Disease markers in exhaled breath:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Dekker
2003
|
| Schriftenreihe: | Lung biology in health and disease
170 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and indexes. |
| Beschreibung: | 534 S. graph. Darst. |
| ISBN: | 0824708172 |
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| 650 | 4 | |a Biological Markers |x analysis | |
| 650 | 4 | |a Breath tests | |
| 650 | 4 | |a Carbon monoxide |x Pathophysiology | |
| 650 | 4 | |a Lung Diseases | |
| 650 | 4 | |a Lungs |x Diseases |x Diagnosis | |
| 650 | 4 | |a Nitric Oxide |x analysis | |
| 650 | 4 | |a Nitric oxide |x Pathophysiology | |
| 650 | 4 | |a Respiration | |
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Datensatz im Suchindex
| _version_ | 1804129483272224768 |
|---|---|
| adam_text | CONTENTS
Introduction Claude Lenfant Hi
Preface v
Contributors xi
Part One PHYSIOLOGICAL ASPECTS OF DISEASE
MARKERS IN EXHALED GASES
Nitric Oxide
1. Nitric Oxide as a Biological Mediator 3
Maria G. Belvisi, Jane A. Mitchell, and Sir Magdi H. Yacoub
I. Introduction 3
II. Nitric Oxide Synthesis by Different Cell Types 4
III. Release of NO by Nerves: Neuronal NOS 5
IV. Release of NO by Endothelial Cells: Endothelial NOS 7
V. Release of NO by Cells Induced to Express NOS:
Inducible NOS 8
xvii
xviii Contents
VI. Classification of NOS Isoforms 10
VII. Inhibition of NOS by Substrate Analog and Non Amino
Acid Inhibitors: Interactions with Different NOS
Isoforms 10
VIII. Effector Mechanisms Utilized by NO 12
IX. Nitric Oxide, Pathophysiological States, and Therapeutic
Possibilities 17
X. Summary 18
References 18
2. Physiology of Exhaled Nitric Oxide 29
L. Christofer Adding and Lars E. Gustafsson
I. Introduction 29
II. Measurement Techniques of Exhaled NO 30
III. Metabolism of Exhaled NO 35
IV. Physiological Factors Regulating Exhaled NO 39
V. Physiological Role of NO in the Respiratory System 48
VI. Summary 52
References 53
3. Molecular and Cellular Sources of Exhaled Nitric
Oxide 73
Aaron Deykin, Anthony F. Massaro, Lester Kobzik,
George T. De Sanctis, and Jeffrey M. Drazen
I. Introduction to Exhaled NO 73
II. Enzymatic Source of Exhaled NO 74
III. Cellular Sources of Exhaled NO 82
IV. Anatomical Sources of Exhaled NO 82
V. Conclusions 85
References 85
4. Determinants of Exhaled Nitric Oxide: Influence of
Ventilation and Pulmonary Blood Flow 91
Ndndor Marczin, I. Gavin Wright, and Sir Magdi H.
Yacoub
I. Introduction 91
II. Influence of Ventilation 92
III. Role of Pulmonary Blood Flow 105
References 111
Contents xix
Carbon Monoxide
5. Heme Oxygenase 1 in Lung Disease 117
Patty J. Lee, Leo E. Otterbein, Jigme M. Sethi, Madhu
Sasidhar, and Augustine M. K. Choi
I. Introduction 117
II. HOI and Lung Disease 119
III. Mechanisms of HOI 125
IV. HO2 and Lung Disease 126
V. Conclusions and Future Directions 126
References 127
6. Carbon Monoxide: A Gaseous Molecule with Anti
Inflammatory Properties 133
Leo E. Otterbein, Danielle Morse, Jeffrey T. Chapman, and
Augustine M. K. Choi
I. Historical Perspective 133
II. Heme Oxygenase 137
III. Bilirubin 139
IV. Ferritin 139
V. Carbon Monoxide 140
VI. Summary and Future Directions 146
References 149
Markers of Oxidative Damage
7. Role of Reactive Oxygen and Nitrogen Species in Lung
Injury 159
Ian C. Davis, Judy M. Hickman Davis, J. Russell Lindsey, and
Sadis Matalon
I. Introduction 159
II. Chemistry and Biochemistry of Reactive Oxygen and
Nitrogen Species 160
III. Biological Effects of Reactive Oxygen and Nitrogen
Species 164
IV. Reactive Species in Acute Lung Injury 176
V. Summary 182
References 182
xx Contents
Part Two METHODOLOGICAL AND TECHNICAL ASPECTS
8. Exhaled Nitric Oxide, Carbon Monoxide, and Breath
Condensate 199
Sergei A. Kharitonov and Peter J. Barnes
I. Introduction 199
II. Nitric Oxide 200
III. Carbon Monoxide 203
IV. Exhaled Breath Condensate 207
V. Future Directions 209
References 211
9. Analysis of Volatile Organic Compounds in the Breath 219
Michael Phillips
I. History of Breath Tests 219
II. Classification of Breath Tests 220
III. Breath VOC Analysis: The Major Technical Problems 221
IV. Conclusions 229
References 229
Part Three PATHOLOGICAL ASPECTS
