Verfügbarkeit: Clinical management of chronic obstructive pulmonary disease

Clinical management of chronic obstructive pulmonary disease:

Gespeichert in:

Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	New York [u.a.] Dekker 2002
Schriftenreihe:	Lung biology in health and disease 165
Schlagworte:	Bronchopneumopathies obstructives Muscles respiratoires - physiologie Lungs > Diseases, Obstructive Pulmonary Disease, Chronic Obstructive > complications Pulmonary Disease, Chronic Obstructive > diagnosis Pulmonary Disease, Chronic Obstructive > therapy Respiratory Muscles > physiology Obstruktive Ventilationsstörung Aufsatzsammlung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	Includes index
Beschreibung:	XLIV, 1072 S. Ill., graph. Darst.
ISBN:	0824706102

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adam_text	CONTENTS Introduction Claude Lenfant Hi Preface v Contributors ix Foreword Gordon L. Snider xxix Part One DIAGNOSIS AND FOLLOW UP 1. The Lung in Transition from Health to Disease 1 Manuel G. Cosio, David H. Eidelman, and James G. Martin I. Introduction 1 II. Age Related Decline in Lung Function 2 III. Detection Techniques for the Assessment of Early Altered Lung Function 4 IV. Structure Function Correlations for Tests Based on Small Airways Dysfunction 7 V. Airway Inflammatory Responses to Irritants 8 VI. Biochemical Markers of Early Lung Inflammation in Smokers 8 VII. Differences in Airway Inflammation Between Smokers with and Without COPD 9 xv XVi Contents VIII. Heterogeneity in the Patterns of Lung Damage in Smokers 12 IX. Risk Factors for the Development of COPD 13 X. The Tip of the Iceberg 16 XL Conclusions 17 References 17 2. Clinical Examination in Clinical Obstructive Pulmonary Disease and Correlation with Functional Abnormalities 23 Robert G. Badgett and David Tanaka I. What Are the Best Findings to Diagnose COPD 23 II. How Well Does History and Physical Examination Diagnose COPD? 27 III. Summary 29 References 32 3. Technique and Interpretation of Blood Gases in Stable Chronic Obstructive Pulmonary Disease 35 Alain Harf I. Blood Gases: Techniques of Evaluation 35 II. Blood Gases: Interpretation 43 References 49 4. Basic Spirometry in COPD 53 Marc Zelter I. Introduction 53 II. Assessment of Flow Limitation in COPD 54 III. Lung Volume Measurements 59 IV. Reference Values for Flows and Volumes 61 V. Bronchial Hyperreactivity Testing 62 VI. How Often Should Lung Function Be Assessed? 63 VII. Conclusion 63 References 63 5. Imaging Techniques of the Thorax in Stable Chronic Obstructive Pulmonary Disease Patients 69 Philippe Grenier and Catherine Beigelman I. Introduction 69 II. Radiographic Manifestations 70 III. CT Manifestations 75 IV. CT Quantification of Emphysema 82 V. Nuclear Medicine 85 VI. Magnetic Resonance Imaging 85 References 0Q Contents Xvii 6. Diagnosis, Initial Assessment, and Follow Up of COPD 95 Paul A. Vermeire I. Introduction 95 II. Diagnosis 95 III. Needs and Objectives of the Initial Assessment After First Diagnosis 96 IV. Components of Initial Assessment After Diagnosis of COPD 97 V. Follow Up 107 VI. Concluding Remarks 109 References 109 7. Assessment and Management of Dyspnea in Chronic Obstructive Pulmonary Disease 113 Denis E. O Donnell I. Introduction 113 II. Mechanisms of Dyspnea in COPD 114 III. Assessment of Dyspnea 122 IV. Management of Dyspnea in Advanced COPD 132 V. Experimental Approaches to Dyspnea Management 152 VI. Summary 157 References 158 8. The Assessment of Health Related Quality of Life Among Patients with Chronic Obstructive Pulmonary Disease 171 David H. Au, J. Randall Curtis, and Leonard D. Hudson I. Introduction 171 II. Terms and Definitions 172 III. Relevance and Use of Health Related Quality of Life 175 IV. Generic Versus Disease Specific Instruments 176 V. Generic Health Related Quality of Life Instruments in COPD 176 VI. Disease Specific Measurements in COPD 179 VII. Future Directions 181 VIII. Summary 181 References 182 9. Disability in Chronic Obstructive Pulmonary Disease 187 Abebaw M. Yohannes and Martin J. Connolly I. Introduction 187 II. Impairment, Disability and Handicap 188 