Immunology of diabetes: autoimmune mechanisms and the prevention and cure of type 1 diabetes
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Sprache: | English |
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New York, NY
New York Acad. of Sciences
2002
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Schriftenreihe: | Annals of the New York Academy of Sciences
958 |
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Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XIV, 440 S. Ill., graph. Darst. |
ISBN: | 1573313629 1573313637 |
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245 | 1 | 0 | |a Immunology of diabetes |b autoimmune mechanisms and the prevention and cure of type 1 diabetes |c ed. by C. B. Sanjeevi |
264 | 1 | |a New York, NY |b New York Acad. of Sciences |c 2002 | |
300 | |a XIV, 440 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
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490 | 1 | |a Annals of the New York Academy of Sciences |v 958 | |
650 | 4 | |a Auto-immunité - Congrès | |
650 | 7 | |a Diabète - Aspect génétique - Congrès |2 ram | |
650 | 7 | |a Diabète - Aspect immunologique - Congrès |2 ram | |
650 | 4 | |a Diabète - Immunologie - Congrès | |
650 | 4 | |a Immunogénétique - Congrès | |
650 | 7 | |a Immunogénétique - Congrès |2 ram | |
650 | 4 | |a Autoimmunity |v Congresses | |
650 | 4 | |a Diabetes Mellitus, Type 1 |x immunology |v Congresses | |
650 | 4 | |a Diabetes Mellitus, Type 1 |x prevention & control |v Congresses | |
650 | 4 | |a Diabetes Mellitus, Type 1 |x therapy |v Congresses | |
650 | 4 | |a Diabetes |x Immunological aspects |v Congresses | |
650 | 4 | |a Immunogenetics |v Congresses | |
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Datensatz im Suchindex
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adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume
958
April
2002
/IMMUNOLOGY OF DIABETES
Autoimmune mechanisms and the
prevention and cure of
type
1
diabetes
Editor and Conference Organizer
C. B. Sanjeevi
This volume is the result of a conference entitled Immunology of Diabetes: The Fifth
Congress of the Immunology of Diabetes Society, which was held on February
14-16,
2001
in Madras, India.
CONTENTS
Preface. By C. B. Sanjeevi
............................................. xiii
International Workshop on Lessons from Animal Models for Human Type
1
Diabetes: Analyzing Target
Autoantigens
of Humoral Immunity in Non-
obese Diabetic Mice. By Ezio Bonifacio, Mark Atkinson, George
Eisenbarth,
David Serreze, Thomas W. H. Kay, Edwin Lee-Chan,
andBhagirath Singh
............................................ 1
Part I. Infection and Autoimmunity
Antiinfection
Immunity and Autoimmunity. By Rolf M.
Zinkernagel
...... 3
Viruses and Diabetes. By
Elmar Jaeckel,
Michael Manns, and
Matthias von
HĚrrath....................................
