NMR spectroscopy of glycoconjugates:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Weinheim
Wiley-VCH
2003
|
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | Angekündigt u.d.T.: NMR of glycoconjugates |
Beschreibung: | XV, 320 S. Ill., graph. Darst. |
ISBN: | 3527304142 |
Internformat
MARC
LEADER | 00000nam a2200000 c 4500 | ||
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001 | BV014601903 | ||
003 | DE-604 | ||
005 | 20021207 | ||
007 | t | ||
008 | 020731s2003 ad|| |||| 00||| eng d | ||
016 | 7 | |a 965848574 |2 DE-101 | |
020 | |a 3527304142 |9 3-527-30414-2 | ||
035 | |a (OCoLC)50099691 | ||
035 | |a (DE-599)BVBBV014601903 | ||
040 | |a DE-604 |b ger |e rakwb | ||
041 | 0 | |a eng | |
049 | |a DE-355 |a DE-M49 | ||
050 | 0 | |a QD325 | |
050 | 0 | |a QP702.G577 | |
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084 | |a CHE 244f |2 stub | ||
084 | |a CHE 850f |2 stub | ||
245 | 1 | 0 | |a NMR spectroscopy of glycoconjugates |c ed. by J. Jiménez-Barbero ... |
246 | 1 | 3 | |a NMR of glycoconjugates |
264 | 1 | |a Weinheim |b Wiley-VCH |c 2003 | |
300 | |a XV, 320 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
500 | |a Angekündigt u.d.T.: NMR of glycoconjugates | ||
650 | 7 | |a Espectroscopia |2 larpcal | |
650 | 7 | |a Ressonância magnética nuclear |2 larpcal | |
650 | 4 | |a Glycoconjugates |x Analysis | |
650 | 4 | |a Glycoconjugates |x chemistry | |
650 | 4 | |a Magnetic Resonance Spectroscopy |x methods | |
650 | 4 | |a Nuclear magnetic resonance spectroscopy | |
650 | 0 | 7 | |a NMR-Spektroskopie |0 (DE-588)4075421-2 |2 gnd |9 rswk-swf |
650 | 0 | 7 | |a Glykokonjugate |0 (DE-588)4131221-1 |2 gnd |9 rswk-swf |
655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
689 | 0 | 0 | |a Glykokonjugate |0 (DE-588)4131221-1 |D s |
689 | 0 | 1 | |a NMR-Spektroskopie |0 (DE-588)4075421-2 |D s |
689 | 0 | |5 DE-604 | |
700 | 1 | |a Jiménez-Barbero, Jesús |e Sonstige |4 oth | |
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Datensatz im Suchindex
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adam_text |
V
CONTENTS
PREFACE
XI
ABBREVIATIONS
XIII
PART
A
PARAMETERS,
TECHNIQUES
AND
EXPERIMENTS
1
1
RELAXATION
AND
DYNAMICS
3
GORAN
WIDMALM
1.1
INTRODUCTION
3
1.2
THEORY
4
1.3
OLIGOSACCHARIDE
FLEXIBILITY
AND
DYNAMICS
10
1.3.1
FLEXIBILITY
OF
A
DISACCHARIDE
10
1.3.2
ANISOTROPIC
MOTION
OF
A
PENTASACCHARIDE
13
1.3.3
OLIGOSACCHARIDE
DYNAMICS
FROM
OFF-RESONANCE
ROESY
15
1.3.4
RIGID
VERSUS
FLEXIBLE:
A
TRISACCHARIDE
CASE
16
1.3.5
SLOW
DYNAMICS
OF
A
TRIDECASACCHARIDE
18
1.4
CONCLUDING
REMARKS
19
1.5
ACKNOWLEDGEMENTS
19
1.6
REFERENCES
20
2
RESIDUAL
DIPOLAR
COUPLINGS
IN
BACTERIAL
POLYSACCHARIDES
23
MANUEL
MARTIN-PASTOR
AND
C.
