Chimeric toxins: mechanisms of action and therapeutic applications
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Taylor & Francis
2002
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Cellular and molecular mechanisms of toxin action
4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 271 S. Ill., graph. Darst. |
| ISBN: | 0415283868 |
Internformat
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| 245 | 1 | 0 | |a Chimeric toxins |b mechanisms of action and therapeutic applications |c ed. by Haya Lorberboum-Galski ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London [u.a.] |b Taylor & Francis |c 2002 | |
| 300 | |a XVI, 271 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Cellular and molecular mechanisms of toxin action |v 4 | |
| 650 | 4 | |a Antitoxins | |
| 650 | 4 | |a Immunotoxins |x pharmacology | |
| 650 | 4 | |a Immunotoxins |x therapeutic use | |
| 650 | 4 | |a Recombinant Fusion Proteins |x therapeutic use | |
| 650 | 4 | |a Toxins | |
| 650 | 4 | |a Toxins |x Therapeutic use | |
| 650 | 0 | 7 | |a Toxin |0 (DE-588)4127018-6 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804129284407689216 |
|---|---|
| adam_text | Contents
List of figures vii
List of tables jx
List of contributors xj
Preface to the series xiii
Preface xv
1 Bacterial and plant toxins general mode of action 1
A.E. FRANKEL AND P.I). HALL
2 Diphtheria toxin structure, function, and its clinical applications 14
R.C. RATTS ANDJ.C. VANDERSPEK
3 Ricin A: structure, function and its clinical applications 37
M.COLOMBATT1
4 Pathways of delivering toxins into the cytosol of target cells 86
J. M. LORD, P.J. DAY, M.E. JACKSON, S.R. OWENS, J.C. SIMPSON,
D.C. SMITH ANDL.M. ROBERTS
5 Engineering immunotoxins for improving their therapeutic activity 99
C. COHEN, G. DENKBERG, M. EPEL ANDY. REITER
6 Ligand receptor interactions studied with chimeric proteins 135
H. LORBERBOUM GALSKI
7 Chimeric proteins: a novel approach for eliminating specific cell
populations for targeted human therapy 148
A. BEN YEHUDAH, R. BELOSTOTSKY. R. AQEILAN, Y. AZAR.
I. STEINBERGER, A. FISHMAN. A. NECIIUSHTAN, S. YARKONI AND
H. LORBERBOUM GALSKI
8 Chimeric neurotoxins a molecular neurosurgery approach 168
P. LAZAROVICI
9 Targeted immunotherapy of autoimmune diseases by chimeric toxins 179
B.A. HOLDER ANDJ.G. KRUEGER
vi Contents
10 Immunotoxins for targeted cancer therapy 203
R.J. KREITMAN
11 Molecular targeting of brain tumors with cytotoxins:
novel bacterial toxin containing anti brain tumor therapeutics 222
W. DEBINSKI
12 Toxin in the development of vaccines 247
C. T. HSU, C. Y. TING ANDJ. HWANG
Index 261
Figures
1.1 The a carbon backbone of DT 2
1.2 Model of cell intoxication by diphtheria toxin 3
1.3 The a carbon backbone of PE 4
1.4 Model of cell intoxication by Pseudomonas exotoxin 5
1.5 The a carbon backbone of ricin 6
1.6 Model of cell intoxication by ricin 7
2.1 Schematic representation of DT Fragments A and B 15
4.1 Schematic representations of protein toxin structure 87
