Nelson Textbook of pediatrics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2004
|
| Ausgabe: | 17. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XLVIII, [8], 2618 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| ISBN: | 0721695566 0808922696 |
Internformat
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| 245 | 1 | 0 | |a Nelson Textbook of pediatrics |c Richard E. Behrman ... |
| 246 | 1 | 3 | |a Textbook of pediatrics |
| 250 | |a 17. ed. | ||
| 264 | 1 | |a Philadelphia [u.a.] |b Saunders |c 2004 | |
| 300 | |a XLVIII, [8], 2618 S. |b Ill., graph. Darst. |e 1 CD-ROM (12 cm) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Kindergeneeskunde |2 gtt | |
| 650 | 7 | |a Kinderheilkunde |2 swd | |
| 650 | 4 | |a Pédiatrie | |
| 650 | 4 | |a Pediatrics | |
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| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Behrman, Richard E. |d 1931- |e Sonstige |0 (DE-588)171971043 |4 oth | |
| 700 | 1 | |a Nelson, Waldo E. |d 1898-1997 |e Sonstige |0 (DE-588)12222776X |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009994054&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1818239762568314880 |
|---|---|
| adam_text |
S r Contents
Pattl The Field of Pediatrics 1
Chapter 1 Overview of Pediatrics 1
Richard E. Behrman
Chapter 2 Ethics in Pediatric Care 6
Robert M. Nelson and Norman Fost
Chapter 3 Cultural Issues in Pediatric Care 10
JillE.Korbin
Chapter 4 Child Health in the Developing World 12
Kristine Torjesen and Karen Olness
Chapter 5 Preventive Pediatrics 14
Theodore C. Sectish
Chapter 6 TheWell Child 20
Paul L. McCarthy
HH| Growth and Development 23
Robert D. Needlman
Chapter 7 Overview and Assessment of
Variability 23
Chapter 8 Fetal Growth and Development 27
Chapter 9 The Newborn 30
Chapter 10 The FirstYear 31
Chapter 11 The Second Year 38
Chapter 12 PreschoolYears 44
Chapter 13 Middle Childhood 51
Chapter 14 Adolescence 53
Chapter 15 Assessment of Growth 58
Chapter 16 Developmental Assessment 62
HHj Psychologic Disorders 67
Chapter 17 Assessment and Interviewing 67
17.1 The Clinical Interview (History) 67
Neil W. Boris, Marc A. Forman, and Jorge H. Daruna
17.2 Psychosocial Problems 70
Richard Dalton and Marc A. Forman
Chapter 18 Psychiatric Considerations of Central
Nervous System Injury 71
Jorge H. Daruna, Marc A. Forman, and Neil W. Boris
Chapter 19 Psychosomatic Illness 72
Alessandra N. Kazura, Neil W. Boris, and Richard Dalton
Chapter 20 Vegetative Disorders 73
20.1 Rumination Disorder 73
Neil W. Boris and Richard Dalton
20.2 Pica 73
Neil W. Boris and Richard Dalton
20.3 Enuresis (Bed wetting) 74
Neil W. Boris and Richard Dalton
20.4 Encopresis 75
Neil W. Boris and Richard Dalton
20.5 Sleep Disorders 75
Judith A. Owens
Chapter 21 Habit Disorders 80
Neil W. Boris and Richard Dalton
Chapter 22 Anxiety Disorders 81
Brian Stafford, Neil W. Boris, and Richard Dalton
Chapter 23 Mood Disorders 84
Neil W. Boris, Richard Dalton, and Marc A. Forman
23.1 Major Depression 84
23.2 Dysthymic Disorder 85
23.3 Bipolar Disorder 85
Chapter 24 Suicide and Attempted Suicide 86
Neil W. Boris and Richard Dalton
Chapter 25 Disruptive Behavioral Disorders 88
Neil W. Boris and Richard Dalton
Chapter 26 Sexual Behavior and Its Variations 90
Richard Dalton
26.1 Gender Identity Disorder 91
26.2 Homosexuality 91
Chapter 27 Pervasive Developmental Disorders and
Childhood Psychosis 93
Richard Dalton, Marc A. Forman, and Neil W. Boris
27.1 Autistic Disorder 93
27.2 Asperger Disorder 94
27.3 Childhood Disintegrative Disorder 94
27.4 Rett Disorder 94
27.5 Childhood Schizophrenia 94
Chapter 28 Psychologic Treatment of Children and
Adolescents 95
Richard Dalton
xxlii .
XXVi Contents
Chapter 75 Defects in Metabolism of Lipids 433
75.1 Disorders of Mitochondrial Fatty Acid
Oxidation 433
Charles P. Venditti and Charles A. Stanley
75.2 Disorders of Very Long Chain Fatty Acids 437
Hugo W. Moser
75.3 Disorders of Lipoprotein Metabolism and
Transport 445
Andrew M. Tershakovec and Daniel J. Rader
75.4 Lipidoses 459
Margaret M. McGovern and Robert J. Desnick
75.5 Mucolipidoses 467
Margaret M. McGovern and Robert J. Desnick
Chapter 76 Defects in Metabolism of
Carbohydrates 468
76.1 Glycogen Storage Diseases 469
Yuan Tsong Chen
76.2 Defects in Galactose Metabolism 475
Yuan Tsong Chen
76.3 Defects in Fructose Metabolism 476
Yuan Tsong Chen
76.4 Defects in Intermediary Carbohydrate Metabolism
Associated with Lactic Acidosis 477
Yuan Tsong Chen
76.5 Deficiency of Xylulose Dehydrogenase (Essential
Benign Pentosuria) 480
Yuan Tsong Chen
76.6 Disorders of Glycoprotein Degradation and
Structure 480
Margaret M. McGovern and Robert J. Desnick
Chapter 77 Mucopolysaccharidoses 482
Robert M. Kliegman and Joseph L. Muenzer
Chapter 78 Disorders of Purine and Pyrimidine
Metabolism 486
James C. Harris
Chapter 79 Progeria 494
W.Ted Brown
Chapter 80 The Porphyrias 495
Shigeru Sassa
Chapter 81 Hypoglycemia 505
Mark A. Sperling
rffiffjXt: The Fetus and the Neonatal Infant 519
Section 1: Noninfectious Disorders 519
Chapter 82 Overview of Mortality and
Morbidity 519
Barbara J. Stoll and Robert M. Kliegman
Chapter 83 The Newborn Infant 523
Barbara J. Stoll and Robert M. Kliegman
83.1 History in Neonatal Pediatrics 523
83.2 Physical Examination of the Newborn Infant 524
83.3 Routine Delivery Room Care 527
83.4 Nursery Care 529
83.5 Parent Infant Bonding 529
Chapter 84 High Risk Pregnancies 532
Barbara J. Stoll and Robert M. Kliegman
Chapter 85 The Fetus 536
Barbara J. Stoll and Robert M. Kliegman
85.1 Fetal Growth and Maturity 536
85.2 Fetal Distress 536
85.3 Maternal Disease and the Fetus 539
85.4 Maternal Medication and Toxin Exposure and the
Fetus 540
85.5 Teratogens 542
85.6 Radiation 542
85.7 Intrauterine Diagnosis of Fetal Disease 542
85.8 Treatment and Prevention of Fetal Disease 545
Chapter 86 The High Risk Infant 547
Barbara J. Stoll and Robert M. Kliegman
86.1 Multiple Pregnancies 548
86.2 Prematurity and Intrauterine Growth
Retardation 550
86.3 Post Term Infants 558
86.4 Large for Gestational Age 558
86.5 Infant Transport 559
Chapter 87 Clinical Manifestations of Diseases
in the Newborn Period 559
Barbara J. Stoll and Robert M. Kliegman
Chapter 88 Nervous System Disorders 561
Barbara J. Stoll and Robert M. Kliegman
88.1 The Cranium 562
88.2 Intracranial Intraventricular Hemorrhage and
Periventricular Leukomalacia 562
88.3 Spine and Spinal Cord 564
88.4 Peripheral Nerve Injuries 565
88.5 Hypoxia Ischemia 566
88.6 Intrauterine Infection 568
Chapter 89 Delivery Room Emergencies 569
Barbara J. Stoll and Robert M. Kliegman
Chapter 90 Respiratory Tract Disorders 573
Barbara J. Stoll and Robert M. Kliegman
90.1 Transition to Pulmonary Respiration 573
90.2 Apnea 573
90.3 Hyaline Membrane Disease (Respiratory Distress
Syndrome) 575
90.4 Transient Tachypnea of the Newborn 583
90.5 Aspiration of Foreign Material (Fetal Aspiration
Syndrome, Aspiration Pneumonia) 583
90.6 Meconium Aspiration 583
90.7 Persistent Pulmonary Hypertension of
the Newborn (Persistent Fetal
Circulation) 584
90.8 Extrapulmonary Extravasation of Air
(Pneumothorax, Pneumomediastinum,
Pulmonary Interstitial Emphysema) 586
90.9 Pulmonary Hemorrhage 587
Chapter 91 Digestive System Disorders 588
Barbara J. Stoll and Robert M. Kliegman
91.1 Meconium Ileus in Cystic Fibrosis 589
91.2 Neonatal Necrotizing Enterocolitis
(NEC) 590
91.3 Jaundice and Hyperbilirubinemia in the
Newborn 592
91.4 Kernicterus 596
Chapter 92 Blood Disorders 599
Barbara J. Stoll and Robert M. Kliegman
92.1 Anemia in the Newborn Infant 599
92.2 Hemolytic Disease of the Newborn
(Erythroblastosis Fetalis) 601
92.3 Plethora in the Newborn Infant (Polycythemia) 606
92.4 Hemorrhage in the Newborn Infant 606
Chapter 93 Genitourinary System 608
Barbara J. Stoll and Robert M. Kliegman
Chapter 94 The Umbilicus 608
Barbara J. Stoll and Robert M. Kliegman
Chapter 95 Metabolic Disturbances 609
Barbara J. Stoll and Robert M. Kliegman
Chapter 96 The Endocrine System 613
Barbara J. Stoll and Robert M. Kliegman
96.1 Infants of Diabetic Mothers 613
96.2 Hypoglycemia 614
Chapter 97 Dysmorphology 616
Kenneth Lyons Jones
Section 2: Infections of the Neonatal Infant 623
Barbara J. Stoll
Chapter 98 Pathogenesis and
Epidemiology 623
98.1 Modes of Transmission and Pathogenesis 623
98.2 Immunity 625
98.3 Etiology of Fetal and Neonatal Infection 626
98.4 Epidemiology of Early and Late Onset Neonatal
Infections 627
98.5 Clinical Manifestations of Transplacental
Intrauterine Infections 630
98.6 Diagnosis 633
98.7 Treatment 636
98.8 Complications and Prognosis 638
98.9 Prevention 638
¦HH Special Health Problems During
^^^H Adolescence 64i
Chapter 99 The Epidemiology of Adolescent
Health Problems 641
ReneeR. Jenkins
Chapter 100 Delivery of Health Care to
Adolescents 643
ReneeR. Jenkins
100.1 Legal Issues 644
100.2 Screening Procedures 645
100.3 Health Enhancement 646
Chapter 101 Depression 646
ReneeR. Jenkins
Contents XXVH
Chapter 102 Suicide 648
ReneeR. Jenkins
Chapter 103 Violent Behavior 649
Renee R. Jenkins
Chapter 104 Anorexia Nervosa and
Bulimia 652
IrisF.Litt
Chapter 105 Substance Abuse 653
Renee R. Jenkins
105.1 Alcohol 657
105.2 Marijuana 657
105.3 Tobacco 658
105.4 Volatile Substances 658
105.5 Hallucinogens 659
105.6 Cocaine 660
105.7 Amphetamines 660
105.8 Opiates 660
105.9 Anabolic Steroids 661
Chapter 106 The Breast 662
ReneeR. Jenkins
Chapter 107 Menstrual Problems 663
Renee R. Jenkins
107.1 Amenorrhea 664
107.2 Abnormal Uterine Bleeding 665
107.3 Dysmenorrhea 666
107.4 Premenstrual Syndrome 667
Chapter 108 Contraception 667
Renee R. Jenkins
108.1 Barrier Methods 668
108.2 Spermicides 668
108.3 Combination Methods 668
108.4 Hormonal Methods 668
108.5 Emergency Contraception 671
108.6 Intrauterine Devices 671
Chapter 109 Pregnancy 671
Renee R. Jenkins
Chapter 110 Sexually Transmitted
Diseases 673
ReneeR. Jenkins
Chapter 111 Chronic Fatigue Syndrome 677
HalB. Jenson
¦The Immunologjc System and
Disorders hi
Section 1: Evaluation of the Immune System 681
Rebecca H.Buckley
Chapter 112 Evaluation of Suspected
Immunodeficiency 681
Section 2: The T , B , and NK Cell Systems 683
Rebecca H. Buckley
XXViii Contents
Chapter 113 T Lymphocytes, B Lymphocytes, and
Natural Killer Cells 683
Chapter 114 Primary Defects of Antibody
Production 689
114.1 Treatment of B Cell Defects 693
Chapter 115 Primary Defects of Cellular
Immunity 693
Chapter 116 Primary Combined Antibody and
Cellular Immunodeficiencies 695
116.1 Severe Combined Immunodeficiency (SCID) 695
116.2 Combined Immunodeficiency (CID) 697
116.3 Treatment of Cellular or Combined
Immunodeficiency 700
Section 3: The Phagocytic System 701
Chapter 117 Neutrophils 701
Laurence A. Boxer
Chapter 118 Monocytes and Macrophages 707
Richard B. Johnston, Jr.