III. Severity of Disease 189 IV. Social Care Support and Disabling COPD 191 xviii Contents V. Why Measure Physical Disability in the Elderly with COPD? 191 VI. Disease Specific Physical Disability Scale 192 VII. Statutory Support 195 VIII. Conclusion 195 References 196 10. The General Practitioner and the Chronic Obstructive Pulmonary Disease Patient 201 C. P. van Schayck, P. M. van Grunsven, C. van Weel, and G. van den Boom I. Introduction 201 II. Pathophysiology 202 III. Treatment of COPD with Inhaled Corticosteroids 203 IV. Treatment of COPD with N Acetylcysteine 206 V. Nondrug Treatment Options 207 VI. Management of COPD in Primary Care 207 VII. Aims of Treatment 209 VIII. Treatment Strategy 210 IX. Summary 215 References 215 Part Two PATHOPHYSIOLOGICAL TREATMENTS 11. Genetics of Chronic Obstructive Pulmonary Disease and Emphysema: Diagnostic Applications and Therapeutic Perspectives 221 Andrew J. Sandford and Peter D. Pare I. Introduction 221 II. Genetic Epidemiology of COPD 221 III. Identification of Susceptibility Genes 222 IV. Genes Involved in the Pathogenesis of COPD 224 V. Proteolysis Antiproteolysis 226 VI. Inflammatory Mediators 229 VII. Xenobiotic Metabolizing Enzymes 230 VIII. Cystic Fibrosis Transmembrane Regulator 232 IX. Diagnostic and Therapeutic Implications of COPD Genetics 233 X. Conclusions 234 References 235 12. Is There a Place or a Future for Antioxidant Therapy in COPD? 245 Bruno Housset and Bernard Maitre I. Nature of Oxygen Derived Metabolites 245 Contents xix II. Toxic Effects of Oxygen Derived Metabolites 246 III. Antioxidants 247 IV. COPD and Oxidant Burden 248 V. Antioxidant Therapy in COPD 249 References 251 Part Three PHARMACOLOGICAL THERAPY 13. Methodology of Therapeutic Trials in COPD 255 Yves Lacasse and Gordon H. Guyatt I. Introduction 255 II. Study Population: What is COPD? 256 III. Intervention 259 IV. Outcomes 259 V. Design 261 VI. Analysis and Interpretation 265 VII. Overviews and Meta Analyses 276 VIII. Conclusion 278 References 278 14. Beta2 Adrenergic Bronchodilators in the Treatment of Stable COPD 287 Michael L. Ayers and Donald A. Mahler I. Introduction 287 II. Pharmacology and Pharmacokinetics 288 III. Administration 289 IV. Goals of Therapy 289 V. Is Testing for Acute Bronchodilator Responsiveness Useful? 290 VI. Short Acting (32 Agonists 291 VII. Long Acting (5, Agonists 293 VIII. Side Effects 299 IX. For Which COPD Patients Should Long Acting p2 Adrenergic Agonists Be Prescribed? 300 References 301 15. The Indications and Use of Inhaled Anticholinergic Agents in COPD Patients 305 Stephen Corne and N. Anthonisen I. Introduction 305 II. Cholinergic Receptors in the Lung 306 III. Pharmacology 307 IV. Safety and Side Effects 308 xx Contents V. Effects on Mucociliary Clearance 308 VI. Dose Response 309 VII. Comparison of Bronchodilator Response of Anticholinergics With p Agonists in COPD 309 VIII. Combination Therapy: Is There a Rationale for Its Use? 314 IX. Do Anticholinergics Improve Symptoms and Quality of Life in COPD? 317 X. Method of Delivery: Nebulizer vs. MDI 320 References 320 16. Steroids in Stable COPD 329 J. C. Yernault I. Acute Exacerbations 329 II. Short Term (3 Month) Effects of Oral (Alone, or Compared to Inhaled) Steroids in Stable COPD 332 III. Long Term Effects of Oral Steroids in Stable COPD 338 IV. Short Term ( 3 Months) Effects of Inhaled Steroids in Stable COPD 339 V. Long Term Effects of Inhaled Steroids in Stable COPD 343 VI. Conclusion 350 Addendum 350 References 351 17. Is There a Place for Vasodilators in Stable COPD? 359 George Cremona and Tim Higenbottam I. Introduction 359 II. Anatomical Changes in the Pulmonary Vascular Bed Associated with Chronic Obstructive Airways Disease 360 III. Pulmonary Hemodynamics in Stable COPD Patients 361 IV. Gas Exchange in Stable COPD Patients 361 V. Pathophysiology of Chronic Hypoxic Pulmonary Hypertension 364 VI. Rationale for Vasodilator Therapy in Stable COPD Patients 368 VII. Conclusion 374 References 374 18. Is There a Place for Respiratory Analeptics or Related Drugs in Stable COPD Patients? 