Alternative toxicological methods:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, Fla. [u.a.]
CRC Press
2003
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 591 S. Ill., graph. Darst. |
| ISBN: | 084931528X |
Internformat
MARC
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| 264 | 1 | |a Boca Raton, Fla. [u.a.] |b CRC Press |c 2003 | |
| 300 | |a 591 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Animais de laboratório (testes;toxicidade;métodos) |2 larpcal | |
| 650 | 4 | |a Expérimentation animale - Alternative | |
| 650 | 4 | |a Medicina experimental | |
| 650 | 7 | |a Medicina veterinária |2 larpcal | |
| 650 | 4 | |a Alternative toxicity testing | |
| 650 | 4 | |a Animal Testing Alternatives | |
| 650 | 4 | |a Toxicity Tests | |
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| 700 | 1 | |a Katz, Sidney A. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804129679383199744 |
|---|---|
| adam_text | Contents
Parti
Progress in the Validation and Regulatory Acceptance of Alternatives 1
Neil L. Wilcox
Chapter 1
Historical Developments in the Humane Care and Use of Research Animals:
The First 4000 Years 3
Harry Salem and Sidney A. Katz
Chapter 2
A History of Interagency Approaches to Alternatives and Establishment
of the Interagency Regulatory Alternatives Group 9
Sidney Green
Chapter 3
The Interagency Coordinating Committee on the Validation of Alternative
Methods (ICCVAM): Recent Progress in the Evaluation of Alternative
Toxicity Testing Methods 15
William S. Stokes
Chapter 4
Validation and Regulatory Acceptance of Alternative Test Methods: Current
Situation in the European Union 31
Julia H. Fentem and Michael Balls
Chapter 5
Integrated In Vitro Approaches for Assessing Systemic Toxicity 43
Anna Forsby and Bas Blaauboer
Chapter 6
Summary of the OECD s New Guidance Document on the Recognition,
Assessment, and Use of Clinical Signs as Humane Endpoints for
Experimental Animals Used in Safety Evaluation 51
Errol Zeiger
Chapter 7
Pain and Distress Management in Animal Research and Testing:
The Humane Society of the United States Pain and Distress Initiative 61
Martin L. Stephens, Frandne Dolins, Lori Donley, Adrienne M. Navarro,
Kathleen M. Conlee, and Andrew N. Rowan
I
Part II
Development of Predictive Methods Based on Mechanisms
of Eye Irritation at the Ocular Surface: Meeting Industry
and Regulatory Needs 75
Sherry L. Ward and Wiley A. Chambers
Chapter 8
Meeting Industry and Regulatory Needs for Alternative Test Methods
to the Draize Rabbit Eye Irritation Test 77
Sherry L. Ward
Chapter 9
The Ocular Surface: Barrier Function and Mechanisms of Injury and Repair 89
Martin Reim
Chapter 10
Evaluation and Refinement of the Bovine Cornea Opacity
and Permeability Assay 109
John L. Ubels, James D. Paauw, and Phillip L. Casterton
Chapter 11
Corneal Organ Culture for Ocular Toxicity Test of Commercial
Hair Care Products 117
Fu Shin X. Yu and Ke Ping Xu
Chapter 12
Human Corneal Equivalents for In Vitro Testing 125
May Griffith and Erik Suuronen
Chapter 13
The EpiOcular Prediction Model: A Reproducible In Vitro Means
of Assessing Ocular Irritancy 131
Mitchell Klausner, Patrick J. Hayden, Bridget A. Breyfogle,
Kristen L. Bellavance, Melissa M. Osborn, Daniel R. Cerven,
George L. DeGeorge, and Joseph Kubilus
Chapter 14
Three Dimensional Construct of the Human Corneal Epithelium
for In Vitro Toxicology 147
D.H. Nguyen, Roger W. Beuerman, Bart DeWever, and Martin Rosdy
Chapter 15
The Human Corneal Epithelial HCE T TEP Assay for Eye Irritation:
Scientific Relevance and Summary of Prevalidation Study Results 161
Sherry L. Ward, Maximo Gacula, Jr., and Henry F. Edelhauser
Part III
Dermal Testing Alternatives 187
Harry Salem and Sidney A. Katz
Chapter 16
Alternative Methods for Dermal Toxicity Testing 189
Robert L. Bronaugh
Chapter 17
Allergic Contact Hypersensitivity: Mechanisms and Methods 193
Denise M. Sailstad
Chapter 18
Validating In Vitro Dermal Absorption Studies: An Introductory Case Study ....207
Robert P. Zendzian and Michael Dellarco
Chapter 19
A Molecular Diagnostic Approach to Irritant or Allergic Patch
Testing Using the DermPatch 221