Chapter 119 Eosinophils 709
Laurence A. Boxer
Chapter 120 Disorders of Phagocyte Function 710
Laurence A. Boxer
Chapter 121 Leukopenia 717
Laurence A. Boxer
Chapter 122 Leukocytosis 723
Laurence A. Boxer
Section 4: The Complement System 725
Richard B. Johnston, Jr.
Chapter 123 The Complement System 725
Chapter 124 Disorders of the Complement
System 728
124.1 Evaluation 728
124.2 Primary Deficiencies of Complement
Components 728
124.3 Deficiencies of Plasma, Membrane, or Serosal
Complement Control Proteins 730
124.4 Secondary Disorders of Complement 730
124.5 Treatment of Complement Disorders 731
Section 5: Hematopoietic Stem Cell
Transplantation 732
Kent A. Robertson
Chapter 125 Clinical Indications 732
Chapter 126 Matching and Rejection 737
Chapter 127 Graft versus Host Disease (GVHD) 738
Chapter 128 Principles of Immuno
suppression 740
Chapter 129 Late Effects of Stem Cell
Transplantation 741
BBBjl Allergic Disorders 743
Chapter 130 Allergy and the Immunologic Basis of
Atopic Disease 743
Donald Y. M. Leung
Chapter 131 Diagnosis of Allergic Disease 747
Dan Atkins and Donald Y. M. Leung
Chapter 132 Principles of Treatment of Allergic
Disease 752
Dan Atkins and Donald Y. M. Leung
Chapter 133 Allergic Rhinitis 759
Henry Milgrom and Donald Y. M. Leung
Chapter 134 Childhood Asthma 760
Andrew H. Liu, Joseph D. Spahn, and Donald Y. M. Leung
Chapter 135 Atopic Dermatitis (Atopic
Eczema) 774
Donald Y. M. Leung
Chapter 136 Urticaria and Angioedema
(Hives) 778
Donald Y. M. Leung
Chapter 137 Anaphylaxis 781
Hugh A. Sampson and Donald Y. M. Leung
Chapter 138 Serum Sickness 782
Scott H. Sicherer and Donald Y. M. Leung
Chapter 139 Adverse Reactions to Drugs 783
Mark Boguniewicz
Chapter 140 Insect Allergy 786
Scott H. Sicherer and Donald Y. M. Leung
Chapter 141 Ocular Allergies 788
Mark Boguniewicz
Chapter 142 Adverse Reactions to Foods 789
Hugh A. Sampson and Donald Y. M. Leung
¦Rheumatic Diseases of Childhood
(Connective Tissue Diseases,
Collagen Vascular Diseases) 793
Chapter 143 Evaluation of Suspected Rheumatic
Disease 793
Michael L. Miller
Chapter 144 Treatment of Rheumatic
Diseases 795
Daniel J. Lovell, Michael L. Miller, and James T. Cassidy
Chapter 145 Juvenile Rheumatoid Arthritis 799
Michael L. Miller and James T. Cassidy
Chapter 146 Ankylosing Spondylitis and Other
Spondyloarthropathies 805
Michael L. Miller and Ross E. Petty
Chapter 147 Postinfectious Arthritis and Related
Conditions 808
Michael L. Miller and James T. Cassidy
Chapter 148 Systemic Lupus Erythematosus 80
Marisa S. Klein Gitelman and Michael L. Miller
148.1 Neonatal Lupus 813
Chapter 149 Juvenile Dermatomyositis 813
Lauren M. Pachman
Chapter 150 Scleroderma 816
Michael L. Miller
Chapter 151 Beh ;et Disease 819
Abraham Gedalia
Chapter 152 Sjogren Syndrome 820
Abraham Gedalia
Chapter 153 Familial Mediterranean Fever 821
Abraham Gedalia
Chapter 154 Amyloidosis 822
Abraham Gedalia
Chapter 155 Sarcoidosis 822
Margaret W. Leigh
Chapter 156 Kawasaki Disease 823
Anne H. Rowley and Stanford T. Shulman
Chapter 157 Vasculitis Syndromes 826
Michael L. Miller and Lauren M. Pachman
157.1 Henoch Schonlein Purpura 826
157.2 Takayasu Arteritis 828
157.3 Polyarteritis Nodosa 829
157.4 Wegener Granulomatosis 830
157.5 Other Vasculitic Syndromes 831
Chapter 158 Musculoskeletal Pain
Syndromes 831
Michael L. Miller
158.1 Reflex Sympathetic Dystrophy 832
158.2 Erythromelalgia 832
Chapter 159 Miscellaneous Conditions Associated
with Arthritis 832
Michael L. Miller
^^^H Infectious Diseases 835
Section 1: General Considerations 835
Chapter 160 Diagnostic Microbiology 835
Anita K. M. Zaidi and Donald A. Goldmann
Chapter 161 Fever 839
Keith R. Powell
Chapter 162 FeverWithout a Focus 841
Keith R. Powell
Chapter 163 Sepsis and Shock 846
Anne Stormorken and Keith R. Powell
Contents XXI
Chapter 164 Infections in Immunocompromised
Persons 851
Marian G. Michaels and Michael Green
9 Chapter 165 Infection Associated with Medical
Devices 858
Patricia M. Flynn and Fred F. Barrett
Section 2: Gram Positive Bacterial Infections 861
Chapter 166 Staphylococcus 861
James K. Todd
166.1 Staphylococcus aureus 861
166.2 Toxic Shock Syndrome 865
166.3 Coagulase Negative Staphylococci 866
Chapter 167 Streptococcus pneumoniae
(Pneumococcus) 867
Jon S. Abramson and Gary D. Overturf
Chapter 168 Group A Streptococcus 870
Michael A. Gerber
168.1 Rheumatic Fever 874
Chapter 169 Group B Streptococcus 879
Catherines. Lachenauer and Michael R. Wessels
Chapter 170 Non Group A or B
Streptococci 883
Michael A. Gerber
Chapter 171 Enterococcus 884
David B. Haslam
Chapter 172 Diphtheria {Corynebacterium
diphtheriae) 886
Sarah S. Long
Chapter 173 Listeria monocytogenes 890
Roberts. Baltimore
Chapter 174 Actinomyces 892
Richard F. Jacobs and Gordon E. Schutze
Chapter 175 Nocardia 894
Richard F. Jacobs and Gordon E. Schutze
Section 3: Gram Negative Bacterial Infections 896
Chapter 176 Neisseria meningitidis
(Meningococcus) 896
Charles R. Woods
Chapter 177 Neisseria gonorrhoeae
(Gonococcus) 899
ToniDarville
Chapter 178 Haemophilus influenzae 904
Robert S.Daum
Chapter 179 Chancroid
(Haemophilus ducreyi) 908
ParvinAzimi
Chapter 180 Pertussis (Bordetella pertussis and
B. parapertussis) 908
Sarahs. Long
XXX Contents
Chapter 181 Salmonella 912
Thomas G. Cleary
181.1 Nontyphoidal Salmonellosis 912
181.2 Enteric Fever 916
Chapter 182 Shigella 919
Thomas G. Cleary
Chapter 183 Escherichia coli 921
Theresa J. Ochoa and Thomas G. Cleary
Chapter 184 Cholera (Vibrio cholerae) 924
Gloria P. Heresi and James R. Murphy
Chapter 185 Campylobacter 926
Gloria P. Heresi and James R. Murphy
Chapter 186 Yersinia 929
James R. Murphy and Gloria P. Heresi
186.1 Yersinia enterocolitica 929
186.2 Yersinia pseudotuberculosis 930
186.3 Plague (Yersiniapestis) 930
Chapter 187 Aeromonas and Plesiomonas 932
James R. Murphy and Gloria P. Heresi
187.1 Aeromonas 932
187.2 Plesiomonas shigelloides 933
Chapter 188 Pseudomonas, Burkholderia, and
Stenotrophomonas 933
Robert S. Baltimore
188.1 Pseudomonas aeruginosa 934
188.2 Burkholderia 936
188.3 Stenotrophomonas 936
Chapter 189 Tularemia (Francisella
tularensis) 937
Gordon E. Schutze and Richard F. Jacobs
Chapter 190 Brucella 939
Gordon E. Schutze and Richard F. Jacobs
Chapter 191 Legionella 941
Lucy Tompkins
Chapter 192 Bartonella 943
Barbara W. Stechenberg
192.1 Bartonellosis (Bartonella bacilliformis) 943
192.2 Cat Scratch Disease (Bartonella henselae) 944
192.3 Trench Fever (Bartonella quintana) 946
192.4 Bacillary Angiomatosis and Bacillary
Peliosis Hepatis (Bartonella henselae and
Bartonella quintana) 946
Section 4: Anaerobic Bacterial Infections 947
Chapter 193 Botulism (Clostridium
botulinum) 947
Robert Schechter and Stephen S. Arnon
Chapter 194 Tetanus (Clostridium tetani) 951
Stephen S. Arnon
Chapter 195 Clostridium difficile Associated
Diarrhea 953
Margaret C. Fisher
Chapter 196 Other Anaerobic Infections 954
Margaret C. Fisher
Section 5: Mycobacterial Infections 958
Chapter 197 Tuberculosis (Mycobacterium
tuberculosis) 958
Flor M. Munoz and Jeffrey R. Starke
Chapter 198 Hansen Disease {Mycobacterium
leprae) 972
DwightA. Powell
Chapter 199 Nontuberculous Mycobacteria 975
DwightA. Powell
Section 6: Spirochetal Infections 978
Chapter200 Syphilis(Treponemapallidum) 978
Parvin Azimi
Chapter 201 NonvenerealTreponemal
Infections 982
Parvin Azimi
201.1 Yaws (Treponemapertenue) 982
201.2 Bejel (Endemic Syphilis) (Treponema pallidum
subsp. endemicum) 983
201.3 Pinta (Treponema carateum) 983
Chapter 202 Leptospira 983
Parvin Azimi
Chapter 203 Relapsing Fever (Borrelia) 985
Parvin Azimi
Chapter 204 Lyme Disease
(Borrelia burgdorferi) 986
Eugene D. Shapiro
Section 7: Mycoplasmal Infections 990
DwightA. Powell
Chapter 205 Mycoplasma pneumoniae 990
Chapter 206 Genital Mycoplasmas (Mycoplasma
hominis and Ureaplasma urealyticum) 992
Section 8: Chlamydial Infections 994
Margaret R. Hammerschlag
Chapter 207 Chlamydia pneumoniae 994
Chapter 208 Chlamydia trachomatis 995
208.1 Trachoma 995
208.2 Genital Tract Infections 996
208.3 Conjunctivitis and Pneumonia in Newborns 997
208.4 Lymphogranuloma Venereum (LGV) 998
Chapter 209 Psittacosis (Chlamydiapsittaci) 998
Section 9: Rickettsial Infections 999
J. Stephen Dumler
Chapter 210 Spotted Fever Group
Rickettsioses 999
210.1 Rocky Mountain Spotted Fever
(Rickettsia rickettsii) 999
210.2 Mediterranean Spotted Fever or Boutonneuse
Fever (Rickettsia conorii) 1003
210.3 Rickettsialpox (Rickettsia akari) 1003
Chapter 211 ScrubTyphus
(Orientia tsutsugamushi) 1004
Chapter 212 Typhus Group Rickettsioses 1005
212.1 Murine Typhus (Rickettsia typhi) 1005
212.2 Epidemic Typhus (Rickettsiaprowazekii) 1006
