . . 169 1.4.4
CROSSOVER FROM NEAR EQUILIBRIUM TO FAR FROM EQUILIBRIUM UNBONDING . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 172 1.4.5 EFFECT OF
SOFT-POLYMER LINKAGES ON DYNAMIC STRENGTHS OF BONDS . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . 175 1.4.6 FAILURE OF A COMPLEX
BOND AND UNEXPECTED TRANSITIONS IN STRENGTH . . . . . . . . . . . . . .
. . . . . . . . . . . . . 177 1.5 SUMMARY . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 185 PART 2: P. WILLIAMS AND E. EVANS
186 2 DYNAMIC FORCE SPECTROSCOPY. II. MULTIPLE BONDS 187 2.1 HIDDEN
MECHANICS IN DETACHMENT OF MULTIPLE BONDS . . . . . . . . . 187 2.2
IMPACT OF COOPERATIVITY . . . . . . . . . . . . . . . . . . . . . . . .
188 2.3 UNCORRELATED FAILURE OF BONDS LOADED IN SERIES . . . . . . . . .
. . . 191 2.3.1 MARKOV SEQUENCE OF RANDOM FAILURES . . . . . . . . . . .
. . 191 2.3.2 MULTIPLE-COMPLEX BONDS . . . . . . . . . . . . . . . . . .
. . 193 XXIX 2.3.3 MULTIPLE-IDEAL BONDS . . . . . . . . . . . . . . . .
. . . . . . 194 2.3.4 EQUIVALENT SINGLE-BOND APPROXIMATION . . . . . . .
. . . . . 195 2.4 UNCORRELATED FAILURE OF BONDS LOADED IN PARALLEL . . .
. . . . . . . . 198 2.4.1 MARKOV SEQUENCE OF RANDOM FAILURES . . . . . .
. . . . . . . 198 2.4.2 EQUIVALENT SINGLE-BOND APPROXIMATION . . . . . .
. . . . . . 198 2.5 POISSON STATISTICS AND BOND FORMATION . . . . . . .
. . . . . . . . . 199 2.6 SUMMARY . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 203 SEMINAR 1. POLYMERIZATION FORCES BY M.
DOGTEROM 205 COURSE 5. THE PHYSICS OF LISTERIA PROPULSION BY J. PROST
215 1 INTRODUCTION 217 2 A GENUINE GEL 218 2.1 A LITTLE CHEMISTRY . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 218 2.2 ELASTIC
BEHAVIOUR . . . . . . . . . . . . . . . . . . . . . . . . . . . . 220 3
HYDRODYNAMICS AND MECHANICS 220 3.1 MOTION IN THE LABORATORY FRAME . . .
. . . . . . . . . . . . . . . . . 220 3.2 PROPULSION AND STEADY VELOCITY
REGIMES . . . . . . . . . . . . . . . . 221 3.3 GEL/BACTERIUM FRICTION
AND SALTATORY BEHAVIOUR . . . . . . . . . . . 223 4 BIOMIMETIC APPROACH
225 4.1 A SPHERICAL LISTERIA . . . . . . . . . . . . . . . . . . . . . .
. . . . . 225 4.2 SPHERICAL SYMMETRY . . . . . . . . . . . . . . . . . .
. . . . . . . . 226 4.3 STEADY STATE . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 227 4.4 GROWTH WITH SPHERICAL SYMMETRY . . . .
. . . . . . . . . . . . . . . 229 4.5 SYMMETRY BREAKING . . . . . . . .
. . . . . . . . . . . . . . . . . . . 229 4.6 LIMITATIONS OF THE
APPROACH AND POSSIBLE IMPROVEMENTS . . . . . . 231 5 CONCLUSION 234 XXX
COURSE 6. PHYSICS OF COMPOSITE CELL MEMBRANE AND ACTIN BASED
CYTOSKELETON BY E. SACKMANN, A.R. BAUSCH AND L. VONNA 237 1 ARCHITECTURE
OF COMPOSITE CELL MEMBRANES 239 1.1 THE LIPID/PROTEIN BILAYER IS A
MULTICOMPONENT SMECTIC PHASE WITH MOSAIC LIKE ARCHITECTURE . . . . . . .