7
Theiler s Virus-Mediated Autoimmunity: Local Presentation of CNS Anti¬
gens and Epitope Spreading. By S. Mark Tompkins. Kevin G. Fuller,
and Stephen D. Miller
.......................................... 26
Part II. Role of the Gut Immune System in the Pathogenesis
of Type
1
Diabetes
The Gut Immune System and Type
1
Diabetes,
ßy
Outi Vaarala
.......... 39
Oral Tolerance, Systemic
Immunoregulation,
and Autoimmunity. By
Stephan
Strobel
................................................ 47
Part III. Toward a Cure for Type
1
Diabetes
Use of In Viiro-Generated, Stem Cell-Derived Islets to Cure Type
1
Diabetes:
How Close Are We? By A. B. Peck, J. G. Cornelius, M. Chaudhari,
D. Shatz, and V. K. Ramiya
....................................... 59
A View on Beta Cell Transplantation in Diabetes. By Daniel Pipeleers, Bart
Keymeulen,
Lucienne Chatenoud,
Christel Hendrieckx,
Zhidong
Ling, Chant
al Mathieu,
Bart
Roep, and
Dirk Yseb aert............ 69
Regulatory Natural Killer
Τ
Cells Protect against Spontaneous and Recurrent
Type
1
Diabetes. By
Sha y
an Sharif,
Guillermo
A. Arreaza,
PeterZucker, and Terry L. Delovitch
............................ 77
Part IV. Latent Autoimmune Diabetes in Adults
(LADA)
Beta Cell Rest and Recovery
—
Does It Bring Patients with Latent Auto¬
immune Diabetes in Adults to Euglycemia? By Jerry P. Palmer
....... 89
Autoantibody Profile and Epitope Mapping in Latent Autoimmune Diabetes
in Adults. By Alberto Falorni and
Filippo Calcinaro
............. 99
Genetics of Latent Autoimmune Diabetes in Adults. By C. B. Sanjeevi,
G. Gambelunghe, A. Falorni, A. Shtauvere-Brameus, and
A. Kanungo
..................................................... 107
Latent Autoimmune Diabetes in Adults. By
Mona Landin-Olsson.......... 112
Insulin Intervention to Preserve
β
Cells in Slowly Progressive Insulin-
Dependent (Type
1)
Diabetes Mellitus. By Tetsuro Kobayashi,
Taro
Maruyama, Akira Shimada, Akira Kasuga,
Azuma
Kanatsuka,
Izumi
Takei, Shoichiro Tanaka, and Junichi Yokoyama
............. 117
Part V. Malnutrition Modulated Diabetes Mellitus:
Does It Have an Autoimmune Basis?
Clinicoepidemiological and Biochemical
Profile
of Malnutrition-Modulated
Diabetes Mellitus. By
К. С
Samal, A. Kanungo, and
C.B.
Sanjeevi
... 131
Molecular Mechanisms Involved in the Etiopathogenesis of Malnutrition-
Modulated Diabetes Mellitus. By A. KANUNGO,
К. С
Samal, AND
С. В.
Sanjeevi
................................................... 138
Immunogenetic Studies on Malnutrition-Modulated Diabetes Mellitus. By
С. В.
Sanjeevi, A. Kanungo, and
К. С
Samal
...................... 144
Part VI.
Τ
Cells and
В
Cells in Type
1
Diabetes
Antidiabetogenic Effect of Mycophenolate Mofetil Is Associated with Down-
Regulation of Adhesive Interactions and Autoreactive Cell Activation.
By D. Maksimovic, M.
Mostarica Stojkovic,
and
S. Stosic-Grujicic
............................................... 148
Corticosteroid-Responsive Diabetes Mellitus Associated with Autoimmune
Pancreatitis: Pathological Examinations of the Endocrine and
Exocrine
Pancreas. By Shoichiro Tanaka, Tetsuro Kobayashi,
Koji
Nakanishi,
Minoru Okubo,
Masato Odawara, Toshio
Murase,
Masaji Hashimoto,
Goro
Watanabe, Hiroshi Matsushita,
HlDETOSHI INOKO, AND
KÁŽUC
TaKEUCHI
.......................... 152
Fas
Stimulation
Results in Selective Islet Infiltrate Apoptosis in Situ and
Reversal of Diabetes. By
Vikas
R. Dharntdharka, Yancy van Patten,
F.
Rena
В
ahjat, and Michael Clare-Salzler
...................... 160
Molecular Mimicry in Type
1
Diabetes: Immune Cross-Reactivity between
Islet Autoantigen and Human Cytomegalovirus but Not Coxsackie Virus.
By B.
O. Roep,
H. S. Hiemstra,
N.
C. Schloot, R. R. P.
de Vries,
A. Chaudhuri, P.
О.
Behan, and
J.