Chapter 213 Ehrlichiosisand Anaplasmosis 1006
Chapter 214 Q Fever [Coxiella burnetii) 1009
Section 10: Mycotic Infections 1011
Chapter 215 Candida 1011
Martin E. Weisse and Stephen C. Aronoff
215.1 Neonatal Infections 1012
215.2 Infections in Immunocompetent Children and
Adolescents 1013
215.3 Infections in Immunocompromised Children and
Adolescents 1013
215.4 Chronic Mucocutaneous Candidiasis 1014
Chapter 216 Cryptococcus neoformans 1014
Stephen C. Aronoff
Chapter 217 Malassezia 1016
Martin E. Weisse
Chapter 218 Aspergillus 1016
Stephen C. Aronoff
218.1 Hypersensitivity Syndromes 1016
218.2 Saprophytic (Noninvasive) Syndromes 1017
218.3 Invasive Disease 1017
Chapter 219 Histoplasmosis (Histoplasma
capsulatum) 1018
Stephen C. Aronoff
Chapter 220 Blastomycosis (Blastomyces
dermatitidis) 1020
Robin B. Churchill and Stephen C. Aronoff
Chapter 221 Coccidioidomycosis (Coccidioides
immitis) 1021
Demosthenes Pappagianis
Chapter 222 Paracoccidioides
brasiliensis 1023
Robin B. Churchill and Stephen C. Aronoff
Chapter 223 Sporotrichosis
(Sporothrix schenckii) 1024
Robin B. Churchill and Stephen C. Aronoff
Chapter 224 Zygomycosis 1025
Robin B. Churchill and Stephen C. Aronoff
Section 11: Viral Infections 1026
Chapter 225 Measles 1026
Yvonne Maldonado
225.1 Subacute Sderosing Panencephalitis 1030
Chapter 226 Rubella 1032
Yvonne Maldonado
226.1 Progressive Rubella Panencephalitis 1034
Contents xxxi
Chapter 227 Mumps 1035
Yvonne Maldonado
Chapter 228 Polioviruses 1036
Eric A. F.Simoes
Chapter 229 Nonpolio Enteroviruses 1042
Mark J. Abzug
Chapter 230 Parvovirus B19 1048
William C. Koch
Chapter 231 Herpes Simplex Virus 1051
Steve Kohl
Chapter 232 Varicella ZosterVirus 1057
Martin G. Myers, Lawrence R. Stanberry, and Jane F. Seward
Chapter 233 Epstein BarrVirus 1062
Hal B. Jenson
Chapter 234 Cytomegalovirus 1066
Sergio Stagno
Chapter 235 Roseola (Human Herpesviruses
6 and 7) 1069
Charles T. Leach
Chapter 236 Human Herpesvirus8 1072
Charles T. Leach
Chapter 237 Influenza Viruses 1072
Peter Wright
Chapter 238 ParainfluenzaViruses 1075
Peter Wright
Chapter 239 Respiratory Syncytial Virus 1076
Kenneth Mclntosh
Chapter 240 Adenoviruses 1079
Kenneth Mclntosh
Chapter 241 Rhinoviruses 1080
Kenneth Mclntosh
Chapter 242 Rotavirus and Other Agents of Viral
Gastroenteritis 1081
Dorsey M.Bass
Chapter 243 Human Papillomaviruses 1084
Anna Barbara Moscicki
Chapter 244 Arboviral Encephalitis in
North America 1086
Scott B. Halstead
Chapter 245 Arboviral Encephalitis Outside
North America 1089
Scott B. Halstead
245.1 Venezuelan Equine Encephalitis 1089
245.2 Japanese Encephalitis 1090
245.3 Tick Bome Encephalitis 1091
Chapter 246 Dengue Fever and Dengue
Hemorrhagic Fever 1092
Scott B. Halstead
Chapter 247 Yellow Fever 1095
Scott B. Halstead
xxxii Contents
Chapter 248 OtherViral Hemorrhagic Fevers 1096
Scott B. Halstead
Chapter 249 Lymphocytic Choriomeningitis
Virus 1099
Hal B. Jenson
Chapter 250 Hantaviruses 1100
Scott B. Halstead
Chapter 251 Rabies 1101
William G. Adams
Chapter 252 Polyomaviruses 1105
Hal B. Jenson
Chapter 253 Transmissible Spongiform
Encephalopathies 1105
David M. Asher
Chapter 254 Acquired Immunodeficiency
Syndrome (Human Immunodeficiency
Virus) 1109
Ram Yogev and Ellen Gould Chadwick
Chapter 255 HumanT Cell Lymphotropic Viruses
Types I and II 1121
Hal B. Jenson
Section 12: Protozoan Diseases 1122
Chapter 256 Primary Amebic
Meningoencephalitis 1122
Martin E. Weisse and Stephen C. Aronoff
Chapter 257 Amebiasis 1123
Chandy C. John and Robert A. Salata
Chapter 258 Giardiasisand Balantidiasis 1125
Larry K. Pickering
258.1 Giardia lamblia 1125
258.2 Balantidiasis 1127
Chapter 259 Spore Forming Intestinal
Protozoa 1128
Patricia M. Flynn
Chapter 260 Trichomoniasis (Trichomonas
vagina I is) 1129
Chandy C. John and Robert A. Salata
Chapter 261 Leishmaniasis (Leishmania) 1130
Peter C. Melby
Chapter 262 AfricanTrypanosomiasis
(Sleeping Sickness; Trypanosoma brucei
complex) 1134
Robert A. Bonomo and Robert A. Salata
Chapter 263 AmericanTrypanosomiasis (Chagas
Disease; Trypanosoma cruzi) 1136
Robert A. Bonomo and Robert A. Salata
Chapter 264 Malaria (Plasmodium) 1139
Peter J. Krause
Chapter 265 Babesiosis(Babesia) 1143
Peter J. Krause
Chapter 266 Toxoplasmosis (Toxoplasma
gondii) 1144
Rima McLeod and Jack S. Remington
Chapter 267 Pneumocystis carinii 1154
Walter T. Hughes
Section 13: Helminthic Diseases 1155
Chapter 268 Ascariasis (Ascaris
lumbricoides) 1155
SheralS. Patel and James W. Kazura
Chapter 269 Hookworms (Ancylostoma and
Necator americanus) 1156
Peter Hotez
269.1 Cutaneous Larva Migrans 1158
Chapter 270 Trichuriasis (Trichuris trichiura) 1158
Sheral S. Patel and James W. Kazura
Chapter 271 Enterobiasis (Enterobius
vermicularis) 1159
Sheral S. Patel and James W. Kazura
Chapter 272 Strongyloidiasis (Strongyloides
stereo ra I is) 1160
Sheral S. Patel and James W. Kazura
Chapter 273 Lymphatic Filariasis (Brugia malayi,
Brugia timori, and Wuchereria bancrofti) 1161
Sheral S. Patel and James W. Kazura
Chapter 274 Other Tissue Nematodes 1162
Sheral S. Patel and James W. Kazura
Chapter 275 Toxocariasis (Visceral and Ocular
Larva Migrans) 1164
Sheral S. Patel and James W. Kazura
Chapter 276 Trich i nosis (Trichinella spiralis) 1166
Sheral S. Patel and James W. Kazura
Chapter 277 Schistosomiasis (Schistosoma) 1166
Charles H. King
Chapter 278 Flukes (Liver, Lung, and
Intestinal) 1168
Charles H. King
Chapter 279 Adult Tapeworm Infections 1169
Ronald Blanton
Chapter 280 Cysticercosis 1171
Ronald Blanton
Chapter 281 Echinococcosis (Echinococcus
granulosus and E. multilocularis) 1173
Ronald Blanton
Section 14: Preventive Measures 1174
Chapter 282 Immunization Practices 1174
Georges Peter
Chapter 283 Infection Control and
Prophylaxis 1184 ,
Margaret C. Fisher
Chapter 284 Child Care and Communicable
Diseases 1187
Larry K. Pickering
Chapter 285 Health Advice for ChildrenTraveling
Internationally 1189
Chandy C. John and Robert A. Salata
[||[[b1 The Digestive System 1197
Section 1: Clinical Manifestations of Gastrointestinal
Disease 1197
Robert Wyllie
Chapter 286 Normal Digestive Tract
Phenomena 1197
Chapter 287 Major Symptoms and Signs of
Digestive Tract Disorders 1198
Section 2: The Oral Cavity 1204
Norman Tinanoff
Chapter 288 Development and Developmental
Anomalies of theTeeth 1204
Chapter 289 Disorders of the Oral Cavity Associated
with Other Conditions 1206
Chapter 290 Malocclusion 1206
Chapter 291 Cleft Lip and Palate 1207
Chapter 292 Syndromes with Oral
Manifestations 1209
Chapter 293 Dental Caries 1209
Chapter 294 Periodontal Diseases 1212
Chapter 295 Dental Trauma 1213
Chapter 296 Common Lesions of the Oral Soft
Tissues 1214
Chapter 297 Diseases of the Salivary Glands and
Jaws 1215
Chapter 298 Diagnostic Radiology in Dental
Assessment 1216
Section 3: The Esophagus 1217
Susan Orenstein. John Peters, Seema Khan, Nader Youssef, and
Sunny Zaheed Hussain
Chapter 299 Embryology, Anatomy, and Function of
the Esophagus 1217
299.1 Common Clinical Manifestations and
Diagnostic Aids 1218
Chapter 300 Congenital Anomalies: Esophageal
Atresia and Tracheoesophageal Fistula 1219
300.1 Congenital Anomalies: Laryngotracheoesophageal
Clefts 1220
Contents xxxiii
Chapter 301 Obstructing and Motility Disorders of
the Esophagus 1220
Chapter 302 Dysmotility 1220
Chapter 303 Hiatal Hernia 1221
Chapter 304 Gastroesophageal Reflux Disease
(GERD) 1222
304.1 Complications of GERD 1224
Chapter 305 Non GERD Esophagitis 1224
Chapter 306 Esophageal Perforation 1225
Chapter 307 Esophageal Varices 1225
Chapter 308 fngestions 1225
308.1 Foreign Bodies in the Esophagus 1225
308.2 Caustic Ingestions 1226
Section 4: Stomach and Intestines 1228
Chapter 309 Normal Development, Structure, and
Function 1228
Robert Wyllie
Chapter 310 Pyloric Stenosis and Congenital
Anomalies of the Stomach 1229
Robert Wyllie
310.1 Hypertrophic Pyloric Stenosis 1229
310.2 Congenital Gastric Outlet Obstruction 1231
310.3 Gastric Duplication 1231
310.4 Gastric Volvulus 1231
310.5 Hypertrophic Gastropathy 1231
Chapter 311 Intestinal Atresia, Stenosis, and
Ma I rotation 1232
Robert Wyllie
311.1 Duodenal Obstruction 1233
311.2 Jejunal and Heal Atresia and Obstruction 1234
311.3 Malrotation 1235
Chapter 312 Intestinal Duplications, Meckel
Diverticulum, and Other Remnants of the
Omphalomesenteric Duct 1236
Robert Wyllie
312.1 Intestinal Duplication 1236
312.2 Meckel Diverticulum and Other Remnants
of the Omphalomesenteric Duct 1236
Chapter 313 Motility Disorders and Hirschsprung
Disease 1237
Robert Wyllie
313.1 Chronic Intestinal Pseudo Obstruction 1237
313.2 Functional Constipation 1238
313.3 Congenital Aganglionic Megacolon
(Hirschsprung Disease) 1239
