Molecular mechanisms of synaptic plasticity: implications for immediate early gene expression and learning
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Göttingen
Cuvillier
2002
|
| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Groningen, Univ., Diss., 2002. - Zsfassung in niederländ. Sprache |
| Beschreibung: | 181 S. Ill., graph. Darst. |
| ISBN: | 3898734935 |
Internformat
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| 245 | 1 | 0 | |a Molecular mechanisms of synaptic plasticity |b implications for immediate early gene expression and learning |c door Ingrid Maria Nijholt |
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| 264 | 1 | |a Göttingen |b Cuvillier |c 2002 | |
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Datensatz im Suchindex
| _version_ | 1804129464586600448 |
|---|---|
| adam_text | Contents
page
Chapter 1: General introduction 1
1. Synaptic plasticity 1
1.1 Basic principles of synaptic transmission 2
1.2 Second messenger pathways 3
1.2.1 Protein kinases 4
1.2.2 Protein phosphatases 5
1.2.3 Phosphoproteins 6
1.3 Glutamate receptors 7
1.3.1 NMDA receptor 7
2. Synaptic plasticity and gene expression 9
2.1 CREB 10
2.2 FOS 11
3. Synaptic plasticity and learning and memory 12
3.1 Hippocampus 12
3.2 Long term potentiation and depression as a model for learning 12
and memory
3.3 Influence of stress on synaptic plasticity and learning and memory 14
3.3.1 Corticotropin releasing factor as mediator of the stress 15
response
Chapter 2: Modulation of hvpothalamic NMDA receptor function by cyclic 33
AMP dependent protein kinase and phosphatases
Chapter 3: The phosphoprotein DARPP 32 mediates cAMP dependent 45
potentiation of striatal N methyl D aspartate responses
Chapter 4: In vivo NMDA/dopamine interaction resulting in FOS production 62
in the limbic system and basal ganglia of the mouse brain.
Chapter 5: In vivo CREB phosphorylation mediated by dopamine and NMDA 79
receptor activation in mouse hippocampus and caudate nucleus.
Chapter 6: The corticotropin releasing factor receptor 1 antagonist CP 154,526 87
markedly enhances associative learning and paired pulse
facilitation immediately after a stressful experience.
Chapter 7: Priming of long term potentiation in mouse hippocampus by 101
corticotropin releasing factor and acute stress: implications for
hippocampus dependent learning.
Chapter 8: Modulation of neuronal excitability and associative learning by 117
different corticotropin releasing factor signaling cascades in
mouse hippocampus
Chapter 9: Summary and general discussion 135
1. Brain regional differences in the modulation of the NMD A 135
receptors by phosphorylation events
1.1 DARPP 32 136
1.2 Possible physiological relevance of PKA mediated NMDA receptor 138
modulation in the hypothalamus
1.3 Direct versus indirect phosphorylation of the NMDA receptor 138
2. Brain regional differences in gene expression 139
2.1 Specificity in signaling pathways 140
3. Synaptic plasticity and learning and memory 143
3.1 Metaplasticity 143
3.2 Correlation between synaptic plasticity and learning 146
3.2.1 Possible role of calcium/calmodulin dependent protein 147
kinase II
3.2.2 Comparison between two mouse inbred strains Balb/c and 148
C57BIV6N
4. Concluding remarks 149
Nederlandse samenvatting 159
Supplement: NS 257, a novel competitive AMPA receptor antagonist, 165
interacts with kainate and NMDA receptors.
List of publications 179
Dankwoord 183
Curriculum vitae 185
|
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| isbn | 3898734935 |
| language | English |
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| spelling | Nijholt, Ingrid Maria 1973- Verfasser (DE-588)124049346 aut Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning door Ingrid Maria Nijholt 1. Aufl. Göttingen Cuvillier 2002 181 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: Groningen, Univ., Diss., 2002. - Zsfassung in niederländ. Sprache NMDA-Rezeptor (DE-588)4264187-1 gnd rswk-swf Gedächtnisleistung (DE-588)4123259-8 gnd rswk-swf Synapse (DE-588)4184224-8 gnd rswk-swf Lernfähigkeit (DE-588)4129684-9 gnd rswk-swf Plastizität Physiologie (DE-588)4174847-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Gedächtnisleistung (DE-588)4123259-8 s Lernfähigkeit (DE-588)4129684-9 s Synapse (DE-588)4184224-8 s Plastizität Physiologie (DE-588)4174847-5 s NMDA-Rezeptor (DE-588)4264187-1 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009981696&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nijholt, Ingrid Maria 1973- Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning NMDA-Rezeptor (DE-588)4264187-1 gnd Gedächtnisleistung (DE-588)4123259-8 gnd Synapse (DE-588)4184224-8 gnd Lernfähigkeit (DE-588)4129684-9 gnd Plastizität Physiologie (DE-588)4174847-5 gnd |
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| title | Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning |
| title_auth | Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning |
| title_exact_search | Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning |
| title_full | Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning door Ingrid Maria Nijholt |
| title_fullStr | Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning door Ingrid Maria Nijholt |
| title_full_unstemmed | Molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning door Ingrid Maria Nijholt |
| title_short | Molecular mechanisms of synaptic plasticity |
| title_sort | molecular mechanisms of synaptic plasticity implications for immediate early gene expression and learning |
| title_sub | implications for immediate early gene expression and learning |
| topic | NMDA-Rezeptor (DE-588)4264187-1 gnd Gedächtnisleistung (DE-588)4123259-8 gnd Synapse (DE-588)4184224-8 gnd Lernfähigkeit (DE-588)4129684-9 gnd Plastizität Physiologie (DE-588)4174847-5 gnd |
| topic_facet | NMDA-Rezeptor Gedächtnisleistung Synapse Lernfähigkeit Plastizität Physiologie Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009981696&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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