LC/MS applications in drug development:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Wiley
2002
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| Schriftenreihe: | Wiley-Interscience series on mass spectrometry
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 243 S. Ill., graph. Darst. |
| ISBN: | 0471405205 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | LC/MS APPLICATIONS IN DRUG DEVELOPMENT MIKE S. LEE IWILEY- INTERSCIENCE
A JOHN WILEY & SONS, INC., PUBLICATION CONTENTS PREFACE IX
ACKNOWLEDGMENTS XI 1. INTRODUCTION 1 EMERGING ANALYTICAL NEEDS / 1
INTEGRATION OF LC/MS INTO DRUG DEVELOPMENT / 3 PARTNERSHIPS AND
ACCEPTANCE / 6 OVERVIEW / 10 2. DRUG DEVELOPMENT OVERVIEW 11 ANALYSIS
PERSPECTIVES / 11 THE FOUR STAGES OF DRUG DEVELOPMENT / 12 DRUG
DISCOVERY / 14 PRECLINICAL DEVELOPMENT / 15 CLINICAL DEVELOPMENT / 16
MANUFACTURING / 17 3. ACCELERATED DRUG DEVELOPMENT 19 ACCELERATED
DEVELOPMENT STRATEGIES / 20 QUANTITATIVE AND QUALITATIVE PROCESS
ELEMENTS / 20 VI CONTENTS QUANTITATIVE PROCESS PIPELINE / 24 QUALITATIVE
PROCESS PIPELINE / 25 MOTIVATING FACTORS / 27 ANALYSIS OPPORTUNITIES FOR
ACCELERATED DEVELOPMENT / 28 FULL-TIME EQUIVALENT / 28 SAMPLE THROUGHPUT
MODEL / 29 ELIMINATION MODEL / 29 RATE-DETERMINING EVENT MODEL / 31
ACCELERATED DEVELOPMENT PERSPECTIVES / 33 4. LC/MS DEVELOPMENT 34 THE
ELEMENTS OF LC/MS APPLICATION / 34 HPLC / 35 MASS SPECTROMETRY / 35
LC/MS INTERFACE / 36 LC/MS GROWTH / 38 5. STRATEGIES 41 STANDARD METHODS
/ 43 TEMPLATE STRUCTURE IDENTIFICATION / 46 DATABASES / 49 SCREENING /
50 INTEGRATION / 53 MINIATURIZATION / 55 PARALLEL PROCESSING / 56
VISUALIZATION / 58 AUTOMATION / 61 SUMMARY / 63 6. LC/MS APPLICATIONS 65
DRUG DISCOVERY / 65 PROTEOMICS / 68 PROTEIN EXPRESSION PROFILING / 70
QUANTITATION / 76 CONTENTS VII GLYCOPROTEIN MAPPING / 78 NATURAL
PRODUCTS DEREPLICATION / 83 LEAD IDENTIFICATION SCREENING / 88
BIOAFFINITY SCREENING / 89 COMBINATORIAL LIBRARY SCREENING / 92
OPEN-ACCESS LC/MS / 96 STRUCTURE CONFIRMATION / 97 HIGH THROUGHPUT / 100
PURIFICATION / 102 COMBINATORIAL MIXTURE SCREENING / 103 IN VIVO DRUG
SCREENING / 106 PHARMACOKINETICS / 109 IN VITRO DRUG SCREENING / 115
METABOLIC STABILITY SCREENING / 118 MEMBRANE PERMEABILITY / 119
DRUG-DRUG INTERACTION / 121 METABOLITE IDENTIFICATION / 122 PRECLINICAL
DEVELOPMENT / 123 METABOLITE IDENTIFICATION / 125 IMPURITY
IDENTIFICATION / 132 DEGRADANT IDENTIFICATION / 140 CLINICAL DEVELOPMENT
/ 145 QUANTITATIVE BIOANALYSIS*SELECTED ION MONITORING / 148
QUANTITATIVE BIOANALYSIS*SELECTED REACTION MONITORING / 152 QUANTITATIVE
BIOANALYSIS*AUTOMATED SOLID-PHASE EXTRACTION / 156 QUANTITATIVE
BIOANALYSIS*AUTOMATED ON-LINE EXTRACTION / 162 METABOLITE IDENTIFICATION
/ 165 DEGRADANT IDENTIFICATION / 168 MANUFACTURING / 171 IMPURITY
IDENTIFICATION USING DATA-DEPENDENT ANALYSIS / 173 VIII CONTENTS PEPTIDE
MAPPING IN QUALITY CONTROL / 176 PATENT PROTECTION / 178 7. FUTURE
APPLICATIONS AND PROSPECTS 183 WORKSTATIONS / 183 MULTIDIMENSIONAL
ANALYSIS / 186 MINIATURIZATION / 187 INFORMATION MANAGEMENT / 189
STRATEGIC OUTSOURCING / 190 SUMMARY / 191 8. PERSPECTIVES ON THE FUTURE
GROWTH OF LC/MS 192 9. CONCLUSIONS 195 GLOSSARY 197 REFERENCES 205 INDEX
235
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:10:36Z |
| institution | BVB |
| isbn | 0471405205 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010169965 |
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| physical | XII, 243 S. Ill., graph. Darst. |
| publishDate | 2002 |
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| publisher | Wiley |
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| series2 | Wiley-Interscience series on mass spectrometry |
| spelling | Lee, Mike S. Verfasser aut LC/MS applications in drug development Mike S. Lee New York, NY Wiley 2002 XII, 243 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Wiley-Interscience series on mass spectrometry Arzneimittelanalyse Drugs - Analysis HPLC-MS Pharmacology - History Pharmakologie Arzneimittelanalyse idszbz Arzneimittelanalyse swd HPLC-MS swd LC-MS idszbz Pharmakologie swd Geschichte Drugs Analysis Pharmacology History GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010169965&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lee, Mike S. LC/MS applications in drug development Arzneimittelanalyse Drugs - Analysis HPLC-MS Pharmacology - History Pharmakologie Arzneimittelanalyse idszbz Arzneimittelanalyse swd HPLC-MS swd LC-MS idszbz Pharmakologie swd Geschichte Drugs Analysis Pharmacology History |
| title | LC/MS applications in drug development |
| title_auth | LC/MS applications in drug development |
| title_exact_search | LC/MS applications in drug development |
| title_full | LC/MS applications in drug development Mike S. Lee |
| title_fullStr | LC/MS applications in drug development Mike S. Lee |
| title_full_unstemmed | LC/MS applications in drug development Mike S. Lee |
| title_short | LC/MS applications in drug development |
| title_sort | lc ms applications in drug development |
| topic | Arzneimittelanalyse Drugs - Analysis HPLC-MS Pharmacology - History Pharmakologie Arzneimittelanalyse idszbz Arzneimittelanalyse swd HPLC-MS swd LC-MS idszbz Pharmakologie swd Geschichte Drugs Analysis Pharmacology History |
| topic_facet | Arzneimittelanalyse Drugs - Analysis HPLC-MS Pharmacology - History Pharmakologie LC-MS Geschichte Drugs Analysis Pharmacology History |
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