313.4 Superior Mesenteric Artery Syndrome (Wilkie
Syndrome, Cast Syndrome, Arteriomesenteric
Duodenal Compression Syndrome) 1241
Chapter 314 Ileus, Adhesions, Intussusception, and
Closed Loop Obstructions 1241
Robert Wyllie
314.1 Ileus 1241
314.2 Adhesions 1241
i
XXXiv Contents
314.3 Intussusception 1242
314.4 Closed Loop Obstructions 1243
Chapter 315 Foreign Bodies and Bezoars 1244
Robert Wyllie
315.1 Foreign Bodies in the Stomach and Intestine 1244
315.2 Bezoars 1244
Chapter 316 Peptic Ulcer Disease 1244
Francisco A. Sylvester
316.1 Secondary or Stress (Peptic) Ulcer Disease 1246
316.2 Zollinger Ellison Syndrome 1247
Chapter 317 Inflammatory Bowel Disease 1248
Jeffrey Hyams
317.1 Chronic Ulcerative Colitis 1249
317.2 Crohn Disease (Regional Enteritis,
Regional lleitis, Granulomatous Colitis) 1252
317.3 Beh^et Syndrome 1255
Chapter 318 Food Allergy (Food
Hypersensitivity) 1255
Jeffrey Hyams
Chapter 319 Eosinophilic Gastroenteritis 1257
Jeffrey Hyams
Chapter 320 Malabsorptive Disorders 1257
Manuel Garcia Careaga and John A. Kerner
320.1 Evaluation of Children with Suspected Intestinal
Malabsorption 1257
320.2 Chronic Malnutrition 1261
320.3 Liver and Biliary Disorders 1261
320.4 Intestinal Infections 1261
320.5 Immunodeficiency 1262
320.6 Stagnant Loop Syndrome (Blind Loop Syndrome:
Bacterial Overgrowth Syndrome) 1262
320.7 Short Bowel Syndrome 1262
320.8 Gluten Sensitive Enteropathy (Celiac Disease,
Celiac Sprue) 1264
320.9 Immunoproliferative Small Intestinal
Disease 1266
320.10 Other Malabsorptive Snydromes 1266
320.11 Enzyme Deficiencies 1267
320.12 Defects of Absorption or Transport 1268
Chapter 321 Gastroenteritis 1272
Larry K. Pickering and John D. Snyder
Chapter 322 Chronic Diarrhea 1276
FayezK. Ghishan
Chapter 323 Recurrent Abdominal Pain of
Childhood 1281
Robert Wyllie
Chapter 324 Acute Appendicitis 1283
Gary E. Hartman
Chapter 325 Surgical Conditions of the Anus,
Rectum, and Colon 1285
Alberto Peiia
325.1 Anorectal Malformations 1285
325.2 Anal Fissure 1288
325.3 Perianal Abscess and Fistula 1288
325.4 Hemorrhoids 1289
325.5 Rectal Prolapse 1289
325.6 Pilonidal Sinus and Abscess 1289
Chapter 326 Tumors of the Digestive Tract 1289
Joel Shilyansky
326.1 Diarrhea from Hormone Secreting Tumors 1292
Chapter 327 Inguinal Hernias 1293
John J. Aiken
Section 5: Exocrine Pancreas 1298
Steven L. Werlin
Chapter 328 Embryology, Anatomy, and
Physiology 1298
328.1 Anatomic Abnormalities 1298
328.2 Physiology 1298
Chapter 329 Pancreatic FunctionTests 1299
Chapter 330 Disorders of the Exocrine
Pancreas 1299
Chapter 331 Treatment of Pancreatic
Insufficiency 1300
Chapter 332 Pancreatitis 1300
332.1 Acute Pancreatitis 1300
332.2 Chronic Pancreatitis 1302
Chapter 333 Pseudocyst of the Pancreas 1303
Chapter 334 PancreaticTumors 1303
Section 6: The Liver and Biliary System 1304
Chapter 335 Development and Function of the Liver
and Biliary System 1304
Michael D. Bates and William F. Balistreri
Chapter 336 Manifestations of Liver Disease 1308
Vicky Lee Ng and William F. Balistreri
336.1 Evaluation of Patients with Possible Liver
Dysfunction 1312
Chapter 337 Cholestasis 1314
Hassan H. A Kader and William F. Balistreri
337.1 Neonatal Cholestasis 1314
337.2 Cholestasis in the Older Child 1319
Chapter 338 Metabolic Diseases of the Liver 1319
Jeffrey A. Rudolph and William F. Balistreri
338.1 Inherited Deficient Conjugation of Bilirubin
(Familial Nonhemolytic Unconjugated
Hyperbilirubinemia) 1320
338.2 Wilson Disease 1321
338.3 Hepatic Copper Overload Syndrome 1323
338.4 Indian Childhood Cirrhosis 1323
338.5 Neonatal Iron Storage Disease (NISD) 1323
338.6 Miscellaneous Metabolic Diseases of the Liver 1323
Chapter 339 Viral Hepatitis 1324
John D. Snyder and Larry K. Pickering
339.1 Hepatitis in Neonates 1331
Chapter 340 Liver Abscess 1332
Jeffrey Schwimmer and William F. Balistreri
Chapter 341 Liver Disease Associated with Systemic
Disorders 1333
Jeffrey Schwimmer and William F. Balistreri
Chapter 342 Reye Syndrome and the Mitochondrial
Hepatopathies 1335
Jeffrey A. Rudolph and William F. Balistreri
Chapter 343 Autoimmune (Chronic) Hepatitis 1337
Benjamin L. Shneider and Frederick J. Suchy
Chapter 344 Drug andToxin lnduced Liver
Injury 1339
Frederick J. Suchy
Chapter 345 Fulminant Hepatic Failure 1341
Frederick J. Suchy
Chapter 346 Cystic Diseases of the Biliary Tract and
Liver 1343
Frederick J. Suchy
Chapter 347 Diseases of the Gallbladder 1345
Frederick J. Suchy
Chapter 348 Portal Hypertension and
Va rices 1346
Frederick J. Suchy
Chapter 349 Liver Transplantation 1349
Kenneth L. Cox
Section 7: Peritoneum 1351
Chapter 350 Malformations 1351
Jeffrey S. Hyams
Chapter 351 Ascites 1351
Jeffreys. Hyams
351.1 Chylous Ascites 1351
Chapter 352 Peritonitis 1351
Jeffreys. Hyams
352.1 Acute Primary Peritonitis 1352
352.2 Acute Secondary Peritonitis 1352
352.3 Acute Secondary Localized Peritonitis
(Peritoneal Abscess) 1353
Chapter 353 Diaphragmatic Hernia 1353
Gary E. Hartman
353.1 Foramen of Morgagni Hernia 1355
353.2 Paraesophageal Hernia 1355
353.3 Eventration 1355
Chapter 354 Epigastric Hernia 1355
Gary E. Hartman
3 54.1 Incisional Hernia 1356
HHj|H The Respiratory System 1357
Section 1: Development and Function 1357
Chapter 355 Development of the Respiratory
System 1357
Gabriel G. Haddad and J. Julio Perez Fontdn
Contents XXXV
Chapter 356 Regulation of Respiration 1359
Gabriel G. Haddad
Chapter 357 Respiratory Pathophysiology 1362
J. Julio Perez Fontdn and Gabriel G. Haddad
357.1 Respiratory Failure 1370
J. Julio Perez Fontdn and Gabriel G. Haddad
357.2 Congenital Central Hypoventilation Syndrome
(Ondine Curse) 1372
Gabriel G. Haddad
Chapter 358 Defense Mechanisms and Metabolic
Functions of the Lung 1373
Gabriel G. Haddad and J. Julio Perez Fontdn
358.1 Defense Mechanisms 1373
358.2 Metabolic Functions 1375
Chapter 359 Diagnostic Approach to Respiratory
Disease 1375
Gabriel G. Haddad and Regina M. Palazzo
Chapter 360 Sudden Infant Death Syndrome 1380
Carl E. Hunt and Fern R. Hauck
Section 2: Upper Respiratory Tract 1386
Chapter 361 Congenital Disorders of the
Nose 1386
Joseph Haddad Jr.
Chapter 362 Acquired Disorders of the
Nose 1387
Joseph Haddad Jr.
362.1 Foreign Body 1387
362.2 Epistaxis 1387
Chapter 363 Nasal Polyps 1388
Joseph Haddad Jr.
Chapter 364 The Common Cold 1389
Ronald B. Turner and Gregory F. Hayden
Chapter 365 Sinusitis 1391
Diane E. Pappas and J. Owen Hendley
Chapter 366 Acute Pharyngitis 1393
Gregory F. Hayden and Ronald B. Turner
Chapter 367 Retropharyngeal Abscess, Lateral
Pharyngeal (Parapharyngeal) Abscess, and
Peritonsillar Cellulitis/Abscess 1394
Diane E. Pappas and J. Owen Hendley
Chapter 368 Tonsils and Adenoids 1396
Ralph F. Wetmore
Chapter 369 Obstructive Sleep Apnea and
Hypoventilation 1397
Carol L. Rosen, Lewis J. Kass, and Gabriel G. Haddad
Section 3: Disorders of the Lungs and Lower
Airways 1401
Thomas P. Green and Susanna A. McColley
Chapter 370 Chronic or Recurrent Respiratory
Symptoms 1401
Thomas F. Boat
i
XXXVi Contents
Chapter 371 Acute Inflammatory Upper Airway
Obstruction 1405
Genie E. Roosevelt
371.1 Infectious Upper Airway Obstruction 1405
371.2 Bacterial Tracheitis 1409
Chapter 372 Congenital Anomalies of the
Larynx 1409
Lauren D. Holinger
372.1 Laryngomalacia 1409
372.2 Congenital Subglottic Stenosis 1409
372.3 Vocal Cord Paralysis 1410
372.4 Congenital Laryngeal Webs and Atresia 1410
372.5 Congenital Subglottic Hemangioma 1410
372.6 Laryngoceles and Saccular Cysts 1410
372.7 Posterior Laryngeal Cleft and
Laryngotracheoesophageal Cleft 1410
Chapter 373 Foreign Bodies of the Airway 1410
Lauren D. Holinger
373.1 Laryngeal Foreign Bodies 1411
373.2 Tracheal Foreign Bodies 1411
373.3 Bronchial Foreign Bodies 1411
Chapter 374 Laryngotracheal Stenosis, Subglottic
Stenosis 1412
Lauren D. Holinger
374.1 Congenital Subglottic Stenosis 1412
374.2 Acquired Laryngotracheal Stenosis 1412
Chapter 375 Congenital Anomalies of theTrachea
and Bronchi 1412
Lauren D. Holinger
375.1 Vascular and Cardiac Anomalies 1412
375.2 Tracheal Stenoses, Webs, and Atresia 1412
375.3 Foregut Cysts 1413
Chapter 376 Bronchomalacia and
Tracheomalacia 1413
Jonathan D. Finder
Chapter 377 Neoplasms of the Larynxjrachea, and
Bronchi 1413
Lauren D. Holinger
377.1 Vocal Nodules 1413
377.2 Recurrent Respiratory Papillomatosis
(RRP) 1413
377.3 Congenital Subglottic Hemangioma 1414
377.4 Vascular Anomalies 1414
377.5 Other Laryngeal Neoplasms 1414
377.6 Tracheal Neoplasms 1414
377.7 Bronchial Tumors 1414
Chapter 378 Inflammatory Disorders of the Small
Airways 1414
Denise Goodman
378.1 Bronchitis 1414
378.2 Bronchiolitis 1415
Chapter 379 Wheezing in Infants 1417
Marzena Krawiec and Robert F. Lemanske, Jr.
