Clinical management of chronic obstructive pulmonary disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Dekker
2002
|
| Schriftenreihe: | Lung biology in health and disease
165 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes index |
| Beschreibung: | XLIV, 1072 S. Ill., graph. Darst. |
| ISBN: | 0824706102 |
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| 245 | 1 | 0 | |a Clinical management of chronic obstructive pulmonary disease |c ed. by Thomas Similowski ... |
| 264 | 1 | |a New York [u.a.] |b Dekker |c 2002 | |
| 300 | |a XLIV, 1072 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Lung biology in health and disease |v 165 | |
| 500 | |a Includes index | ||
| 650 | 7 | |a Bronchopneumopathies obstructives |2 ram | |
| 650 | 2 | |a Muscles respiratoires - physiologie | |
| 650 | 4 | |a Lungs |x Diseases, Obstructive | |
| 650 | 4 | |a Pulmonary Disease, Chronic Obstructive |x complications | |
| 650 | 4 | |a Pulmonary Disease, Chronic Obstructive |x diagnosis | |
| 650 | 4 | |a Pulmonary Disease, Chronic Obstructive |x therapy | |
| 650 | 4 | |a Respiratory Muscles |x physiology | |
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Datensatz im Suchindex
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| adam_text | CONTENTS
Introduction Claude Lenfant Hi
Preface v
Contributors ix
Foreword Gordon L. Snider xxix
Part One DIAGNOSIS AND FOLLOW UP
1. The Lung in Transition from Health to Disease 1
Manuel G. Cosio, David H. Eidelman, and James G. Martin
I. Introduction 1
II. Age Related Decline in Lung Function 2
III. Detection Techniques for the Assessment of Early Altered
Lung Function 4
IV. Structure Function Correlations for Tests Based on Small
Airways Dysfunction 7
V. Airway Inflammatory Responses to Irritants 8
VI. Biochemical Markers of Early Lung Inflammation in
Smokers 8
VII. Differences in Airway Inflammation Between Smokers with
and Without COPD 9
xv
XVi Contents
VIII. Heterogeneity in the Patterns of Lung Damage in Smokers 12
IX. Risk Factors for the Development of COPD 13
X. The Tip of the Iceberg 16
XL Conclusions 17
References 17
2. Clinical Examination in Clinical Obstructive Pulmonary
Disease and Correlation with Functional Abnormalities 23
Robert G. Badgett and David Tanaka
I. What Are the Best Findings to Diagnose COPD 23
II. How Well Does History and Physical Examination
Diagnose COPD? 27
III. Summary 29
References 32
3. Technique and Interpretation of Blood Gases in Stable Chronic
Obstructive Pulmonary Disease 35
Alain Harf
I. Blood Gases: Techniques of Evaluation 35
II. Blood Gases: Interpretation 43
References 49
4. Basic Spirometry in COPD 53
Marc Zelter
I. Introduction 53
II. Assessment of Flow Limitation in COPD 54
III. Lung Volume Measurements 59
IV. Reference Values for Flows and Volumes 61
V. Bronchial Hyperreactivity Testing 62
VI. How Often Should Lung Function Be Assessed? 63
VII. Conclusion 63
References 63
5. Imaging Techniques of the Thorax in Stable Chronic
Obstructive Pulmonary Disease Patients 69
Philippe Grenier and Catherine Beigelman
I. Introduction 69
II. Radiographic Manifestations 70
III. CT Manifestations 75
IV. CT Quantification of Emphysema 82
V. Nuclear Medicine 85
VI. Magnetic Resonance Imaging 85
References 0Q
Contents Xvii
6. Diagnosis, Initial Assessment, and Follow Up of COPD 95
Paul A. Vermeire
I. Introduction 95
II. Diagnosis 95
III. Needs and Objectives of the Initial Assessment After First
Diagnosis 96
IV. Components of Initial Assessment After Diagnosis of
COPD 97
V. Follow Up 107
VI. Concluding Remarks 109
References 109
