The chromaffin cell: transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA]
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adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 971
October 2002
THE CHROMAFFIN CELL
TRANSMITTER BIOSYNTHESIS,
STORAGE, RELEASE, ACTIONS,
AND INFORMATICS
11th INTERNATIONAL SYMPOSIUM ON
CHROMAFFIN CELL BIOLOGY
Editors
Daniel T. O Connor and Lee E. Eiden
This volume is the result of a conference entitled the 11th International Symposium on
Chromaffin Cell Biology, held on September 3 8,2001 in San Diego, California, USA.
CONTENTS
Preface. By Daniel T. O Connor xv
A Twenty Year Trip through the Chromaffin Cell. By Antonio G. GarcIa ... 1
Part I. Molecular Biology of the Chromaffin Cell
Molecular Biology of the Chromaffin Cell. By Jose MariA Trifar6 11
Cholinergic and Peptidergic Regulation of Phenylethanolamine ./V Methyl
transferase Gene Expression. By Dona Lee Wong, Leah J. Anderson,
and Tze Chun Tai 19
Neuroendocrine Cell Type Specific and Inducible Expression of
Chromogranin/Secretogranin Genes: Crucial Promoter Motifs. By
Sushil K. Mahata, Nitish R. Mahapatra, Manjula Mahata, and
Daniel T. O Connor 27
: Effects of Short and Long Term Nicotine Treatment on Intracellular Calcium
I and Tyrosine Hydroxylase Gene Expression. By ESTHER L. SABBAN AND
I VolodiaD. Gueorguiev 39
Proinflammatory Cytokines TNF a and IL la Stimulate Neuropeptide Gene
Expression in Adrenochromaffin Cells. By V. Turquier, H. Vaudry,
L. Yon, CM. Hsu, D. Ait Ali, L. Grumolato, L.E. Eiden,
and Y. Anouar 45
Proteolytic Processing of Chromogranins Is Modified in Brains of Transgenic
Mice. By ANDREA LASLOP, ALEXANDRA BECKER, IRIS LlNDBERG, AND
Reiner Fischer Colbrie 49
Influence of the Anx7 (+/ ) Knockout Mutation and Fasting Stress on the
Genomics of the Mouse Adrenal Gland. By Meera Srivastava, Preeti
Kumar, Ximena Leighton, Mirta Glasman, Gertrude Goping,
Ofer Eidelman, and Harvey B. Pollard 53
Hypoxia Activates Multiple Transcriptional Pathways in Mouse Pheochromo
cytoma Cells. By Marian J. Evinger, Stefan Cikos, Victoria
Nwafor Anene, James F. Powers, and Arthur S. Tischler 61
Phosphorylation of Tyrosine Hydroxylase in Isolated Mice Adrenal Glands.
By Karen Toska, Rune Kleppe, Philip Cohen, and Jan Haavik 66
Part II. Catecholamine Metabolism
Catecholamine Metabolism: An Update on Key Biosynthetic Enzymes and
Vesicular Monoamine Transporters. By TORGEIR Flatmark, BJ0RG
ALMAS, AND MICHAEL G. ZlEGLER 69
Location, Development, Control, and Function of Extraadrenal Phenylethano
lamine yV Methyltransferase. By Michael G. Ziegler, Xuping Bao,
Brian P. Kennedy, Alex Joyner, and Robert Enns 76
Phenylethanolamine N Methyltransferase Gene Regulation by cAMP
Dependent Protein Kinase A and Protein Kinase C Signaling Pathways.