Chapter 380 Emphysema and
Overinflation 1419
Steven Boas and Glenna B. Winnie
Chapter 381 ocpAntitrypsin Deficiency and
Emphysema 1421
Glenna B. Winnie and Steven Boas
Chapter 382 Other Distal Airway Diseases 1422
Steven Boas
382.1 Bronciolitis Obliterans 1422
382.2 Follicular Bronchitis 1422
382.3 Pulmonary Alveolar Microlithiasis 1422
Chapter 383 Congenital Disorders of the
Lung 1423
Thomas P. Green and Jonathan D. Finder
383.1 Pulmonary Agenesis and Aplasia 1423
383.2 Pulmonary Hypoplasia 1423
383.3 Cystic Adenomatoid Malformation 1424
383.4 Pulmonary Sequestration 1424
383.5 Bronchogenic Cysts 1425
383.6 Congenital Pulmonary Lymphangiectasia 1425
383.7 Lung Hernia 1425
383.8 Other Congenital Malformations of
the Lung 1425
Chapter 384 Pulmonary Edema 1426
Robert Mazor and Thomas P. Green
Chapter 385 Aspiration Syndromes 1427
John L. Colombo
Chapter 386 Chronic Recurrent Aspiration 1428
John L. Colombo
Chapter 387 Gastroesophageal Reflux and
Respiratory Disorders 1430
John L. Colombo
Chapter 388 Parenchymal Disease with Prominent
Hypersensitivity, Eosinophilic Infiltration, or
Toxin Mediated Injury 1430
Oren Lakser
388.1 Hypersensitivity to Inhaled Materials 1430
388.2 Silo Filler Disease 1431
388.3 Paraquat Lung 1431
388.4 Eosinophilic Lung Disease (Formerly Loffler
Syndrome) 1432
Chapter 389 Pneumonia 1432
Theodore C. Sectish and Charles G. Prober
Chapter 390 Slowly Resolving Pneumonia 1435
Oren Lakser
Chapter 391 Bronchiectasis 1436
Oren Lakser
Chapter 392 Pulmonary Abscess 1437
Oren Lakser
Chapter 393 Cystic Fibrosis 1437
Thomas F. Boat
Chapter 394 Primary Ciliary Dyskinesia (Immotile
Cilia Syndrome) 1450
Gabriel G.Haddad
Chapter 395 Interstitial Lung Diseases 1451
Michelle S. Howenstine
I
I
Chapter 396 Pulmonary Alveolar Proteinosis 1453
Aaron Hatnvas, Lawrence M. Nogee, andF. Sessions Cole
Chapter 397 Inherited Disorders of Surfactant
Protein Metabolism 1454
Aaron Hamvas, LawrenceM. Nogee, andF. Sessions Cole
Chapter 398 Pulmonary Hemosiderosis 1455
Dorr G. Dearborn
Chapter 399 Pulmonary Hemorrhage, Embolism,
and Infarction 1457
Daniel Sloniewsky and Thomas P. Green
399.1 Pulmonary Embolism and Infarction 1457
399.2 Hemoptysis 1458
Chapter 400 Atelectasis 1459
RannaA. Rozenfeld
Chapter 401 Pulmonary Tumors 1461
Susanna A. McColley and Paul R. Haut
Chapter 402 Pleurisy 1461
Glenna B. Winnie
402.1 Dry or Plastic Pleurisy 1461
402.2 Serofibrinous Pleurisy 1462
402.3 Purulent Pleurisy (Empyema) 1462
Chapter 403 Pneumothorax 1463
Glenna B. Winnie
Chapter 404 Pneumomediastinum 1465
Glenna B. Winnie
Chapter 405 Hydrothorax 1465
Glenna B. Winnie
Chapter 406 Hemothorax 1465
Glenna B. Winnie
Chapter 407 Chylothorax 1466
Glenna B. Winnie
Chapter 408 Bronchopulmonary Dysplasia 1466
Steven Lestrud
Chapter 409 Skeletal Diseases Influencing
Pulmonary Function 1467
Steven Boas
409.1 Pectus Excavatum (Funnel Chest) 1467
409.2 Pectus Carinatum and Fissuri Sterni 1468
409.3 Asphyxiating Thoracic Dystrophy
(Thoracic Pelvic Phalangeal Dystrophy) 1468
409.4 Achondroplasia 1468
409.5 Kyphoscoliosis: Adolescent Idiopathic Scoliosis and
Congential Scoliosis 1469
409.6 Congenital Rib Anomalies 1469
Chapter 410 Neuromuscular Diseases with
Pulmonary Consequences 1469
David Gozal
Chapter 411 Extrapulmonary Diseases with
Pulmonary Manifestations 1471
Susanna A. McColley
Chapter 412 Chronic Severe Respiratory
Insufficiency 1472
Zehava Noah and Cynthia Budek
Contents XXXVii
Part XIX The Cardiovascular System 1475
Section 1: Developmental Biology of the Cardiovascular
System 1475
Daniel Bernstein
Chapter 413 Cardiac Development 1475
413.1 Early Cardiac Morphogenesis 1475
413.2 Cardiac Looping 1475
413.3 Cardiac Septation 1475
413.4 Aortic Arch Development 1477
413.5 Cardiac Differentiation 1478
413.6 Developmental Changes in Cardiac Function 1478
Chapter 414 The Fetal to Neonatal Circulatory
Transition 1479
414.1 The Fetal Circulation 1479
414.2 The Transitional Circulation 1479
414.3 The Neonatal Circulation 1479
414.4 Persistent Pulmonary Hypertension of the
Neonate (Persistence of Fetal Circulatory
Pathways) 1481
Section 2: Evaluation of the Cardiovascular System 1481
Daniel Bernstein
Chapter 415 History and Physical
Examination 1481
Chapter 416 Laboratory Evaluation 1488
416.1 Radiologic Assessment 1488
416.2 Electrocardiography 1489
416.3 Hematologic Data 1493
416.4 Echocardiography 1493
416.5 Exercise Testing 1495
416.6 MRI, Electron Beam CT, and Radionuclide
Studies 1496
416.7 Cardiac Catheterization 1496
Section 3: Congenital Heart Disease 1499
Daniel Bernstein
Chapter 417 Epidemiology and Genetic Basis of
Congenital Heart Disease 1499
Chapter 418 Evaluation of the Infant or Child with
Congenital Heart Disease 1502
Chapter 419 Acyanotic Congenital Heart Disease:
The Left to Right Shunt Lesions 1503
419.1 Atrial Septal Defect 1503
419.2 Ostium Secundum Defect 1504
419.3 Sinus Venosus Atrial Septal Defect 1505
419.4 Partial Anomalous Pulmonary Venous
Return 1505
419.5 Atrioventricular Septal Defects (Ostium Primum and
Atrioventricular Canal or Endocardial Cushion
Defects) 1506
419.6 Ventricular Septal Defect 1508
419.7 Supracristal Ventricular Septal Defect with Aortic
Insufficiency 1510
419.8 Patent Ductus Arteriosus 1510
419.9 Aorticopulmonary Window Defect 1512
XXXVlii Contents
419.10 Coronary Arteriovenous Fistula
(Coronary Cameral Fistula) 1512
419.11 Ruptured Sinus of Valsalva Aneurysm 1512
Chapter 420 Acyanotic Congenital Heart Disease:
The Obstructive Lesions 1513
420.1 Pulmonary Valve Stenosis with Intact Ventricular
Septum 1513
420.2 Infundibular Pulmonary Stenosis and Double
Chamber Right Ventricle 1515
420.3 Pulmonary Stenosis in Combination with an
Intracardiac Shunt 1515
420.4 Peripheral Pulmonary Stenosis 1515
420.5 Aortic Stenosis 1516
420.6 Coarctation of the Aorta 1518
420.7 Coarctation with Ventricular Septal Defect 1520
420.8 Coarctation with Other Cardiac Anomalies and
Interrupted Aortic Arch 1520
420.9 Congenital Mitral Stenosis 1520
420.10 Pulmonary Venous Hypertension 1521
Chapter 421 Acyanotic Congenital Heart Disease:
Regurgitant Lesions 1522
421.1 Pulmonary Valvular Insufficiency and Congenital
Absence of the Pulmonary Valve 1522
421.2 Congenital Mitral Insufficiency 1522
421.3 Mitral Valve Prolapse 1522
421.4 Tricuspid Regurgitation 1523
Chapter 422 Cyanotic Congenital Heart Disease:
Evaluation of the Critically III Neonate with
Cyanosis and Respiratory Distress 1523
Chapter 423 Cyanotic Congenital Heart Lesions:
Lesions Associated with Decreased Pulmonary
Blood Flow 1524
423.1 Tetralogy of Fallot 1524
42 3.2 Pulmonary Atresia with Ventricular
Septal Defect 1528
42 3.3 Pulmonary Atresia with Intact Ventricular
Septum 1529
423.4 Tricuspid Atresia 1530
423.5 Double Outlet Right Ventricle with Pulmonary
Stenosis 1532
423.6 Transposition of the Great Arteries with Ventricular
Septal Defect and Pulmonary Stenosis 1532
423.7 Ebstein Anomaly of the Tricuspid Valve 1532
Chapter 424 Cyanotic Congenital Heart Disease:
Lesions Associated with Increased Pulmonary
Blood Flow 1534
424.1 d Transposition of the Great Arteries 1534
424.2 d Transposition of the Great Arteries with Intact
Ventricular Septum 1535
424.3 Transposition of the Great Arteries with Ventricular
Septal Defect 1536
424.4 1 Transposition of the Great Arteries (Corrected
Transposition) 1537
424.5 Double Outlet Right Ventricle Without Pulmonary
Stenosis 1538
424.6 Double Outlet Right Ventricle with
Transposition of the Great Arteries (Taussig Bing
Anomaly) 1538
424.7 Total Anomalous Pulmonary Venous Return 1538
424.8 Truncus Arteriosus 1540
424.9 Single Ventricle (Double Inlet Ventricle,
Univentricular Heart) 1541
424.10 Hypoplastic Left Heart Syndrome 1541
424.11 Abnormal Positions of the Heart and the
Heterotaxy Syndromes (Asplenia,
Polysplenia) 1544
Chapter 425 Other Congenital Heart and Vascular
Malformations 1545
42 5.1 Anomalies of the Aortic Arch 1545
42 5.2 Anomalous Origin of the Coronary Arteries 1545
425.3 Pulmonary Arteriovenous Fistula 1547
425.4 Ectopia Cordis 1548
42 5.5 Diverticulum of the Left Ventricle 1548
Chapter 426 Pulmonary Hypertension 1548
426.1 Primary Pulmonary Hypertension 1548
426.2 Pulmonary Vascular Disease (Eisenmenger
Syndrome) 1549
Chapter 427 General Principles of Treatment of
Congenital Heart Disease 1551
Section 4: Cardiac Arrhythmias 1554
AnneDubin
Chapter 428 Disturbances of Rate and Rhythm
of the Heart 1554
428.1 Sinus Arrhythmias and Extrasystoles 15 54
428.2 Supraventricular Tachycardia 1559
428.3 Ventricular Tachyarrhythmias 1561
428.4 Long Q T Syndrome 1562
428.5 Bradyarrhythmias 1562
428.6 Sick Sinus Syndrome 1563
428.7 Sudden Death 1563
Section 5: Acquired Heart Disease 1565
Daniel Bernstein
Chapter 429 Infective Endocarditis 1565
Chapter 430 Rheumatic Heart Disease 1570
Section 6: Diseases of the Myocardium and
Pericardium 1572
Daniel Bernstein
Chapter 431 Diseases of the Myocardium 1572
431.1 Dilated Cardiomyopathy 1572
431.2 Hypertrophic Cardiomyopathy 1575
431.3 Restrictive Cardiomyopathy 1576
431.4 Myocarditis 1576
431.5 Nonviral Causes of Myocarditis 1577
431.6 Endocardial Fibroelastosis 1578
Chapter 432 Diseases of the Pericardium 1579
432.1 Constrictive Pericarditis 1581
Chapter 433 Tumors of the Heart 1581
Section 7: Cardiac Therapeutics 1582
Daniel Bernstein
Chapter 434 Heart Failure 1582
434.1 Cardiogenic Shock 1586
Chapter 435 Pediatric Heart and Heart Lung
Transplantation 1587
435.1 Pediatric Heart Transplantation 1587
435.2 Heart Lung and Lung Transplantation 1590
Section 8: Diseases of the Peripheral Vascular
System 1591
Daniel Bernstein
Chapter 436 Disease of the Blood Vessels
(Aneurysms and Fistulas) 1591
436.1 Kawasaki Disease 1591
436.2 Arteriovenous Fistulas 1591
Chapter 437 Systemic Hypertension 1592
HHIJ Diseases of the Blood 1599
Section 1: The Hematopoietic System 1599
Chapter 438 Development of the Hematopoietic
System 1599
Robin K. Ohls and Robert D. Christensen
Chapter 439 The Anemias 1604
Bertil Glader
Section 2: Anemias of Inadequate Production 1606
Bertil Glader
Chapter 440 Congenital Hypoplastic Anemia
(Diamond Blackfan Anemia) 1606
Chapter 441 Pearson Marrow Pancreas
Syndrome 1607
Chapter 442 Acquired Pure Red Blood Cell
Anemias 1608
Chapter 443 Anemia of Chronic Disorders
(ACD) and Renal Disease 1609
Chapter 444 Congenital Dyserythropoietic
Anemias (CDA) 1609
Chapter 445 Physiologic Anemia of Infancy 1610
Chapter 446 Megaloblastic Anemias 1611
446.1 Folk Acid Deficiency 1611
446.2 Vitamin B12 (Cobalamin) Deficiency 1612
446.3 Other Rare Megaloblastic Anemias 1613
Chapter 447 Iron Deficiency Anemia 1614
Chapter 448 Other Microcytic Anemias 1616
Section 3: Hemolytic Anemias 1617
Chapter 449 Definitions and Classification of
Hemolytic Anemias 1617
George B.Segel
