Aqueous polymer dispersions for extended release dosage forms:
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2002
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 227 S. Ill., graph. Darst. : 21 cm |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS LIST OF FIGURES IV LIST OF TABLES X 1 INTRODUCTION 1
1.1 COATING OF SOLID DOSAGE FORMS 1 1.2 AQUEOUS POLYMER DISPERSIONS 2
1.3 EXCIPIENTS FOR EXTENDED RELEASE COATINGS 5 1.3.1 POLYMERS 5 1.3.1.1
ETHYLCELLULOSE 5 1.3.1.2 ACRYLATES 8 1.3.1.3 POLYVINYLACETATE 11 1.3.2
ADDITIONAL EXCIPIENTS 12 1.3.2.1 PLASTICIZER...., 12 1.3.2.2 PORE FORMER
16 1.3.2.3 PIGMENTS AND ANTI-TACKING AGENTS 17 1.4 REDISPERSIBLE POLYMER
POWDERS 19 1.5 COATING-EQUIPMENT AND PROCESS CONDITIONS 20 1.5.1 COATING
METHODS FOR PHARMACEUTICAL PRODUCTS 20 1.5.2 PROCESS PARAMETERS 22 1.6
MECHANISM OF DRUG RELEASE FROM COATED PELLETS 25 1.7 COMPACTION OF
COATED PELLETS 32 1.8 IN VITRO AND IN VIVO RELEASE CONDITIONS 38 1.9
RESEARCH OBJECTIVES 45 1.9.1 DEVELOPMENT OF A REDISPERSIBLE
ETHYLCELLULOSE POLYMER POWDER 45 1.9.2 DEVELOPMENT OF A NEW AQUEOUS
POLYMER DISPERSION FOR EXTENDED RELEASE DOSAGE FORMS 45 1.9.3 COLLOIDAL
AND FILM PROPERTIES OF EUDRAGIT RL/RS 46 1.9.4 INFLUENCE OF FATTY FOOD
ON COATED DOSAGE FORMS 46 2 MATERIALS AND EXPERIMENTAL PROCEDURE 47 2.1
MATERIALS 47 2.2 METHODS 49 2.2.1 SPRAY-DRYING 49 2.2.2 FREEZE-DRYING 49
2.2.3 REDISPERSIBILITY STUDIES 49 2.2.4 PREPARATION OF ETHYLCELLULOSE
DISPERSIONS 49 2.2.5 PREPARATION OF COATED PELLETS 50 2.2.6 CURING OF
COATED PELLETS 53 2.2.7 IN VITRO RELEASE STUDIES 53 2.2.8 POLYMERIC FILM
PREPARATION 53 2.2.9 WATER UPTAKE AND LEACHING OF POLYMERIC FILMS 54
2.2.10 PLASTICIZER LEACHING FROM FILMS 54 2.2.11 MECHANICAL PROPERTIES
OF POLYMERIC FILMS 55 2.2.12 DIALYSIS EXPERIMENTS FROM EUDRAGIT RL/RS
30D DISPERSIONS 55 2.2.13 PARTICLE SIZE MEASUREMENT 56 2.2.14 ZETA
POTENTIAL MEASUREMENTS 57 2.2.15 DSC MEASUREMENT 57 2.2.16 MINIMUM
FILM-FORMING TEMPERATURE 57 2.2.17 DRAG RELEASE FROM MATRIX FILMS 57
2.2.18 DIFFUSION TEST 58 2.2.19 WATER VAPOR TRANSMISSION TEST 58 2.2.20
SCANNING ELECTRON MICROSCOPY STUDY 58 2.2.21 FOOD EFFECT STUDIES 58
2.2.22 PREPARATION OF MATRIX TABLETS . . 59 2.2.23 PREPARATION OF
MULTIPLE-UNIT TABLETS 60 2.2.24 SOLUBILITY DETERMINATION 60 3 RESULTS
AND DISCUSSION 61 3.1 REDISPERSIBILITY OF FREEZE- OR SPRAY-DRIED POWDERS
FROM ETHYLCELLULOSE DISPERSIONS 61 3.1.1 TEMPERATURE-DEPENDENT STABILITY
OF AQUACOAT ECD.; 61 3.1.2 DRYING OF THE DISPERSIONS 64 3.1.3
REDISPERSIBILITY OF THE DRIED DISPERSIONS 69 3.1.4 COATING 78 3.1.5 DRY
COATING 87 3.2 KOLLICOAT SR 30 D, A NEW DISPERSION FOR EXTENDED RELEASE
DOSAGE FORMS 91 3.2.1 INVESTIGATION OFTHEPOLYVINYLACETATE DISPERSIONS 92
3.2.2 MECHANICAL PROPERTIES OF POLYMERIC FILMS 95 3.2.3 INFLUENCE OF
PLASTICIZERS ON THE GLASS TRANSITION TEMPERATURE, T G 100 3.2.4 WATER