Melissa M. Fitzgerald, Vera B. Morhenn, Stacey B. Humphrey,
Nirmala Jayakumar, and Lawrence A. Rheins
Chapter 20
In Vitro Skin Equivalent Models for Toxicity Testing 229
Patrick J. Hayden, Seyoum Ayehunie, G. Robert Jackson,
Sarah Kupfer Lamore, Thomas J. Last, Mitchell Klausner,
and Joseph Kubilus
Part IV
A Case Study in the Use of Alternatives to Determine
the Mechanism of Sulfur Mustard Action 249
William J. Smith
Chapter 21
Cellular Resistance of Tetrahymena to Sulfur Mustard 251
Peter L. Platteborze, James E. Sistrunk, and William J. Smith
Chapter 22
Studies of Cellular Biochemical Changes Induced in Human Cells
by Sulfur Mustard 259
William J. Smith, Offie E. Clark III, Fred M. Cowan, Maura E. Dejoseph,
Charisse Davenport, and Clark L. Gross
Chapter 23
Human Keratinocyte Inflammatory Transcript Gene Activity
Following Sulfur Mustard 269
John J. Schlager, Kashif Ali, Hilma R. Benjamin, Claire F. Levine,
Douglas P. Avery, and James H. Clark
Chapter 24
Evaluation of Cytotoxicity Assays of Human Epidermal Keratinocytes
Exposed In Vitro to Sulfur Mustard 281
Susan A. Kelly, Juanita J. Guzman, Clark L. Gross, and William J. Smith
Chapter 25
Comparison of Spectrophotometric and Fluorometric Assays of Proteolysis
in Cultured Human Cells Exposed to Sulfur Mustard 287
Susan A. Kelly, Charlene M. Corun, Marian R. Nelson, Clark L. Gross,
and William J. Smith
Chapter 26
Effects of Low Dose Sulfur Mustard on Growth and DNA Damage
in Human Cells in Culture 295
William J. Smith, Bethany S. Toliver, Offie E. Clark III, Janet Moser,
Eric W. Nealley, Juanita J. Guzman, and Clark L. Gross
Chapter 27
Imaging Sulfur Mustard Lesions in Basal Cells and Human Epidermal
Tissues by Confocal and Multiphoton Laser Scanning Microscopy 303
Robert J. Werrlein and Janna S. Madren Whalley
Chapter 28
Suppression of Sulfur Mustard Increased IL 8 in Human Keratinocyte
Cell Cultures by Serine Protease Inhibitors: Implications for Toxicity
and Medical Countermeasures 313
Fred M. Cowan, Clarence A. Broomfield, and William J. Smith
Chapter 29
Development of Medical Countermeasures to Sulfur Mustard Vesication 323
William J. Smith, Michael C. Babin, Robyn C. Kiser, and Robert P. Casillas
Part V
Neurotoxicology: Molecular Biomarkers, Transgenics,
and Imaging Technologies 329
William J. Slikker, Jr. and Thomas J. Sobotka
Chapter 30
Molecular Neurotoxicology of 6 Hydroxydopamine and Methamphetamine:
Lessons Derived from Transgenic Models 333
Jean Lud Cadet
Chapter 31
A Microassay Method Using a Neuroblastoma Cell Line to Examine
Neurotoxicity of Organophosphate Mixtures 341
Laurie E. Roszell, Benjamin C. Kramer, and Glen J. Leach
Chapter 32
Development of Integrin Expression as a Molecular Biomarker for Early,
Sensitive Detection of Neurotoxicity 347
Joyce E. Royland
Chapter 33
Two Photon Fluorescence Microscopy: A Review of Recent Advances
in Deep Tissue Imaging 361
Chen Yuan Dong, Lily Hsu, Ki Hean Kim, Christof Buehler, Peter D. Kaplan,
Thomas D. Hancewicz, and Peter T. C. So
Part VI
Role of Transgenics and Toxicogenomics in the Development
of Alternative Toxicity Tests 375
Jerry Heindel
Chapter 34
The Application of Genomics and Proteomics to Toxicological Sciences 377
Stephan Chevalier, William D. Pennie, and Ian Kimber
Chapter 35
Use of Transgenic Animals in Regulatory Carcinogenicity Evaluations 391
Frank D. Sistare and Abigail C. Jacobs
Chapter 36
Changes in Gene Expression after Exposure to Organophosphorus
(OP) Agents 413
Jennifer W. Sekowski, Kevin P. O Connell, Akbar S. Khan, James J. Valdes,
Maryanne Vahey, Martin Nau, Maha Khalil, and Mohyee E. Eldefrawi
Part VII
Recent Innovations in Alternatives 429
Harry Salem and Sidney A. Katz
t
Chapter 37
Archival Data in Toxicology: Minimizing Need for Animal Experiments 431
Millard M. Mershon
Chapter 38
Information Management at the Library of Congress: An Overview
with Special Reference to Biomedicine 449
Roman B. Worobec
Chapter 39
World Wide Web Biomedical, Chemical, and Toxicological Information
Resources from the National Library of Medicine 473
George C. Fonger, James Knoben, Stephanie Publicker, Philip Wexler,