Chapter 450 Hereditary Spherocytosis 1620
GeorgeB. Segel
Contents XXXJX
Chapter 451 Hereditary Elliptocytosis 1622
George B. Segel
Chapter 452 Hereditary Stomatocytosis 1622
George B. Segel
Chapter 453 Other Membrane Defects 1622
George B. Segel
Chapter 454 Hemoglobin Disorders 1623
Keith Quirolo and Elliott Vichinsky
454.1 Sickle Cell Disease 1624
454.2 Sickle Cell Trait (Hemoglobin AS) 1628
454.3 Other Hemoglobinopathies 1629
454.4 Unstable Hemoglobin Disorders 1629
454.5 Abnormal Hemoglobins with Increased Oxygen
Affinity 1629
454.6 Abnormal Hemoglobins Causing
Cyanosis 1629
454.7 Hereditary Methemoglobinemia 1629
454.8 Syndromes of Hereditary Persistence of Fetal
Hemoglobin (HPFH) 1630
454.9 Thalassemia Syndromes 1630
Chapter 455 Enzymatic Defects 1635
George B. Segel
455.1 Pyruvate Kinase (PK) Deficiency 1635
455.2 Other Glycolytic Enzyme Deficiencies 1636
455.3 Glucose 6 Phosphate Dehydrogenase (G6PD) and
Related Deficiencies 1636
Chapter 456 Hemolytic Anemias Resulting from
Extracellular Factors 1638
George B. Segel
Chapter 457 Hemolytic Anemias Secondary to Other
Extracellular Factors 1640
George B. Segel
Section 4: Polycythemia (Erythrocytosis) 1641
Bruce M. Camitta
Chapter 458 Primary Polycythemia (Polycythemia
RubraVera) 1641
Chapter 459 Secondary Polycythemia 1641
Section S: The Pancytopenias 1642
Chapter 460 The Constitutional
Pancytopenias 1642
Alan D.WAndrea
Chapter 461 The Acquired Pancytopenias 1644
Jeffrey D.Hord
Section 6: Risks of Blood Component
Transfusions 1646
Ronald G. Strauss
Chapter 462 Red Blood Cell Transfusions and
ErythropoietinTherapy 1646
Chapter 463 PlateletTransfusions 1647
Chapter 464 Neutrophil (Granulocyte)
Transfusions 1648
xl Contents
Chapter 465 Fresh Frozen Plasma
Transfusions 1649
Chapter 466 Risks of BloodTransfusions 1650
Section 7: Hemorrhagic and Thrombotic Diseases 1651
Robert R. Montgomery and J. Paul Scott
Chapter 467 Hemostasis 1651
467.1 Hemostatic Mechanism 1651
467.2 The Clinical and Laboratory Evaluation 1653
Chapter 468 Hereditary Clotting Factor Deficiencies
(Bleeding Disorders) 1657
468.1 Factor VIII or Factor IX Deficiency
(Hemophilia A or B) 1657
468.2 Factor XI Deficiency (Hemophilia C) 1660
468.3 Deficiencies of the Contact Factors
(Nonbleeding Disorders) 1660
468.4 Factor VII Deficiency 1661
468.5 Factor X Deficiency 1661
468.6 Prothrombin (Factor II) Deficiency 1661
468.7 Factor V Deficiency 1661
468.8 Combined Deficiency of Factors V and VIII 1661
468.9 Fibrinogen Deficiency 1661
468.10 Factor XIII Deficiency (Fibrin Stabilizing Factor or
Transglutaminase Deficiency) 1661
468.11 Antiplasmin or Plasminogen Activator Inhibitor
(PAI) Deficiency 1662
Chapter 469 von Willebrand Disease 1662
Chapter 470 Hereditary Predisposition to
Thrombosis 1664
Chapter 471 Acquired Thrombotic Disorders 1665
471.1 Anticoagulant and Thrombolytic Therapy 1666
Chapter 472 Postneonatal Vitamin K
Deficiency 1668
Chapter 473 Liver Disease 1668
Chapter 474 Acquired Inhibitors of
Coagulation 1668
Chapter 475 Disseminated Intravascular
Coagulation (Consumptive Coagulopathy) 1669
Chapter 476 Platelet and Blood Vessel
Disorders 1670
476.1 Idiopathic Thrombocytopenic Purpura 1670
476.2 Drug Induced Thrombocytopenia 1671
476.3 Nonimmune Platelet Destruction 1671
476.4 Hemolytic Uremic Syndrome (HUS) 1671
476.5 Thrombotic Thrombocytopenic Purpura (TTP) 1672
476.6 Kasabach Merritt Syndrome 1672
476.7 Sequestration 1672
476.8 Congenital Thrombocytopenic Syndromes 1672
476.9 Neonatal Thrombocytopenia 1672
476.10 Thrombocytopenia Due to Acquired Disorders
Causing Decreased Production 1673
476.11 Platelet Function Disorders 1673
476.12 Acquired Disorders of Platelet Function 1673
476.13 Congenital Abnormalities of Platelet Function 1673
476.14 Disorders of the Blood Vessels 1674
Section 8: The Spleen 1675
James French and Bruce M. Camitta
Chapter 477 Anatomy and Function of the
Spleen 1675
Chapter 478 Splenomegaly 1675
Chapter 479 Hyposplenism, Splenic Trauma, and
Splenectomy 1676
Section 9: The Lymphatic System 1677
Bruce M. Camitta
Chapter 480 Anatomy and Function of the
Lymphatic System 1677
Chapter 481 Abnormalities of Lymphatic
Vessels 1677
Chapter 482 Lymphadenopathy 1677
JHHH Cancer and Benign Tumors 1679
Chapter 483 Epidemiology of Childhood and
Adolescent Cancer 1679
James G. Gurney and Melissa L. Bondy
Chapter 484 Molecular and Cellular Biology of
Cancer 1681
Laura L. Worth
Chapter 485 Principles of Diagnosis 1684
Archie Bleyer
Chapter 486 Principles of Treatment 1688
Archie Bleyer
Chapter 487 The Leukemias 1694
David G. Tuber gen and Archie Bleyer
487.1 Acute Lymphoblastic Leukemia 1694
487.2 Acute Myelogenous Leukemia 1696
487.3 Down Syndrome and Acute Leukemia and
Myeloproliferation 1697
487.4 Chronic Myelogenous Leukemia 1697
487.5 Juvenile Chronic Myelogenous
Leukemia 1698
487.6 Infant Leukemia 1698
Chapter 488 Lymphoma 1698
Geralds. Gilchrist
488.1 Hodgkin Disease 1698
488.2 Non Hodgkin Lymphoma 1701
Chapter 489 BrainTumors in Childhood 1702
John F. Kuttesch, Jr. and Joann L. Ater
Chapter 490 Neuroblastoma 1709
Joann L. Ater
Chapter 491 Neoplasms of the Kidney 1711
Norman Jaffe and Vicki Huff
Chapter 492 SoftTissue Sarcomas 1714
CarolaA. S.Arndt
Chapter 493 Neoplasms of Bone 1717
CarolaA. S.Arndt
493.1 Malignant Tumors of Bone 1717
493.2 Benign Tumors and Tumor like Processes of
Bone 1720
Chapter 494 Retinoblastoma 1722
Cynthia E. Herzos
Chapter 495 Gonadal and Germ Cell
Neoplasms 1723
Cynthia E. Herzog
Chapter 496 Neoplasms of the Liver 1725
Cynthia E. Herzog
Chapter 497 Benign Vascular Tumors 1726
Cynthia E. Herzog
Chapter 498 Rare Tumors 1726
Cynthia E. Herzog
Chapter 499 Histiocytosis Syndromes of
Childhood 1727
Stephan Ladisch
RSIM Nephrology 1731
Section 1: Glomerular Disease 1731
Ira D. Davis and Ellis D. Avner
Chapter 500 Introduction to Glomerular
Diseases 1731
500.1 Anatomy of the Glomerulus 1731
500.2 Glomerular Filtration 1732
500.3 Glomerular Diseases 1734
Section 2: Conditions Particularly Associated with
Hematuria 1735
Ira D. Davis and Ellis D. Avner
Chapter 501 Clinical Evaluation of the Child with
Hematuria 1735
Chapter 502 Isolated Glomerular Diseases with
Recurrent Gross Hematuria 1737
502.1 IgA Nephropathy (Berger Nephropathy) 1737
502.2 Alport Syndrome 1738
502.3 Thin Glomerular Basement Membrane
Disease 1739
Chapter 503 Glomerulonephritis Associated with
Infections 1740
503.1 Acute Poststreptococcal Glomerulonephritis 1740
503.2 Other Chronic Infections 1741
Chapter 504 Membranous Glomerulopathy
(Glomerulonephritis) 1741
Chapter 505 Membranoproliferative
(Mesangiocapillary) Glomerulonephritis 1742
Chapter 506 Glomerulonephritis Associated with
Systemic Lupus Erythematosus 1743
Contents xli
Chapter 507 Henoch Schonlein Purpura
Nephritis 1744
Chapter 508 Rapidly Progressive (Crescentic)
Glomerulonephritis 1745
Chapter 509 Goodpasture Disease 1745
Chapter 510 Hemolytic Uremic
Syndrome 1746
Chapter 511 Upper Urinary Tract Causes of
Hematuria 1747
511.1 Interstitial Nephritis 1747
511.2 Toxic Nephropathy 1747
511.3 Cortical Necrosis 1747
511.4 Pyelonephritis 1747
511.5 Nephrocalcinosis 1747
511.6 Vascular Abnormalities 1747
511.7 Renal Vein Thrombosis 1747
511.8 Idiopathic Hypercalciuria 1748
Chapter 512 Hematologic Diseases Causing
Hematuria 1748
512.1 Sickle Cell Nephropathy 1748
512.2 Coagulopathies and
Thrombocytopenia 1749
Chapter 513 Anatomic Abnormalities Associated
with Hematuria 1749
513.1 Congenital Anomalies 1749
513.2 Autosomal Recessive Polycystic Kidney
Disease 1749
513.3 Autosomal Dominant Polycystic Kidney
Disease 1750
513.4 Trauma 1750
513.5 RenalTumors 1750
Chapter 514 Lower Urinary Tract Causes of
Hematuria 1751
514.1 Infectious Causes of Cystitis and
Urethritis 1751
514.2 Hemorrhagic Cystitis 1751
514.3 Heavy Exercise 1751
514.4 Munchausen Syndrome by Proxy 1751
Section 3: Conditions Particularly Associated with
Proteinuria 1751
Beth A. Vogt and Ellis D. Avner
Chapter 515 Introduction to the Child with
Proteinuria 1751
Chapter 516 Transient Proteinuria 1752
Chapter 517 Orthostatic (Postural)
Proteinuria 1752
Chapter 518 Fixed Proteinuria 1752
518.1 Glomerular Proteinuria 1752
518.2 Tubular Proteinuria 1753
Chapter 519 Nephrotic Syndrome 1753
519.1 Idiopathic Nephrotic Syndrome 1755
519.2 Secondary Nephrotic Syndrome 1757
519.3 Congenital Nephrotic Syndrome 1757
(lii Contents
Section 4: Tubular Disorders 1758
Chapter 520 Tubular Function 1758
Katherine MacRae Dell and Ellis D. Avner
Chapter 521 RenalTubularAcidosis 1758
521.1 Proximal (Type II) Renal Tubular Acidosis 1759
Katherine MacRae Dell and Ellis D. Avner
521.2 Distal (Type I) Renal Tubular Acidosis 1760
Katherine MacRae Dell and Ellis D. Avner
521.3 Hyperkalemic (Type IV) Renal Tubular
Acidosis 1761
Katherine MacRae Dell and Ellis D. Avner
521A Rickets Associated with Renal Tubular
Acidosis 1762
Russell W. Chesney
Chapter 522 Nephrogenic Diabetes Insipidus 1762
Katherine MacRae Dell and Ellis D. Avner
Chapter 523 Bartter/Gitelman Syndromes and Other
InheritedTubularTransport Abnormalities 1763
Katherine MacRae Dell and Ellis D. Avner
523.1 Bartter Syndrome 1763
523.2 Gitelman Syndrome 1764
523.3 Other Inherited Tubular Transport
Abnormalities 1764
Chapter 524 Tubulointerstitial Nephritis 1764
Katherine MacRae Dell and Ellis D. Avner
Section 5: Toxic Nephropathies—Renal Failure 1766
Chapter 525 Toxic Nephropathy 1766
Beth A. Vogt and Ellis D. Avner
Chapter 526 Cortical Necrosis 1767
Beth A. Vogt and Ellis D. Avner
Chapter 527 Renal Failure 1767
Beth A. Vogt and Ellis D. Avner
527.1 Acute Renal Failure 1767
527.2 Chronic Renal Failure 1771
527.3 End Stage Renal Disease 1774
Chapter 528 RenalTransplantation 1775
Rodrigo E. Urizar
j||j|j|W| Urologic Disorders in Infants and
IhHH Children i7«o
Jack S. Elder
Chapter 529 Congenital Anomalies and Dysgenesis
of the Kidneys 1783
Chapter 530 Urinary Tract Infections 1785
Chapter 531 VesicoureteraI Reflux 1790
Chapter 532 Obstructions of the Urinary Tract 1794
Chapter 533 Anomalies of the Bladder 1804
Chapter 534 Neuropathic Bladder 1806
Chapter 535 Voiding Dysfunction 1808
Chapter 536 Anomalies of the Penis and
Urethra 1812
Chapter 537 Disorders and Anomalies of the Scrotal
Contents 1817
Chapter 538 Trauma to the Genitourinary
Tract 1821
Chapter 539 Urinary Lithiasis 1822
l*Sf!t)60¥ Gynecologic Problems of
.g^gjvp^ Childhood 1827 Joseph S. Sanfilippo
Chapter 540 History and Physical
Examination 1827
Chapter 541 Vulvovaginitis 1828
Chapter 542 Bleeding 1833
Chapter 543 Breast Disorders 1833
Chapter 544 Hirsutism and Polycystic Ovarian
Syndrome 1835
Chapter 545 Neoplasms 1837
Chapter 546 Vulvovaginal and Miillerian
Anomalies 1839
Chapter 547 Athletic Gynecologic Problems 1842
Chapter 548 Special Gynecologic Needs 1843
Chapter 549 Gynecologic Imaging 1843