ALLEN
BUSH
2.1
INTRODUCTION
23
2.2
PREPARATION
OF
THE
ORIENTED
SAMPLES
24
2.3
NMR
EXPERIMENTS
FOR
THE
MEASUREMENT
OF
DIPOLAR
COUPLINGS
25
2.4
STRUCTURE
DETERMINATION
USING
RESIDUAL
DIPOLAR
COUPLING
29
2.4.1
THEORY
29
2.4.2
RIGID
STRUCTURE
CALCULATIONS
32
2.4.3
STRUCTURE
CALCULATIONS
IN
THE
PRESENCE
OF
FLEXIBILITY
34
2.4.4
STRUCTURE
CALCULATIONS
IN
THE
BOUND
STATE
36
2.5
CONCLUSIONS
36
2.6
REFERENCES
37
VI
CONTENTS
3
DETECTION
OF
HYDROXYL
PROTONS
39
HANS-CHRISTIAN
SIEBERT,
MARTIN
FRANK,
CLAUS-WILHELM
VON
DER
LIETH,
JESUS
JIMENEZ-BARBERO,
AND
HANS-JOACHIM
GABIUS
3.1
3.2
3.3
3.4
3.5
INTRODUCTION
39
HYDROXYL
GROUPS
OF
FREE
CARBOHYDRATES
43
HYDROXYL
GROUPS
OF
BOUND
CARBOHYDRATES
45
CONCLUSIONS
55
REFERENCES
56
4
NMR
OF
CARBOHYDRATES:
ID
HOMONUDEAR
SELECTIVE
METHODS
59
JEAN-ROBERT
BRISSON,
SHIH-CHE
SUE,
WEN-GUEY
WU,
GERALD
MCMANUS,
PHAM
T.
NGHIA,
AND
DUSAN
UHRTN
4.1
4.2
4.2.1
4.3
4.3.1
4.3.2
INTRODUCTION
59
EXPERIMENTAL
ASPECTS
59
DESCRIPTION
OF
THE
PULSE
SEQUENCES
59
EXAMPLES
62
MALTOTRIOSE:
OVERLAPPING
ANOMERIC
RESONANCES
62
DETERMINATION
OF
THE
BOUND
CONFORMATION
OF
A
HEPARIN
DISACCHARIDE,
AND
INTERMOLECULAR
NOES
65
4.3.3
4.3.4
NMR
OF
MIXTURES
70
MEASUREMENT
OF
PROTON-PROTON
RESIDUAL
DIPOLAR
COUPLING
CONSTANTS
IN
OLIGOSACCHARIDES
80
4.3.5
ID
DIRECTED-COSY,
ID
DIRECTED-COSY-COSY
AND
ID-DIRECTED
TOCSY
COSY
81
4.3.6
EVALUATION
OF
COUPLING
CONSTANTS
FROM
EXPERIMENTAL
MULTIPLETS.
SIGN
DETERMINATION
AND
PARAMETERIZATION
OF
THE
ALIGNMENT
TENSOR
88
4.4
4.5
4.6
CONCLUSIONS
90
ACKNOWLEDGEMENTS
90
REFERENCES
90
5
NMR
EXPERIMENTS
FOR
LARGE
CARBOHYDRATES
95
SEBASTIEN
J.F.
VINCENT
5.1
5.2
5.2.1
5.2.2
5.2.3
5.2.4
5.2.5
5.3
5.4
5.5
5.6
INTRODUCTION
95
THE
"
STANDARD
"
STRUCTURAL
ANALYSIS
96
CHEMICAL
ANALYSIS
96
NMR
SPECTROSCOPY
98
NMR
ASSIGNMENT
99
PRIMARY
STRUCTURE
DETERMINATION
101
CROSS-CORRELATED
DIPOLE-DIPOLE
RELAXATION
102
CURRENT
LIMITATIONS
105
OUTLOOK
105
ACKNOWLEDGEMENTS
106
REFERENCES
106
CONTENTS
I
VII
PART
B
STRUCTURAL
AND
CONFORMATIONAL
ANALYSIS
OF
CARBOHYDRATE
MOLECULES
BY
NMR
109
6
COMBINING
NMR
AND
SIMULATION
METHODS
IN
OLIGOSACCHARIDE
CONFORMATIONAL
ANALYSIS
111
THOMAS
WEIMAR
AND
ROBERT
J.
