Operators and promoters: the story of molecular biology and its creators
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berkeley [u.a.]
Univ. of California Press
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references (p. 379-452) and indexes |
| Beschreibung: | XX, 466 S. Ill., graph. Darst. |
| ISBN: | 0520213319 |
Internformat
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| 245 | 1 | 0 | |a Operators and promoters |b the story of molecular biology and its creators |c Harrison Echols. Ed. by Carol A. Gross |
| 264 | 1 | |a Berkeley [u.a.] |b Univ. of California Press |c 2001 | |
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| 500 | |a Includes bibliographical references (p. 379-452) and indexes | ||
| 650 | 7 | |a Moleculaire biologie |2 gtt | |
| 650 | 4 | |a Geschichte | |
| 650 | 4 | |a Genetic Engineering |x history | |
| 650 | 4 | |a Molecular Biology |x history | |
| 650 | 4 | |a Molecular biology |x History | |
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Datensatz im Suchindex
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|---|---|
| adam_text | OPERATORS AND PROMOTERS
The Story of Molecular Biology and Its Creators
HARRISONECHOLS
Edited by Carol A Gross
UNIVERSITYOFCALIFORNIAPRESSBERKELEYLOSANGELESLONDON
CONTENTS
Foreword by Arthur Kornberg xiii
Preface xv
1 BEGINNINGS: SIMPLICITY AND ELEGANCE, DNA AND PROTEIN 1
Proteins 2 DNA 6 Simple Organisms 8 Further Reading 10
2 THE CODE FOR LIFE: DNA TO PROTEIN 11
Genes Code for Proteins 11 Dejining the Coding Problem: The Information People 15
DNA to RNA to Protein:The Biochemical Pathway People 21 Cracking the Code: Synthetic mRNA 26
The Genetic Code: Cod Has an Orderly Mind 32 Further Reading 34
3 TURNING GENES ON AND OFF: GENES THAT CONTROL OTHER GENES 35
Bacterial Growth and the Induced Synthesis of fi-galactosidase: Hie Monod Group 36
The Problem of Lysogeny and Phage X: The Jacob Group 40 Bacterial Sex and Erotic Induction 45
Turning Off Related Genes: The Road to the Repressor and the Operon 49
The Discovery of Messenger RNA 56 What Is the Repressor? 59
Some Comments on the Road to the Operon 59
Positive and Negative Regulation: Two Ways to Run an Operon 60
Multi-Operon Regulation: The Glucose Effect 62 Regulatory Diversity: Review and Preview 63
Further Reading 64
4 REPLICATING THE GENOME 65
DNA Polymerase Replicates DNA 65 The Problems of Replicating a Genome 69
The Genetics of Replication 74 The Fine Structure of DNA Replication 77
The Real Replication Enzyme Is Just Like Pol I 81
A Simple Task That Needs Many Proteins: Priming and Elongating 82
Special Proteins Needed for Genome Replication: Stretching, Unwinding, Untwisting 89
Replicating Duplex DNA 92 Starting Genome Replication: A Special Structure 96
Further Reading 101
5 MAKING RNA FROM DNA 102
The Flow of Biological Information 102 The Transcription Enzyme: RNA Polymerase 103
The Properties of mRNA 105 Developmental Pathways of Phage 108
Lambdology: The Developmental Biology of a Field 110 Lambdology: The Developmental Biology of a Phage 113
Lambdology as a Community 117 The Lac and X Repressors Bind to Operator DNA 120
The Biochemistry of RNA Polymerase 126 Positive and Negative Regulators of the lac Operon 129
The General View of Regulatory Proteins: 1972 131
The Idea of Antitermination Regulation: Problems in Paradise 132
Regulated Termination in the trp Operon: The Attenuator 136
Transcription Termination and How to Avoid It: X N and Q Proteins 142
The Regulator-Operator Interaction: How to Locate a Site on DNA 146
A New Approach to DNA Sequence and Its Recognition: Single-Cleavage Analysis 148
Determining DNA Sequence by DM4 Replication 153 The Molecular Study of Protein-DNA Interactions 155
viii CONTENTS
Building a Regulatory Protein: A DNA-Binding Motif 158
The Regulator-Polymerase Interaction: General Rules? 162 Further Reading 165
6 THE RNA WORLD: NEW PROTEINS AND REVISED RNAS 166
The Anticodon: Base-Pairs Can Wobble 167 Base Sequence of tRNA: A Three-Leaf Clover for Holley 168
Message Decoding: Methods and Protagonists 171 The Problem of Starting a Protein 172
Ending a Protein: The Value of Nonsense 175
Protein Translation Factors -Turning the Gears in Protein Synthesis 178
Using the Ribosome: GTP and Translocation 182 The Ribosome: The Many Faces of an Enigma 189
RNA Slicing in Bacteria 199 RNA Splicing in Eukaryotes 203
The Biochemistry of Splicing: Lariats on a Spliceosome 211
RNA Processing Without Proteins: Catalytic RNA 215 Further Reading 219
7 DNA ON ITS OWN: GENETIC RECOMBINATION 220
General Recombination and the Holliday Model 221 Holliday Intermediates in Cells 225
Genes and Enzymes in Bacterial Recombination 226 The RecA Protein and Branch Migration 228
The RecBCD Protein: Unwinding and Nicking 230 General Recombinational Pathways: The Future 231
Site-Specific Recombination and the Campbell Model 233 Prophage Excision and Excisive Recombination 237
The Biochemistry of Site-Specific Recombination 239