W. Drijfhout
.................... 163
Apoptosis of Autoreactive CD8 Lymphocytes as a Potential Mechanism for
the Abrogation of Type
1
Diabetes by Islet-Specific TNF-Ot Expression
at a Time When the Autoimmune Process Is Already Ongoing. By
Urs
Christen and Matthias G.
von
Herrath
....................... 166
Dendritic Cell-Based Proliferative Assays of Peripheral
T Celí
Responses to
Tetanus Toxoid. By Parth Narendran, Kathryn Elsegood, Nicola
J
.
Leech, and Colin M. Day an
...................................... 170
Role of Donor MHC Class III Genes in the Destruction of Transplanted Islets
in NOD Mice. By Anthony M. Jevnikar, Sean
Prange,
Peter
Zucker,
and Bhagirath Singh
.............................. 175
A New Model for Analyzing Immunomodulation of
Τ
Cell Responses Induced
by Oral Administration of Islet Cell Antigens. By
S0REN
BREGENHOLT,
Mirala
Wang,
Maja
Zdravkovic, Thomas Dyrberg, and
Jacob S. Petersen
................................................ 179
The PEVKEK Region of the Pyridoxal Phosphate Binding Domain of GAD65
Expresses a Dominant
В
Cell Epitope for Type
1
Diabetes Sera. By
Jonathan C.
Tong,
Mark A. Myers, Ian R. Mackay, Paul Z.
Zimmet, and Merrill J. Rowley
................................... 182
IL-
1
β
Expression in Islet Cells of the NOD Mouse and Its Spatial Relationship
to Beta Cells and Inducible Nitric Oxide Synthase. By Shiva Reddy and
May Young
..................................................... 190
Induction of Donor-Specific Tolerance to Islet Allografts in Nonhuman
Primates. By Lakshmi K.
Gaur,
E. Kennedy, Y. Nitta, G. T. Nepom,
K. A. Nelson, M. Allen, and
Å.
Lernmark......................... 194
Induction of Islet Allotolerance in Nonhuman Primates. By Lakshmi K.
Gaur,
Υ. Νπτα, Ε.
Kennedy,
Å.
Lernmark,
K.
A. Nelson,
M.
Allen, and
G. T. Nepom
....................................... 199
The Role of Fas
Ligand
in Beta Cell Destruction in Autoimmune Diabetes of
NOD Mice. By
N.
Petrovsky, D.
Silva.
L. Socha, R.
Slattery. and
B. Charlton
.................................................... 204
Th2 Dominance of
Τ
Helper Cell Response to Preproinsulin in Individuals
with Preclinical Type
1
Diabetes. By
Ivana Durinovic-Belló.
Martina
Riedl.
Silke Rosinger, Nicola
Maœel,
Hubert Kalbacher, Martin
Deeg,
Hans-Jürgen Schreckling,
Michael Schlosser, Manfred Ziegler, Peter Kuehnl, and
Bernhard O. Boehm............................................ 209
Part
VII.
Autoantibodies in Type 1 Diabetes
Prevalence of ICA-1
2
and Other
Autoantibodies in
North Indian Patients with
Early-Onset Diabetes. By
N.
Tandon,
A. Shtauvere-Brameus,
W. A. Hagopian. and
Č.
B. Sanjeevi
.............................. 214
Increased Autoantibodies to SOX
13
in Swedish Patients with Type
1
Diabetes.
By
C. TÖRN,
A. SHTAUVERE-BRAMEUS,
С. В.
SANJEEVI, AND
M. Landin-Olsson
.............................................. 218
Induction of Insulin Autoantibodies and Protection from Diabetes with Sub¬
cutaneous Insulin B:9-23
Peptide
without Adjuvant. By Edwin Liu,
Norio Abiru,
Hiroaki Moriyama, Dongmei
Miao,
and
George S.
Eisenbarth........................................... 224
Autoantibodies and
HLA
Susceptibility Markers in Canadian First-Degree
Relatives of Patients with Type
1
Diabetes. By
M. T. BEHME,
J. L
.