By Tze Chun tai and Dona L. Wong 83
Differentiated PC 12 Cells: A Better Model System for the Study of the
VMAT s Effects on Neuronal Communication. By LESLIE A. SOMBERS,
Tom L. Colliver, and Andrew G. Ewing 86
A Truncated Mouse Phenylethanolamine A^ Methyltransferase Splice Variant
with Dominant Negative Activity. By XUPING BAO, BRIAN KENNEDY,
Robert Enns, Manjula Mahata, Sushil Mahata, Daniel
O Connor, and Michael G. Ziegler 89
Reduction of Adrenal and Kidney Epinephrine and Phenylethanolamine
N Methyltransferase in AP 2 Knockout Mouse Fetuses. By
Brian Kennedy, Robert Enns, Danielle Nelson, Trevor
Williams, Xuping bao, and Michael G. Ziegler 92
Part III. Ions, Channels, and Receptors
Ions, Channels, and Receptors. By David A. Powis and Philip D. Marley .. 95
Enhancement of Neuronal Nicotinic Receptor Activity of Rat Chromaffin
Cells by a Novel Class of Peptides. By ANDREA NlSTRl AND
Silvia Di Angelantonio 100
Calcium Entry, Calcium Redistribution, and Exocytosis. By INMACULADA
Cuchillo IbAnez, almudena Albillos, Marcos Aldea, Gloria :
Arroyo, Jorge Fuentealba, and Antonio G. GarcIa 108 I
Cholinergic Activation of Glucose Transport in Bovine Chromaffin Cells
Involves Calmodulin and Protein Kinase CC, Signaling. By GULDBORG
serck hanssen, mona gr0nning, cathrine fladeby,
and Robert Skar 117
Regulation of Voltage Dependent Sodium Channel Expression in Adrenal
Chromaffin Cells: Involvement of Multiple Calcium Signaling
Pathways. By Hideyuki Kobayashi, Seiji Shiraishi, Toshihiko
Yanagita, Hiroki Yokoo, Ryuichi Yamamoto, Shin Ichi Minami,
Tomokazu Saitoh, and Akihiko Wada 127
Functional Nicotinic Acetylcholine Receptor Expression on Stem and
Progenitor Cells of the Early Embryonic Nervous System. By
A.S. Schneider, P. Atluri, Q. Shen, W. Barnes, S.J. Mah,
D. Stadfelt, S.K. Goderie, S. Temple, and M.W. Fleck 135
Effects of Methyllycaconitine and Related Analogues on Bovine Adrenal
0(304* Nicotinic Acetylcholine Receptors. By Darrell L. Bryant,
R. Benjamin Free, Sara M. Thomasy, David J. Lapinsky,
K.A. Ismail, K.M. Arason, Stephen C. Bergmeier, and
Dennis B. McKay 139
Calcium Transport Proteins in Active Secretory Zones: Na Ca Exchange
Isoforms and Exchanger Kinetic Properties in Chromaffin Granules and
Plasma Membranes. By A.S. SCHNEIDER, S.J. MAH, M. FARHADI,
E. Grindi, andK.H. Davis 142
Evidence for Constitutive Expression of Bovine Adrenal a3p4* Nicotinic
Acetylcholine Receptors. By R. Benjamin Free, Susan B. McKay,
R. Thomas Boyd, and Dennis B. McKay 145
How Does Histamine Evoke Catecholamine Secretion from Bovine
Chromaffin Cells? By Philip D. Marley, Damian Wallace,
Amanda Donald, and Sacha McKenzie 148
In Situ Chelation of Ca2+ in Intracellular Stores Induces Capacitative Ca2+
Entry in Bovine Adrenal Chromaffin Cells. By David A. Powis
andMariannZerbes 150
Serum Deprivation Induced Upregulation of Voltage Dependent Sodium
Channels in Adrenal Chromaffin Cells: Selective Involvement of Extra¬
cellular Signal Regulated Kinase Pathway. By Toshihiko Yanagita,
Hideyuki Kobayashi, Hiroki Yokoo, Tomokazu Saitoh, Shin Ichi
