Molecular infection biology: interactions between microorganisms and cells
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English German |
| Veröffentlicht: |
New York
Wiley-Liss
2002
Heidelberg ; Berlin Spektrum, Akad. Verl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 339 S. Ill., graph. Darst. : 25 cm |
| ISBN: | 0471178462 |
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| 245 | 1 | 0 | |a Molecular infection biology |b interactions between microorganisms and cells |c ed. by Jörg Hacker ; Jürgen Heesemann. [Transl. from German by Renate FitzRoy] |
| 264 | 1 | |a New York |b Wiley-Liss |c 2002 | |
| 264 | 1 | |a Heidelberg ; Berlin |b Spektrum, Akad. Verl. | |
| 300 | |a XVII, 339 S. |b Ill., graph. Darst. : 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Virologia |2 larpcal | |
| 650 | 4 | |a Bacterial Proteins |x biosynthesis | |
| 650 | 4 | |a Host-Parasite Interactions | |
| 650 | 4 | |a Immunity, Cellular | |
| 650 | 4 | |a Infection | |
| 650 | 4 | |a Infection |x microbiology | |
| 650 | 4 | |a Pathology, Molecular | |
| 650 | 4 | |a Virulence (Microbiology) | |
| 650 | 4 | |a Virulence Factors | |
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Datensatz im Suchindex
| _version_ | 1804129308862578688 |
|---|---|
| adam_text | FOREWORD XIII J. SS. KAPER ACKNOWLEDGMENTS XV CONTRIBUTORS XVII CHAPTER I
INTRODUCTION I J. HACKER AND J. HEESEMANN CHAPTER 2 MEDICALLY
SIGNIFICANT PATHOGENS 7 J. HEESEMANN AND J. HACKER 2. 1 WHAT ARE
PATHOGENS? 7 2.2 INFECTIONS OF THE ORAL CAVITY II 2.3 INFECTIONS OF THE
UPPER AND LOWER RESPIRATORYTRACT . . 12 2.4 INFECTIONS OF THE
GASTROINTESTINAL TRACT 15 2.5 INFECTIONS OF THE URINARY TRACT 17 2.6
SEXUALLY TRANSMITTED INFECTIONS 19 2.7 INFECTIONS OF THE CENTRAL NERVOUS
SYSTEM (CNS) 20 2.8 SKIN ANDWOUND INFECTIONS 23 2.9 SERIOUS SYSTEMIC
INFECTIONS, SEPSIS 24 2.10 PATHOLOGICAL IMMUNE RESPONSE AS A RESULT OF
INFECTION 26 BIBLIOGRAPHY 26 CHAPTER 3 HOST DEFENSES AGAINST
MICROORGANISMS: NONSPECIFIC DEFENSES 29 J. HEESEMANN 3. 1 DEFENSE
SYSTEMS AGAINST INFECTION 29 3.2 PHYSICAL BARRIERS AND NORMAL FLORA 30
3.3 RECOGNITION AND TAGGING OF INVADING MICROBES 32 3.3.1 LOCATING
INVADING MICROBES 32 3.3.2 THE COMPLEMENT SYSTEM 35 3.4 ANTIMICROBIAL
PEPTIDES 38 3.5 EFFECTOR CELLS OF THE INNATE IMMUNE SYSTEM 38 3.6
GENETICALLY DETERMINED INFECTION SUSCEPTIBILITY 41 BIBLIOGRAPHY 42
CHAPTER 4 THE ADAPTIVE IMMUNE SYSTEM 45 J. HEESEMANN 4.1 SPECIFIC
DEFENSES AGAINST PATHOGENS 45 4.2 LYMPHATIC ORGANS 46 4.3
ANTIGEN-BINDING RECEPTORS OF B AND T LYMPHOCYTES ... 46 BIBLIOGRAPHY 52
CHAPTER 5 SYMBIOSIS, INFECTION, AND PATHOGENICITY 53 U. HENTSCHEL AND J.