Mahon, and
J. Dupré
....................................... 228
Autoantibodies to Tissue Transglutaminase in Patients from Eastern India
with Malnutrition-Modulated Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, and Non-Insulin-Dependent Diabetes Mellitus. By
A. Kanungo, A. Shtauvere-Brameus,
К. С
Samal, and
С. В.
Sanjeevi
................................................... 232
Distinct IA-2 Autoantibody Epitope Recognition between Childhood-Onset
and Adult-Onset Type
1
Diabetes. By
Еш
Kawasaki, Yasunori Sera,
Norio Abiru,
Mikako Yamauchi, Masako Ozaki, Kenichi
Yamakawa, Takahiro Abe, Shigeo Uotani, Hironori Yamasaki,
Yoshihiko Yamaguchi, and Katsumi Eguchi
..................... 235
Autoantibodies to IA-2 in Type
1
Diabetes: Measurements with a New
Enzyme-Linked Immunosorbent Assay. By
Еш
Kawasaki, Hirokazu
Yamaguchi, Hiroaki Hattori,
Toru
Egashira, and Katsumi Eguchi
241
GAD65 and ICA512 Antibodies in Undernourished and Normally Nourished
South Indian Patients with Diabetes. By A. K. Das, A. Shtauvere-
Brameus, and
С. В.
Sanjeevi
..................................... 247
Relation between Course of Disease in Type
1
Diabetes and Islet Cell
Antibodies. By M. Zamaklar, A. Jotic,
N.
Lalic, K. Lalic,
N.
Rajkovic, and T. Milicic
...................................... 251
Diabetes Prevention Trial
1:
Prevalence of GAD and ICA512 (IA-2) Auto¬
antibodies by Relationship to
Proband.
By
Liping
Yu, David D.
Cuthbertson, George S.
Eisenbarth,
Jeffrey P. Krischer, and
the DPT-1 Participating Investigators
......................... 254
Islet Autoantibodies in Latvian Subjects with Non-Insulin-Dependent
Diabetes Mellitus: Slow-Onset Type
1
Diabetes or Polyendocrine Auto-
immunity? By A. Shtauvere-Brameus, A. Falorni, I. Rumba,
and
C. B. Sanjeevi
.............................................. 259
Low Frequency of Autoantibodies to Islet Cell, Glutamic Acid Decarboxylase,
and Second-Islet Antigen in Patients with Gestational Diabetes Mellitus:
A Follow-up Study. By A. Lapoixa, D.
Fedele,
В.
Pedini,
M. G.
Dal
Frà, M. Sanzari, M.
Masin,
R.
Zanchetta, and
С
Betterle..................................................... 263
Anti-Insulin-like
Growth Factor-1 Autoantibodies in Type
1
Diabetes. By
Taro
Maruyama, Hiroshi Murayama, Atsuo Nagata,
Akira Shimada, Akira Kasuga, and Takao
Săruta
.............. 267
Pancreatic Autoantibodies in Italian Patients with Newly Diagnosed Type
1
Diabetes Mellitus under the Age of
20
Years. By C.
Betterle,
A. Fusari, F.
Presotto,
C. Dal Pra, B.
Pedini,
F. Lazzarotto,
and
R. Zanchetta
................................................... 271
The Number of Markers of Pancreatic Autoimmunity Is Proportional to the Risk
for Type
1
Diabetes Mellitus in Italian and English Patients with Organ-
Specific Autoimmune Diseases. By C.
Betterle,
A. C. Spadaccino,
F.
Presotto,
R.
Zanchetta, B.
Pedini,
M.
Lai,
N.
Α.