WOODS
6.1
6.2
6.2.1
6.2.2
6.2.3
6.2.4
6.2.4.1
6.2.4.2
6.2.4.3
6.2.5
6.2.5.1
6.2.5.2
6.2.5.3
6.3
6.3.1
6.3.2
6.3.3
6.3.4
6.4
INTRODUCTION
111
OLIGOSACCHARIDE
MODELING:
BACKGROUND
AND
THEORY
112
FORCE
FIELDS
112
MOLECULAR
DYNAMICS
SIMULATION
VERSUS
MONTE
CARLO
SAMPLING
114
EXPLICIT
SOLVATION:
WATER
MODELS
116
BOUNDARY
CONDITIONS
117
WATER
DROPLETS
117
PERIODIC
BOUNDARY
CONDITIONS
(PBC)
118
MINIMUM
IMAGE
CONVENTION
119
MD
SIMULATION
OF
OLIGOSACCHARIDES
121
INITIAL
CONFORMATION
121
SOLVATION,
ENERGY
MINIMIZATION
AND
MOLECULAR
DYNAMICS
121
DATA
ANALYSIS
123
NMR
SPECTROSCOPY
OF
OLIGOSACCHARIDES
124
IH^H
NOE
EXPERIMENTS
ON
OLIGOSACCHARIDES
126
ROE
EXPERIMENTS
129
RELAXATION
MATRIX
APPROACH
129
ONE
AND
TWO-DIMENSIONAL
NOE
EXPERIMENTS
130
EXAMPLE
APPLICATION
I:
CONFORMATIONAL
ANALYSIS
OF
A
DISACCHARIDE
EMPLOYING
NOE
CURVES
IN
CONJUNCTION
WITH
MONTE
CARLO
AND
MOLECULAR
DYNAMICS
SIMULATIONS
[66]
132
6.5
EXAMPLE
APPLICATION
II:
PBC
SIMULATION
OF
THE
OLIGOMANNOSIDE
MAN
9
GLCNAC
2
137
6.6
6.7
6.8
CONCLUSIONS
141
ACKNOWLEDGEMENTS
142
REFERENCES
142
7
THE
UNIQUE
SOLUTION
STRUCTURE
AND
IMMUNOCHEMISTRY
OF
THE
CANDIDA
ALBICANS
/71,2-MANNOPYRANAN
CELL
WALL
ANTIGEN
145
MARK
NITZ
AND
DAVID
R.
BUNDLE
7.1
7.2
7.3
7.4
7.4.1
7.4.2
7.4.3
INTRODUCTION
145
CANDIDA
ALBICANS
CELL
WALL
145
HOST
DEFENSES
AGAINST
FUNGAL
INFECTION
146
CHEMICAL
SYNTHESIS
OF
1,2-LINKED
JFF-MANNOPYRANOSE
OLIGOMERS
147
SYNTHESIS
OF
THE
TERMINAL
REDUCING
RESIDUE
148
SYNTHESIS
OF
OLIGOSACCHARIDES
148
SYNTHESIS
OF
A
(L-
2)-/?-MANNOPYRANOTETROSE
TERMINATED
BY
A
THIO-GLYCOSIDIC
LINKAGE
152
7.5
MOLECULAR
MODELING
AND
NMR
OF
(1
-+
2)-/?-MANNOPYRANAN
TRI-,
TETRA
AND
PENTOSE
155
VIII
I
CONTENTS
7.5.1
ASSIGNMENT
OF
AND
13
C
SPECTRA
FOR
(1
-
2)-/?-MANNOPYRANAN
