The practical applicability of toxicokinetic models in the risk assessment of chemicals:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Kluwer Academic Publishers
2002
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | "Proceedings of the symposium The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals held in The Hague, The Netherlands, 17 and 18 February, 2000 organized by Opdenkamp-Registration & Notification, Koninginnegracht 23, 2514 AB, The Hague, The Netherlands.". - Includes bibliographical references |
| Beschreibung: | xi, 194 p. ill. : 24 cm |
| ISBN: | 1402009348 |
Internformat
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Datensatz im Suchindex
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| adam_text | CONTENTS
LIST OF CONTRIBUTORS IX
PREFACE XI
1 THE PRACTICAL APPLICABILITY OF TOXICOKINETIC
MODELS IN THE RISK ASSESSMENT OF CHEMICALS
V.J.FERON 1
1.1 Introduction 1
1.2 Underlying Principles of Toxicokinetic Models I
1.3 Lack of Data 2
1.4 Use of Structure Activity Relationships (SARs) 2
1.5 Standard Tests versus Compound Specific studies 3
1.6 Application of Toxicokinetic Data in Hazard Identification 4
1.7 References 5
2 PHYSIOLOGICALLY BASED PHARMACOKINETIC
MODELING OF THE GLYCOL ETHER, 2 BUTOXETHANOL, AND
ITS APPLICATION IN HUMAN HEALTH RISK ASSESSMENTS
AND EXPOSURE GUIDELINES RICHARD A. CORLEY 7
2.1 Introduction 7
2.2 Exposure Guidelines Using Traditional Approaches 10
2.3 Rationale for the Development of a PBPK Model for BE 13
2.4 Development of a Rat and Human PBPK model for BE and BAA
15
2.5 Use of PBPK model in Risk Assessments 27
2.6 Conclusions 35
2.7 Acknowledgments 36
2.8 References 36
3 APPLICATION OF PHARMACOKINETIC MODELLING TO
BIOLOGICAL MONITORING PIERRE O.DROZ 41
3.1 Introduction 41
3.2 Biological Monitoring 42
3.3 Description of the Pharmacokinetic Models used 43
3.4 Case Studies 45
3.4.1 Tetrahydrofuranet 45
3.4.2 Formic Acid after Methyl Formate or Methanol Exposure
48
3.5 Comments and Conclusion 50
3.6 References 52
4 DERMAL ABSORPTION FROM PESTICIDE RESIDUES DATA
ANALYSIS MICAELAB.REDDY/ANNETTE BUNGE 55
V
4.1 Introduction 55
4.2 Background 56
4.3 The Zendzian Protocol 60
4.4 Results and discussion 61
4.5 Conclusions 76
4.6 references 78
5 INTER SPECIES PHARMACOKINETIC COMPARISON OF
ORGANIC ACID HERBICIDES. IS THE DOG A RELEVANT
SPECIES FOR EVALUATION OF HUMAN HEALTH RISK?
CHARLES TIMCHALK1, RICHARD NOLAN2, RICHARD
BILLINGTON2 AND DAVID L. EISENBRANDT2 79
5.1 Background 80
5.2 Toxicology Background 81
5.3 Hypothesis 82
5.4 Approach 83
5.5 How are organic acids cleared in the kidney of dogs and
excreted in the urine? 89
5.6 Are renal functional changes a toxicological response or a
physiological adaptation associated with the excretion of organic
acids? 93
5.7 What potential mechanism(s) may be responsible for the
reduced elimination of organic acids in the dog? 97
5.8 Is the dog toxicity data obtained with either triclopyr or 2,4 D
of any relevance for the extrapolation of human health risk? 99
5.9 Regulatory Outcomes 100
5.10 Utility of Comparative Pharmacokinetics 103
5.11 Summary Conclusions 104
5.12 References 104
6 MODELING THE UPTAKE AND DISPOSITION OF
HYDROPHOBIC ORGANIC CHEMICALS IN FISH USING A
PHYSIOLOGICALLY BASED APPROACH JOHN W. NICHOLS 109
6.1 Development of PBTK Models for Fish 109
6.2 Branchial Efflux of Organic Chemicals 111
6.2.1 Erickson McKim Gill Models 111
6.2.2 Empirical Relationship Between Log PBW and Log KOW
112
6.3 Chemical Distribution between Blood and Tissues 115
6.3.1 Equilibrium Tissue:Blood Partitioning. 115
6.3.2 Flow vs. Diffusion Limitations 116
6.4 PBTK Models for Fish 117
6.5 TCDD Model 117
6.6 TCB Model 122
6.7 Discussion 128
6.8 References 131
VI
«9
7 CHAIR S INTRODUCTION TO THE SECOND SYMPOSIUM
DAY PETER C. BRAGT 135
7.1 Introduction 135
7.2 Cancer risk assessment ofazo dyes and aromatic amines from
garment and footwear (Speijers et al, 1996; Zeilmaker et al. 1999).