Greggio, and
G. F. BOTTAZzo
.............................................. 276
Women Diagnosed with Gestational Diabetes Mellitus Do Not Carry Anti¬
bodies against Minor Islet Cell Antigens. By Madhuri Balaji,
A. Shtauvere-Brameus, V.Balaji,V.Seshiah,andC. B. Sanjeevi
... 281
Autoimmune Diabetes in
26
Villages outside Madras. By Manjula Datta,
A. Shtauvere-Brameus, V. Gupta, M. K.
Mani,
and
С
B. Sanjeevi
. 285
Diabetes-Related Autoantibodies in Cord Blood from Children of Healthy
Mothers Have Disappeared by the Time the Child Is One Year Old.
By Johnny
Ludvigsson
and
Jeanette Wahlberg
for the
ABIS
Study Group
................................................... 289
BCG
Vaccination and GAD65 and IA-2 Autoantibodies in Autoimmune
Diabetes in Southern India. By
С. В.
Sanjeevi, Ashok K. Das, and
A. Shtauvere-Brameus
.......................................... 293
Antibodies to New Beta Cell Antigen
ICA
12
in Latvian Diabetes Patients. By
A. Shtauvere-Brameus, W. Hagopian, I. Rumba, and
C. B. Sanjeevi
................................................... 297
Part
VIII.
Genetics in Type
1
Diabetes
HLA-DRB
1,
DQB
1,
and DQA
1
Alíele
Profile
in Brazilian Patients with Type
1
Diabetes Mellitus. By A. P. M.
FERNANDES,
P.
LOUZADA-JÚNIOR,
M.
С.
FOSS, AND
E. A. DONADI
..................................... 305
МНС
Class I Chain-Related
Gene Alíeles
5
and
5.1
Are Transmitted More
Frequently to Type
1
Diabetes Offspring in HBDI Families, By
L.
ΝίκίτίΝΑ
Zake,
M. Ghaderi, Y. S. Park, S. Babu,
G.
Eisenbarth,
and
С. В.
Sanjeevi
............................................... 309
Newborn Screening for High-Risk Human Leukocyte Antigen Markers Asso¬
ciated with Insulin-Dependent Diabetes Mellitus: The
ABIS
Study. By
L. Berzina, A. Shtauvere-Brameus, J.
Ludvigsson,
and
С. В.
Sanjeevi
................................................... 312
Molecular Modeling of Eluted Peptides from DQ6 Molecules (DQB
1*0602
and DQB
1
*0604) Negatively and Positively Associated with Type
1
Diabetes. By
С. В.
Sanjeevi,
T.
P. Lybrand, S. Stevanovic, and
H. G.
Rammensee................................................ 317
Contribution of MIC-A Polymorphism to Type
1
Diabetes Mellitus in
Basques. By J.
Ramón
Bilbao, Ainhoa
Martín-Pagóla, Begoña
Calvo,
Guiomar
Perez
de Nanclares, GEPV-N, and Luis
Castaño
321
Genetic Dissection of Type
1
Diabetes Susceptibility Gene, Idd3, by Ancestral
Haplotype
Congenie
Mapping. By HiROSHi Ikegami, Tomomi
Fujisawa, Susumu
Marino,
and Toshio Ogihara
................... 325
ICA12 Autoantibodies Are Associated with
non-DR3/non-DR4
in Patients
with Latent Autoimmune Diabetes in Adults from Northern India. By
M. Gupta.
N.
Tandon.
A. Shtauvere-Brameus, andC. B. Sanjeevi
... 329
Immunogenetics of Autoimmune Diseases in Asian Indians. By
N.
K. Mehra,
GURVINDER
Клик,
UMA
KÄNGA,
AND NlKHIL
TANDON
. ................ 333
CTLA-4 Gene
Polymorphism Contributes to the Genetic Risk for Latent
Autoimmune Diabetes in Adults. By Anna
Cosentino, Giovanni
Gambelunghe,
Cristina
Tortoioli, and AlbertoFalorni
........... 337
MHC Class I Chain-Related
Gene A Alíeles
Distinguish Malnutrition-
Modulated Diabetes, Insulin-Dependent Diabetes, and Non-Insulin-
Dependent Diabetes Mellitus Patients from Eastern India. By
С
B. Sanjeevi, A. Kanungo, L. Berzina, A. Shtauvere-Brameus,
M. Ghaderi, and
К. С
Samal
..................................... 341
DR3 Is Associated with Type
1
Diabetes and Blood Group ABO Incompati¬
bility. By L. Berzina, J.
