Verfügbarkeit: The biology of viruses

The biology of viruses:

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Bibliographische Detailangaben
1. Verfasser:	Voyles, Bruce A. (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	New York McGraw-Hill 2002
Ausgabe:	2. ed.
Schlagworte:	Virus Viruses Viren Biologie Virologie
Online-Zugang:	Publisher description Table of contents Inhaltsverzeichnis
Beschreibung:	Includes bibliographical references and index
Beschreibung:	XV, 408 S. Ill., graph. Darst. : 24 cm
ISBN:	0072370319

Internformat

MARC


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Datensatz im Suchindex

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adam_text	The Biology of Viruses Second Edition Bruce A Vpyles Patricia Armstrong Johnson Professor of Biological Chemistry Professor of Biology Grinnell College Grinnell, Iowa Me Grauu Boston Burr Ridge, IL Dubuque, IA Madison, Wl New York San Francisco St Louis Bangkok Bogota Caracas Kuala Lumpur Lisbon London Madrid Mexico City Milan Montreal New Delhi Santiago Seoul Singapore Sydney Taipei Toronto CONTENTS Preface xiii 1CHAPTER Viruses and Host Cells 1 What Is a Virus? 2 Where Are Viruses Found in Nature? 4 What Are the Physical Properties of Viruses? 5 Size 5 The Genome 5 Virion Architecture 6 What Structural Features of Cells Are Important in Their Role as Viral Hosts? 13 Animal Cells 13 Plant Cells 14 Pmkaryotic Cells 14 Appendages 18 What Genetic Features of Cells Are Important in the Virus-Host Cell Interaction? 19 The Organization of the Host Cell Genome 19 Posttranscriptional Modification ofmRNA 20 intentaiCompartmentalization 21 The Cell Cycle 21 How Does a Virus Reproduce? 22 What Are the Basic Techniques Used to Study the Virus-Host Cell Interaction? 23 Animal Virus Techniques 24 Plant Virus Techniques 27 How Are Viruses Named? 28 The Baltimore Classification 29 Summary: What Is a Virus? 31 vl I Contents CHAPTER/ Getting In: Attachment, Penetration, and Uncoating 3fi Why Does a Virus Infect Only Certain Cells and Not Others? 36 What Types of Interactions Occur Between the Virion and the Cell Surface During Attachment? 38 How Do Bacteriophages Recognize Their Host Cells? 41 T4 Attachment to E coli 42 Other Bacteriophages 44 How Do Bacteriophages Introduce Their Nucleic Acids into Host Cells? 46 Penetration by the Coliphages T2 and T4 46 Other Bacteriophages 49 How Do Animal Viruses Recognize Their Host Cells? 50 Attachment by Naked Viruses 51 Attachment by Enveloped Viruses 53 How Do Animal Viruses Enter Their Host Cells and Uncoat Their Nucleic Acids? 58 General Mechanisms of Penetration and Uncoating 58 Fusion Proteins 60 Penetration by Enveloped Viruses: Fusion with the Plasma Membrane 61 Penetration by Enveloped Viruses: Endocytosis 66 Penetration by Naked Viruses 69 Transport of the Viral Genome into the Nucleus 69 How Do Plant Viruses Infect Their Host Cells? 69 Summary 71 CHAPTER Expressi p in Prokaryotic Hosts 75 on and Replication of the Viral Genome Prok What Are the Essential Features of Genome Replication and Expression in Prokaryotes? 76 DNA Replication in Prokaryotes 76 Transcription in Prokaryotes 78 Translation in Prokaryotes 79 What Strategies Do Prokaryotic Viruses Use to Facilitate Replication and Expression of Their Genomes? 80 What Structural Features Characterize the Genomes of the Double-Stranded DNA Bacteriophages? 83 The T-Series Coliphages 83 Contents I vii How Do the T-Odd Coliphages Express and Replicate Their Genomes? 85 The Bacteriophage T7 85 The Bacteriophage T5 89 How Do the T-Even Coliphages Express and Replicate Their Genomes? 89 How Does Lambda Virus Express and Replicate Its Genome? 94 How Do Single-Stranded DNA Bacteriophages Express and Replicate Their Genomes? 100 How Do RNA Bacteriophages Replicate and Express Their Genomes? 104 General Features of RNA Bacteriophage Replication 104 The Genomes of the RNA Bacteriophages Q/3 and MS2 107 How Do the RNA Bacteriophages Regulate the Amount of Each Protein Synthesized During Their Replication? 