. . . . . . . . . . . . . . 239 1.2 THE SPECTRIN/ACTIN CYTOSKELETON AS
HYPERELASTIC CELL STABILIZER . . . 242 1.3 THE ACTIN CORTEX:
ARCHITECTURE AND FUNCTION . . . . . . . . . . . . . 245 2 PHYSICS OF THE
ACTIN BASED CYTOSKELETON 249 2.1 ACTIN IS A LIVING SEMIFLEXIBLE POLYMER
. . . . . . . . . . . . . . . . . 249 2.2 ACTIN NETWORK AS VISCOELASTIC
BODY . . . . . . . . . . . . . . . . . . 253 2.3 CORRELATION BETWEEN
MACROSCOPIC VISCOELASTICITY AND MOLECULAR MOTIONAL PROCESSES . . . . . .
. . . . . . . . . . . . . . . . . . . . . 258 3 HETEROGENEOUS ACTIN GELS
IN CELLS AND BIOLOGICAL FUNCTION 260 3.1 MANIPULATION OF ACTIN GELS . .
. . . . . . . . . . . . . . . . . . . . . 260 3.2 CONTROL OF
ORGANIZATION AND FUNCTION OF ACTIN CORTEX BY CELL SIGNALLING . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 265 4 MICROMECHANICS AND
MICRORHEOMETRY OF CELLS 267 5 ACTIVATION OF ENDOTHELIAL CELLS: ON THE
POSSIBILITY OF FORMATION OF STRESS FIBERS AS PHASE TRANSITION OF
ACTIN-NETWORK TRIGGERED BY CELL SIGNALLING PATHWAYS 271 6 ON CELLS AS
ADAPTIVE VISCOPLASTIC BODIES 274 7 CONTROLL OF CELLULAR PROTRUSIONS
CONTROLLED BY ACTIN/MYOSIN CORTEX 278 COURSE 7. CELL ADHESION AS WETTING
TRANSITION? BY E. SACKMANN AND R. BRUINSMA 285 1 INTRODUCTION 287 2
MIMICKING CELL ADHESION 292 3 MICROINTERFEROMETRY: A VERSATILE TOOL TO
EVALUATE ADHESION STRENGTH AND FORCES 294 4 SOFT SHELL ADHESION IS
CONTROLLED BY A DOUBLE WELL INTERFACIAL POTENTIAL 294 XXXI 5 HOW IS
ADHESION CONTROLLED BY MEMBRANE ELASTICITY? 297 6 MEASUREMENT OF
ADHESION STRENGTH BY INTERFEROMETRIC CONTOUR ANALYSIS 299 7 SWITCHING ON
SPECIFIC FORCES: ADHESION AS LOCALIZED DEWETTING PROCESS 300 8
MEASUREMENT OF UNBINDING FORCES, RECEPTOR-LIGAND LEVERAGE AND A NEW ROLE
FOR STRESS FIBERS 300 9 AN APPLICATION: MODIFICATION OF CELLULAR
ADHESION STRENGTH BY CYTOSKELETAL MUTATIONS 303 10 CONCLUSIONS 303 A
APPENDIX: GENERIC INTERFACIAL FORCES 304 COURSE 8. BIOLOGICAL PHYSICS IN
SILICO BY R.H. AUSTIN 311 1 WHY MICRO/NANOFABRICATION? 315 LECTURE 1A:
HYDRODYNAMIC TRANSPORT 319 1 INTRODUCTION: THE NEED TO CONTROL FLOWS IN
2 1/2 D 319 2 SOMEWHAT SIMPLE HYDRODYNAMICS IN 2 1/2 D 321 3 THE N-PORT
INJECTOR IDEA 328 4 CONCLUSION 333 LECTURE 1B: DIELECTROPHORESIS AND
MICROFABRICATION 335 1 INTRODUCTION 335 2 METHODS 337 2.1 FABRICATION .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 2.2
VISCOSITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 338 2.3 ELECTRONICS AND IMAGING . . . . . . . . . . . . . . . . . .