Hypoxia
10. Regulation of Nitric Oxide Synthases and Gas Phase Nitric
Oxide by Oxygen 235
Raed A. Dweik and Serpil C. Erzurum
I. Introduction 235
II. Source(s) of NO in Exhaled Breath 235
III. Regulation of NO Synthesis by Oxygen 238
IV. Effect of Oxygen on Exhaled NO 239
V. Regulation of NOS Gene Expression by Oxygen 242
VI. NO as a Mediator of Vascular Response to Oxygen 242
References 243
11. Exhaled Markers in Interstitial Lung Disease and
Pulmonary Hypertension 247
Sergei A. Kharitonov
I. Introduction 247
II. Nitric Oxide 247
Contents xxi
III. Carbon Monoxide 250
IV. Exhaled Breath Condensate 251
References 253
Ischemia Reperfusion
12. Exhaled Nitric Oxide in Human Lung Ischemia
Reperfusion 259
Tamds Kovesi, David Royston, Sir Magdi H. Yacoub, and
Ndndor Marczin
I. Introduction: Lung Ischemia Reperfusion in
Cardiothoracic Surgery 259
II. Mechanisms of Ischemia Reperfusion Injury 260
III. Role of NO in Ischemia Reperfusion 262
IV. Physiology of Exhaled NO 267
V. Exhaled NO Following CPB and Lung Transplantation 268
VI. Summary 274
References 275
13. Monitoring Distant Organ Reperfusion Injury by
Measurement of Volatile Organic Compounds 281
Robert H. Brown and Terence H. Risby
I. Introduction 281
II. Breath Collection 285
III. Breath Analysis 291
IV. Expression of Data 294
V. Organ Systems 295
VI. Interventions 301
VII. Conclusion and Future Directions 302
References 303
Inflammation
14. Exhaled Nitric Oxide, Carbon Monoxide, and Breath
Condensate in Inflammatory Lung Disease and Response
to Medical Treatment 307
Sergei A. Kharitonov and Peter J. Barnes
I. Introduction 307
II. Nitric Oxide 308
III. Carbon Monoxide 317
IV. Exhaled Breath Condensate 320
xxii Contents
V. Future Directions 327
References 328
15. Exhaled Gas Disease Markers in Septicemia: A Possible
Role for Nitric Oxide in Lung Injury 343
John T. Stitt and James S. Douglas
I. Introduction 343
II. Endotoxin Shock 344
III. Sepsis and Lung Injury 345
IV. Exhaled NO as a Marker of Lung Injury 346
V. Influence of Endotoxin on Exhaled NO 346
VI. Role of Increased NO in LPS Induced Lung Injury 355
VII. Conclusions 357
VIII. Clinical Implications 358
References 359
16. Exhaled Breath Markers in Acute Respiratory Distress
Syndrome 363
Jochen Klaus Schubert, Wolfram Miekisch, and Klaus Geiger
I. ARDS Overview 363
II. Special Problems of Gas Sampling in Mechanically
Ventilated Patients 365
III. Clinical Aspects of Exhaled Volatile Substances 369
IV. Specific Patterns of Exhaled Gases in ARDS 372
V. Conclusions 376
References 376
17. Exhaled Nitric Oxide in Lung Transplant Recipients 381
Andrew J. Fisher, Anthony De Soyza, and Paul A. Corris
I. Introduction 381
II. Validation of NO Measurement in Lung Transplant
Recipients 385
III. Effect of Graft Pathology on Exhaled NO in Lung
Transplant 387
IV. Use of Exhaled NO in the Clinical Setting 397
References 397
18. Nitric Oxide in Cystic Fibrosis 403
Thomas J. Kelley and Mitchell L. Drumm
I. Detection of NO and NO Metabolites in the CF Lung 403
II. Possible Mechanisms of Reduced Exhaled NO in CF 404
Contents xxiii
III. Possible Implications of Reduced Epithelial NOS2
Expression and NO Production in CF Airway Disease 408
IV. Summary 412
References 413
19. Exhaled Nitric Oxide in Rheumatic Diseases 421
Giovanni Rolla and Federico Caligaris Cappio
I. Introduction 421
II. NO and Lymphocyte Function 422
III. NO and Apoptosis 423
IV. Specific Diseases 424
V. Conclusions 436
References 436
20. The Disturbance of Metabolism of Oxides of Nitrogen in
Liver Disease: Exhaled Nitric Oxide as a Measure of
Severity 445
Eric Demoncheaux, Tim W. Higenbottam, and Dermot Gleeson
I. Introduction 445
II. Nitrogen: A Multifaceted Atom of Great Biological
Importance 446
III. Whole Body Turnover of Nitrogen and Related Oxides 446
IV. Intraluminal Bowel Bacterial Turnover of Nitrogen
Oxides 450
V. Mechanisms Behind Disturbed Turnover of Oxides of
Nitrogen in Liver Cirrhosis 451
VI. Exhaled Nitric Oxide and Liver Diseases 453
VII. Challenges Left for the Future 454
References 455
Author Index 463
Subject Index 521
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| id | DE-604.BV014758278 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:05:51Z |