lljijllll The Endocrine System 1845
Section 1: Disorders of the Hypothalamus and Pituitary
Gland 1845
Chapter 550 Hormones of the Hypothalamus and
Pituitary 1845
John S. Parks
Chapter 551 Hypopituitarism 1847
John S. Parks
Chapter 552 Diabetes Insipidus 1853
David T. Breault and Joseph A. Majzoub
552.1 Causes of Hypernatremia 1854
Chapter 553 Other Abnormalities of Arginine
Vasopressin Metabolism and Action 1855
David T. Breault and Joseph A. Majzoub
Chapter 554 Hyperpituitarism,Tall Stature, and
Overgrowth Syndromes 1857
Pinchas Cohen
Chapter 555 Physiology of Puberty 1862
Luigi Garibaldi
Chapter 556 Disorders of Pubertal
Development 1863
Luigi Garibaldi
556.1 Gonadotropin Dependent Precocious
Puberty 1863
556.2 Precocious Puberty Resulting from Organic Brain
Lesions 1865
556.3 Precocious Puberty Following Irradiation of the
Brain 1866
556.4 Syndrome of Precocious Puberty and
Hypothyroidism 1866
556.5 Gonadotropin Secreting Tumors 1867
556.6 McCune Albright Syndrome (Precocious Puberty
with Polyostotic Fibrous Dysplasia and Abnormal
Pigmentation) 1867
556.7 Familial Male Gonadotropin Independent
Precocious Puberty 1868
556.8 Incomplete (Partial) Precocious
Development 1868
556.9 Medicational Precocity 1869
Section 2: Disorders of the Thyroid Gland 1870
Stephen LaFranchi
Chapter 557 Thyroid Development and
Physiology 1870
557.1 Thyroid Hormone Studies 1871
Chapter 558 Defects of Thyroxine Binding
Globulin 1872
Chapter 559 Hypothyroidism 1872
Chapter 560 Thyroiditis 1879
Chapter 561 Goiter 1881
561.1 Congenital Goiter 1881
561.2 Endemic Goiter and Cretinism 1882
561.3 Sporadic Goiter 1883
561.4 Intratracheal Goiter 1883
Chapter 562 Hyperthyroidism 1884
562.1 Graves Disease 1884
562.2 Congenital Hyperthyroidism 1886
Chapter 563 Carcinoma of the
Thyroid 1887
563.1 Solitary Thyroid Nodule 1888
563.2 Medullary Carcinoma 1889
Section 3: Disorders of the Parathyroid 1890
Daniel A. Doyle and Angelo M. DiGeorge
Chapter 564 Hormones and Peptides of
Calcium Homeostasis and Bone
Metabolism 1890
Chapter 565 Hypoparathyroidism 1892
Chapter 566 Pseudohypoparathyroidism
(Albright Hereditary Osteodystrophy) 1894
Chapter 567 Hyperparathyroidism 1895
Contents xliii
Section 4: Disorders of the Adrenal Glands 1898
Lenore S. Levirte and Perrin C. White
Chapter 568 The Physiology of the Adrenal
Gland 1898
568.1 Histology and Embryology 1898
568.2 Adrenal Steroid Biosynthesis 1899
568.3 Regulation of the Adrenal Cortex 1900
568.4 Adrenal Steroid Hormone Actions 1901
568.5 Adrenal Medulla 1904
Chapter 569 Adrenocortical Insufficiency 1904
569.1 Primary Adrenal Insufficiency 1904
569.2 Secondary Adrenal Insufficiency 1908
Chapter 570 Congenital Adrenal Hyperplasia and
Related Disorders 1909
570.1 Congenital Adrenal Hyperplasia due to
21 Hydroxylase Deficiency 1909
570.2 Congenital Adrenal Hyperplasia due to
11 P Hydroxylase Deficiency 1913
570.3 Congenital Adrenal Hyperplasia due to 30
Hydroxysteriod Dehydrogenase Deficiency 1913
570.4 Congenital Adrenal Hyperplasia due to
17 Hydroxylase Deficiency 1914
570.5 Lipoid Adrenal Hyperplasia 1914
570.6 Aldosterone Synthase Deficiency 1915
570.7 Glucocorticoid Suppressible
Hyperaldosteronism 1915
Chapter 571 Cushing Syndrome 1916
Chapter 572 PrimaryAldosteronism 1918
Chapter 573 AdrenalTumors 1918
573.1 Virilizing Adrenocortical Tumors 1918
573.2 Feminizing Adrenal Tumors 1919
Chapter 574 Pheochromocytoma 1919
Chapter 575 Adrenal Masses 1920
575.1 Adrenal Incidentaloma 1920
575.2 Adrenal Calcification 1921
Section 5: Disorders of the Gonads 1921
Robert Rapaport
Chapter 576 Development and Function of the
Gonads 1921
Chapter 577 HypofunctionoftheTestes 1924
577.1 Hypergonadotropic Hypogonadism in the Male
(Primary Hypogonadism) 1924
577.2 Hypogonadotropic Hypogonadism in the Male
(Secondary Hypogonadism) 1927
Chapter 578 Pseudoprecocity Resulting from
Tumors of theTestes 1930
Chapter 579 Gynecomastia 1930
Chapter 580 Hypofunction of the Ovaries 1931
580.1 Hypergonadotropic Hypogonadism in the Female
(Primary Hypogonadism) 1931
580.2 Hypogonadotropic Hypogonadism in the Female
(Secondary Hypogonadism) 1935
xliv Contents
Chapter 581 Pseudoprecocity Due to Lesions of the
Ovary 1937
Chapter 582 Intersex 1939
582.1 46,XX Intersex (46,XX with Virilization) 1940
582.2 46,XY Intersex (46,XY with Undervirilization) 1940
582.3 True Gonadal Intersex 1945
Section 6: Diabetes Mellitus in Children 1947
Ramin Alemzadeh and David T. Wyatt
Chapter 583 Diabetes Mellitus 1947
583.1 Introduction and Classification 1947
583.2 Type 1 Diabetes Mellitus (Immune
Mediated) 1948
583.3 Type 2 Diabetes Mellitus 1967
583.4 Other Specific Types of Diabetes 1968
iflMiSt ™e Nervous System 1973
Chapter 584 Neurologic Evaluation 1973
Robert H. A. Haslam
Chapter 585 Congenital Anomalies of the Central
Nervous System 1983
Michael V. Johnston and Stephen Kinsman
585.1 Neural Tube Defects (Dysraphism) 1983
585.2 Spina Bifida Occulta 1983
585.3 Meningocele 1983
585.4 Myelomeningocele 1984
585.5 Encephalocele 1985
585.6 Anencephaly 1986
585.7 Disorders of Neuronal Migration 1986
585.8 Agenesis of the Corpus Callosum 1987
585.9 Agenesis of the Cranial Nerves 1988
585.10 Microcephaly 1988
585.11 Hydrocephalus 1989
585.12 Craniosynostosis 1992
Chapter 586 Seizures in Childhood 1993
Michael V. Johnston
586.1 Febrile Seizures 1994
586.2 Unprovoked Seizures 1994
586.3 Partial Seizures 1995
586.4 Generalized Seizures 1997
586.5 Mechanisms of Seizures 1999
586.6 Treatment of Epilepsy 1999
586.7 Neonatal Seizures 2005
586.8 Status Epilepticus 2007
Chapter 587 Conditions that Mimic Seizures 2009
Michael V. Johnston
Chapter 588 Headaches 2012
Robert H. A. Haslam
588.1 Migraine 2012
588.2 Organic Headaches 2014
588.3 Tension or Stress Headaches 2015
Chapter 589 Neurocutaneous Syndromes 2015
Robert H. A. Haslam
589.1 Neurofibromatosis 2015
589.2 Tuberous Sclerosis 2017
589.3 Sturge Weber Disease 2017
589.4 von Hippel Lindau Disease 2019
589.5 Linear Nevus Syndrome 2019
589.6 PHACE Syndrome 2019
Chapter 590 Movement Disorders 2019
Michael V. Johnston
590.1 Ataxias 2019
590.2 Chorea, Athetosis, Tremor 2020
590.3 Dystonia 2022
590.4 Tics 2023
Chapter 591 Encephalopathies 2023
Michael V. Johnston
591.1 Cerebral Palsy 2024
591.2 MitochondrialEncephalomyopathies 2025
591.3 Other Encephalopathies 2027
Chapter 592 Neurodegenerative Disorders of
Childhood 2029
Michael V. Johnston
592.1 Sphingolipidoses 2029
592.2 Neuronal Ceroid Lipofuscinoses 2032
592.3 Adrenoleukodystrophy 2032
592.4 Sialidosis 2033
592.5 Miscellaneous Disorders 2033
Chapter 593 Acute Stroke Syndromes 2035
Michael V. Johnston
593.1 Arterial Thrombosis/Embolism 2035
593.2 Venous Thrombosis 2036
593.3 Intracranial Hemorrhage 2036
593.4 Differential Diagnosis of Strokelike
Events 2037
Chapter 594 Central Nervous System
Infections 2038
Charles G. Prober
594.1 Acute Bacterial Meningitis Beyond the Neonatal
Period 2038
594.2 Viral Meningoencephalitis 2044
594.3 Eosinophilic Meningitis 2046
Chapter 595 Brain Abscess 2047
Robert H. A. Haslam
Chapter 596 Pseudotumor Cerebri 2048
Robert H. A. Haslam
Chapter 597 Spinal Cord Disorders 2049
Robert H. A. Haslam
597.1 Spinal Cord Tumors 2049
597.2 Spinal Cord Trauma 2050
597.3 Tethered Cord 2050
597.4 Diastematomyelia 2051
597.5 Syringomyelia 2051
597.6 Transverse Myelitis 2051
597.7 Arteriovenous Malformation 2052
UHB Neuromuscular Disorders 2053
Harvey B. Sarnat
Chapter 598 Evaluation and Investigation 2053
j
Chapter 599 Developmental Disorders of
Muscle 2055
599.1 Myotubular Myopathy 2056
599.2 Congenital Muscle Fiber Type Disproportion
(CMFTD) 2057
599.3 Nemaline Rod Myopathy 2058
599.4 Central Core Disease 2059
599.5 Brain Malformations and Muscle
Development 2059
599.6 Amyoplasia 2059
599.7 Muscular Dysgenesis (Proteus Syndrome
Myopathy) 2059
599.8 Benign Congenital Hypotonia 2059
599.9 Arthrogryposis 2059
Chapter 600 Muscular Dystrophies 2060
600.1 Duchenne and Becker Muscular
Dystrophies 2060
600.2 Emery Dreifuss Muscular Dystrophy 2064
600.3 Myotonic Muscular Dystrophy 2064
600.4 Limb Girdle Muscular Dystrophy 2066
600.5 Facioscapulohumeral Muscular
Dystrophy 2067
600.6 Congenital Muscular Dystrophy 2067
Chapter 601 Endocrine Myopathies 2069
Chapter 602 Metabolic Myopathies 2070
602.1 Periodic Paralyses (Potassium Related) 2070
602.2 Malignant Hyperthermia 2070
602.3 Glycogenoses 2070
602.4 Mitochondria! Myopathies 2071
602.5 Lipid Myopathies 2072
602.6 Vitamin E Deficiency Myopathy 2072
Chapter 603 Disorders of Neuromuscular
Transmission and of Motor Neurons 2072
603.1 Myasthenia Gravis 2072
603.2 Spinal Muscular Atrophies 2075
603.3 Other Motor Neuron Diseases 2076
Chapter 604 Hereditary Motor Sensory
Neuropathies 2076
604.1 Peroneal Muscular Atrophy (Charcot Marie Tooth
Disease; HMSN Type I) 2076
604.2 Peroneal Muscular Atrophy
(Axonal Type) 2077
604.3 Dejerine Sottas Disease (HMSN Type III) 2077
604.4 Roussy Levy Syndrome 2077
604.5 Refsum Disease 2077
604.6 Fabry Disease 2077
604.7 Giant Axonal Neuropathy 2078
604.8 Congenital Hypomyelinating
Neuropathy 2078
604.9 Tomaculous Neuropathy 2078
604.10 Leukodystrophies 2078
Chapter 605 Toxic Neuropathies 2078
Chapter 606 Autonomic Neuropathies 2079
606.1 Familial Dysautonomia 2079
606.2 Other Autonomic Neuropathies 2079
Chapter 607 Guillain Barre Syndrome 2080
Chapter 608 Bell Palsy 2081
Contents xlv
PartXXVftt* Disorders of the Eye 2083
Scott E. Olitsky and Leonard B. Nelson
Chapter 609 Growth and Development 2083
Chapter 610 Examination of the Eye 2084
Chapter 611 Abnormalities of Refraction and
Accommodation 2086
Chapter 612 Disorders of Vision 2087
Chapter 613 Abnormalities of Pupil and Iris 2089
Chapter 614 Disorders of Eye Movement and
Alignment 2092
Chapter 615 Abnormalities of the Lids 2097
Chapter 616 Disorders of the Lacrimal
System 2099
Chapter 617 Disorders of the Conjunctiva 2099
Chapter 618 Abnormalities of the Cornea 2103
Chapter 619 Abnormalities of the Lens 2105
Chapter 620 Disorders of the UvealTract 2111
Chapter 621 Disorders of the Retina and
Vitreous 2113
Chapter 622 Abnormalities of the Optic
Nerve 2119
Chapter 623 Childhood Glaucoma 2122
Chapter 624 Orbital Abnormalities 2123
Chapter 625 Injuries to the Eye 2124
(¦(¦¦The Ear 2127
Chapter 626 Clinical Manifestations 2127
Joseph Haddad Jr.
Chapter 627 Hearing Loss 2129
Joseph Haddad Jr.
Chapter 628 Congenital Malformations 2135
Joseph Haddad Jr.
Chapter 629 Diseases of the External Ear 2136
Joseph Haddad Jr.
Chapter 630 Otitis Media 2138
Jack L. Paradise
Chapter 631 The Inner Ear and Diseases of the Bony
Labyrinth 2149
Joseph Haddad Jr.
Chapter 632 Traumatic Injuries of the Ear and
Temporal Bone 2150
Joseph Haddad Jr.
xlvi Contents
Chapter 633 Tumors of the Ear andTemporal
Bone 2151
Joseph Haddad Jr.