Minami, Seiji Shiraishi, Yasuhito Uezono, and Akihiko Wada ... 153
Influence of Ca2+ Removal Mechanisms on Catecholamine Secretion from
Bovine Chromaffin Cells. By Philip D. Marley, Sharon H.A. Wong,
and Sacha McKenzie 156
Mitogen Activated Protein Kinase Is Activated by Ca2+ Entry through L and
N Type Channels and Regulates Ca Induced SNAP 25 Expression. By
Isabel Mendoza, Ernesto Tonk, Pamela Df az Raya,
and Ana M. Cardenas 159
Characterization of [3H]Epibatidine Binding to Nicotinic Receptors from
Bovine Adrenal Medulla. By Dennis B. McKay, R. Benjamin Free,
Daniel J. Kaser, and Susan B. McKay 162
A Single Neuronal Nicotinic Receptor oc3a7p4* Is Present in the Bovine
Chromaffin Cell. By Victoria Maneu, Jonathan Rojo, Jose Mulet,
Luis Miguel Valor, Francisco Sala, Manuel Criado,
Antonio G. GarcIa, and Luis GandIa 165
Different Cellular Distribution of Calbindin D28k: Implications for the
Cytosolic Ca and Exocytotic Signals in Single Bovine and Mouse
Chromaffin Cells. By E. Ales, M. Cano Abad, A.G. GarcIa, and
M.G. L6pez 168
Contribution of Calcium Entry through L Type Calcium Channels to
Chromaffin Cell Death. By M.F. Cano Abad, M. Villarroya,
A.G. GARcfA, N. GabilAn, and M.G. L6pez 171
Modulation of Exocytosis by the Na+/Ca2+ Exchanger of Chromaffin Cells.
By Antonio J. Pintado, Roman Olivares, Ana Ruiz Nuno,
Marcos Aldea, Gloria Arroyo, Almudena Albillos,
Luis GandIa, Carmen Montiel, and Antonio G. GarcIa 174
Part IV. Exocytosis
Exocytosis: The Chromaffin Cell As a Model System. By Marie France
Bader, Ronald W. Holz, Konosuke Kumakura,
and Nicolas Vitale 178
Pharmacological Regulation of the Late Steps of Exocytosis. By
rlcardo borges, j. david machado, gema betancor, and
Marcial Camacho 184
Regulated Secretion in Chromaffin Cells: An Essential Role for ARF6
Regulated Phospholipase D in the Late Stages of Exocytosis. By
Nicolas Vitale, Sylvette Chasserot Golaz, and
Marie France Bader 193
Role of CAPS in Dense Core Vesicle Exocytosis. By JAMES J. WASSENBERG
and Thomas F.J. Martin 201
Molecular Analysis of SNAP 25 Function in Exocytosis. By
Margaret E. Graham, Philip Washbourne, Michael C. Wilson,
and Robert D. Burgoyne 210
Molecular Motors Involved in Chromaffin Cell Secretion. By Sergio D. Rose,
Tatiana Lejen, Luciana Casaletti, Roy E. Larson,
Teodora Dumitrescu Pene, and Jose MarIa Trifar6 222
Localization of Phosphatidylinositol 4,5 P2 Important in Exocytosis and a
Quantitative Analysis of Chromaffin Granule Motion Adjacent to the
Plasma Membrane. By Ronald W. Holz and Daniel Axelrod 232
Rim and Exocytosis: Rab3a Binding and Secretion Enhancing Domains Are
Separate and Function Independently. By Lei Sun, Mary A. Bittner,
and Ronald W. Holz 244
The Role of Different Scinderin Domains in the Control of F Actin
Cytoskeleton during Exocytosis. By T. Lejen, T. Dumitrescu Pene,
S.D. Rose, and J M. Trifar6 248
Separating Vesicle Fusion and Exocytosis in Hypertonic Conditions. By
Kevin P. Troyer, Michelle L. Mundorf, Harvey E. Fries,
and R. Mark Wightman 251
i
New Structure Involved in Transient Membrane Fusion and Exocytosis.