HACKER BIBLIOGRAPHY 56 CHAPTER 6 OFFENSIVE PATHOGENICITY FACTORS 57 6. 1
ADHESINS (J. HACKER) 57 6.1.1 THE STRUCTURE OF ADHESINS 57 6.1.2 THE
BIOLOGICAL SIGNIFICANCE OF ADHESION 59 6.2 INVASINS (T. OELSCHLAEGER) 61
6.2.1 INVASION AS A SURVIVAL STRATEGY 61 6.2.2 TRIGGER AND ZIPPER
MECHANISMS 62 6.2.3 THE STRUCTURE OF INVASION SYSTEMS 62 6.2.4
EUKARYOTIC INTERNALIZATION RECEPTORS 65 6.2.5 SIGNAL TRANSDUCTION AND
THE CYTOSKELETON 66 6.2.6 INTRACELLULAR SURVIVAL 67 6.3 TOXINS (J.
REIDI) 67 6.3.1 TOXINS ASVIRULENCE FACTORS 67 6.3.2 TOXIN STRUCTURES .
68 6.3.3 MEMBRANE-DISRUPTING ACTIVITIES OF TOXINS 70 6.3.4 INTERNALIZED
TOXINS 71 6.3.5 NONINTERNALIZED TOXINS: SUPERANTIGENS AND HEAT-STABLE
TOXINS 74 BIBLIOGRAPHY 75 CHAPTER 7 DEFENSIVE PATHOGENICITY FACTORS 77
R. HAAS AND M. HENSEL 7. 1 CAPSULES AND SLIMES 77 7.2 MOLECULAR MIMICRY
AND MODULATION OF THE IMMUNE SYSTEM 78 7.3 LIPOPOLYSACCHARIDES AND O
ANTIGEN 79 7.4 OUTER MEMBRANE PROTEINS 81 7.5 SURFACE LAYER 82 7.6 IGA
PROTEASES 84 7.7 FURTHER ENZYMATIC ACTIVITIES 85 BIBLIOGRAPHY 86 CHAPTER
8 NONSPECIFIC PATHOGENICITY FACTORS 89 J. HACKER 8.1 IRON-UPTAKE SYSTEMS
89 8.2 EXTRACELLULAR ENZYMES 93 8.3 METABOLISM AND PATHOGENICITY 94
BIBLIOGRAPHY 95 CHAPTER 9 PROTEIN SECRETION SYSTEMS 97 }. HEESEMANN
ANDT. OELSCBIAEGER 9.1 OVERVIEW ON BACTERIAL PROTEIN SECRETION 97 9.2
SECRETION SYSTEM TYPE I (SST I) 99 9.3 SECRETION SYSTEM TYPE II (SST II)
99 9.4 SECRETION SYSTEM TYPE III (SST III) 99 9.5 SECRETION SYSTEM TYPE
IV (SST IV) 103 9,6 SECRETION SYSTEM TYPEV (SSTV) 104 BIBLIOGRAPHY 1 05
CHAPTER 10 MICROBIAL SURFACE VARIATION AND PATHOGENICITY . . 107 J.