. . . . . . 338 2.4 DNA SAMPLES . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 338 3 RESULTS 339 3.1 BASIC RESULTS AND
DIELECTROPHORETIC FORCE EXTRACTION . . . . . . . . . 339 4 DATA AND
ANALYSIS 343 XXXII 5 ORIGIN OF THE LOW FREQUENCY DIELECTROPHORETIC FORCE
IN DNA 347 6 CONCLUSION 353 LECTURE 2A: HEX ARRAYS 356 1 INTRODUCTION
356 2 EXPERIMENTAL APPROACH 360 3 CONCLUSIONS 364 LECTURE 2B: THE DNA
PRISM 366 1 INTRODUCTION 366 2 DESIGN 366 3 RESULTS 367 4 CONCLUSIONS
372 LECTURE 2C: BIGGER IS BETTER IN RACHETS 374 1 THE PROBLEMS WITH
INSULATORS IN RACHETS 374 2 AN EXPERIMENTAL TEST 375 3 CONCLUSIONS 381
LECTURE 3: GOING AFTER EPIGENETICS 382 1 INTRODUCTION 382 2 THE
NEARFIELD SCANNER 383 3 THE CHIP 384 4 EXPERIMENTS WITH MOLECULES 387 5
CONCLUSIONS 391 LECTURE 4: FRACTIONATING CELLS 392 1 INTRODUCTION 392 2
BLOOD SPECIFICS 392 3 MAGNETIC SEPARATION 397 XXXIII 4 MICROFABRICATION
398 5 MAGNETIC FIELD GRADIENTS 399 6 DEVICE INTERFACE 401 7 A
PRELIMINARY BLOOD CELL RUN 406 8 CONCLUSIONS 409 LECTURE 5: PROTEIN
FOLDING ON A CHIP 411 1 INTRODUCTION 411 2 TECHNOLOGY 412 3 EXPERIMENTS
415 4 CONCLUSIONS 418 COURSE 9. SOME PHYSICAL PROBLEMS IN BIOINFORMATICS
BY E.D. SIGGIA 421 1 INTRODUCTION 423 2 NEW TECHNOLOGIES 425 3 SEQUENCE
COMPARISON 427 4 CLUSTERING 430 5 GENE REGULATION 432 COURSE 10. THREE
LECTURES ON BIOLOGICAL NETWORKS BY M.O. MAGNASCO 435 1 ENZYMATIC
NETWORKS. PROOFREADING KNOTS: HOW DNA TOPOISOMERASES DISENTANGLE DNA 438
1.1 LENGTH SCALES AND ENERGY SCALES . . . . . . . . . . . . . . . . . .
. . 439 1.2 DNA TOPOLOGY . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 440 1.3 TOPOISOMERASES . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 441 1.4 KNOTS AND SUPERCOILS . . . . . . . . . . . . .
. . . . . . . . . . . . . 444 1.5 TOPOLOGICAL EQUILIBRIUM . . . . . . .
. . . . . . . . . . . . . . . . . 446 1.6 CAN TOPOISOMERASES RECOGNIZE
TOPOLOGY? . . . . . . . . . . . . . . . 447 1.7 PROPOSAL: KINETIC
PROOFREADING . . . . . . . . . . . . . . . . . . . . 448 XXXIV 1.8 HOW
TO DO IT TWICE . . . . . . . . . . . . . . . . . . . . . . . . . . . 449
1.9 THE CARE AND PROOFREADING OF KNOTS . . . . . . . . . . . . . . . . .
. 451 1.10 SUPPRESSION OF SUPERCOILS . . . . . . . . . . . . . . . . . .
. . . . . . 453 1.11 PROBLEMS AND OUTLOOK . . . . . . . . . . . . . . .
. . . . . . . . . . 455 1.12 DISQUISITION . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 457 2 GENE EXPRESSION NETWORKS. METHODS
FOR ANALYSIS OF DNA CHIP EXPERIMENTS 457 2.1 THE REGULATION OF GENE
EXPRESSION . . . . . . . . . . . . . . . . . . 457 2.2 GENE EXPRESSION
ARRAYS . . . . . . . . . . . . . . . . . . . . . . . . . 460 2.3
ANALYSIS OF ARRAY DATA . . . . . . . . . . . . . . . . . . . . . . . . .
463 2.4 SOME SIMPLIFYING ASSUMPTIONS . . . . . . . . . . . . . . . . . .
. . . 464 2.5 PROBESET ANALYSIS . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 466 2.6 DISCUSSION . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 470 3 NEURAL AND GENE EXPRESSION NETWORKS:
SONG-INDUCED GENE EXPRESSION IN THE CANARY BRAIN 471 3.1 THE STUDY OF
SONGBIRDS . . . . . . . . . . . . . . . . . . . . . . . . . 472 3.2
CANARY SONG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 473 3.3 ZENK . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 474 3.4 THE BLUSH . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 476 3.5 HISTOLOGICAL ANALYSIS . . . . . . . . . . .
. . . . . . . . . . . . . . . 476 3.6 NATURAL VS. ARTIFICIAL . . . . . .
. . . . . . . . . . . . . . . . . . . . 479 3.7 THE BLUSH II: GAP . . .
. . . . . . . . . . . . . . . . . . . . . . . . 480 3.8 MEDITATION . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . 481 COURSE 11.