AND WATER VAPOR UPTAKE OF KOLLICOAT SR 30 D FILMS 104 3.2.5 COATING OF
PELLETS IN A FLUIDIZED BED COATER 108 3.2.5.1 ANTI-TACKING AGENTS 108
3.2.5.2 PORE FORMER 110 3.2.5.3 PLASTICIZER 116 3.2.5.4 CURING 118
3.2.5.5 INFLUENCE OF DISSOLUTION MEDIUM AND DRUG 127 3.2.5.6 PRODUCT
TEMPERATURE 129 3.2.5.7 INFLUENCE OF BATCH OF DISPERSION 131 3.2.6
COMPACTION OF COATED PELLETS 134 3.2.7 MANUFACTURE OF GRANULES AND
MATRIX TABLETS 142 3.3 COLLOIDAL AND FILM PROPERTIES OF EUDRAGIT RL/RS
147 3.3.1 DIALYSIS OF EUDRAGIT RL/RS POLYMER DISPERSIONS 147 3.3.2
INTRINSIC VISCOSITY MEASUREMENTS 151 3.3.3 WATER UPTAKE STUDIES 155
3.3.4 DRUG RELEASE FROM MATRIX FILMS AND PERMEATION THROUGH FILMS 163
3.3.5 COUNTERION-EFFECTS 166 3.4 IN VITRO FOOD EFFECT STUDIES 176 4
SUMMARY AND CONCLUSION 187 5 ZUSAMMENFASSUNG 192 6 BIBLIOGRAPHY 198 7
PUBLICATIONS 226 8 CURRICULUM VITAE 227 IN
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| indexdate | 2024-07-09T19:04:26Z |
| institution | BVB |
| language | English |
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| spelling | Wagner, Klaus Verfasser aut Aqueous polymer dispersions for extended release dosage forms vorgelegt von Klaus Wagner 2002 X, 227 S. Ill., graph. Darst. : 21 cm txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2002 Hochschulschrift gtt Polymerdispersion (DE-588)4175228-4 gnd rswk-swf Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Polymerdispersion (DE-588)4175228-4 s Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009935872&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wagner, Klaus Aqueous polymer dispersions for extended release dosage forms Hochschulschrift gtt Polymerdispersion (DE-588)4175228-4 gnd Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd |
| subject_GND | (DE-588)4175228-4 (DE-588)4165181-9 (DE-588)4113937-9 |
| title | Aqueous polymer dispersions for extended release dosage forms |
| title_auth | Aqueous polymer dispersions for extended release dosage forms |
| title_exact_search | Aqueous polymer dispersions for extended release dosage forms |
| title_full | Aqueous polymer dispersions for extended release dosage forms vorgelegt von Klaus Wagner |
| title_fullStr | Aqueous polymer dispersions for extended release dosage forms vorgelegt von Klaus Wagner |
| title_full_unstemmed | Aqueous polymer dispersions for extended release dosage forms vorgelegt von Klaus Wagner |
| title_short | Aqueous polymer dispersions for extended release dosage forms |
| title_sort | aqueous polymer dispersions for extended release dosage forms |
| topic | Hochschulschrift gtt Polymerdispersion (DE-588)4175228-4 gnd Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd |
| topic_facet | Hochschulschrift Polymerdispersion Kontrollierte Wirkstofffreisetzung |
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