By S J. Cho, A. Wakade, G.D. Pappas, and B.P. Jena 254
Exocytosis Studies in a Chromaffin Cell Free System: Imaging of Single
Vesicle Exocytosis in a Chromaffin Cell Free System Using Total
Internal Reflection Fluorescence Microscopy. By ULRICH K. WlEGAND,
Andrew Don Wauchope, Ioulia Matskevich, Rory R. Duncan,
Jennifer Greaves, Michael J. Shipston, David K. Apps,
and Robert H. Chow 257
Intracellular Protein Trafficking into Catecholamine Storage Vesicles: Novel
Chimeric Photoproteins Visualized by Deconvolution Fluorescence
Microscopy. By Laurent Taupenot, Kimberly L. Harper, Nitish R.
Mahapatra, Robert J. Parmer, and Daniel T. O Connor 262
Effects of Extremely Low Frequency Electromagnetic Field Stimulation on
Cultured Chromaffin Cells. By Leticia Verdugo DJAZ, Tatiana
Olivares Banuelos, Luz Navarro, and Rene Drucker ColIn 266
Calmodulin Inhibitors Block Quantal Catecholamine Release and Increase
Acidification of Neurosecretory Granules in Rat Adrenal Chromaffin
Cells. By R.G.W. Staal, E. Mosharov, and D. Sulzer 269
Roles of Actin Filaments and the Actin Myosin Interaction in the Regulation
of Exocytosis in Chromaffin Cells. By NOBUYUKI SASAKAWA,
Mica Ohara Imaizumi, Sinngo Okubo, Sanae Hosaka, Mitsunori
Hayashi, and Konosuke Kumakura 273
Use of ANF EGFP for the Visualization of Secretory Vesicles in Bovine
Adrenal Chromaffin Cells. By JENNIFER GREAVES, RORY R. DUNCAN,
Sompol Tapechum, David K. Apps, Michael J. Shipston,
and Robert H. Chow 275
Thyroid Hormones Regulate Adrenal Chromaffin Cell SNAP 25. By
K. Langley, R. Hepp, N.J. Grant, D. Aunis, and A. Rodriguez Pena 277
Characterization of Constitutive Protein Secretion in PC 12 Cells That Lack
the Regulated Secretory Pathway. By SVEN ULRIK GORR AND
RenuK. Jain 281
A Novel Nongenomic Action of Estrogens: The Regulation of Exocytotic
Kinetics. By J. David Machado, Carmen Alonso, Araceli
Morales, and Ricardo Borges 284
Annexin 7: A Non SNARE Proteolytic Substrate for Botulinum Toxin Type
C in Secreting Chromaffin Cells. By H. Caohuy and H.B. Pollard .... 287
Which Step of Exocytosis Is Regulated by the Monomeric GTPase Rab3a? By
Jean Sebastien Schonn, Claire Desnos, Francois Darchen,
and Jean Pierre Henry 291
Part V. Neuropeptides and Chromogranins
Neuropeptides and Chromogranins: Session Overview. By ANDREA LASLOP
and Sushil K. Mahata 294
Inositol l,4,5 TrisphosphateReceptor/Ca2+Channel Modulatory Role of
Chromogranins A and B. By Seung Hyun Yoo, Seung Ho So, Yang
Hoon Huh, and Hee Yun Park 300
WE 14, a Chromogranin A Derived Neuropeptide. By W.J. CURRY,
S.C. Barkatullah, A.N. Johansson, J.G. Quinn, P. Norlen,
C.K. Connolly, A.P. McCollum, and CM. McVicar 311
Neuroendocrine Secretory Protein 55: A Novel Marker for the Constitutive
Secretory Pathway. By Reiner Fischer Colbrie, Susanne Eder,
Paola Lovisetti Scamihorn, Alexandra Becker, and
AndreaLaslop 317
Large Dense Core Secretory Granule Biogenesis Is under the Control of Chro¬
mogranin A in Neuroendocrine Cells. By Taeyoon Kim,
JUNG HWA TAO CHENG, LEE E. ElDEN, AND Y. PENG LOH 323
Catecholamine and Neuropeptide Y Secretion from Human Adrenal
Chromaffin Cells: Effect of Nicotine and KC1. By ClAudia Cavadas,