383 Roberto Duranti, Giorgio Scano, and Nicolino Ambrosino I. Introduction 383 II. Almintrine Bismesylate 385 III. Analeptics 389 lit Contents xxj IV. Narcotic Antagonists 390 V. Progestational Hormones 390 VI. Carbonic Anhydrase Inhibitors 392 VII. Tricyclic Antidepressants 393 VIII. Theophyllines 395 IX. Conclusion 395 References 396 19. Should Drugs Affecting Mucus Properties Be Used in COPD? Clinical Evidence 405 Julia A. Nightingale and Duncan F. Rogers I. Introduction 405 II. Mucolytics 409 III. Mucoregulators ( Blocked Sulfhydryl Group) 411 IV. Expectorants 413 V. Muscarinic Receptor Antagonists (Anticholinergics) 415 VI. Recombinant Human DNase 415 VII. Corticosteroids 416 VIII. Erythromycin 417 IX. Summary and Conclusions 417 References 417 Part Four TREATMENT AND PREVENTION OF INFECTION 20. Indications for and Choice of Antibiotics in COPD 427 5. Ewig, R. Rodriguez Roisin, and A. Torres I. Introduction 427 II. Colonization of Stable COPD Patients 428 III. Role of Bacteria and Viruses in COPD Exacerbations 432 IV. Predictors of Particular Microorganisms 436 V. Antibiotics in COPD 437 VI. Conclusions 444 References 444 Part Five ASSOCIATED DISEASES AND THEIR THERAPY 21. The Diagnosis and Management of Lung Cancer in COPD 451 V. Ninane, T. Berghmans, and J. P. Sculier I. Epidemiological Data 451 II. Early Detection 454 III. Treatment 455 IV. Elective Chest Irradiation of Limited Non Small Cell Lung Cancer 460 V. Endoscopic Palliation of Central Airway Obstruction 465 xxii Contents VI. Chemotherapy for Advanced Non Small Cell Lung Cancer 465 VII. Treatment of Small Cell Lung Cancer 466 References 466 22. The Heart in the Stable COPD Patient 475 Teofilo L. Lee Chiong, Jr., and Richard A. Matthay I. Introduction 475 II. Incidence 475 III. The Pulmonary Circulation in COPD 476 IV. The Right Ventricle in COPD 478 V. The Left Ventricle in COPD 481 VI. Etiology of Pulmonary Artery Hypertension in COPD 482 VII. Natural History of Untreated Cor Pulmonale 485 VIII. Prognosis of Patients with Cor Pulmonale 486 IX. Cardiac Arrhythmia in Patients with COPD 487 X. Edema Formation in COPD 490 XI. Evaluating Cardiac Function in Patients with COPD 493 XII. Therapy for Cor Pulmonale Secondary to COPD 500 XIII. Conclusion 514 Acknowledgments 515 References 515 23. COPD and the Left Heart 533 Teofilo L. Lee Chiong, Jr., and Richard A. Matthay I. Introduction 533 II. Left Ventricular Dysfunction in COPD 534 III. Normal Left Ventricular Performance in COPD 536 IV. Mechanisms of Left Ventricular Dysfunction in COPD 537 V. Effects of Medications on Left Ventricular Performance and Lung Function in COPD 540 VI. Summary 543 Acknowledgment 543 References 544 24. Anxiety and Depression in COPD 549 Noemi Eiser I. Introduction 549 II. Depression 550 III. Anxiety and Panic 554 IV. Chronic Obstructive Pulmonary Disease 558 V. Prevalence of Anxiety and Depression in Patients with COPD 562 VI. Effects of Treatment of Mood Disorders in COPD Patient 564 Contents KXlil VII. Incorporation of Psychological Therapy into Pulmonary Rehabilitation 570 VIII. Summary and Conclusions 571 References 573 25. Sleep Related Respiratory Disorders in COPD: When and How to Make the Diagnosis 583 Isabelle Arnulf, Jean Philippe Derenne, and William A. Whitelaw I. Introduction 583 II. Methods of Investigations of Sleep Related Respiratory Disorders in COPD 584 III. Night Sleep Related Respiratory Phenomena 585 IV. Pathophysiology 588 V. Consequences 590 VI. When and How to Evaluate Sleep In COPD 594 References 596 26. Sleep Related Respiratory Disorders in COPD: Who and How to Treat 603 Ana C. Krieger and David M. Rapoport and Patrick Levy I. Introduction 603 II. Mechanisms 604 III. Who to Study 606 IV. How to Treat 609 V. Final Remarks , 614 VI. Conclusions 614 References 614 Part Six RESPIRATORY MUSCLES, NUTRITION AND PHYSIOTHERAPY 27. The Relevance of Respiratory Muscles in COPD Patients and How to Assess Their Function 621 G. Czaika, A. Grassino, and P. Begin I. Introduction 621 II. Factors Leading to Respiratory Muscle Dysfunction 622 III. Methods for Evaluating Respiratory Muscle Function 629 References 632 28. Corticosteroids and Muscle Function in