TRI-,
TETRA
AND
PENTOSE
OLIGOMERS
156
7.5.2
7.5.3
7.5.4
7.5.5
7.5.6
7.5.7
7.5.8
7.5.9
ANALYSIS
OF
NOE
CONTACTS
FOR
(1
-
2)-/?-MANNOPYRANAN
OLIGOMERS
160
MOLECULAR
DYNAMICS
SIMULATIONS
163
RESULTS
OF
TRISACCHARIDE
MODELING
163
RESULTS
OF
TETRASACCHARIDE
MODELING
165
RESULTS
OF
PENTASACCHARIDE
MODELING
167
CONCLUSIONS
ABOUT
MOLECULAR
MODELING
168
CONFORMATIONAL
ANALYSIS
OF
THE
THIO-TETRASACCHARIDE
170
ANALYSIS
OF
THE
'
H
AND
13
C
NMR
SPECTRA
OF
PROPYL
/?(L-2)-THIO-TETRA
MANNOPYRANOSIDE
(6)
172
7.5.10
7.5.11
CONFORMATIONAL
ANALYSIS
OF
THIO-LINKED
TETRASACCHARIDE
6
173
COMPARISON
OF
THE
NATIVE
TETRASACCHARIDE
WITH
THE
THIOGLYCOSIDE
MIMETIC
173
7.6
7.6.1
7.6.2
7.6.3
7.6.4
7.6.5
7.7
7.8
DEVELOPMENT
OF
AN
ANTI-CANDIDA
ALBICANS
VACCINE
176
SYNTHESIS
OF
C.
ALBICANS
CONJUGATE
VACCINES
177
IMMUNIZATION
OF
EXPERIMENTAL
ANIMALS
178
ANALYSIS
OF
ANTIBODY
LEVELS
178
ANTIBODY
LEVELS
IN
MICE
AND
RABBITS
179
BINDING
OF
PROPYL
(1
-
2)-/?-MANNOSIDES
TO
MONOCLONAL
ANTIBODIES
180
CONCLUSIONS
184
REFERENCES
184
8
NMR
OF
SULFATED
OLIGO
AND
POLYSACCHARIDES
189
MILOS
HRICOVINI,
PEDRO
M.
NIETO,
AND
GIANGIACOMO
TORRI
8.1
8.1.1
PRIMARY
AND
SECONDARY
STRUCTURES
189
THE
EFFECT
OF
SO3
GROUPS
UPON
NMR
CHEMICAL
SHIFTS
AND
COUPLING
CONSTANTS
190
8.1.2
8.2
8.2.1
8.2.2
8.2.3
8.3
8.4
8.4.1
8.4.2
8.5
THE
EFFECT
OF
SO3
GROUPS
UPON
THE
STRUCTURE
192
THREE-DIMENSIONAL
STRUCTURE
194
COUPLING
CONSTANTS
195
NUCLEAR
OVERHAUSER
EFFECT
(NOE)
203
CHEMICAL
SHIFTS
205
DYNAMICS
OF
SULFATED
SACCHARIDES
IN
SOLUTION
206
INTERACTIONS
WITH
IONS
AND
PROTEINS
213
INTERACTIONS
WITH
METAL
IONS
213
INTERACTIONS
WITH
PROTEINS
216
REFERENCES
222
9
RESIDUAL
DIPOLAR
COUPLINGS:
STRUCTURE
AND
DYNAMICS
OF
GLYCOLIPIDS
231
JAMES
H.
PRESTEGARD
AND
J.