Carlos Alberto Fontes Ribeiro, Maria Dulce Cotrim,
Francois Mosimann, Hans R. Brunner, and Eric Grouzmann 332
Differential Secretion of Catecholamine and Neuropeptide Y in Response to
KC1 from Mice Chromaffin Cells. By CLAUDIA CAVADAS,
Ant6nioPedroSilva,MariaDulceCotrim,CarlosAlbertoFontes
Ribeiro, Hans R. Brunner, and Eric Grouzmann 335
Agonist Stimulated Neuropeptide and Catecholamine Release from Bovine
Adrenal Chromaffin Cells. By R.A. Bundey, T. Toneff, J. Pottenger,
B.P. Kennedy, M.G.Ziegler,andV.Y. Hook 338
Region Specific Antibodies against Chromogranin B Display Different
Immunoreactivity in the Human Pancreatic Islet Cell Types. By
Guida Maria Portela Gomes and Mats Stridsberg 341
Localization of Secretory Granule Marker Protein Chromogranin B in the
Nucleus. By Seung Hyun Yoo, Soon Hee You, Moon Kyung Kang,
Yang Hoon Huh, and Chan Seob Shim 345
Catestatin (Chromogranin A344 358) Stimulates Release of Histamine from
Rat Pleural and Peritoneal Mast Cells. By P G. Kruger, S.K. Mahata,
and K.B. Helle 349
The N Terminal Domain of Chromogranin A (CgAl 40) Interacts with Mono
layers of Membrane Lipids of Fungal and Mammalian Compositions. By
R. Maget Dana, M H. Metz Boutigue, and K.B. Helle 352
Regulation of Endothelial Cell Shape and Barrier Function by Chromogranin
A. By E. Ferrero, E. Magni, F. Curnis, A. Villa, M.E. Ferrero,
and A. Corti 355
Structural and Biological Characterization of Chromofungin, the Antifungal
Chromogranin A (47 66) Derived Peptide. By K. LUGARDON,
S. Chasserot Golaz, A.E. Kieffer, R. Maget Dana, G. Nullans,
B. Kieffer, D. Aunis, and M.H. Metz Boutigue 359
Vasostatins Exert Negative Inotropism in the Working Heart of the Frog. By
A. CORTI, C. MANNARINO, R. MAZZA, B. COLOMBO, R. LONGHI,
AND B. TOTA 362
Part VI. Novel Chromaffin Cell Models
Chromaffin Cells as Models of Endocrine Cells and Neurons. By
Arthur S. Tischler 366 ;
I
Plasticity of Pheochromocytoma Cell Lines from Neurofibromatosis
Knockout Mice. By James F. Powers, Kimberley H. Schelling,
Jaime M. Brachold, and Arthur S. Tischler 371
Genomic and Physiological Analysis of Oxygen Sensitivity and Hypoxia
Tolerance in PC12 Cells. By Karen Seta, Hie Won Kim, Tsuneo
Ferguson, Richard Kim, Peterson Pathrose, Yong Yuan,
Gang Lu, Zachary Spicer, and David E. Millhorn 379
Circle of Life of Secretory Vesicles in Gastric Enterochromaffin Like Cells.
By Robert Zanner, Manfred Gratzl, and Christian Prinz 389
Part VII. Proteolytic Processing and Trafficking
Protein Trafficking to Chromaffin Granules and Proteolytic Processing within
Regulated Secretory Vesicles of Neuroendocrine Chromaffin Cells. By
Vivian Hook and Marie Helene Metz Boutigue 397
Expression and Functional Characterization of the Serine Protease Inhibitor
Neuroserpin in Endocrine Cells. By Rena M. Hill, Leigh C. Coates,
parmjeet K. Parmar, Eva Mezey, John F. Pearson,
and Nigel P. Birch 406
Mechanism of Sorting Proopiomelanocortin and Proenkephalin to the
Regulated Secretory Pathway of Neuroendocrine Cells. By Y. PENG LOH,
Alex Maldonado, Chunfa Zhang, Winnie H. Tam,
AND NlAMH CAWLEY 416
Novel Chromaffin Granule Serpins, Endopin 1 and Endopin 2: Endogenous
Protease Inhibitors with Distinct Target Protease Specificities.
