ABO-incompatible kidney transplantation:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2001
|
| Ausgabe: | 1. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XVII, 154 S. Ill., graph. Darst. |
| ISBN: | 0444505431 |
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| 100 | 1 | |a Takahashi, Kōta |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a ABO-incompatible kidney transplantation |c Kota Takahashi |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2001 | |
| 300 | |a XVII, 154 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a ABO Blood-Group System |x immunology | |
| 650 | 4 | |a Antibodies |x blood | |
| 650 | 4 | |a Blood Group Incompatibility | |
| 650 | 4 | |a Blood groups |x ABO system | |
| 650 | 4 | |a Kidney Transplantation |x immunology | |
| 650 | 4 | |a Kidneys |x Transplantation |x Immunological aspects | |
| 650 | 0 | 7 | |a AB-Null-System |0 (DE-588)4141078-6 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804129310993285120 |
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| adam_text | CONTENTS
Preface v
Personal History vii
Chapter 1. History 1
References 2
Chapter 2. Current status of treatment for chronic renal failure and
factors behind increasing use of ABO incompatible
kidney transplantation in Japan 5
References 8
Chapter 3. Indications and considerations 9
3.1. Indications 9
3.2. Crossmatch test 9
3.3. Anti A/anti B (anti A, anti B, and anti AB) antibodies 9
3.4. Age and dialysis history 9
3.4.1. Recipient 10
3.4.2. Donor 10
3.5. Infection 10
3.6. Anticoagulation therapy 10
3.7. Informed consent 10
References 10
Chapter 4. Blood group antigens and their antibodies 13
4.1. ABO blood group antigens 13
4.2. Measuring anti A and anti B antibodies 16
4.3. Origin of ABO blood group glycosyltransferase 16
4.4. ABO blood group antigens and other blood group antigens .... 17
Acknowledgements 19
References 19
xi
xii Contents
Chapter 5. Rejection 21
5.1. Considerations regarding rejection mechanism 21
5.2. Mechanism of rejection in ABO incompatible kidney trans¬
plantation 24
Acknowledgements 30
References 30
Chapter 6. Immunosuppressive therapy 31
6.1. Considerations for immunosuppressive therapy in kidney trans¬
plantation 31
6.2. Induction period immunosuppressive therapy in ABO incom¬
patible kidney transplantation 32
6.2.1. Pretransplant extracorporeal immunomodulation 33
6.2.1.1. Actual status of extracorporeal immunomodulation and blood
purification techniques 34
6.2.1.1.1. Simple plasma exchange 34
6.2.1.1.2. Fractional plasma exchange 35
6.2.1.1.3. Blood adsorption and immunoadsorption 37
6.2.2. Pharmacotherapy for immunosuppression 43
6.2.2.1. Evolution of induction period immunosuppressive therapy in
ABO incompatible kidney transplantation 43
6.2.2.1.1. Stage 1: January 1989 through March 1996 43
6.2.2.1.2. Stage 2: April 1996 through February 1999 46
6.2.2.1.3. Stage 3: March 1999 through December 1999 46
6.2.2.1.4. Stage 4: January 2000 to present 46
6.2.2.2. Immunosuppressive agents for induction period 48
6.2.2.2.1. Calcineurin inhibitors 48
6.2.2.2.2. Steroid 51
6.2.2.2.3. Cyclophosphamide 51
6.2.2.2.4. Antilymphocyte globulin 52
6.3. Immunosuppressive therapy for maintenance period 52
6.3.1. Calcineurin inhibitors 52
6.3.2. Steroid 52
6.3.3. Antimetabolites 52
6.3.3.1. Azathioprine 53
6.3.3.2. Mizoribine 53
6.3.3.3. Mycophenolate mofetil 55
6.4. Treatment for rejection 56
6.4.1. Treatment for cellular rejection 57
6.4.2. Treatment for humoral rejection 57
6.4.2.1. Removal of causal factors, removal of anti A/anti B antibod¬
ies, and the use of extracorporeal immunomodulation 57
6.4.2.2. Anticoagulation therapy 58
Contents xiii