GLASHKA
9.1
9.2
9.3
9.4
9.5
INTRODUCTION
231
GLYCOLIPID
STRUCTURE
IN
SOLUTION
232
GLYCOLIPID
STRUCTURE
IN
A
MEMBRANE
ENVIRONMENT
233
LARGER
MEMBRANE
ASSEMBLIES
234
THEORY
OF
RESIDUAL
DIPOLAR
COUPLINGS
234
CONTENTS
IIX
9.6
DATA
COLLECTION
AND
STRUCTURE
OF
OLIGOSACCHARIDES
FROM
RESIDUAL
DIPOLAR
COUPLINGS
237
9.7
9.8
9.9
9.10
9.11
INSIGHT
INTO
DYNAMICS
239
GLYCOLIPIDS
ANCHORED
TO
MEMBRANES
239
GLYCOLIPID
STRUCTURE
USING
13
C
OBSERVATION
241
OTHER
TECHNIQUES
AND
FUTURE
TRENDS
243
REFERENCES
243
10
ACTIVATED
SUGARS
247
CELINE
MONTEIRO
AND
CATHERINE
HERVE
DU
PENHOAT
10.1
10.2
10.2.1
10.2.2
10.2.3
10.2.4
10.2.5
10.2.6
10.2.7
INTRODUCTION
247
NMR
METHODS
FOR
CONFORMATIONAL
ANALYSIS
OF
SUGAR
NUCLEOTIDES
248
NOMENCLATURE
248
SAMPLE
PREPARATION
251
NMR
EXPERIMENTS
251
VICINAL
HOMO
AND
HETERONUCLEAR
COUPLING
CONSTANTS
252
HYDRODYNAMIC
MODELING
254
HOMONUDEAR
RELAXATION
DATA
257
RELAXATION
AND
FREQUENCY
SHIFTS
IN
THE
PRESENCE
OF
PARAMAGNETIC
CATIONS
260
10.3
10.4
10.5
10.6
10.7
MONOVALENT
CATIONS
261
DIVALENT
CATIONS
263
TRIVALENT
CATIONS
267
PERSPECTIVES
267
REFERENCES
269
PARTC
INTERACTIONS
OF
CARBOHYDRATES
WITH
BIOMOLECULES
INVESTIGATED
BY
NMR
TECHNIQUES
AND
APPLICATIONS
273
11
NMR
ANALYSIS
OF
CARBOHYDRATE
-
CARBOHYDRATE
INTERACTIONS
275
ARMIN
GEYER
11.1
11.2
11.3
11.4
11.5
11.6
INTRODUCTION
275
MEMBRANE
MODELS
FOR
HIGH-RESOLUTION
NMR
276
CARBOHYDRATE
-
CARBOHYDRATE
AFFINITIES
277
LEWIS'
1
GLYCOSPHINGOLIPIDS
278
COVALENT
TETHERING
OF
LE
X
UNITS
[27]
280
REFERENCES
287
12
TR-NOE
EXPERIMENTS
TO
STUDY
CARBOHYDRATE-PROTEIN
INTERACTIONS
289
JESUS
JIMENEZ-BARBERO
AND
THOMAS
PETERS
12.1
12.2
12.2.1
12.2.1.1
12.2.2
12.2.2.1
12.2.2.2
INTRODUCTION
289
THE
TR-NOE
EXPERIMENT
290
EXPERIMENTAL
ASPECTS
292
SAMPLE
PREPARATION
AND
EXPERIMENTAL
SET-UP
292
VARIATIONS
IN
THE
REGULAR
2D
SEQUENCE
294
ID
EXPERIMENTS
294
3D
EXPERIMENTS
295
X
I
CONTENTS
12.2.3
12.2.3.1
12.2.3.2
12.2.3.3
12.2.3.4
12.2.3.5
12.2.4
12.2.5
12.2.5.1
12.2.5.2
12.2.5.3
12.2.5.4
12.2.5.5
12.2.5.6
12.2.6
12.3
HOW
TO
SOLVE
EXPERIMENTAL
COMPLICATIONS
295
SUPPRESSION
OF
THE
PROTEIN
ENVELOPE
295
PRESENCE
OF
SPIN
DIFFUSION
295
IDENTIFICATION
OF
SPIN
DIFFUSION
BY
TR-ROESY
296
SUPPRESSION
OF
SPIN
DIFFUSION
VIA
MINSY
297
SUPPRESSION
OF
SPIN
DIFFUSION
VIA
QUIET-NOESY
297
EXPERIMENTAL
PROTOCOL
FOR
TR-NOE
EXPERIMENTS
298
APPLICATIONS
AND
EXAMPLES
299
RECOGNITION
OF
THE
GLOBAL
MINIMUM
CONFORMATION
299
SIMULTANEOUS
RECOGNITION
OF
DIFFERENT
CONFORMATIONS
301
PROTEIN-INDUCED
CONFORMATIONAL
SELECTIONS
301
PROTEIN-INDUCED
CONFORMATIONAL
VARIATIONS
302
USE
OF
STRUCTURALLY
MODIFIED
CARBOHYDRATE
ANALOGS
303
OTHER
DEVELOPMENTS
306
PERSPECTIVES
306
REFERENCES
307
SUBJECT
INDEX
311 |
any_adam_object | 1 |
building | Verbundindex |
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genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
genre_facet | Aufsatzsammlung |
id | DE-604.BV014601903 |
illustrated | Illustrated |