108 Summary 113 CHAPTERT {Expression and Replication of the Viral Genome in Eukaryotic Hosts; The RNA Viruses 11s What Features of a Eukaryotic Cell s Genetic System Influence Viral Replication and Gene Expression? 116 What Structural Features Distinguish the Positive-Strand RNA Viruses of Animals? 118 What Strategies Do the Animal Positive-Strand Viruses Use to Express and Replicate Their Polycistronic Genomes? 120 Picornaviruses 121 How Are Host and Poliovirus mRNAs Distinguished? 124 How Is Translation of Poliovirus mRNA Begun? 125 How Does Poliovirus Replicate Its Genome? 126 Togaviruses 129 Coronaviruses 133 How Is a Nested Set of mRNAs Synthesized? 135 What Strategies Do Plant Positive-Strand Viruses Use to Express and Replicate Their Genomes? 137 What Structural Features Distinguish the Negative-Strand RNA Viruses? 140 What Strategies Do Negative-Strand Viruses Use to Express and Replicate Their Genomes? 143 Rhabdoviruses 143 Paramyxovi ruses 145 Filoviruses 145 Orthomyxoviruses 147 Can a Viral Genome Have Both Positive- and Negative-Strand RNA? 150 viii I Contents How Do Double-Stranded RNA Viruses Express and Replicate Their Genomes? 151 What Structural Features Distinguish the Retroviruses from Other Positive-Strand RNA Viruses? 154 How Does Reverse Transcription Work? 157 How Does Retrovirus Proviral DNA Become Incorporated into the Host Cell s Genome? 160 How Are Retrovirus Genes Expressed? 162 How Do Retroviruses Replicate Their Genomes? 163 How Do the Lentiviruses Differ from the Oncoviruses? 164 Functions of the HIV-1 Regulatory and Accessory Gene Products 165 Summary 167 CHAPTERj Expression and Replication of the Viral Genome in Eukaryotic Hosts: The DNA Viruses 171 What Structural Features Distinguish Eukaryotic DNA Viruses? 172 What Outcomes Are Possible When a DNA Virus Infects an Animal Cell? 175 How Do Animal Viruses with Double-Stranded DNA Genomes Express and Replicate Those Genomes? 177 The Papovaviruses 177 The Adenoviruses 181 • The Herpesviruses 184 The Poxviruses 186 How Do Animal Single-Stranded DNA Viruses Express and Replicate Their Genomes? 188 How Do Plant Single-Stranded DNA Viruses Express and Replicate Their Genomes? 191 What Features Set-Hepadnaviruses and Caulimoviruses Apart from Other Eukaryotic DNA Viruses ? 193 The Hepadnaviruses 193 The Caulimoviruses 197 Summary 199 CHAPTERO Assembly, Maturation, and Release of Virions 201 What Is the Evidence That Viruses Self-Assemble? 202 What Basic Strategies Are Used to Assemble Capsids? 203 How Are Rigid Helical Virions Assembled? 203 How Does the Assembly of Flexible and Rigid Helical Capsids Differ? 209 Contents I ix How Are the Capsids of Icosahedral RNA Viruses Assembled? 210 The Assembly of Poliovirus 213 How Is the RNA Arranged in an Icosahedral Capsid? 215 How Are Simple Icosahedral DNA Bacteriophages Assembled? 215 How Are the Capsids of Complex Bacteriophages Assembled? 219 What Strategies Do DNA Bacteriophages Use to Fill Their Capsids? 220 How Are the Icosahedral DNA Viruses of Eukaryotes Assembled? 223 How Do Viruses with Segmented Genomes Ensure That Virions Contain a Copy of Each Segment? 223 How Do Viruses Exit Their Host Cells? 224 How Do Naked Viruses Exit Their Host Cells? 224 How Do Enveloped Viruses Acquire Their Envelopes? 225 How Do Nucleocapsids Identify Modified Membrane Locations for Budding? 227 How Does a Virus Target a Particular Membrane Region as the Site of Budding? 227 Do All Viruses Bud Through the Cytoplasmic Membrane? 229 Summary 232 CHAPTER / Effects of Viral Infection on Host Cells: Cytological and Inductive Effects ?35 What Morphological Changes in Host Cells Are Associated with Viral Infections? 236 What Causes Cytopathic Effects in Animal Cells? 240 What Strategies Do Viruses Use to Inhibit Eukaryotic Host Cell Protein Synthesis? 241 Competition 243 Inhibition of Host mRNA Transport from the Nucleus 244 Degradation of Host mRNA 244 Blockage of Initiation Complex Formation 245 Covalent Modification of Translation-Related Components 245 Increases in Intracellular Cation Concentrations 248 Viral Inhibitory Factors 249 How Do Viruses Inhibit the Transcription of Their Hosts Genomes? 