Ludvigsson,
V. Sadauskaite-Kuehne,
N.
Nelson, A. Shtauvere-Brameus, and
C.B.
Sanjeevi
............. 345
Microsatellite
Alíele
5
of MHC Class I Chain-Related Gene A Increases the
Risk for Insulin-Dependent Diabetes Mellitus in Latvians. By
A. Shtauvere-Brameus, M. Ghaderi, I. Rumba, and C. B. Sanjeevi
... 349
Microsatellite
Alíele A5.
1
of MHC Class I Chain-Related Gene A Is Associ¬
ated with Latent Autoimmune Diabetes in Adults in Latvia. By
L. Berzina, A. Shtauvere-Brameus, I. Rumba, and
С
B. Sanjeevi
.... 353
Tumor Necrosis
Factor
-α
Alíele
2
Shows an Association with Insulin-
Dependent Diabetes Mellitus in Latvians. By A. Shtauvere-Brameus,
P. Dabadghao, I. Rumba, and
С
B. Sanjeevi
....................... 357
The Combination of Several Polymorphic
Amino
Acid Residues in the DQoc
and
DQß
Chains Forms a Domain Structure Pattern and Is Associated
with Insulin-Dependent Diabetes Mellitus. By
C.B.
Sanjeevi,
M. Landin-Olsson,
I. Kockum, G.
Dahlquist, and
Å.
Lernmark ... 362
Part IX. Miscellaneous Poster Papers
Mothers of Children in
ABIS,
a Population-Based Screening for Prediabetes,
Experience Few Ethical Conflicts and Have a Positive Attitude. By
Johnny
Ludvigsson,
Ulrica
Gustafsson-Stolt, Per-Erik
Liss, and
Tommy
Svensson
for the
ABIS
Study Group
...................... 376
Immunomodulatory Effect of Tungstate on Streptozotocin-Induced Experi¬
mental Diabetes in Rats. By R. Palanivel and D. Sakthisekaran
...... 382
Retinopathy Screening in Children and Adolescents with Diabetes. By
V. Raman, F. Campbell, P. Holland, T. Chapman, T. Dabbs,
H. J. BODANSKY, AND D. P. O NEILL
................................ 387
Clinical Association of Autoimmune Diseases with Diabetes Mellitus:
Analysis from Southern India. By G. R. Sridhar and G. Nagamani
___ 390
Activation of IL-1 Signaling Pathway in Schwann Cells during Diabetic
Neuropathy. By
Dusanka S.
Skundric, Rujuan Dai, Jascinth James,
and Robert P. Lisak
............................................. 393
The Lymphocyte as a Cellular Model to Study Insights into the Pathophysiol-
ogy of Diabetes and Its Complications. By M. Balasubramanyam,
С
Premanand, and V. Mohan
................................... 399
HLA
Class I and Class II Association with Ankylosing Spondylitis in a
Southern Indian Population. By Radha Madhavan, M. Parthiban,
C. Panchapakesa Rajendran, A.
N.
Chandrasekaran, L.
Zake,
and
C. B. Sanjeevi
........................................... 403
IgM, IgG,
and IgA Response to Enterobacteria in Patients with Ankylosing
Spondylitis in Southern India. By Radha Madhavan, R. Porkodi,
C. Panchapakesa Rajendran, A.
N.