MORSCHHAEUSER 1 0.1 PHASE VARIATION 107 10.1.1 PHASE VARIATION BY
SITE-SPECIFIC RECOMBINATION 107 10.1.2 PHASE VARIATION BY DIFFERENTIAL
DNA METHYLATION 109 10.1.3 PHASE VARIATION BY INSERTION AND DELETION OF
NUCLEOTIDES 110 10.2 ANTIGENIC VARIATION 112 10.2.1 ANTIGENIC VARIATION
BY SITE-SPECIFIC RECOMBINATION .... 112 10.2.2 ANTIGENIC VARIATION BY
HOMOLOGOUS RECOMBINATION ... 114 10.2.3 ANTIGENIC VARIATION THROUGH
INSERTION AND DELETION OF NUCLEOTIDES 117 10.3 MOBILE GENETIC ELEMENTS,
AMPLIFICATIONS, AND DELETIONS : F 17 10.3.1 PHASE VARIATION THROUGH IS
ELEMENTS 118 10.3.2 GENE AMPLIFICATION 118 10.3.3 GENE DELETIONS 119
BIBLIOGRAPHY 119 CHAPTER I ( REGULATION OF VIRULENCE-ASSOCIATED GENES
121 J. MORSCHHAEUSER .1 GENERAL MECHANISMS INVIRULENCE GENE REGULATION
.... 121 .1.1 REGULATION OF TRANSCRIPTION 121 .1.2 REGULATION THROUGH
TERMINATION/ANTITERMINATION 124 .1.3 DIFFERENTIAL MRNA STABILITY 125
.1.4 REGULATION OF TRANSLATION 127 .1.5 POSTTRANSLATIONAL REGULATION
MECHANISMS 128 .2 GENE REGULATION THROUGH TWO-COMPONENT SYSTEMS ... 128
.3 QUORUM SENSING SYSTEMS 132 .4 COORDINATION OF GENE EXPRESSION 133
.4.1 OPERONS 133 .4.2 REGULONS 134 .4.3 STIMULONS 134 1.4.4 GLOBAL
REGULATION MECHANISMS 134 BIBLIOGRAPHY 1 36 CHAPTER 12 INFECTION ECOLOGY
137 / HACKER 1 2.1 INFECTIONS AND MICROBIAL ECOLOGY 137 12.2
ENVIRONMENTAL SIGNALS AND STRESS 138 12.3 DORMANTVARIANTS AND INFECTION
139 12.4 COMPETITION AMONG MICROBES 141 12.5 RESERVOIRS AND TRANSMISSION
142 BIBLIOGRAPHY 144 CHAPTER 13 PARALLELS BETWEEN PLANT AND HUMAN
PATHOGENS 145 J. HACKER SSIBLIOGRAPHY 147 CHAPTER 14 EVOLUTIONARY
INFECTION BIOLOGY 149 J. HACKER 14.1 PRINCIPLES OF EVOLUTION 149 14.2
NEW SELECTION CONDITIONS: NEW PATHOGENS 150 14.3 THE CLONE CONCEPT 152
14.4 POINT MUTATIONS, REARRANGEMENTS, AND EVOLUTION IN QUANTUM LEAPS 153
14.5 HORIZONTAL GENE TRANSFER 155 14.5.1 TRANSFORMATION AND GENERATION
OF MOSAIC GENES 155 14.5.2 BACTERIOPHAGES AND TRANSDUCTION 155 14.5.3
PLASMIDS ANDTRANSPOSONS 156 14.5.4 PATHOGENICITY ISLANDS AND GENOMIC
ISLANDS 158 14.6 GENOME PLASTICITY VERSUS GENETIC STABILITY . .* 160
BIBLIOGRAPHY 161 CHAPTER 15 CELLULAR MICROBIOLOGY 163 I OEHCHLAEGER AND J.
HEESEMANN 15.1 THE MICROANATOMY OF ANIMAL CELLS 163 15.2 THE STRUCTURE
OF EPITHELIAL AND ENDOTHELIAL TISSUES IN THE HOST 164 15.3 PRINCIPLES OF
SIGNAL TRANSDUCTION 166 15.4 INTERACTION BETWEEN MICROORGANISMS AND HOST
CELL RECEPTORS 15.5 INDUCED REARRANGEMENTS OF THE CYTOSKELETON 15.6
CELLULAR MICROBIOLOGY ANDTOXINS 15.7 ENDOCYTOSIS AND VESICLE TRANSPORT
15.8 HICROBES AND APOPTOSIS BIBLIOGRAPHY CHAPTER 16 IN VIVO EXPRESSION
OF PATHOGENICITY M. HENSEL 16.1 GENE EXPRESSION IN VITRO AND IN VIVO
16.2 GENE EXPRESSION IN THE STATIONARY PHASE 16.3 EXPERIMENTAL
APPROACHES TO THE ANALYSIS OF IN VIVO GENE EXPRESSION 16.3.1 PROTEOMIC
ANALYSIS AND SUBTRACTIONTECHNIQUES 16.3.2 GENETIC METHODS 16.3.3 DNA
CHIP TECHNOLOGY BIBLIOGRAPHY CHAPTER 17 GENOMICS,TRANSCRIPTOMICS, AND
PROTEOMICS .... J. REIDL AND J. HACKER 1 7. 1 BACTERIAL GENOME RESEARCH
17.2 GENOME ANALYSIS: APPLICATIONS IN INFECTION BIOLOGY .... 17.3 DNA
ARRAYS 17.4 ANALYSIS OF PROTEIN PATTERNS (PROTEOME) 191 BIBLIOGRAPHY 193
CHAPTER 18 MOLECULAR DIAGNOSIS AND EPIDEMIOLOGY 195 J. HACKER AND J.