Stable COPD 639 Ghislaine Gayan Ramirez and Marc Decramer I. Introduction 639 II. Studies In Experimental Animals 640 XXIV Contents III. Studies In Patients 643 IV. Potential Mechanisms of Steroid Induced Myopathy 650 V. Diagnosis and Therapy of Steroid Induced Myopathy 652 VI. Conclusions 654 Acknowledgments 654 References 654 29. Pharmacotherapy and Hormone Therapy of the Respiratory Muscles in Stable COPD 659 Michael I. Polkey and John Moxham I. General Rationale for Pharmacotherapy and Hormone Therapy 659 II. Discussion of Specific Agents 666 III. Conclusion 674 References 674 30. Nutritional Assessment and Support of the Stable COPD Patient 681 A. M. W. J. Schols and E. F. M. Wouters I. Rationale for Nutritional Support 682 II. Body Composition 684 III. Causes of Weight Loss and Muscle Wasting 686 IV. Assessment of Energy Balance 689 V. Outcome of Nutritional Intervention 690 VI. Timing of Nutritional Support 691 VII. Macronutrient Composition of Nutritional Supplement 692 VIII. Practical Implementation of Nutritional Support 696 References 696 31. Respiratory Physiotherapy in Stable COPD 703 Gail Dechman I. Introduction 703 II. Secretion Removal Techniques 704 III. Secretion Mobilization Techniques 706 IV. Physiological Effects of Enhanced Secretion Clearance 709 V. Breathing Exercise 711 VI. Exercise 713 VII. Conclusion 723 References 724 32. Exercise in Stable COPD 731 Claudio Ferdinando Donner and Antonio Patessio I. Introduction 731 Contents X v II. Factors Limiting Exercise Tolerance 732 III. Therapeutic Strategies 736 IV. Conclusion 747 V. References 748 33. Respiratory Muscle Training in Chronic Obstructive Pulmonary Disease 759 Thomas L. Clanton and Philip T. Diaz I. Introduction 759 II. Rationale for Respiratory Muscle Training in COPD 760 III. Unresolved Issues Related to Training Methods: A Review of the Literature 766 IV. Conclusions and Speculations 775 References 776 Part Seven INSTRUMENTAL TREATMENTS 34. Long Term Oxygen Therapy in Stable COPD 781 Emmanuel Weitzenblum, Ari Chaouat, Romain Messier, Roland Schott, and Monique Oswald I. Arguments for LTOT in Hypoxemic COPD: The Beneficial Effects of LTOT 781 II. Indications of LTOT in COPD 792 III. Home Oxygen 798 References 807 35. Domiciliary Noninvasive Ventilatory Support 813 Stefano Nava and Paolo Navalesi I. Introduction 813 II. What Determines the Prognosis in Advanced COPD? 814 III. What Causes CO2 Retention in COPD Patients? 815 IV. Rationale for Using Long Term Noninvasive Ventilation 817 V. Clinical Studies 822 VI. When Should NIMV Be Started? 831 VII. How to Set Domiciliary Ventilation 834 VIII. How to Follow the Patients at Home 839 IX. Conclusions 840 Acknowledgments 840 References 840 xxvi Contents 36. The Indications for and Management of Tracheostomy in COPD 849 Jean Frangois Muir and Antoine Cuvelier I. Physiological Basis for Chronic Mechanical Ventilation 851 II. Results of HMVT in COPD 853 III. Indications for HMVT in COPD 859 IV. Methods 862 V. From the Hospital to Home 864 References 865 Part Eight SURGERY 37. Management of the COPD Patient Undergoing Surgery 871 B. Dureuil I. Introduction 871 II. Pathophysiology of Postoperative Respiratory Complications 872 III. COPD as a Patient Related Risk Factor 874 IV. Preoperative Evaluation and Preparation 875 V. Preoperative Preparation of Stable COPD Patients 879 VI. Intraoperative Management 881 VII. Postoperative Care and Risk Reduction Strategies 884 VIII. Conclusion 887 References 888 38. Lung Volume Reduction Surgery and Chronic Obstructive Pulmonary Disease 895 P. M. A. Calverley and M. Fournier I. Introduction 895 II. Theoretical Considerations 896 III. Physiological and Clinical Effects of LVRS 898 IV. Surgical Aspects of LVRS 905 V. Assessing the Cost of LVRS 909 VI. The Future of LVRS 912 References 914 39. Lung Transplantation and COPD 921 E. P. Tnilock I. Background 921 II. Recipient Selection 923 III. Timing Transplantation 925 IV. Bridging to Transplantation 927 Contents vvv, , V. Choice of Procedure 929 VI. Outcomes 930 VII. Summary 935 References 935 Part Nine PERSPECTIVES 40. New Treatments for COPD 943 Peter J. Barnes I. Introduction 943 II. New Bronchodilators 944 III. Smoking Cessation 945 IV. Mediator Antagonists 946 V. New Anti Inflammatory Treatments 948 VI. Protease Inhibitors 952 VII. Mucoregulators 955 VIII. Alveolar Repair 957 IX. Route of Delivery 957 X. Future Directions 957 References 959 Part Ten MANAGEMENT OF COPD THROUGH THE WORLD 41. Critical Comparison of Guidelines 965 Nicolas Roche and Gerard J. Huchon I. Introduction 965 II. Areas of Concordance and Discrepancies between Guidelines 966 III. What is a Good Clinical Practice Guideline? 