Chandrasekaran,
K. R. Umadevi, and Raja Alamelu
............................... 408
Class II MHC
Alíeles
in Rheumatoid Arthritis in Tamilnadu, India: Is There
an Association? By M. Parthiban, Radha Madhavan, R. Porkodi,
С
Panchapakesa Rajendran, L.
Zake,
С. В.
Sanjeevi, and
A.
N.
Chandrasekaran
........................................... 412
A Comparative Study of the Knowledge, Beliefs, and Practices of Diabetic
Patients Cared for at a Teaching Hospital (Free Service) and
Those Cared for by Private Practitioners (Paid Service). By
G. SrVAGNANAM, K. NAMASIVAYAM, M. RAJASEKARAN,
P. Thirumalaikolundusubramanian, and
С
Ravindranath
........... 416
Treatment-Seeking Behavior and Compliance of Diabetic Patients in a
Rural Area of South India. By G. Srinivas, E. Suresh, M. Jagadees an.
E. Amalraj, and Manjula Datta
.................................. 420
Cardiovascular Function in Patients with Insulin-Dependent Diabetes
Mellitus: A Study Using Noninvasive Methods. By S. K.
Rajan
and
Shefali M. Gokhale
............................................. 425
Could Parenting Stress and Lack of Support/Confidence Function as Mediat¬
ing Mechanisms between Certain Environmental Factors and the
Development of Autoimmunity in Children? A Study within
ABIS, ßy
Anneli
Sepa,
Ann
Frodi, and
Johnny Ludvigsson
................ 431
Index
of Contributors
.................................................. 437
Financial assistance was received from:
Major Sponsor
•
NOVO
NORDISK
PHARMA INDIA LIMITED (INDIA)
Sponsors
•
NATIONAL INSTITUTES OF HEALTH (USA)
•
PEPTOR LTD (ISRAEL)
•
BAYER(USA)
•
JUVENILE DIABETES FOUNDATION INTERNATIONAL (USA)
•
NOVO
NORDISK
A/S
(DENMARK)
Contributors
• LIFESCAN
(INDIA)
•
AVENTIS (INDIA AND EUROPE)
•
USV (INDIA)
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums.
|
any_adam_object | 1 |
author_GND | (DE-588)124024548 |
building | Verbundindex |
bvnumber | BV014438132 |
callnumber-first | Q - Science |
callnumber-label | Q11 |
callnumber-raw | Q11 RC660 |
callnumber-search | Q11 RC660 |
callnumber-sort | Q 211 |
callnumber-subject | Q - General Science |
ctrlnum | (OCoLC)49376241 (DE-599)BVBBV014438132 |
dewey-full | 500 616.4/62/079 |
dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
dewey-ones | 500 - Natural sciences and mathematics 616 - Diseases |
dewey-raw | 500 616.4/62/079 |
dewey-search | 500 616.4/62/079 |
dewey-sort | 3500 |
dewey-tens | 500 - Natural sciences and mathematics 610 - Medicine and health |
discipline | Allgemeine Naturwissenschaft Medizin |
format | Book |
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genre | (DE-588)1071861417 Konferenzschrift 2001 Madras gnd-content |
genre_facet | Konferenzschrift 2001 Madras |
id | DE-604.BV014438132 |
illustrated | Illustrated |
indexdate | 2024-07-09T19:02:45Z |
institution | BVB |
isbn | 1573313629 1573313637 |
language | English |
lccn | 2002004277 |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009869124 |
oclc_num | 49376241 |
open_access_boolean | |
owner | DE-20 DE-12 |
owner_facet | DE-20 DE-12 |
physical | XIV, 440 S. Ill., graph. Darst. |
publishDate | 2002 |
publishDateSearch | 2002 |
publishDateSort | 2002 |
publisher | New York Acad. of Sciences |
record_format | marc |
series | Annals of the New York Academy of Sciences |
series2 | Annals of the New York Academy of Sciences |