indexdate | 2024-08-23T00:23:42Z |
institution | BVB |
isbn | 3527304142 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009925353 |
oclc_num | 50099691 |
open_access_boolean | |
owner | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM |
owner_facet | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM |
physical | XV, 320 S. Ill., graph. Darst. |
publishDate | 2003 |
publishDateSearch | 2003 |
publishDateSort | 2003 |
publisher | Wiley-VCH |
record_format | marc |
spelling | NMR spectroscopy of glycoconjugates ed. by J. Jiménez-Barbero ... NMR of glycoconjugates Weinheim Wiley-VCH 2003 XV, 320 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Angekündigt u.d.T.: NMR of glycoconjugates Espectroscopia larpcal Ressonância magnética nuclear larpcal Glycoconjugates Analysis Glycoconjugates chemistry Magnetic Resonance Spectroscopy methods Nuclear magnetic resonance spectroscopy NMR-Spektroskopie (DE-588)4075421-2 gnd rswk-swf Glykokonjugate (DE-588)4131221-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Glykokonjugate (DE-588)4131221-1 s NMR-Spektroskopie (DE-588)4075421-2 s DE-604 Jiménez-Barbero, Jesús Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009925353&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | NMR spectroscopy of glycoconjugates Espectroscopia larpcal Ressonância magnética nuclear larpcal Glycoconjugates Analysis Glycoconjugates chemistry Magnetic Resonance Spectroscopy methods Nuclear magnetic resonance spectroscopy NMR-Spektroskopie (DE-588)4075421-2 gnd Glykokonjugate (DE-588)4131221-1 gnd |
subject_GND | (DE-588)4075421-2 (DE-588)4131221-1 (DE-588)4143413-4 |
title | NMR spectroscopy of glycoconjugates |
title_alt | NMR of glycoconjugates |
title_auth | NMR spectroscopy of glycoconjugates |
title_exact_search | NMR spectroscopy of glycoconjugates |
title_full | NMR spectroscopy of glycoconjugates ed. by J. Jiménez-Barbero ... |
title_fullStr | NMR spectroscopy of glycoconjugates ed. by J. Jiménez-Barbero ... |
title_full_unstemmed | NMR spectroscopy of glycoconjugates ed. by J. Jiménez-Barbero ... |
title_short | NMR spectroscopy of glycoconjugates |
title_sort | nmr spectroscopy of glycoconjugates |
topic | Espectroscopia larpcal Ressonância magnética nuclear larpcal Glycoconjugates Analysis Glycoconjugates chemistry Magnetic Resonance Spectroscopy methods Nuclear magnetic resonance spectroscopy NMR-Spektroskopie (DE-588)4075421-2 gnd Glykokonjugate (DE-588)4131221-1 gnd |
topic_facet | Espectroscopia Ressonância magnética nuclear Glycoconjugates Analysis Glycoconjugates chemistry Magnetic Resonance Spectroscopy methods Nuclear magnetic resonance spectroscopy NMR-Spektroskopie Glykokonjugate Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009925353&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT jimenezbarberojesus nmrspectroscopyofglycoconjugates AT jimenezbarberojesus nmrofglycoconjugates |