and Georgette Whiting
Chapter 40
In Silico Approaches for Physiologically Based Pharmacokinetic Modeling 479
Martin Beiiveau and Kannan Krishnan
Chapter 41
In Silico Application of Quantum Chemical Methods for Relating Toxicity
to Chemical Reactivity 533
William White
Chapter 42
In Silico Cardiac Toxicity: Increasing the Discovery of Therapeutics
through High Performance Computing 543
Csaba K. Zoltani and Steven I. Baskin
Chapter 43
Submillimeter Wave Frequency Studies of the Vibrational Modes
of Deoxyribonucleic Acid: A Metric for Mutagenicity? 559
T.R. Globus, B.L. Gelmont, M. Bykhovskaia, J. Hesler, D.L. Woolard,
A.C. Samuels, J.O. Jensen, H. Salem, and W.R. Loerop
Chapter 44
Trophoblast Toxicity Assay (TTA): A Gestational Toxicity Test Using
Human Placental Trophoblasts 567
Harvey J. Kliman
Index 581
|
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| id | DE-604.BV015022663 |
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| indexdate | 2024-07-09T19:08:58Z |
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| isbn | 084931528X |
| language | English |
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| spelling | Alternative toxicological methods ed. by Harry Salem ... Boca Raton, Fla. [u.a.] CRC Press 2003 591 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Animais de laboratório (testes;toxicidade;métodos) larpcal Expérimentation animale - Alternative Medicina experimental Medicina veterinária larpcal Alternative toxicity testing Animal Testing Alternatives Toxicity Tests Alternative (DE-588)4138905-0 gnd rswk-swf Toxikologische Bewertung (DE-588)4303356-8 gnd rswk-swf Alternative Medizin (DE-588)4112639-7 gnd rswk-swf Tierversuch (DE-588)4060137-7 gnd rswk-swf Toxizitätstest (DE-588)4060540-1 gnd rswk-swf Toxizitätstest (DE-588)4060540-1 s Alternative Medizin (DE-588)4112639-7 s DE-604 Tierversuch (DE-588)4060137-7 s Alternative (DE-588)4138905-0 s 1\p DE-604 Toxikologische Bewertung (DE-588)4303356-8 s 2\p DE-604 Salem, Harry Sonstige oth Katz, Sidney A. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010091535&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Alternative toxicological methods Animais de laboratório (testes;toxicidade;métodos) larpcal Expérimentation animale - Alternative Medicina experimental Medicina veterinária larpcal Alternative toxicity testing Animal Testing Alternatives Toxicity Tests Alternative (DE-588)4138905-0 gnd Toxikologische Bewertung (DE-588)4303356-8 gnd Alternative Medizin (DE-588)4112639-7 gnd Tierversuch (DE-588)4060137-7 gnd Toxizitätstest (DE-588)4060540-1 gnd |
| subject_GND | (DE-588)4138905-0 (DE-588)4303356-8 (DE-588)4112639-7 (DE-588)4060137-7 (DE-588)4060540-1 |
| title | Alternative toxicological methods |
| title_auth | Alternative toxicological methods |
| title_exact_search | Alternative toxicological methods |
| title_full | Alternative toxicological methods ed. by Harry Salem ... |
| title_fullStr | Alternative toxicological methods ed. by Harry Salem ... |
| title_full_unstemmed | Alternative toxicological methods ed. by Harry Salem ... |
| title_short | Alternative toxicological methods |
| title_sort | alternative toxicological methods |
| topic | Animais de laboratório (testes;toxicidade;métodos) larpcal Expérimentation animale - Alternative Medicina experimental Medicina veterinária larpcal Alternative toxicity testing Animal Testing Alternatives Toxicity Tests Alternative (DE-588)4138905-0 gnd Toxikologische Bewertung (DE-588)4303356-8 gnd Alternative Medizin (DE-588)4112639-7 gnd Tierversuch (DE-588)4060137-7 gnd Toxizitätstest (DE-588)4060540-1 gnd |
| topic_facet | Animais de laboratório (testes;toxicidade;métodos) Expérimentation animale - Alternative Medicina experimental Medicina veterinária Alternative toxicity testing Animal Testing Alternatives Toxicity Tests Alternative Toxikologische Bewertung Alternative Medizin Tierversuch Toxizitätstest |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010091535&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT salemharry alternativetoxicologicalmethods AT katzsidneya alternativetoxicologicalmethods |