136
7.3 Calculation of human toxicity thresholds for TCDD (Zeilmaker
and Van Eijkeren, 1998) 137
7.4 PBPK simulated adduct formation as a result ofbenzopyrene
administration (Zeilmaker et al, 1997 1999). 137
7.5 Model for estimating lipophilic contaminants in cattle (Freijer
etal,1999). 138
7.6 Last, but certainly not at least, the modelling of consumer
exposure (Van Veen et al, 1994 now). 138
8 CAN BIOLOGICALLY BASED MODELS OF
CARCINOGENESIS BE USED FOR RISK ASSESSMENT ?
POTENTIALS AND LIMITATIONS OF CARCINOGENESIS MODELS
ANNETTE KOPP SCHNEIDER 141
8.1 Introduction 141
8.2 Models of carcinogenesis 142
8.3 Quantitative risk assessment with multistage models 147
8.4 Summary 151
8.5 References 151
9 THE PREDICTION OF SYSTEMIC TOXICITY BY
INTEGRATING THE RESULTS OF BIOKINETIC MODELS AND
BIOLOGICALLY BASED IN VITRO TEST METHODS BAS J.
BLAAUBOER1 155
9.1 Introduction 156
9.2 Integration of kinetic and dynamic data to estimate systemic
toxicity. 160
9.3 Biokinetic modelling 163
9.4 In vitro and other non animal studies for obtaining compound
specific parameters for the use in PB BK models 164
9.5 Toxicity test batteries: in vitro approaches 168
9.6 Results of the ECITTS project 169
9.7 Discussion 177
9.7.1 Kinetics 177
9.7.2 Dynamics 182
9.8 Conclusions from the ECITTS study 185
9.9 A generic scheme for evaluating chemical toxicity 185
9.10 Concluding remarks 188
9.11 References 189
vn
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| spelling | The practical applicability of toxicokinetic models in the risk assessment of chemicals edited by J. Krüse ... Dordrecht Kluwer Academic Publishers 2002 xi, 194 p. ill. : 24 cm txt rdacontent n rdamedia nc rdacarrier "Proceedings of the symposium The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals held in The Hague, The Netherlands, 17 and 18 February, 2000 organized by Opdenkamp-Registration & Notification, Koninginnegracht 23, 2514 AB, The Hague, The Netherlands.". - Includes bibliographical references Biochemical toxicology Congresses Health risk assessment Congresses Pharmacokinetics Congresses Toxikologische Analyse (DE-588)4078371-6 gnd rswk-swf Tierversuch (DE-588)4060137-7 gnd rswk-swf Chemikalie (DE-588)4009833-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Chemikalie (DE-588)4009833-3 s Toxikologische Analyse (DE-588)4078371-6 s Tierversuch (DE-588)4060137-7 s DE-604 Krüse, Jacob Sonstige oth Symposium "The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals" (2000, Hague, Netherlands) Sonstige (DE-588)16139449-8 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010006199&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The practical applicability of toxicokinetic models in the risk assessment of chemicals Biochemical toxicology Congresses Health risk assessment Congresses Pharmacokinetics Congresses Toxikologische Analyse (DE-588)4078371-6 gnd Tierversuch (DE-588)4060137-7 gnd Chemikalie (DE-588)4009833-3 gnd |
| subject_GND | (DE-588)4078371-6 (DE-588)4060137-7 (DE-588)4009833-3 (DE-588)1071861417 |
| title | The practical applicability of toxicokinetic models in the risk assessment of chemicals |
| title_auth | The practical applicability of toxicokinetic models in the risk assessment of chemicals |
| title_exact_search | The practical applicability of toxicokinetic models in the risk assessment of chemicals |
| title_full | The practical applicability of toxicokinetic models in the risk assessment of chemicals edited by J. Krüse ... |
| title_fullStr | The practical applicability of toxicokinetic models in the risk assessment of chemicals edited by J. Krüse ... |
| title_full_unstemmed | The practical applicability of toxicokinetic models in the risk assessment of chemicals edited by J. Krüse ... |
| title_short | The practical applicability of toxicokinetic models in the risk assessment of chemicals |
| title_sort | the practical applicability of toxicokinetic models in the risk assessment of chemicals |
| topic | Biochemical toxicology Congresses Health risk assessment Congresses Pharmacokinetics Congresses Toxikologische Analyse (DE-588)4078371-6 gnd Tierversuch (DE-588)4060137-7 gnd Chemikalie (DE-588)4009833-3 gnd |
| topic_facet | Biochemical toxicology Congresses Health risk assessment Congresses Pharmacokinetics Congresses Toxikologische Analyse Tierversuch Chemikalie Konferenzschrift |
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