6.5. Effects and complications of splenectomy 58
Acknowledgements 60
References 60
Chapter 7. Surgical procedures 63
7.1. Introduction 63
7.2. Kidney transplantation 63
7.3. Splenectomy 64
7.3.1. Procedure 64
7.3.1.1. Invasive surgery 64
7.3.1.2. Laparoscopic surgery 64
7.3.1.3. Partial splenic embolization 64
7.3.2. Timing of splenectomy 64
7.4. Other surgical procedures 65
7.5. Donor nephrectomy 65
Acknowledgements 65
References 66
Chapter 8. Prevention and treatment of infections 67
8.1. Basic considerations for posttransplant infections 67
8.2. Prevention and treatment for cytomegalovirus infection 69
8.2.1. Prophylactic therapy 69
8.2.2. Pre emptive therapy 69
8.2.3. Treatment 70
8.2.3.1. Tissue injury caused by CMV , . . . 70
8.2.3.2. Overresponse of host defense mechanism against CMV infected
cells 70
8.3. Vaccination 70
Acknowledgements 71
References 71
Chapter 9A. Current status of ABO incompatible kidney transplantation
in Japan, 1999: results of a questionnaire based survey .... 73
9A. 1. Introduction 73
9A.2. Objectives, target population, and methodology of the ques¬
tionnaire based survey 73
9A.3. Current status of ABO incompatible kidney transplantation in
Japan 74
9A.4. Follow up survey and statistical analysis of patients undergoing
ABO incompatible kidney transplantation 74
9A.4.1. Subject population 74
9A.4.2. Statistical analysis 75
xiv Contents
9A.4.3. Methods of pretransplant antibody removal 75
9A.4.4. Splenectomy and posttransplant anticoagulation therapy 75
9A.4.5. Immunosuppressive therapy 76
9A.4.6. Incidence of rejection 76
9A.4.7. Overall patient survival rate and graft survival rate 76
9A.4.8. Graft survival rate by time when transplantation was performed . 76
9A.4.9. Graft survival rate by donor recipient relationship 76
9A.4.10. Graft survival rate by age of recipient 76
9A.4.11. Graft survival rate by differences in blood type 77
9A.4.12. Graft survival rate by number of HLA A, B, and DR antigen
mismatches 78
9A.4.13. Graft survival rate by type of immunosuppressant used 78
9A.4.14. Graft survival rate by use or non use of anticoagulation therapy . 79
9A.4.15. Major complications posttransplant 81
9A.4.16. Mortality and graft loss 81
9A.5. Discussion 83
9A.5.1. Number of ABO incompatible kidney transplantations 83
9A.5.2. Patient characteristics 83
9A.5.3. Results 83
9A.5.3.1. Overall patient survival rate and graft survival rate 83
9A.5.3.2. Graft survival rate by date of transplantation 84
9A.5.3.3. Graft survival rate by age of recipient 84
9A.5.3.4. Graft survival rate by blood type and number of HLA antigen
mismatches 84
9A.5.3.5. Graft survival rate by type of immunosuppressant used 84
9A.5.3.6. Graft survival rate by the use or non use of anticoagulation
therapy 85
9A.5.3.7. Deaths and complications 85
9A.5.3.8. Causes of graft loss 85
9A.6. Future considerations 85
9A.7. Summary 85
9A.8. Conclusion 86
Acknowledgements 86
References 86
Chapter 9B. ABO incompatible kidney transplantation in Japan by
recipient and donor age, and major causal factors affecting
differences: results of a questionnaire based survey 89
9B. 1. Introduction 89
9B.2. Subjects and methods 90
9B.2.1. Objectives, subjects, and methods used in the questionnaire
based survey 90
9B.3. Follow up survey and statistical analysis of ABO incompatible
kidney transplantation patients 90
Contents xv
9B.3.1. Subject population 90
9B.3.1.1. Comparison by recipient age 91
9B.3.1.2. Comparison by donor age 91
9B.3.2. Statistical analysis 93
9B.4. Results 93
9B.4.1. Overall patient survival rate and graft survival rate 93
9B.4.2. Graft survival rate by recipient age and by donor age 94
9B.4.2.1. Graft survival rate by recipient age 94