| institution | BVB |
| isbn | 0824708172 |
| language | English |
| lccn | 2002034855 |
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| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Disease markers in exhaled breath ed. by Nándor Marczin ... New York Dekker 2003 534 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 170 Includes bibliographical references and indexes. Analyse de l'air expiré Biomarqueurs Marqueurs biologiques ram Monoxyde d'azote - Physiopathologie ram Monoxyde d'azote - analyse Monoxyde de carbone - Physiopathologie ram Poumon - Maladies - Diagnostic ram Respiration Tests à l'hydrogène expiré ram Biochemical markers Biological Markers analysis Breath tests Carbon monoxide Pathophysiology Lung Diseases Lungs Diseases Diagnosis Nitric Oxide analysis Nitric oxide Pathophysiology Atemgasanalyse (DE-588)4260324-9 gnd rswk-swf Kohlenmonoxid (DE-588)4164521-2 gnd rswk-swf Stickstoffmonoxid (DE-588)4183282-6 gnd rswk-swf Biomarker (DE-588)4425928-1 gnd rswk-swf Atemwegskrankheit (DE-588)4003360-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Atemwegskrankheit (DE-588)4003360-0 s Biomarker (DE-588)4425928-1 s Atemgasanalyse (DE-588)4260324-9 s DE-604 Stickstoffmonoxid (DE-588)4183282-6 s Kohlenmonoxid (DE-588)4164521-2 s Marczin, Nándor Sonstige oth Lung biology in health and disease 170 (DE-604)BV000008326 170 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009994126&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Disease markers in exhaled breath Lung biology in health and disease Analyse de l'air expiré Biomarqueurs Marqueurs biologiques ram Monoxyde d'azote - Physiopathologie ram Monoxyde d'azote - analyse Monoxyde de carbone - Physiopathologie ram Poumon - Maladies - Diagnostic ram Respiration Tests à l'hydrogène expiré ram Biochemical markers Biological Markers analysis Breath tests Carbon monoxide Pathophysiology Lung Diseases Lungs Diseases Diagnosis Nitric Oxide analysis Nitric oxide Pathophysiology Atemgasanalyse (DE-588)4260324-9 gnd Kohlenmonoxid (DE-588)4164521-2 gnd Stickstoffmonoxid (DE-588)4183282-6 gnd Biomarker (DE-588)4425928-1 gnd Atemwegskrankheit (DE-588)4003360-0 gnd |
| subject_GND | (DE-588)4260324-9 (DE-588)4164521-2 (DE-588)4183282-6 (DE-588)4425928-1 (DE-588)4003360-0 (DE-588)4143413-4 |
| title | Disease markers in exhaled breath |
| title_auth | Disease markers in exhaled breath |
| title_exact_search | Disease markers in exhaled breath |
| title_full | Disease markers in exhaled breath ed. by Nándor Marczin ... |
| title_fullStr | Disease markers in exhaled breath ed. by Nándor Marczin ... |
| title_full_unstemmed | Disease markers in exhaled breath ed. by Nándor Marczin ... |
| title_short | Disease markers in exhaled breath |
| title_sort | disease markers in exhaled breath |
| topic | Analyse de l'air expiré Biomarqueurs Marqueurs biologiques ram Monoxyde d'azote - Physiopathologie ram Monoxyde d'azote - analyse Monoxyde de carbone - Physiopathologie ram Poumon - Maladies - Diagnostic ram Respiration Tests à l'hydrogène expiré ram Biochemical markers Biological Markers analysis Breath tests Carbon monoxide Pathophysiology Lung Diseases Lungs Diseases Diagnosis Nitric Oxide analysis Nitric oxide Pathophysiology Atemgasanalyse (DE-588)4260324-9 gnd Kohlenmonoxid (DE-588)4164521-2 gnd Stickstoffmonoxid (DE-588)4183282-6 gnd Biomarker (DE-588)4425928-1 gnd Atemwegskrankheit (DE-588)4003360-0 gnd |
| topic_facet | Analyse de l'air expiré Biomarqueurs Marqueurs biologiques Monoxyde d'azote - Physiopathologie Monoxyde d'azote - analyse Monoxyde de carbone - Physiopathologie Poumon - Maladies - Diagnostic Respiration Tests à l'hydrogène expiré Biochemical markers Biological Markers analysis Breath tests Carbon monoxide Pathophysiology Lung Diseases Lungs Diseases Diagnosis Nitric Oxide analysis Nitric oxide Pathophysiology Atemgasanalyse Kohlenmonoxid Stickstoffmonoxid Biomarker Atemwegskrankheit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009994126&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
| work_keys_str_mv | AT marczinnandor diseasemarkersinexhaledbreath |