7. Assessment and Management of Dyspnea in Chronic
Obstructive Pulmonary Disease 113
Denis E. O Donnell
I. Introduction 113
II. Mechanisms of Dyspnea in COPD 114
III. Assessment of Dyspnea 122
IV. Management of Dyspnea in Advanced COPD 132
V. Experimental Approaches to Dyspnea Management 152
VI. Summary 157
References 158
8. The Assessment of Health Related Quality of Life Among
Patients with Chronic Obstructive Pulmonary Disease 171
David H. Au, J. Randall Curtis, and Leonard D. Hudson
I. Introduction 171
II. Terms and Definitions 172
III. Relevance and Use of Health Related Quality of Life 175
IV. Generic Versus Disease Specific Instruments 176
V. Generic Health Related Quality of Life Instruments in
COPD 176
VI. Disease Specific Measurements in COPD 179
VII. Future Directions 181
VIII. Summary 181
References 182
9. Disability in Chronic Obstructive Pulmonary Disease 187
Abebaw M. Yohannes and Martin J. Connolly
I. Introduction 187
II. Impairment, Disability and Handicap 188
III. Severity of Disease 189
IV. Social Care Support and Disabling COPD 191
xviii Contents
V. Why Measure Physical Disability in the Elderly with COPD? 191
VI. Disease Specific Physical Disability Scale 192
VII. Statutory Support 195
VIII. Conclusion 195
References 196
10. The General Practitioner and the Chronic Obstructive
Pulmonary Disease Patient 201
C. P. van Schayck, P. M. van Grunsven, C. van Weel, and G. van
den Boom
I. Introduction 201
II. Pathophysiology 202
III. Treatment of COPD with Inhaled Corticosteroids 203
IV. Treatment of COPD with N Acetylcysteine 206
V. Nondrug Treatment Options 207
VI. Management of COPD in Primary Care 207
VII. Aims of Treatment 209
VIII. Treatment Strategy 210
IX. Summary 215
References 215
Part Two PATHOPHYSIOLOGICAL TREATMENTS
11. Genetics of Chronic Obstructive Pulmonary Disease and
Emphysema: Diagnostic Applications and Therapeutic
Perspectives 221
Andrew J. Sandford and Peter D. Pare
I. Introduction 221
II. Genetic Epidemiology of COPD 221
III. Identification of Susceptibility Genes 222
IV. Genes Involved in the Pathogenesis of COPD 224
V. Proteolysis Antiproteolysis 226
VI. Inflammatory Mediators 229
VII. Xenobiotic Metabolizing Enzymes 230
VIII. Cystic Fibrosis Transmembrane Regulator 232
IX. Diagnostic and Therapeutic Implications of COPD Genetics 233
X. Conclusions 234
References 235
12. Is There a Place or a Future for Antioxidant Therapy in
COPD? 245
Bruno Housset and Bernard Maitre
I. Nature of Oxygen Derived Metabolites 245
Contents xix
II. Toxic Effects of Oxygen Derived Metabolites 246
III. Antioxidants 247
IV. COPD and Oxidant Burden 248
V. Antioxidant Therapy in COPD 249
References 251
Part Three PHARMACOLOGICAL THERAPY
13. Methodology of Therapeutic Trials in COPD 255
Yves Lacasse and Gordon H. Guyatt
I. Introduction 255
II. Study Population: What is COPD? 256
III. Intervention 259
IV. Outcomes 259
V. Design 261
VI. Analysis and Interpretation 265
VII. Overviews and Meta Analyses 276
VIII. Conclusion 278
References 278
14. Beta2 Adrenergic Bronchodilators in the Treatment of Stable
COPD 287
Michael L. Ayers and Donald A. Mahler
I. Introduction 287
II. Pharmacology and Pharmacokinetics 288
III. Administration 289
IV. Goals of Therapy 289
V. Is Testing for Acute Bronchodilator Responsiveness
Useful? 290
VI. Short Acting (32 Agonists 291
VII. Long Acting (5, Agonists 293
VIII. Side Effects 299
IX. For Which COPD Patients Should Long Acting
p2 Adrenergic Agonists Be Prescribed? 300
References 301
15. The Indications and Use of Inhaled Anticholinergic Agents in
COPD Patients 305