HEESEMANN 18.1 DETERMINATION OF SPECIES AND SUBSPECIES 195 18.1.1
CLASSICAL METHODS 195 18.1.2 MOLECULAR METHODS 196 18.1.3 IN SITU
HYBRIDIZATIONS 200 18.2 DETERMINATION OF PATHOTYPES 200 18.3
DETERMINATION OF RESISTANCE 201 18.4 MOLECULAR EPIDEMIOLOGY 202 18.5
INTEGRATED APPROACHES: USE OF MICROARRAYS 204 BIBLIOGRAPHY 205 CHAPTER
19 THERAPEUTIC PROBLEMS WITH INFECTIOUS DISEASES 207 W. ZIEBUHR 19.1
DEVELOPMENT OF ANTIBIOTIC RESISTANCE IN BACTERIA 207 19.2 MOLECULAR
MECHANISMS OF ANTIBIOTIC RESISTANCE 209 19.2.1 RESISTANCE DUE TO
MODIFICATION OF THE ANTIBIOTIC 209 19.2.2 RESISTANCE DUE TO MODIFICATION
OF THE TARGET STRUCTURE 209 19.2.3 ACTIVE EFFLUX AND MULTIDRUG
RESISTANCE 210 19.3 TRENDS IN THE DEVELOPMENT OF NEW ANTIBIOTICS 210
19.3.1 FLUORQUINOLONES 211 19.3.2 STREPTOGRAMINS 211 19.3.3
OXAZOLIDINONES 211 1 9.3.4 LANTIBIOTICS 212 19.4 NEW CONCEPTS IN
THETREATMENT OF INFECTIONS 212 BIBLIOGRAPHY 213 CHAPTER 20 THE
DEVELOPMENT OF VACCINES 215 J. HEESEMANN 20.1 THE HISTORY OF VACCINE
DEVELOPMENT 215 20.2 THE PRINCIPLES OF VACCINE DEVELOPMENT 216 20.3
KILLED/INACTIVATED VACCINES 218 20.4 ADJUVANTS 220 20.5 LIVE VACCINES
221 BIBLIOGRAPHY 222 CHAPTER 21 INFECTION MODELS 225 21.1 ESCHERICHTA
COLI (}. HACKER) 225 21.1.1 GENERAL REMARKS 225 21.1.2 HORIZONTAL GENE
TRANSFER IN ESCHERICHIA COLI 226 21.1.3 ESCHERICHIA COLI PATHOTYPES 227
21.2 VIBRIO CHOLERAE (]. REIDL) 231 21.2.1 PATHOGENESIS AND
PATHOGENICITY FACTORS 231 21.2.2 EVOLUTION AND TRANSMISSION OF VIRULENCE
FACTORS 232 21.3 YERSINIAE, SHIGELLAE, SALMONELLAE, AND LISTERIAE (J.