4.2 Proposed route of cell entry for protein toxins 94
5.1 Immunotoxins: first generation conjugates and second generation
recombinant molecules 102
5.2 Recombinant immunotoxins: design, cloning, construction, and
composition of scFv and dsFv immunotoxins 104
5.3 Recombinant Fv fragments 106
5.4 Recombinant scFv immunotoxin 107
5.5 The mode of action of Pseudomonas Exotoxin A 110
6.1 IL2R a, j8 and y subunits gene expression in human B cell lines
analyzed by PCR 137
6.2 Cytotoxic activity of IL2 PE664Glu on human B cell lines 140
6.3 Cytotoxic activity of MBP PE40 chimeric proteins against anti MBP
T cell lines 143
6.4 Effect of the partially purified GnRH PE66 on various cell lines 144
7.1 Mode of action of chimeric proteins 149
7.2 Structure of PE and its modified forms 149
7.3 Effect of MBP PE40 on rat Kla anti MBP T cells 151
7.4 Effect of MBP PE40 on EAE in SJL mice 1 53
7.5 Cytotoxic activity of various chimeric proteins against MC 9 cells 154
7.6 Inhibition of the PCA reaction in mice treated with Fct^.j PE^ 156
7.7 The Effect of Fc2 .3 PE4oon seratonin release from C57 cells 157
7.8 Effect of partially purified GnRH PE66 on various primary cultures 160
7.9 Effect of L GnRH PE66 on average tumor size (colon carcinoma) in
nude mice 161
9.1 A variety of fusion toxins, chimeric toxins and other chimeric proteins 187
10.1 Schematic structure of immunotoxins 207
11.1 Schematic drawing of two bacterial toxins, PE A and DT 226
11.2 Schema of a recombinant cytotoxin targeted to cancer cells 227
viii List of figures
11.3 Schematic drawing of interleukin 13 (IL13) based cytotoxins
containing derivatives of either PE or DT 231
11.4 Autoradiography of the binding of I25I IL13.E13K PE38QQR
cytotoxin to a GBM specimen 232
11.5 Northern blot analysis of human IL13Ra2 transcripts,
human IL4 Ra and that of action in normal human organs 235
11.6 Bottom view of the predicted three dimensional structure of
human 1L 13, as visualized using WebLab ViewerPro 237
12.1 PE and modified PEs with sequential deletion at carboxyl terminal 249
12.2 Effects of vaccination with PEIF, OprF, and nontoxic PE 253
12.2 Degeneration of the ovaries of rabbits immunized with PEIa GnRH12 255
Color Plates
I The a carbon backbone of DT
(See Chapter 1, p. 2. Arthur E. Frankel and Philip D. Hall)
II Model of cell intoxication by diphtheria toxin
(See Chapter 1, p. 3. Arthur E. Frankel and Philip D. Hall)
III The a carbon backbone of PE
(See Chapter 1, p. 4. Arthur E. Frankel and Philip D. Hall)
IV Model of cell intoxication by Pseudomonas exotoxin
(See Chapter 1, p. 5. Arthur E. Frankel and Philip D. Hall)
V The a carbon backbone of ricin
(See Chapter 1, p. 6. Arthur E. Frankel and Philip D. Hall)
VI Model of cell intoxication by ricin
(See Chapter 1, p. 7. Arthur E. Frankel and Philip D. Hall)
VII Recombinant Fv fragments
(See Chapter 5, p. 106. Yoram Reiter et al.)
VIII Recombinant scFv immunotoxin
(See Chapter 5, p. 107. Yoram Reiter et al.)