By Vivian Y.H. Hook, Sukkid Yasothornsrikul, and
Shin Rong Hwang 426
The Local Chromaffin Cell Plasminogen/Plasmin System and the Regulation
of Catecholamine Secretion. By QUIAO JIANG, SUKKID
Yasothornsrikul, Laurent Taupenot, Lindsey A. Miles,
and Robert J. Parmer 445
Composition of the Heme Centers in Chromaffin Granule Cytochrome b^[.
By Yury Kamensky, Richard J. Kulmacz, and Graham Palmer ... 450
Chromaffin Cell Plasminogen Receptors. By Lindsey A. Miles, Stephen B.
Hawley, and Robert J. Parmer 454
Part VIII. The PACAP/VIP Peptide Family in Chromaffin Cells
Fast Breaking Results on the PACAP/VIP/Secretin Peptide Family in
Chromaffin Cells. By David Vaudry and Laurent Taupenot 460
Pituitary Adenylate Cyclase Activating Polypeptide Regulates Neuroendocrine
Markers and Transcription Factors in Differentiating Pheochromocytoma
Cells. By L. Grumolato, D. Alexandre, V. TURQUIER,
D. Ait Ali, A. Fournier, H. Vaudry, and Y. Anouar 467
Pituitary Adenylate Cyclase Activating Polypeptide Stimulates Secreto
neurin Release and Secretogranin II Gene Transcription in Bovine
Adrenochromaffin Cells. By V. TURQUIER, L. YON, L. GRUMOLATO,
D. Alexandre, A. Fournier, H. Vaudry, and Y. Anouar 471
Role of Protein Kinases in Neuropeptide Gene Regulation by PACAP in
Chromaffin Cells: A Pharmacological and Bioinformatic Analysis.
By Carol Hamelink, Hyeon Woo Lee, Chang Mei Hsu,
and Lee E. Eiden 474
PC 12 Cells as a Model to Study the Neurotrophic Activities of PACAP. By
David Vaudry, Yun Chen, Chang Mei Hsu, and Lee E. Eiden 491
Part IX. Chromaffin Cells and Human Disease
Catecholaminergic Pathways, Chromaffin Cells, and Human Disease. By
Robert J. Parmer and Oren Zinder 497
Genetic Basis of Clinical Catecholamine Disorders. By EMILY M. GARLAND,
Maureen K. Hahn, Terry P. Ketch, Nancy R. Keller,
Chun Hyung Kim, Kwang Soo Kim, Italo Biaggioni,
John R. Shannon, Randy D. Blakely, and David Robertson 506
Virally Mediated Delivery of Enkephalin and Other Neuropeptide Transgenes
in Experimental Pain Models. By STEVEN P. WILSON AND
David C. Yeomans 515
Regulation of Catecholamine Synthesis by Leptin. By IZUMI Shibuya,
Kensuke Utsunomiya, Yumiko Toyohira, Susumu Ueno,
Masato Tsutsui, Tat Beng Cheah, Yoichi Ueta, Futoshi Izumi,
and nobuyuki yanagihara 522
Studies of the Dysglycemic Peptide, Pancreastatin, Using a Human Forearm
Model. By Peter E. Cadman, Fangwen Rao, Sushil K. Mahata,
and Daniel T. O Connor 528
Malignant and Benign Pheochromocytoma: Chromaffin Granule Transmitters
and the Response to Medical and Surgical Treatment. By Fangwen Rao,
Harry R. Keiser, and Daniel T. O Connor 530
The Catecholamine Release Inhibitory Catestatin Region of Chromogranin
A: Early Decline in Humans at Genetic Risk of Hypertension. By
Daniel T. O Connor, Mala T. Kailasam, Brian P. Kennedy,
Michael G. Ziegler, Noboru Yanaihara, and Robert J. Parmer .. 533
Loss of the Neurofibromin NFl Gene Product and Composite
Pheochromocytoma. By Noriko Kimura, Masayuki Fukase,
Atsushi Wakita, and Itaru Kimura 536
Effect of Cyclic AMP on PC 12 Cellular Content and Release of Dopamine and
l Methyl 4 Phenylpyridinium. By Laura Ribeiro, Isabel Azevedo,
and Fatima Martel 539
Implication of Endogenous Morphine in the Communication between Neuro
endocrine and Immune Systems. By Yannick Goumon, George B.