Stephen Corne and N. Anthonisen
I. Introduction 305
II. Cholinergic Receptors in the Lung 306
III. Pharmacology 307
IV. Safety and Side Effects 308
xx Contents
V. Effects on Mucociliary Clearance 308
VI. Dose Response 309
VII. Comparison of Bronchodilator Response of
Anticholinergics With p Agonists in COPD 309
VIII. Combination Therapy: Is There a Rationale for Its Use? 314
IX. Do Anticholinergics Improve Symptoms and Quality of
Life in COPD? 317
X. Method of Delivery: Nebulizer vs. MDI 320
References 320
16. Steroids in Stable COPD 329
J. C. Yernault
I. Acute Exacerbations 329
II. Short Term (3 Month) Effects of Oral (Alone, or Compared
to Inhaled) Steroids in Stable COPD 332
III. Long Term Effects of Oral Steroids in Stable COPD 338
IV. Short Term ( 3 Months) Effects of Inhaled Steroids in
Stable COPD 339
V. Long Term Effects of Inhaled Steroids in Stable COPD 343
VI. Conclusion 350
Addendum 350
References 351
17. Is There a Place for Vasodilators in Stable COPD? 359
George Cremona and Tim Higenbottam
I. Introduction 359
II. Anatomical Changes in the Pulmonary Vascular Bed
Associated with Chronic Obstructive Airways Disease 360
III. Pulmonary Hemodynamics in Stable COPD Patients 361
IV. Gas Exchange in Stable COPD Patients 361
V. Pathophysiology of Chronic Hypoxic Pulmonary
Hypertension 364
VI. Rationale for Vasodilator Therapy in Stable COPD
Patients 368
VII. Conclusion 374
References 374
18. Is There a Place for Respiratory Analeptics or Related Drugs
in Stable COPD Patients? 383
Roberto Duranti, Giorgio Scano, and Nicolino Ambrosino
I. Introduction 383
II. Almintrine Bismesylate 385
III. Analeptics 389
lit
Contents xxj
IV. Narcotic Antagonists 390
V. Progestational Hormones 390
VI. Carbonic Anhydrase Inhibitors 392
VII. Tricyclic Antidepressants 393
VIII. Theophyllines 395
IX. Conclusion 395
References 396
19. Should Drugs Affecting Mucus Properties Be Used in COPD?
Clinical Evidence 405
Julia A. Nightingale and Duncan F. Rogers
I. Introduction 405
II. Mucolytics 409
III. Mucoregulators ( Blocked Sulfhydryl Group) 411
IV. Expectorants 413
V. Muscarinic Receptor Antagonists (Anticholinergics) 415
VI. Recombinant Human DNase 415
VII. Corticosteroids 416
VIII. Erythromycin 417
IX. Summary and Conclusions 417
References 417
Part Four TREATMENT AND PREVENTION OF INFECTION
20. Indications for and Choice of Antibiotics in COPD 427
5. Ewig, R. Rodriguez Roisin, and A. Torres
I. Introduction 427
II. Colonization of Stable COPD Patients 428
III. Role of Bacteria and Viruses in COPD Exacerbations 432
IV. Predictors of Particular Microorganisms 436
V. Antibiotics in COPD 437
VI. Conclusions 444
References 444
Part Five ASSOCIATED DISEASES AND THEIR THERAPY
21. The Diagnosis and Management of Lung Cancer in COPD 451
V. Ninane, T. Berghmans, and J. P. Sculier
I. Epidemiological Data 451
II. Early Detection 454
III. Treatment 455
IV. Elective Chest Irradiation of Limited Non Small Cell Lung
Cancer 460
V. Endoscopic Palliation of Central Airway Obstruction 465
xxii Contents
VI. Chemotherapy for Advanced Non Small Cell Lung Cancer 465
VII. Treatment of Small Cell Lung Cancer 466
References 466
22. The Heart in the Stable COPD Patient 475
Teofilo L. Lee Chiong, Jr., and Richard A. Matthay
I. Introduction 475
II. Incidence 475
III. The Pulmonary Circulation in COPD 476
IV. The Right Ventricle in COPD 478
V. The Left Ventricle in COPD 481
VI. Etiology of Pulmonary Artery Hypertension in COPD 482
VII. Natural History of Untreated Cor Pulmonale 485
VIII. Prognosis of Patients with Cor Pulmonale 486
IX. Cardiac Arrhythmia in Patients with COPD 487