975 IV. Are Recommendations on COPD Good Guidelines? Lessons from Experiences in Asthma 978 V. How Could COPD Guidelines be Improved? 979 VI. What are the Main Unanswered Questions? 980 References 981 42. Epidemiology and Management of COPD in Russia 987 4. C. Chuchalin and S. N. Avdeev I. History 987 II. Morbidity and Mortality 989 III. Smoking 991 IV. Occupational Factors 991 V. Air Pollution 992 xxviii Contents VI. Genetics 993 VII. Consequences of the Catastrophe at Chernobyl 994 VIII. Climatic Conditions 997 IX. Management 999 References 1003 43. Epidemiology and Management of Stable COPD in Africa 1007 N. A it Khaled, P. Chaulet, D. Enarson, and K. Slama I. Epidemiology 1007 II. Management of Stable COPD in Africa 1018 III. Conclusion 1026 Acknowledgment 1026 References 1026 44. Chronic Obstructive Pulmonary Disease in Latin America 1031 Alvaro Undurraga, Patricio Gonzalez, and Bartolome Celli I. Introduction 1031 II. Latin America: The Facts 1031 III. COPD in Latin America 1033 IV. Some Etiopathogenic Factors of COPD 1035 V. Latin American COPD Consensus 1040 VI. Final Comments 1040 References 1041 45. The Point of View of the WHO on Chronic Obstructive Pulmonary Disease 1045 Nikolai Khaltaev I. Introduction 1045 II. Definition and Classification 1046 III. Epidemiology 1047 IV. Risk Factors 1053 V. Conclusion 1054 References 1055 Index 1059
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series	Lung biology in health and disease
series2	Lung biology in health and disease
spelling	Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ... New York [u.a.] Dekker 2002 XLIV, 1072 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 165 Includes index Bronchopneumopathies obstructives ram Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Obstruktive Ventilationsstörung (DE-588)4213128-5 s DE-604 Similowski, Thomas Sonstige oth Whitelaw, William A. Sonstige oth Derenne, Jean-Philippe Sonstige oth Lung biology in health and disease 165 (DE-604)BV000008326 165 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009878423&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Clinical management of chronic obstructive pulmonary disease Lung biology in health and disease Bronchopneumopathies obstructives ram Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd
subject_GND	(DE-588)4213128-5 (DE-588)4143413-4
title	Clinical management of chronic obstructive pulmonary disease
title_auth	Clinical management of chronic obstructive pulmonary disease
title_exact_search	Clinical management of chronic obstructive pulmonary disease
title_full	Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ...
title_fullStr	Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ...
title_full_unstemmed	Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ...
title_short	Clinical management of chronic obstructive pulmonary disease
title_sort	clinical management of chronic obstructive pulmonary disease
topic	Bronchopneumopathies obstructives ram Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd
topic_facet	Bronchopneumopathies obstructives Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung Aufsatzsammlung
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009878423&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV000008326
work_keys_str_mv	AT similowskithomas clinicalmanagementofchronicobstructivepulmonarydisease AT whitelawwilliama clinicalmanagementofchronicobstructivepulmonarydisease AT derennejeanphilippe clinicalmanagementofchronicobstructivepulmonarydisease

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