IX Bottom view of the predicted three dimensional structure of human IL13, as
visualized using WebLab ViewerPro
(See Chapter 11, p. 237. Waldemar Debinski)
Tables
1.1 Mechanisms of cell resistance to DT chimeric proteins 3
1.2 Mechanisms of resistance to PE hybrid proteins 5
1.3 Cellular phenotypes for ricin toxin resistance 8
2.1 Current and potential therapeutic applications of diphtheria based
fusion protein toxins 16
5.1 Examples of recombinant immunotoxins against cancer 100
5.2 Examples for improving recombinant immunotoxins by
antibody engineering 114
6.1 Expression of the a, /3, y IL2R subunits in the various B cell lines,
determined by PCR analysis 138
6.2 Effect of IL2 PE664Glu on B cell lines representing different
stages of B cell lineage ontogeny 139
6.3 Comparison of binding affinities, activation and ID50 values for
DAB389IL2 and its variant mutated chimeras 141
7.1 A Effect of MBP PE40 on EAE in SJL mice 152
7.1B Reversal of EAE by MBP PE^ after the appearance of
the clinical disease 153
7.2 Inhibition of the PCA reaction in mice treated with Fc2.3 PE4O
for 7 days 155
7.3 Effect of GnRH PE66 and L GnRH PE66 on various cell lines 159
8.1 Suicide transport toxins, immunolesioning chimeric toxins and
nocitoxins 170
9.1 Fusion toxins 182
9.2 Chimeric toxins 184
9.3 Other engineered immune modulators (potentially toxic) 185
10.1 Results of recent clinical trials of chimeric toxins against cancer 205
11.1 A list of third generation of IL13 multiple mutant based,
PE38QQR or PElE containing cytotoxins 239
12.1 ToxicityofPE(A576 613)in5 and9 week oldICRmice 250
12.2 Active immunization against PE intoxication in 1CR mice
preimmunized with different doses of PE(A 576 613) 251
12.3 Opsonophagocytosis of different strains of P. aeruginosa by murine
peritoneal macrophages 252
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| indexdate | 2024-07-09T19:02:41Z |
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| isbn | 0415283868 |
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| series | Cellular and molecular mechanisms of toxin action |
| series2 | Cellular and molecular mechanisms of toxin action |
| spelling | Chimeric toxins mechanisms of action and therapeutic applications ed. by Haya Lorberboum-Galski ... 1. publ. London [u.a.] Taylor & Francis 2002 XVI, 271 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cellular and molecular mechanisms of toxin action 4 Antitoxins Immunotoxins pharmacology Immunotoxins therapeutic use Recombinant Fusion Proteins therapeutic use Toxins Toxins Therapeutic use Toxin (DE-588)4127018-6 gnd rswk-swf Chimäre Biologie (DE-588)4214783-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Toxin (DE-588)4127018-6 s Chimäre Biologie (DE-588)4214783-9 s DE-604 Lorberboum-Galski, Haya Sonstige oth Cellular and molecular mechanisms of toxin action 4 (DE-604)BV014580402 4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009866640&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chimeric toxins mechanisms of action and therapeutic applications Cellular and molecular mechanisms of toxin action Antitoxins Immunotoxins pharmacology Immunotoxins therapeutic use Recombinant Fusion Proteins therapeutic use Toxins Toxins Therapeutic use Toxin (DE-588)4127018-6 gnd Chimäre Biologie (DE-588)4214783-9 gnd |
| subject_GND | (DE-588)4127018-6 (DE-588)4214783-9 (DE-588)4143413-4 |
| title | Chimeric toxins mechanisms of action and therapeutic applications |
| title_auth | Chimeric toxins mechanisms of action and therapeutic applications |
| title_exact_search | Chimeric toxins mechanisms of action and therapeutic applications |
| title_full | Chimeric toxins mechanisms of action and therapeutic applications ed. by Haya Lorberboum-Galski ... |
| title_fullStr | Chimeric toxins mechanisms of action and therapeutic applications ed. by Haya Lorberboum-Galski ... |
| title_full_unstemmed | Chimeric toxins mechanisms of action and therapeutic applications ed. by Haya Lorberboum-Galski ... |
| title_short | Chimeric toxins |
| title_sort | chimeric toxins mechanisms of action and therapeutic applications |
| title_sub | mechanisms of action and therapeutic applications |
| topic | Antitoxins Immunotoxins pharmacology Immunotoxins therapeutic use Recombinant Fusion Proteins therapeutic use Toxins Toxins Therapeutic use Toxin (DE-588)4127018-6 gnd Chimäre Biologie (DE-588)4214783-9 gnd |
| topic_facet | Antitoxins Immunotoxins pharmacology Immunotoxins therapeutic use Recombinant Fusion Proteins therapeutic use Toxins Toxins Therapeutic use Toxin Chimäre Biologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009866640&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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