DNA-Protein Interactions in Site-Specific Recombination 242 Other Site-Specific Recombinases 245
Transposition and Replicative Site-Specific Recombination 24 7 The IS Insertion Elements 249
Mu:A Phage That Does Not Integrate Like Lambda 251
Identifying the Mu Components Needed for Transposition 254 A Unifying Model for Transposition 256
Transposition: Why Have It? 258 Further Reading 260
CONTENTS i x
REGULATING THE REGULATORS:
DEVELOPMENTAL AND SALVATIONAL DECISIONS 261
The Lysis-Lysogeny Decision by Phage X: ell as the Master Regulator 262
Regulating the Regulator: Control of ell Activity 266
Molecular Decision Making: Primary and Secondary Switches 268
Lifestyle Crises and Salvational Decisions 273 The Heat Shock Response and Molecular Chaperones 273
Heat Shock: From- Cell Biology to Molecular Biology 274
Regulation and Function of Heat Shock Proteins in E coli 275
Regulation of the Heat Shock Response: New Promoter Recognition by RNA Polymerase 277
Regulation of the Regulator: Post-Transcriptional Control of a32 279
The Heat Shock Response in Eukaryotic Cells 280 Regulated DNA Repair and Mutagenesis 282
The UVR Pathway of Excision Repair 283 RecA-Mediated Recombinational Repair 284
The SOS Response to DNA Damage 286
The Biochemistry of SOS Regulation: Induction by Repressor Cleavage 290
Induced Mutation in the SOS Response 293 Further Reading 295
MAKING DNA FROM RNA: THE STRANGE LIFE OF THE RETROVIRUS
Quantitative Animal Virology :The Plaque and Focus Assays 297 Making DNA from RNA
The Path from Virus to Provirus and Back Again 301 The Wild Ride of Reverse Transcriptase
The Retrovirus and Its Cancer Gene 308 Retroviruses as Transposons 312
The HIV Retrovirus 314 Further Reading 317
X CONTENTS
GENETIC ENGINEERING: GENES AND PROTEINS O N DEMAND 318
The Social Context for Basic Research in Biology 318 A Biological Revolution from the Unpredictable 319
Hitchhiking Genes and Multiplying Vectors 319
Biological Roots: Phage with Bacterial Genes and Cohesive Sites 321
Biological Roots: Restriction Enzymes for Pieces of DNA 321 The Engineered Joining of DNA Molecules 333
DNA Cloning: Amplification of Foreign DNA by a Plasmid Vector 338
Safety Concerns and Regulatory Policy 340
Genetic Engineering: A Giant Leap for Eukaryotic Molecular Biology 344
The Industrial and Medical Ramifications of Genetic Engineering 347 Further Reading 349
Afterword by Tom Cech 350
Timeline 352 Glossary 359 Notes 379 Name Index 453 Subject Index 458
CONTENTSxi
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| language | English |
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| publisher | Univ. of California Press |
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| spelling | Echols, Harrison Verfasser aut Operators and promoters the story of molecular biology and its creators Harrison Echols. Ed. by Carol A. Gross Berkeley [u.a.] Univ. of California Press 2001 XX, 466 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references (p. 379-452) and indexes Moleculaire biologie gtt Geschichte Genetic Engineering history Molecular Biology history Molecular biology History Geschichte (DE-588)4020517-4 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 s Geschichte (DE-588)4020517-4 s DE-604 Gross, Carol A. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009887275&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Echols, Harrison Operators and promoters the story of molecular biology and its creators Moleculaire biologie gtt Geschichte Genetic Engineering history Molecular Biology history Molecular biology History Geschichte (DE-588)4020517-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4020517-4 (DE-588)4039983-7 |
| title | Operators and promoters the story of molecular biology and its creators |
| title_auth | Operators and promoters the story of molecular biology and its creators |
| title_exact_search | Operators and promoters the story of molecular biology and its creators |
| title_full | Operators and promoters the story of molecular biology and its creators Harrison Echols. Ed. by Carol A. Gross |
| title_fullStr | Operators and promoters the story of molecular biology and its creators Harrison Echols. Ed. by Carol A. Gross |
| title_full_unstemmed | Operators and promoters the story of molecular biology and its creators Harrison Echols. Ed. by Carol A. Gross |
| title_short | Operators and promoters |
| title_sort | operators and promoters the story of molecular biology and its creators |
| title_sub | the story of molecular biology and its creators |
| topic | Moleculaire biologie gtt Geschichte Genetic Engineering history Molecular Biology history Molecular biology History Geschichte (DE-588)4020517-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Moleculaire biologie Geschichte Genetic Engineering history Molecular Biology history Molecular biology History Molekularbiologie |
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