9B.4.2.2. Graft survival rates at 1,3, 5, and 7 years by donor age 94
9B.5. Discussion 97
9B.5.1. Overall patient survival rate and graft survival rate 97
9B.5.2. Graft survival rate by recipient age 97
9B.5.3. Graft survival rate by donor age 99
9B.6. Conclusion 99
Acknowledgements 99
References 99
Chapter 10. Case studies 101
10.1. Introduction , 101
10.2. Stage 1 immunosuppressive therapy (January 1989 through
March 1996) 101
10.2.1. Cases in which the clinical course was uneventful 101
10.2.1.1. Case 1: a 28 year old man, blood type O, Rh+, with end stage
renal disease (ESRD) due to chronic glomerulonephritis 101
10.2.1.1.1. Discussion 102
10.2.1.2. Case 2: a 34 year old woman, blood type O, Rh+, with ESRD
due to chronic glomerulonephritis 102
10.2.1.2.1. Discussion 102
10.2.2. ABO incompatible partial kidney transplantation, second graft . 105
10.2.2.1. Case 3: a girl, 8 years and 2 months of age, blood type O, Rh+,
HLA A, B, DR; A24, A31, B51. BW55. DR4. DR8 105
10.2.2.1.1. Reasons for partial kidney transplantation 106
10.2.2.1.2. Second kidney transplantation 106
10.2.2.1.3. Discussion 108
10.2.3. First report of successful pregnancy and delivery in a woman
following ABO incompatible kidney transplantation Ill
10.2.3.1. Case 4: a 33 year old woman, blood type O. Rh+. with ESRD
due to reflux nephropathy. HLA A. B. DR: A24. A24. B35.
DR8, DR12 Ill
10.2.3.1.1. Discussion 113
10.2.4. A patient who developed hypersensitivity to BiosynsorbR 113
10.2.4.1. Case 5: a 27 year old man, blood type O, Rh+. with ESRD due
to chronic glomerulonephritis 113
10.2.4.1.1. Discussion 114
xvi Contents
10.2.5. A case of rebound following pretransplant antibody removal,
with subsequent graft loss due to humoral rejection 116
10.2.5.1. Case 6: a 40 year old woman, blood type O, Rh+, with ESRD
due to chronic glomerulonephritis 116
10.2.5.1.1. Discussion 116
10.2.6. Cases in which hyperacute humoral rejection developed during
surgery as a result of transfusion with frozen blood plasma of
the same blood type as the recipient 118
10.2.6.1. Case 7: a 15 year old girl, blood type A,, Rh+, with ESRD due
to focal glomerular sclerosis (FGS) 118
10.2.6.2. Case 8: a 35 year old man, blood type B, Rh+, with ESRD due
to chronic glomerulonephritis 121
10.2.6.2.1. Discussion 121
10.2.7. Three HLA A, B, DR identical cases 121
10.2.7.1. Cases 9, 10 and 11: a 25 year old woman, a 49 year old
man and a 34 year old man with ABO incompatible kidney
transplantation in which donor and recipient were HLA A, B,
DR identical 121
10.2.7.1.1. Discussion 124
10.2.8. A case of acute humoral rejection triggered by bacterial infec¬
tion 124
10.2.8.1. Case 11: a 34 year old man, blood type O, Rh+, with ESRD
due to chronic glomerulonephritis 124
10.2.8.1.1. Discussion 124
10.3. Stage 2 immunosuppressive therapy (April 1996 through Febru¬
ary 1999) 128
10.3.1. A case of accelerated acute rejection caused by poor absorption
of tacrolimus 128
10.3.1.1. Case 12: a 29 year old man, blood type O, Rh+, with ESRD
due to Alport s syndrome 128
10.3.1.1.1. Discussion 129
10.3.2. A case in which the clinical course was uneventful 131
10.3.2.1. Case 13: a 30 year old man, blood type A,, Rh+, with ESRD
due to IgA nephropathy 131
10.3.2.1.1. Discussion 131
10.3.3. Case of repeated episodes of acute rejection, developing into
chronic rejection 3 months posttransplant 133
10.3.3.1. Case 14: a 34 year old man, blood type B, Rh+, with ESRD
due to IgA nephropathy 133
10.3.3.1.1. Discussion 135
10.4. Stage 3 immunosuppressive therapy (March 1999 through De¬
cember 1999) 137
10.4.1. A case in which the clinical course was uneventful 137
10.4.1.1. Case 15: a 24 year old woman, blood type B, Rh+, with ESRD