Gary L. Darmstadt and Robert Sidbury
Chapter 634 Morphology of the Skin 2153
Chapter 635 Evaluation of the Patient 2154
635.1 Cutaneous Manifestations of Systemic
Diseases 2155
Chapter 636 Principles of Therapy 2159
Chapter 637 Diseases of the Neonate 2161
Chapter 638 Cutaneous Defects 2164
Chapter 639 Ectodermal Dysplasias 2166
Chapter 640 Vascular Disorders 2167
Chapter 641 Cutaneous Nevi 2172
Chapter 642 Hyperpigmented Lesions 2176
Chapter 643 Hypopigmented Lesions 2178
Chapter 644 Vesiculobullous Disorders 2181
Chapter 645 Eczematous Disorders 2188
Chapter 646 Photosensitivity 2191
Chapter 647 Diseases of the Epidermis 2195
Chapter 648 Disorders of Keratinization 2200
Chapter 649 Diseases of the Dermis 2204
Chapter 650 Diseases of Subcutaneous
Tissue 2210
Chapter 651 Disorders of the Sweat
Glands 2213
Chapter 652 Disorders of Hair 2215
Chapter 653 Disorders of the Nails 2219
Chapter 654 Disorders of the Mucous
Membranes 2220
Chapter 655 Cutaneous Bacterial
Infections 2222
Chapter 656 Cutaneous Fungal Infections 2230
Chapter 657 Cutaneous Viral Infections 2235
Chapter 658 Arthropod Bites and
Infestations 2237
Chapter 659 Acne 2242
Chapter 660 Tumors of the Skin 2246
Chapter 661 Nutritional Dermatoses 2248
PartXXXI Bone and Joint Disorders 2251
Section 1: Orthopedic Problems 2251
Chapter 662 Growth and Development 2251
George H. Thompson
Chapter 663 Evaluation of the Child 2251
George H. Thompson
Chapter 664 The Foot and Toes 2254
George H. Thompson
664.1 Metatarsus Adductus 2255
664.2 Calcaneovalgus Feet 2255
664.3 Talipes Equinovarus (Clubfoot) 2256
664.4 Congenital Vertical Talus 2256
664.5 Hypermobile Pes Planus (Flexible Flatfeet) 2257
664.6 Tarsal Coalition 2257
664.7 CavusFeet 2257
664.8 Osteochondroses 2257
664.9 Puncture Wounds of the Foot 2258
664.10 Toe Deformities 2258
664.11 Painful Foot 2260
664.12 Shoes 2260
Chapter 665 Torsional and Angular
Deformities 2261
George H. Thompson
665.1 Normal Developmental Alignment 2261
665.2 Internal Femoral Torsion 2262
665.3 Internal Tibial Torsion 2263
665.4 External Femoral Torsion 2263
665.5 External Tibial Torsion 2264
665.6 Genu Varum (Bowlegs) 2264
665.7 Genu Valgum (Knock Knees) 2266
66 5.8 Congenital Angular Deformities of the Tibia and
Fibula 2269
Chapter 666 Leg Length Discrepancy 2270
George H. Thompson
Chapter 667 The Knee 2271
George H. Thompson
667.1 Discoid Lateral Meniscus 2272
667.2 Popliteal Cyst 2272
667.3 Osteochondritis Dissecans 2272
667.4 Osgood Schlatter Disease 2272
667.5 Idiopathic Adolescent Anterior Knee Pain
Syndrome 2272
667.6 Patella Subluxation and Dislocation 2273
Chapter 668 The Hip 2273
George H. Thompson
668.1 Developmental Dysplasia of the Hip 2273
668.2 Transient Monoarticular Synovitis 2276
668.3 Legg Calve Perthes Disease 2276
668.4 Slipped Capital Femoral Epiphysis 2278
Chapter 669 The Spine 2280
George H. Thompson
669.1 Idiopathic Scoliosis 2280
669.2 Congenital Scoliosis 2282
669.3 Neuromuscular Scoliosis, Genetic Syndromes, and
Compensatory Scoliosis 2283
669.4 Kyphosis (Round Back) 2284
669.5 Back Pain in Children 2285
669.6 Spondylolysis and Spondylolisthesis 2285
669.7 Disk Space Infection 2286
669.8 Intervertebral Disk Herniation 2287
669.9 Tumors 2287
Chapter 670 The Neck 2288
George H. Thompson
670.1 Torticollis 2288
670.2 Klippel Feil Syndrome 2289
670.3 Atlantoaxial Instability 2289
Chapter 671 The Upper Limb 2290
George H. Thompson
671.1 Sprengel Deformity 2290
671.2 Shoulder Dislocation 2290
671.3 Nursemaid's Elbow 2290
671.4 Panner Disease 2291
671.5 Ganglion 2291
671.6 Radial Clubhand 2291
671.7 Polydactyly 2292
671.8 Syndactyly 2292
671.9 Congenital Trigger Thumb and Finger 2292
Chapter 672 Arthrogryposis 2292
George H. Thompson
672.1 Amyoplasia 2292
Chapter 673 Common Fractures 2294
George H. Thompson
673.1 Pediatric Fracture Patterns 2294
673.2 Clavicular Fractures 2295
673.3 Proximal Humerus Fractures 2295
672.4 Distal Humerus Fractures 2295
673.5 Distal Radius and Ulna Fractures 2296
673.6 Phalangeal Fractures 2296
673.7 Toddler Fracture 2296
673.8 Lateral Malleolar Fractures 2296
673.9 Metatarsal Fractures 2296
673.10 Toe Phalangeal Fractures 2296
673.11 Operative Treatment 2297
Chapter 674 Osteomyelitis and Suppurative
Arthritis 2297
Richard M. Lampe
Section 2: Sports Medicine 2302
Albert C. Hergenroeder and Joseph N. Chorley
Chapter 675 Epidemiology and
Prevention of Injuries 2302
Chapter 676 Management of Musculoskeletal
Injury 2306
676.1 Growth Plate Injuries 2307
676.2 Shoulder Injuries 2308
676.3 Elbow Injuries 2308
676.4 Back Injuries 2309
676.5 Hip and Pelvis Injuries 2310
676.6 Knee Injuries 2310
676.7 Shin Splints and Stress Fractures of the
Lower Leg 2312
676.8 Ankle Injuries 2312
676.9 Foot Injuries 2313
Contents xlvi
Chapter 677 Head and Neck Injuries 2313
Chapter 678 Heat Injuries 2314
Chapter 679 Female Athletes: Menstrual Problems
and the Risk for Osteopenia 2315
Chapter 680 ErgogenicAids 2316
Chapter 681 Specific Sports and Associated
Injuries 2316
Section 3: The Skeletal Dysplasias 2320
Chapter 682 General Considerations 2320
William A. Horton and Jacqueline T. Hecht
Chapter 683 Disorders Involving Cartilage Matrix
Proteins 2324
William A. Horton and Jacqueline T. Hecht
Chapter 684 Disorders InvolvingTransmembrane
Receptors 2328
William A. Horton and Jacqueline T. Hecht
Chapter 685 Disorders Involving lonTransporter 2330
William A. Horton and Jacqueline T. Hecht
Chapter 686 Disorders InvolvingTranscription
Factors 2332
William A. Horton and Jacqueline T. Hecht
Chapter 687 Disorders Involving Defective Bone
Resorption 2333
William A. Horton and Jacqueline T. Hecht
Chapter 688 Disorders for Which Defects Are Poorly
Understood or Unknown 2334
William A. Horton and Jacqueline T. Hecht
Chapter 689 Osteogenesis Imperfects 2336
John C. Marini
Chapter 690 Marfan Syndrome 2338
Luther K. Robinson
Section 4: Metabolic Bone Disease 2341
Russell W. Chesney
Chapter 691 Bone Structure, Growth, and Hormonal
Regulation 2341
Chapter 692 Primary Chondrodystrophy
(Metaphyseal Dysplasia) 2343
Chapter 693 Idiopathic Hypercalcemia 2343
Chapter 694 Hypophosphatasia 2344
Chapter 695 Hyperphosphatasia 2344
Chapter 696 Familial Hypophosphatemia
(Vitamin D Resistant Rickets, X Linked
Hypophosphatemia) 2345
Chapter 697 Vitamin D Dependent Rickets
(Pseudovitamin D Deficiency, Hypocalcemic
Vitamin D Resistant Rickets) 2346
xlviii Contents
Chapter 698 Oncogenous Rickets (Primary
Hypophosphatemic Rickets Associated with
Tumor) 2346
Chapter 699 Osteoporosis 2347
HHHl Environmental Health
ShSBBBh Hazards 2349 Chapter 700 Pediatric Radiation Injuries 2349
Fred A. Mettler, Jr. andMadelyn M. Stazzone
Chapter 701 Chemical Pollutants 2353
Philip J. Landrigan and Joel A. Forman
Chapter 702 Heavy Metal Intoxication 2355
Collin S. Goto
Chapter 703 Lead Poisoning 2358
Morri Markowitz
Chapter 704 Poisonings: Drugs, Chemicals, and
Plants 2362
George C. Rodgers, Jr. and Nancy J. Matyunas
704.1 Epidemiology and Approach to
Management 2362
704.2 Acetaminophen 2366
704.3 Salicylates 2367
704.4 Ibuprofen 2368
704.5 Antidepressants 2368
704.6 Clonidine 2369
704.7 Calcium Channel Blockers 2370
704.8 Iron 2370
704.9 Caustics 2371
704.10 Methanol and Ethylene Glycol 2371
704.11 Hydrocarbons 2372
704.12 Cholinesterase Inhibiting Insecticides 2373
704.13 Toxic Gases 2374
704.14 Plants 2374
Chapter 705 Nonbacterial Food Poisoning 2375
DeniseA. Salerno and Stephen C. Aronoff
705.1 Mushroom Poisoning 2375
705.2 Solanine Poisoning 2376
705.3 Seafood Poisoning 2377
Chapter 706 Biologic and ChemicalTerrorism 2378
Theodore J. Cieslak and Fred M. Henretig
Chapter 707 Animal and Human Bites 2385
Charles M. Ginsburg
Chapter 708 Envenomations 2387
Steve Holve
m^MMM Laboratory Medicine, Drug
illBKSi Therapy, and Reference
'^Slfil^fi Tables 2393
Chapter 709 Laboratory Testing in Infants and
Children 2393
John R Nicholson and Michael A. Pesce
Chapter 710 Reference Ranges for Laboratory Tests
and Procedures 2396
John F. Nicholson and Michael A. Pesce
Chapter 711 Principles of DrugTherapy 2427
Michael D. Reed and Peter Gal
Chapter 712 Medications 2432
Peter Gal and Michael D. Reed
Chapter 713 Herbal Medicines 2502
KathiJ. Kemper and Paula Gardiner
mBgHj Index 2507 |
| any_adam_object | 1 |
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| dewey-ones | 618 - Gynecology, obstetrics, pediatrics, geriatrics |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 17. ed. |
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| genre_facet | Enzyklopädie |
| id | DE-604.BV014757992 |
| illustrated | Illustrated |
| indexdate | 2024-12-12T13:02:42Z |
| institution | BVB |
| isbn | 0721695566 0808922696 |
| language | English |
| lccn | 2002030990 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009994054 |
| oclc_num | 50670367 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-Er8 |
| owner_facet | DE-355 DE-BY-UBR DE-Er8 |
| physical | XLVIII, [8], 2618 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Saunders |
| record_format | marc |
| spelling | Nelson Textbook of pediatrics Richard E. Behrman ... Textbook of pediatrics 17. ed. Philadelphia [u.a.] Saunders 2004 XLVIII, [8], 2618 S. Ill., graph. Darst. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Kindergeneeskunde gtt Kinderheilkunde swd Pédiatrie Pediatrics Pädiatrie (DE-588)4030594-6 gnd rswk-swf 1\p (DE-588)4014986-9 Enzyklopädie gnd-content Pädiatrie (DE-588)4030594-6 s DE-604 Behrman, Richard E. 1931- Sonstige (DE-588)171971043 oth Nelson, Waldo E. 1898-1997 Sonstige (DE-588)12222776X oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009994054&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Nelson Textbook of pediatrics Kindergeneeskunde gtt Kinderheilkunde swd Pédiatrie Pediatrics Pädiatrie (DE-588)4030594-6 gnd |
| subject_GND | (DE-588)4030594-6 (DE-588)4014986-9 |
| title | Nelson Textbook of pediatrics |
| title_alt | Textbook of pediatrics |
| title_auth | Nelson Textbook of pediatrics |
| title_exact_search | Nelson Textbook of pediatrics |
| title_full | Nelson Textbook of pediatrics Richard E. Behrman ... |
| title_fullStr | Nelson Textbook of pediatrics Richard E. Behrman ... |
| title_full_unstemmed | Nelson Textbook of pediatrics Richard E. Behrman ... |
| title_short | Nelson Textbook of pediatrics |
| title_sort | nelson textbook of pediatrics |
| topic | Kindergeneeskunde gtt Kinderheilkunde swd Pédiatrie Pediatrics Pädiatrie (DE-588)4030594-6 gnd |
| topic_facet | Kindergeneeskunde Kinderheilkunde Pédiatrie Pediatrics Pädiatrie Enzyklopädie |
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