X. Edema Formation in COPD 490
XI. Evaluating Cardiac Function in Patients with COPD 493
XII. Therapy for Cor Pulmonale Secondary to COPD 500
XIII. Conclusion 514
Acknowledgments 515
References 515
23. COPD and the Left Heart 533
Teofilo L. Lee Chiong, Jr., and Richard A. Matthay
I. Introduction 533
II. Left Ventricular Dysfunction in COPD 534
III. Normal Left Ventricular Performance in COPD 536
IV. Mechanisms of Left Ventricular Dysfunction in COPD 537
V. Effects of Medications on Left Ventricular Performance and
Lung Function in COPD 540
VI. Summary 543
Acknowledgment 543
References 544
24. Anxiety and Depression in COPD 549
Noemi Eiser
I. Introduction 549
II. Depression 550
III. Anxiety and Panic 554
IV. Chronic Obstructive Pulmonary Disease 558
V. Prevalence of Anxiety and Depression in Patients with
COPD 562
VI. Effects of Treatment of Mood Disorders in COPD Patient 564
Contents KXlil
VII. Incorporation of Psychological Therapy into Pulmonary
Rehabilitation 570
VIII. Summary and Conclusions 571
References 573
25. Sleep Related Respiratory Disorders in COPD: When and How
to Make the Diagnosis 583
Isabelle Arnulf, Jean Philippe Derenne, and William A. Whitelaw
I. Introduction 583
II. Methods of Investigations of Sleep Related Respiratory
Disorders in COPD 584
III. Night Sleep Related Respiratory Phenomena 585
IV. Pathophysiology 588
V. Consequences 590
VI. When and How to Evaluate Sleep In COPD 594
References 596
26. Sleep Related Respiratory Disorders in COPD: Who and How
to Treat 603
Ana C. Krieger and David M. Rapoport and Patrick Levy
I. Introduction 603
II. Mechanisms 604
III. Who to Study 606
IV. How to Treat 609
V. Final Remarks , 614
VI. Conclusions 614
References 614
Part Six RESPIRATORY MUSCLES, NUTRITION AND
PHYSIOTHERAPY
27. The Relevance of Respiratory Muscles in COPD Patients and
How to Assess Their Function 621
G. Czaika, A. Grassino, and P. Begin
I. Introduction 621
II. Factors Leading to Respiratory Muscle Dysfunction 622
III. Methods for Evaluating Respiratory Muscle Function 629
References 632
28. Corticosteroids and Muscle Function in Stable COPD 639
Ghislaine Gayan Ramirez and Marc Decramer
I. Introduction 639
II. Studies In Experimental Animals 640
XXIV Contents
III. Studies In Patients 643
IV. Potential Mechanisms of Steroid Induced Myopathy 650
V. Diagnosis and Therapy of Steroid Induced Myopathy 652
VI. Conclusions 654
Acknowledgments 654
References 654
29. Pharmacotherapy and Hormone Therapy of the Respiratory
Muscles in Stable COPD 659
Michael I. Polkey and John Moxham
I. General Rationale for Pharmacotherapy and Hormone
Therapy 659
II. Discussion of Specific Agents 666
III. Conclusion 674
References 674
30. Nutritional Assessment and Support of the Stable COPD
Patient 681
A. M. W. J. Schols and E. F. M. Wouters
I. Rationale for Nutritional Support 682
II. Body Composition 684
III. Causes of Weight Loss and Muscle Wasting 686
IV. Assessment of Energy Balance 689
V. Outcome of Nutritional Intervention 690
VI. Timing of Nutritional Support 691
VII. Macronutrient Composition of Nutritional Supplement 692
VIII. Practical Implementation of Nutritional Support 696
References 696
31. Respiratory Physiotherapy in Stable COPD 703
Gail Dechman
I. Introduction 703
II. Secretion Removal Techniques 704
III. Secretion Mobilization Techniques 706
IV. Physiological Effects of Enhanced Secretion Clearance 709
V. Breathing Exercise 711
VI. Exercise 713
VII. Conclusion 723
References 724
32. Exercise in Stable COPD 731
Claudio Ferdinando Donner and Antonio Patessio
I. Introduction 731