spelling | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes ed. by C. B. Sanjeevi New York, NY New York Acad. of Sciences 2002 XIV, 440 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 958 Auto-immunité - Congrès Diabète - Aspect génétique - Congrès ram Diabète - Aspect immunologique - Congrès ram Diabète - Immunologie - Congrès Immunogénétique - Congrès Immunogénétique - Congrès ram Autoimmunity Congresses Diabetes Mellitus, Type 1 immunology Congresses Diabetes Mellitus, Type 1 prevention & control Congresses Diabetes Mellitus, Type 1 therapy Congresses Diabetes Immunological aspects Congresses Immunogenetics Congresses Diabetes mellitus Typ 1 (DE-588)1194595685 gnd rswk-swf Immunologie (DE-588)4026637-0 gnd rswk-swf Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2001 Madras gnd-content Diabetes mellitus Typ 1 (DE-588)1194595685 s Immunologie (DE-588)4026637-0 s DE-604 Autoaggressionskrankheit (DE-588)4003935-3 s Sanjeevi, Carani B. Sonstige (DE-588)124024548 oth Annals of the New York Academy of Sciences 958 (DE-604)BV002532608 958 Digitalisierung TU Muenchen application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009869124&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes Annals of the New York Academy of Sciences Auto-immunité - Congrès Diabète - Aspect génétique - Congrès ram Diabète - Aspect immunologique - Congrès ram Diabète - Immunologie - Congrès Immunogénétique - Congrès Immunogénétique - Congrès ram Autoimmunity Congresses Diabetes Mellitus, Type 1 immunology Congresses Diabetes Mellitus, Type 1 prevention & control Congresses Diabetes Mellitus, Type 1 therapy Congresses Diabetes Immunological aspects Congresses Immunogenetics Congresses Diabetes mellitus Typ 1 (DE-588)1194595685 gnd Immunologie (DE-588)4026637-0 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd |
subject_GND | (DE-588)1194595685 (DE-588)4026637-0 (DE-588)4003935-3 (DE-588)1071861417 |
title | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes |
title_auth | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes |
title_exact_search | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes |
title_full | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes ed. by C. B. Sanjeevi |
title_fullStr | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes ed. by C. B. Sanjeevi |
title_full_unstemmed | Immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes ed. by C. B. Sanjeevi |
title_short | Immunology of diabetes |
title_sort | immunology of diabetes autoimmune mechanisms and the prevention and cure of type 1 diabetes |
title_sub | autoimmune mechanisms and the prevention and cure of type 1 diabetes |
topic | Auto-immunité - Congrès Diabète - Aspect génétique - Congrès ram Diabète - Aspect immunologique - Congrès ram Diabète - Immunologie - Congrès Immunogénétique - Congrès Immunogénétique - Congrès ram Autoimmunity Congresses Diabetes Mellitus, Type 1 immunology Congresses Diabetes Mellitus, Type 1 prevention & control Congresses Diabetes Mellitus, Type 1 therapy Congresses Diabetes Immunological aspects Congresses Immunogenetics Congresses Diabetes mellitus Typ 1 (DE-588)1194595685 gnd Immunologie (DE-588)4026637-0 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd |
topic_facet | Auto-immunité - Congrès Diabète - Aspect génétique - Congrès Diabète - Aspect immunologique - Congrès Diabète - Immunologie - Congrès Immunogénétique - Congrès Autoimmunity Congresses Diabetes Mellitus, Type 1 immunology Congresses Diabetes Mellitus, Type 1 prevention & control Congresses Diabetes Mellitus, Type 1 therapy Congresses Diabetes Immunological aspects Congresses Immunogenetics Congresses Diabetes mellitus Typ 1 Immunologie Autoaggressionskrankheit Konferenzschrift 2001 Madras |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009869124&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV002532608 |
work_keys_str_mv | AT sanjeevicaranib immunologyofdiabetesautoimmunemechanismsandthepreventionandcureoftype1diabetes |