due to chronic glomerulonephritis 137
Contents xvii
10.4.1.1.1. Discussion 137
10.5. Stage 4 (most recent) immunosuppressive therapy at our insti¬
tution 139
10.5.1. Cases in which the clinical course was uneventful 139
10.5.1.1. Case 16: a 30 year old man, blood type B, Rh+, with ESRD
due to chronic glomerulonephritis 139
10.5.1.2. Case 17: a 23 year old man, blood type O, Rh+, with ESRD
due to Alport s syndrome 140
10.6. Discussion 140
Acknowledgements 143
References 143
Chapter 11. Findings of ABO incompatible transplantation and future
tasks 145
11.1. Background 145
11.2. Indications 145
11.3. Crossmatch test and crossmatch positive patients 146
11.3.1. Testing methods for the crossmatch test 146
11.3.2. Kidney transplantation for T cell crossmatch positive patients .. 146
11.4. Rejection 146
11.4.1. Cellular rejection and humoral rejection 146
11.4.2. Factors that trigger rejection 147
11.5. Anti A/anti B (anti A, anti B, and anti AB) antibodies 147
11.6. Immunosuppressive therapy 148
11.6.1. Removal of anti A/anti B antibodies 148
11.6.2. Immunosuppressive agents 148
Acknowledgements 148
References 148
Closing Remarks 149
Subject Index 151
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| id | DE-604.BV014496104 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:03:07Z |
| institution | BVB |
| isbn | 0444505431 |
| language | English |
| lccn | 2001040584 |
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| physical | XVII, 154 S. Ill., graph. Darst. |
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| spelling | Takahashi, Kōta Verfasser aut ABO-incompatible kidney transplantation Kota Takahashi 1. ed. Amsterdam [u.a.] Elsevier 2001 XVII, 154 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index ABO Blood-Group System immunology Antibodies blood Blood Group Incompatibility Blood groups ABO system Kidney Transplantation immunology Kidneys Transplantation Immunological aspects AB-Null-System (DE-588)4141078-6 gnd rswk-swf Nierentransplantation (DE-588)4042284-7 gnd rswk-swf Nierentransplantation (DE-588)4042284-7 s AB-Null-System (DE-588)4141078-6 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009882980&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Takahashi, Kōta ABO-incompatible kidney transplantation ABO Blood-Group System immunology Antibodies blood Blood Group Incompatibility Blood groups ABO system Kidney Transplantation immunology Kidneys Transplantation Immunological aspects AB-Null-System (DE-588)4141078-6 gnd Nierentransplantation (DE-588)4042284-7 gnd |
| subject_GND | (DE-588)4141078-6 (DE-588)4042284-7 |
| title | ABO-incompatible kidney transplantation |
| title_auth | ABO-incompatible kidney transplantation |
| title_exact_search | ABO-incompatible kidney transplantation |
| title_full | ABO-incompatible kidney transplantation Kota Takahashi |
| title_fullStr | ABO-incompatible kidney transplantation Kota Takahashi |
| title_full_unstemmed | ABO-incompatible kidney transplantation Kota Takahashi |
| title_short | ABO-incompatible kidney transplantation |
| title_sort | abo incompatible kidney transplantation |
| topic | ABO Blood-Group System immunology Antibodies blood Blood Group Incompatibility Blood groups ABO system Kidney Transplantation immunology Kidneys Transplantation Immunological aspects AB-Null-System (DE-588)4141078-6 gnd Nierentransplantation (DE-588)4042284-7 gnd |
| topic_facet | ABO Blood-Group System immunology Antibodies blood Blood Group Incompatibility Blood groups ABO system Kidney Transplantation immunology Kidneys Transplantation Immunological aspects AB-Null-System Nierentransplantation |
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