250 How Do Viruses Inhibit the Replication of Their Hosts Genomes? 251 How Do Bacteriophages Inhibit the Metabolism of Their Host Cells? 251 How Do Host Cells Fight Back Against the Viruses That Infect Them? 253 What Types of Antiviral Defenses Do Prokaryotic Cells Have? 253 What Types of Antiviral Defenses Do Eukaryotic Cells Have? 256 Interferon Proteins and Interferon Genes 257 Synthesis of Interferon 257 The Action of Interferon 258 x I Contents The Antiviral State 260 The 2,5-OligoA System 260 The Protein Kinase System 262 Other Interferon-Related Activities 262 What Countermeasures Do Viruses Have to Combat the Host Interferon System Defenses? 262 What Clinical Use Is Made of Interferon and Other Antiviral Agents? 264 Antiviral Drugs 265 Summary 271 CHAPTER O Effects of Viral Infection on Host Cells: Integrated Viruses and Persistent Infections 975 Why Is Every Viral Infection Not Productive? 276 What Interaction Between a Bacteriophage and Host Cell Gives Rise to the Lysogenic State? 279 What Genetic Events Permit a Lambda Virus to Become Lysogenic? 283 How Are the Events Leading to the Lytic Cycle Prevented? 285 How Is X DNA Integration Accomplished? 285 What Determines if a Particular Lambda Virus Infection Results in Lysogeny or the Complete Lytic Cycle? 286 How Is Lysogeny Reversed? 286 What Effects May Lysogeny Have on the Host Bacterium? 287 What Is the Evolutionary Significance of Lysogeny? 290 Under What Circumstances Do Animal Viruses Become Inserted into Their Host Cells Genomes? 290 What Effect Does Integration of an Animal Virus Have on a Host Cell? 292 How Do Animal Cells Regulate Their Cell Cycles? 294 How Do Retroviruses Transform Animal Cells? 297 Why Do Viral Oncogenes Cause Transformation When Their Equivalent Cellular Proto-Oncogenes Do Not? 299 What Mechanisms Besides Viral Oncogenes Do Retroviruses Use to Transform Cells? 302 How Is Transformation of Animal Cells by DNA Viruses Different from That Caused by RNA Viruses? 304 What Is the Mechanism of Transformation by DNA Viruses? 304 The Papovaviruses 305 the SV40 T Antigens 306 The Adenoviruses 308 Contents I xi What Human Tumors May Be Caused by DNA Viruses? 308 The Papillomaviruses 308 The Herpesviruses 310 Besides Integration into the Host Cell Genome, How May a Virus Infection Persist? 311 What Effect Does a Persistent Infection Have on the Host Organism? 314 How Do the Herpesviruses Establish Their Latent Infections? 315 Summary 315 CHAPTER V Subviral Entities, Viral Evolution, and Viral Emergence 391 What Structural Features Distinguish Viroids from Viruses? 322 What Proteins Do Viroids Encode? 324 What Host Enzymes Do Viroids Use to Replicate Themselves? 325 What Is the Mechanism of Viroid Replication? 325 How Do Viroids Cause Plant Diseases? 327 What Other Subviral Entities Have Been Found? 327 How Do Satellite RNAs and Satellite Viruses Replicate? 328 How Is Hepatitis Delta Virus Replicated? 329 What Other Subviral Entities Infect Animal Cells? 330 How Do Prions Replicate? 333 Yeast Prion Model Systems 334 What Is the Origin of the Various Types of Subcellular Entities? 334 The Origins of Subviral Entities 336 What Factors Affect Viral Evolution? 337 What Constrains or Counters the Effects of Mutation and Recombination in the Evolution of Viruses? 338 How Do Nonhuman Viruses Gain the Ability to Infect Humans? 340 Zoonotic Viruses 341 The Origin of HIV 342 Summary 343 Appendix A The Virologist s Toolkit 347 Appendix B CKaracteristics of Selected Viruses 373 Glossary 383 Credits 389 Index 391
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title	The biology of viruses
title_auth	The biology of viruses
title_exact_search	The biology of viruses
title_full	The biology of viruses Bruce A. Voyles
title_fullStr	The biology of viruses Bruce A. Voyles
title_full_unstemmed	The biology of viruses Bruce A. Voyles
title_short	The biology of viruses
title_sort	the biology of viruses
topic	Virus Viruses Viren (DE-588)4063589-2 gnd Biologie (DE-588)4006851-1 gnd Virologie (DE-588)4063597-1 gnd
topic_facet	Virus Viruses Viren Biologie Virologie
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