HEESEMANN AND M. HENSEL) 234 21.3.1 GENERAL REMARKS 234 21.3.2 YERSINIA
ENTEROCOLITICA AND YERSINIA PSEUDOTUBERCULOSIS .... 235 21.3.3 SHIGELLAE
237 21.3.4 SOLMONELLA ENTERICA 239 21.3.5 LISTERIA MONOCYTOGENES 241
21.4 STAPHYLOCOCCI (W. ZIEBUHR) 243 21.4.1 GENERAL REMARKS 243 21.4.2
ADHESION, COLONIZATION, AND BIOFILM FORMATION 244 21.4.3 STAPHYLOCOCCAL
INFECTIONS 245 21.4.4 ANTIBIOTIC RESISTANCE 246 21.4.5
PHENOTYPEVARIABILITY AS A PATHOGENETIC PRINCIPLE 247 2 [ .5 STREPTOCOCCI
(J. HACKER) 247 21.5.1 GENERAL REMARKS 247 21.5.2 ADHERENCE AND INVASION
248 21.5.3 TOXIN FORMATION : 250 21.5.4 ENVIRONMENTAL REGULATION AND
PHENOTYPEVARIABILITY ... 251 21.6 LEGIONEILA PNEUMOPHILA (J. HACKER) 252
21.6.1 ENVIRONMENTAL BACTERIA AND PATHOGENIC AGENTS 252 21.6.2
INTRACELLULAR MULTIPLICATION IN AMOEBAE AND MACROPHAGES 253 21.7
HELICOBACTER PYLORI (R. HAAS) 256 21.7.1 THE HELICOBACTER PYLORI
INFECTION 256 21.7.2 MICROBIOLOGY OF HETICOBACTER PYLORI 257 21.7.3
VIRULENCE FACTORS IN HELICOBACTER PYLORI 257 21.7.4 DIAGNOSIS AND
THERAPY 258 21.8 TOXOPLASMA GONDII (J. HEESEMANN) 259 21.8.1 GENERAL
REMARKS 259 21.8.2 FORM AND ULTRASTRUCTURE 260 21.8.3 INVASION
MECHANISMS 260 21.8.4 STAGE CONVERSION 261 21.9 CANDIDA ALBICANS (J.
HACKER) 262 21.9.1 FUNGAL INFECTIONS - THE HOST IS CRUCIAL 262 21.9.2
PATHOGENICITY IN CANDIDA ALBICANS 262 21.9.3 DIMORPHISM AND PHENOTYPIC
SWITCHING 264 BIBLIOGRAPHY 266 CHAPTER 22 FUTURE DEVELOPMENTS 271 J.
HACKER AND J. HEESEMANN BIBLIOGRAPHY 275 CHAPTER 23 METHODS OF MOLECULAR
INFECTION BIOLOGY 277 23. 1 INTRODUCTION (J. HACKER) 277 23.2 MOLECULAR
TYPING OF PATHOGENS (W. ZIEBUHR) 277 23.3 FLUORESCENCE-BASED IN SITU
HYBRIDIZATION (J. HACKER) . . . 280 23.4 ISLAND PROBING (]. HACKER) 282
23.5 REPRESENTATIVE DIFFERENCE ANALYSIS (J. HACKER) 283 23.6 MRNA
DIFFERENTIAL DISPLAY (J. HACKER) 285 23.7 IN VIVO EXPRESSION TECHNOLOGY
(M. HENSEI) 286 23.8 SIGNATURE-TAGGED MUTAGENESIS (M. HENSEI) 288 23.9
REPORTER GENE TECHNOLOGIES (M. HENSEI) 289 23.10 DIFFERENTIAL
FLUORESCENCE INDUCTION (M. HENSEI) 290 23.1 I IDENTIFICATION OF
VIRULENCE-ASSOCIATED BACTERIOPHAGES (J. REIDI) 291 23.12 SHUTTLE
MUTAGENESIS (R. HAAS) 293 23.13 GENOMICS (J. REIDI) 295 BIBLIOGRAPHY 296
APPENDIX 301 INDEX 323
|
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| id | DE-604.BV014489745 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:03:05Z |
| institution | BVB |
| isbn | 0471178462 |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009881853 |
| oclc_num | 49775467 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-526 DE-634 DE-11 |
| owner_facet | DE-M49 DE-BY-TUM DE-526 DE-634 DE-11 |
| physical | XVII, 339 S. Ill., graph. Darst. : 25 cm |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Wiley-Liss Spektrum, Akad. Verl. |
| record_format | marc |