Stefano, Dominique Aunis, and Marie Helene Metz Boutigue ... 542
Part X. Developmental Biology and Trophic Factors
From the Neural Crest to Chromaffin Cells: Introduction to a Session on
Chromaffin Cell Development. By Chaya Kalcheim, Keith Langley,
and Klaus Unsicker 544
Gene Targeting Reveals Multiple Essential Functions of the Neuregulin
Signaling System during Development of the Neuroendocrine and
Nervous Systems. By Steven A. Crone and Kuo Fen Lee 547
Generation of Neuroendocrine Chromaffin Cells from Sympathoadrenal
Progenitors: Beyond the Glucocorticoid Hypothesis. By Katrin Huber,
Stephanie Combs, Uwe Ernsberger, Chaya Kalcheim,
and Klaus Unsicker 554
Chromogranin A Activated Microglial Cells Induce Neuronal Apoptosis. By
Gabrielle Ulrich, Jaroslava Ciesielski Treska, Laurent
Taupenot, and Marie France Bader 560
Dissociated Human Embryonic and Fetal Adrenal Glands in Neural Stem
Cell Culture System: Open Fate for Neuronal, Nonneuronal, and
Chromaffin Lineages? By Jean Claude Bes and Jacqueline Sagen .. 563
Acute Stimulation by IGF I of Amino Acid Transport System A in Chromaf¬
fin Cells Depends on PI3 Kinase Activation and the Electrochemical
Gradient of Na+. By Tine V. Karlsen and Guldborg Serck Hanssen 573
Part XI. Neuroinformatics Workshop:
Computing the Chromaffin Cell
Computing the Chromaffin Cell: A Research Community Curator/User
Approach to Biocomputation for Chromaffin Cell Biology. By
Lee E. Eiden and Michael D. Hirsch 576
Metabioinformatics: The Ecology of an Intellectual Collective. By
Susan K. Burgess 584
Science s Signal Transduction Knowledge Environment: The Connections
Maps Database. By NANCY R. GOUGH 585
The Bioinformatics of Molecular Interactions: What Do Saccharomyces
cerevisiae Interaction Networks Tell Us about Human Cells?
By Christopher Hogue 588
Pathfinder and Other Tools for Analyzing Signal Transduction Networks.
By Larry Lok 589
The Virtual Cell: An Integrated Modeling Environment for Experimental and
Computational Cell Biology. By Ion I. Moraru, James C. Schaff,
Boris M. Slepchenko, and Leslie M. Loew 595
Computational Analysis of Isoform Specific Signal Regulation by
CEACAM1—A Cell Adhesion Molecule Expressed in PC 12 Cells.
By Bjorn Obrink, Hiroki Saw a, Inka Scheffrahn, Bernhard B.
Singer, Kristmundur Sigmundsson, Ulla Sundberg, Robert
Heymann, Nicole Beauchemin, Gehzi Weng, Prahlad Ram,
and Ravi Iyengar 597
Analysis of Signaling Pathways Using Functional Proteomics. By
Katheryn A. Resing 608
A Neuroscience Knowledge Management Systems Approach: Application to
Functional Proteomics/Genomics of the Chromaffin Cell. By
Michael D. Hirsch 615
Part XII. New Technologies in Exocytosis and Ion Movement
New Technologies in Exocytosis and Ion Movement. By Harvey B.