THINKING ABOUT THE BRAIN BY W. BIALEK 485 1 INTRODUCTION 487 2 PHOTON
COUNTING 491 3 OPTIMAL PERFORMANCE AT MORE COMPLEX TASKS 501 4 TOWARD A
GENERAL PRINCIPLE? 518 5 LEARNING AND COMPLEXITY 538 6 A LITTLE BIT
ABOUT MOLECULES 552 7 SPECULATIVE THOUGHTS ABOUT THE HARD PROBLEMS 564
SEMINARS BY PARTICIPANTS 579
|
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| ctrlnum | (OCoLC)76460289 (DE-599)BVBBV016480602 |
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| format | Conference Proceeding Book |
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| genre_facet | Konferenzschrift 2001 Les Houches |
| id | DE-604.BV016480602 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:11:00Z |
| institution | BVB |
| institution_GND | (DE-588)1019153-7 (DE-588)10048170-X |
| isbn | 3540441328 2868836186 |
| language | English French |
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| physical | XXXIV, 580 S. Ill., graph. Darst. : 23 cm |
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| spelling | Physics of bio-molecules and cells = Physique de biomolécules et des cellules École de Physique des Houches - UJF & INPG-Grenoble, a NATO Advanced Study Institute, LesHouches, Session LXXV, 2 - 7 July 2001. Ed. by H. Flyvbjerg ... Publ. in cooperation with the NATO Scientific Affair Division Physique de biomolécules et des cellules Berlin ; Heidelberg ; New York ; Barcelona ; Hong Kong ; London Springer 2002 Les Ulis ; Paris ; Cambridge EDP Sciences XXXIV, 580 S. Ill., graph. Darst. : 23 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Biomolecules Congresses Biomolecules Analysis Congresses Biomolekül (DE-588)4135124-1 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Biophysik (DE-588)4006891-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2001 Les Houches gnd-content Biomolekül (DE-588)4135124-1 s Biophysik (DE-588)4006891-2 s DE-604 Zelle (DE-588)4067537-3 s Flyvbjerg, Henrik Sonstige oth NATO Division of Scientific Affairs Sonstige (DE-588)1019153-7 oth Ecole d'Été de Physique Théorique 75 2001 Les Houches Sonstige (DE-588)10048170-X oth SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010188469&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Physics of bio-molecules and cells = Physique de biomolécules et des cellules Biomolecules Congresses Biomolecules Analysis Congresses Biomolekül (DE-588)4135124-1 gnd Zelle (DE-588)4067537-3 gnd Biophysik (DE-588)4006891-2 gnd |
| subject_GND | (DE-588)4135124-1 (DE-588)4067537-3 (DE-588)4006891-2 (DE-588)1071861417 |
| title | Physics of bio-molecules and cells = Physique de biomolécules et des cellules |
| title_alt | Physique de biomolécules et des cellules |
| title_auth | Physics of bio-molecules and cells = Physique de biomolécules et des cellules |
| title_exact_search | Physics of bio-molecules and cells = Physique de biomolécules et des cellules |
| title_full | Physics of bio-molecules and cells = Physique de biomolécules et des cellules École de Physique des Houches - UJF & INPG-Grenoble, a NATO Advanced Study Institute, LesHouches, Session LXXV, 2 - 7 July 2001. Ed. by H. Flyvbjerg ... Publ. in cooperation with the NATO Scientific Affair Division |
| title_fullStr | Physics of bio-molecules and cells = Physique de biomolécules et des cellules École de Physique des Houches - UJF & INPG-Grenoble, a NATO Advanced Study Institute, LesHouches, Session LXXV, 2 - 7 July 2001. Ed. by H. Flyvbjerg ... Publ. in cooperation with the NATO Scientific Affair Division |
| title_full_unstemmed | Physics of bio-molecules and cells = Physique de biomolécules et des cellules École de Physique des Houches - UJF & INPG-Grenoble, a NATO Advanced Study Institute, LesHouches, Session LXXV, 2 - 7 July 2001. Ed. by H. Flyvbjerg ... Publ. in cooperation with the NATO Scientific Affair Division |
| title_short | Physics of bio-molecules and cells |
| title_sort | physics of bio molecules and cells physique de biomolecules et des cellules |
| title_sub | = Physique de biomolécules et des cellules |
| topic | Biomolecules Congresses Biomolecules Analysis Congresses Biomolekül (DE-588)4135124-1 gnd Zelle (DE-588)4067537-3 gnd Biophysik (DE-588)4006891-2 gnd |
| topic_facet | Biomolecules Congresses Biomolecules Analysis Congresses Biomolekül Zelle Biophysik Konferenzschrift 2001 Les Houches |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010188469&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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