| spelling | Molekulare Infektionsbiologie Molecular infection biology interactions between microorganisms and cells ed. by Jörg Hacker ; Jürgen Heesemann. [Transl. from German by Renate FitzRoy] New York Wiley-Liss 2002 Heidelberg ; Berlin Spektrum, Akad. Verl. XVII, 339 S. Ill., graph. Darst. : 25 cm txt rdacontent n rdamedia nc rdacarrier Virologia larpcal Bacterial Proteins biosynthesis Host-Parasite Interactions Immunity, Cellular Infection Infection microbiology Pathology, Molecular Virulence (Microbiology) Virulence Factors Infektion (DE-588)4161650-9 gnd rswk-swf Medizinische Mikrobiologie (DE-588)4038264-3 gnd rswk-swf Pathogener Mikroorganismus (DE-588)4044890-3 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Infektion (DE-588)4161650-9 s Molekularbiologie (DE-588)4039983-7 s DE-604 Pathogener Mikroorganismus (DE-588)4044890-3 s Medizinische Mikrobiologie (DE-588)4038264-3 s Hacker, Jörg 1952- Sonstige (DE-588)128960280 oth OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009881853&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular infection biology interactions between microorganisms and cells Virologia larpcal Bacterial Proteins biosynthesis Host-Parasite Interactions Immunity, Cellular Infection Infection microbiology Pathology, Molecular Virulence (Microbiology) Virulence Factors Infektion (DE-588)4161650-9 gnd Medizinische Mikrobiologie (DE-588)4038264-3 gnd Pathogener Mikroorganismus (DE-588)4044890-3 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4161650-9 (DE-588)4038264-3 (DE-588)4044890-3 (DE-588)4039983-7 |
| title | Molecular infection biology interactions between microorganisms and cells |
| title_alt | Molekulare Infektionsbiologie |
| title_auth | Molecular infection biology interactions between microorganisms and cells |
| title_exact_search | Molecular infection biology interactions between microorganisms and cells |
| title_full | Molecular infection biology interactions between microorganisms and cells ed. by Jörg Hacker ; Jürgen Heesemann. [Transl. from German by Renate FitzRoy] |
| title_fullStr | Molecular infection biology interactions between microorganisms and cells ed. by Jörg Hacker ; Jürgen Heesemann. [Transl. from German by Renate FitzRoy] |
| title_full_unstemmed | Molecular infection biology interactions between microorganisms and cells ed. by Jörg Hacker ; Jürgen Heesemann. [Transl. from German by Renate FitzRoy] |
| title_short | Molecular infection biology |
| title_sort | molecular infection biology interactions between microorganisms and cells |
| title_sub | interactions between microorganisms and cells |
| topic | Virologia larpcal Bacterial Proteins biosynthesis Host-Parasite Interactions Immunity, Cellular Infection Infection microbiology Pathology, Molecular Virulence (Microbiology) Virulence Factors Infektion (DE-588)4161650-9 gnd Medizinische Mikrobiologie (DE-588)4038264-3 gnd Pathogener Mikroorganismus (DE-588)4044890-3 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Virologia Bacterial Proteins biosynthesis Host-Parasite Interactions Immunity, Cellular Infection Infection microbiology Pathology, Molecular Virulence (Microbiology) Virulence Factors Infektion Medizinische Mikrobiologie Pathogener Mikroorganismus Molekularbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009881853&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | UT molekulareinfektionsbiologie AT hackerjorg molecularinfectionbiologyinteractionsbetweenmicroorganismsandcells |