Pollard and David K. Apps 617
The Association of Vesicular Contents and Its Effects on Release.
By R. Mark Wightman, Kevin P. Troyer, Michelle L. Mundorf,
and Rebecca Catahan 620
A New Green Fluorescent Protein Construct for Localizing and Quantifying
Peptide Release. By Weiping Han, Danqing Li, and
Edwin S. Levitan 627
Subcellular Ca2+ Dynamics Measured with Targeted Aequorin in Chromaffm
Cells. By Maria Teresa Alonso, Mayte Montero, Estela
Carnicero, Javier GARCiA SANCHO, and Javier Alvarez 634
Efficacy of Semliki Forest Virus Transduction of Bovine Adrenal Chromaffm
Cells: An Analysis of Heterologous Protein Targeting and Distribution.
By Rory R. Duncan, Jennifer Greaves, Sompol Tapechum,
David K. Apps, Michael J. Shipston, and Robert H. Chow 641
New Approaches for Analysis of Amperometrical Recordings. By
J. Francisco G6mez, Miguel A. Brioso, J. David Machado,
Jose L. Sanchez, and Ricardo Borges 647
Index of Contributors 655
Financial assistance was received from:
Major Sponsors
• NATIONAL INSTITUTE OF MENTAL HEALTH
• UNIVERSITY OF CALIFORNIA BIOTECHNOLOGY PROGRAM
• UNIVERSITY OF CALIFORNIA LIFE SCIENCES
INFORMATICS PROGRAM
• INTERNATIONAL UNION OF BIOCHEMISTRY AND
MOLECULAR BIOLOGY
Sponsors
• MERCK AND COMPANY, INC.
• AVENTIS PHARMACEUTICALS, INC.
• SANKYO PHARMACEUTICALS, INC.
Trainee Travel Grant Sponsor
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums.
|
any_adam_object | 1 |
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bvnumber | BV014700101 |
ctrlnum | (OCoLC)216904146 (DE-599)BVBBV014700101 |
format | Conference Proceeding Book |
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genre_facet | Konferenzschrift 2001 San Diego Calif. |
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illustrated | Illustrated |
indexdate | 2024-07-09T19:05:13Z |
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language | English |
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spelling | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] ed. by Daniel T. O'Connor ... New York, NY New York Acad. of Sciences 2002 XVI, 659 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 971 Chromaffine Zelle (DE-588)4199644-6 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2001 San Diego Calif. gnd-content Chromaffine Zelle (DE-588)4199644-6 s DE-604 O'Connor, Daniel T. Sonstige oth International Symposium on Chromaffin Cell Biology 11 2001 San Diego, Calif. Sonstige (DE-588)10049504-7 oth Annals of the New York Academy of Sciences 971 (DE-604)BV002532608 971 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009967676&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] Annals of the New York Academy of Sciences Chromaffine Zelle (DE-588)4199644-6 gnd |
subject_GND | (DE-588)4199644-6 (DE-588)1071861417 |
title | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] |
title_auth | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] |
title_exact_search | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] |
title_full | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] ed. by Daniel T. O'Connor ... |
title_fullStr | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] ed. by Daniel T. O'Connor ... |
title_full_unstemmed | The chromaffin cell transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] ed. by Daniel T. O'Connor ... |
title_short | The chromaffin cell |
title_sort | the chromaffin cell transmitter biosynthesis storage release actions and informatics this volume is the result of a conference entitled the 11th international symposium on chromaffin cell biology held on september 3 8 2001 in san diego california usa |
title_sub | transmitter biosynthesis, storage, release, actions, and informatics ; [this volume is the result of a conference entitled the 11th International Symposium on Chromaffin Cell Biology, held on September, 3 - 8, 2001 in San Diego, California, USA] |
topic | Chromaffine Zelle (DE-588)4199644-6 gnd |
topic_facet | Chromaffine Zelle Konferenzschrift 2001 San Diego Calif. |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009967676&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV002532608 |
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