Contents X v
II. Factors Limiting Exercise Tolerance 732
III. Therapeutic Strategies 736
IV. Conclusion 747
V. References 748
33. Respiratory Muscle Training in Chronic Obstructive
Pulmonary Disease 759
Thomas L. Clanton and Philip T. Diaz
I. Introduction 759
II. Rationale for Respiratory Muscle Training in COPD 760
III. Unresolved Issues Related to Training Methods: A Review
of the Literature 766
IV. Conclusions and Speculations 775
References 776
Part Seven INSTRUMENTAL TREATMENTS
34. Long Term Oxygen Therapy in Stable COPD 781
Emmanuel Weitzenblum, Ari Chaouat, Romain Messier, Roland
Schott, and Monique Oswald
I. Arguments for LTOT in Hypoxemic COPD: The Beneficial
Effects of LTOT 781
II. Indications of LTOT in COPD 792
III. Home Oxygen 798
References 807
35. Domiciliary Noninvasive Ventilatory Support 813
Stefano Nava and Paolo Navalesi
I. Introduction 813
II. What Determines the Prognosis in Advanced
COPD? 814
III. What Causes CO2 Retention in COPD Patients? 815
IV. Rationale for Using Long Term Noninvasive
Ventilation 817
V. Clinical Studies 822
VI. When Should NIMV Be Started? 831
VII. How to Set Domiciliary Ventilation 834
VIII. How to Follow the Patients at Home 839
IX. Conclusions 840
Acknowledgments 840
References 840
xxvi Contents
36. The Indications for and Management of Tracheostomy in
COPD 849
Jean Frangois Muir and Antoine Cuvelier
I. Physiological Basis for Chronic Mechanical Ventilation 851
II. Results of HMVT in COPD 853
III. Indications for HMVT in COPD 859
IV. Methods 862
V. From the Hospital to Home 864
References 865
Part Eight SURGERY
37. Management of the COPD Patient Undergoing Surgery 871
B. Dureuil
I. Introduction 871
II. Pathophysiology of Postoperative Respiratory
Complications 872
III. COPD as a Patient Related Risk Factor 874
IV. Preoperative Evaluation and Preparation 875
V. Preoperative Preparation of Stable COPD Patients 879
VI. Intraoperative Management 881
VII. Postoperative Care and Risk Reduction Strategies 884
VIII. Conclusion 887
References 888
38. Lung Volume Reduction Surgery and Chronic Obstructive
Pulmonary Disease 895
P. M. A. Calverley and M. Fournier
I. Introduction 895
II. Theoretical Considerations 896
III. Physiological and Clinical Effects of LVRS 898
IV. Surgical Aspects of LVRS 905
V. Assessing the Cost of LVRS 909
VI. The Future of LVRS 912
References 914
39. Lung Transplantation and COPD 921
E. P. Tnilock
I. Background 921
II. Recipient Selection 923
III. Timing Transplantation 925
IV. Bridging to Transplantation 927
Contents vvv, ,
V. Choice of Procedure 929
VI. Outcomes 930
VII. Summary 935
References 935
Part Nine PERSPECTIVES
40. New Treatments for COPD 943
Peter J. Barnes
I. Introduction 943
II. New Bronchodilators 944
III. Smoking Cessation 945
IV. Mediator Antagonists 946
V. New Anti Inflammatory Treatments 948
VI. Protease Inhibitors 952
VII. Mucoregulators 955
VIII. Alveolar Repair 957
IX. Route of Delivery 957
X. Future Directions 957
References 959
Part Ten MANAGEMENT OF COPD THROUGH THE WORLD
41. Critical Comparison of Guidelines 965
Nicolas Roche and Gerard J. Huchon
I. Introduction 965
II. Areas of Concordance and Discrepancies between
Guidelines 966
III. What is a Good Clinical Practice Guideline? 975
IV. Are Recommendations on COPD Good Guidelines?
Lessons from Experiences in Asthma 978
V. How Could COPD Guidelines be Improved? 979
VI. What are the Main Unanswered Questions? 980
References 981
42. Epidemiology and Management of COPD in Russia 987
4. C. Chuchalin and S. N. Avdeev
I. History 987
II. Morbidity and Mortality 989
III. Smoking 991
IV. Occupational Factors 991
V. Air Pollution 992
xxviii Contents
VI. Genetics 993
VII. Consequences of the Catastrophe at Chernobyl 994
VIII. Climatic Conditions 997
IX. Management 999
References 1003
43. Epidemiology and Management of Stable COPD in Africa 1007
N. A it Khaled, P. Chaulet, D. Enarson, and K. Slama
I. Epidemiology 1007
II. Management of Stable COPD in Africa 1018
III. Conclusion 1026
Acknowledgment 1026
References 1026
44. Chronic Obstructive Pulmonary Disease in Latin America 1031
Alvaro Undurraga, Patricio Gonzalez, and Bartolome Celli
I. Introduction 1031
II. Latin America: The Facts 1031
III. COPD in Latin America 1033
IV. Some Etiopathogenic Factors of COPD 1035
V. Latin American COPD Consensus 1040
VI. Final Comments 1040
References 1041
45. The Point of View of the WHO on Chronic Obstructive
Pulmonary Disease 1045
Nikolai Khaltaev
I. Introduction 1045
II. Definition and Classification 1046
III. Epidemiology 1047
IV. Risk Factors 1053
V. Conclusion 1054
References 1055
Index 1059
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV014471902 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:02:59Z |
| institution | BVB |
| isbn | 0824706102 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009878423 |
| oclc_num | 49527077 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 |
| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | XLIV, 1072 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Dekker |
| record_format | marc |
| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ... New York [u.a.] Dekker 2002 XLIV, 1072 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 165 Includes index Bronchopneumopathies obstructives ram Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Obstruktive Ventilationsstörung (DE-588)4213128-5 s DE-604 Similowski, Thomas Sonstige oth Whitelaw, William A. Sonstige oth Derenne, Jean-Philippe Sonstige oth Lung biology in health and disease 165 (DE-604)BV000008326 165 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009878423&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Clinical management of chronic obstructive pulmonary disease Lung biology in health and disease Bronchopneumopathies obstructives ram Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd |
| subject_GND | (DE-588)4213128-5 (DE-588)4143413-4 |
| title | Clinical management of chronic obstructive pulmonary disease |
| title_auth | Clinical management of chronic obstructive pulmonary disease |
| title_exact_search | Clinical management of chronic obstructive pulmonary disease |
| title_full | Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ... |
| title_fullStr | Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ... |
| title_full_unstemmed | Clinical management of chronic obstructive pulmonary disease ed. by Thomas Similowski ... |
| title_short | Clinical management of chronic obstructive pulmonary disease |
| title_sort | clinical management of chronic obstructive pulmonary disease |
| topic | Bronchopneumopathies obstructives ram Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd |
| topic_facet | Bronchopneumopathies obstructives Muscles respiratoires - physiologie Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive complications Pulmonary Disease, Chronic Obstructive diagnosis Pulmonary Disease, Chronic Obstructive therapy Respiratory Muscles physiology Obstruktive Ventilationsstörung Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009878423&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
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