Relaxin 2000: proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia
Gespeichert in:
| Körperschaft: | |
|---|---|
| Weitere Verfasser: | |
| Format: | Tagungsbericht Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Kluwer Academic Publishers
2001
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xxi, 460 p. ill. (some col.) : 25 cm |
| ISBN: | 1402000685 |
Internformat
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| 300 | |a xxi, 460 p. |b ill. (some col.) : 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804129268523859968 |
|---|---|
| adam_text | Coments
Preface xiii
Relaxin 2000 Committees xv
Sponsors xvii
Young Investigators Awards xviii
In memoriam xix
Abbreviations xxi
Photo xxii
Section 1: Plenary Lecture
Hooked on relaxin: A career long love affair with a fickle and elusive hormone 3
B.G. Steinetz
Section 2: Reproductive Physiology of Relaxin I Peripartum Period
Effects of relaxin on the cervix and the vagina in the rat 27
O.D. Sherwood and S. Zhao
Relaxin retards apoptosis in the cervix and the vagina during pregnancy in rats 35
5. Zhao and O. D. Sherwood
Synthesis and function of relaxin in human endometrium 41
G. Weiss, S. Palejwala, L. Tseng andL.T. Goldsmith
Analysis of relaxin deficient mice 47
L. Zhao, P.J. Roche, J. M. Gunnerson, C. Samuel, V.E. Hammond,
F. Beck, E. M.Wintour and G.W. Tregear
Relaxin is a key regulatory peptide in the reproductive tract of the pregnant tammar
wallaby, Macropus eugenii 53
L.J. Parry
Characterization of preprorelaxin in a marsupial, the tammar wallaby, Macropus
eugenii 59
L.J. Parry and R. Ivell
vi
Section 3: Reproductive Physiology of Relaxin II Uterus and
Implantation
Relaxin induces specific alterations in gene expression in the human endometrium 65
E.N. Unemori, M. Lewis, B.H. Grove and U. Deshpande
Relaxin is an important factor for uterine differentiation and implantation in the
marmoset monkey 73
A. Einspanier
Relaxin and porcine uterine growth and remodeling 83
J. Lenhart, K. Ohleth, P.Ryan, J. Wang Lee and C. Bagnell
Relaxin and placental dysfunction in the horse 91
P. Ryan, W. Vaala, K. Bennett Wimbush and C. Bagnell
Intersection of the relaxin and estrogen signalling pathways in the uterus 101
R.D. Koos and S.B. Pillai
Relaxin up regulates rat uterine vascular endothelial growth factor mRNA in vivo 109
S.B. Pillai, O.D. Sherwood and R.D. Koos
Comparative aspects of relaxin and relaxin like factor (Insulin3) in the placental
trophoblast 115
T. Klonisch and S. Hombach Klonisch
Secretion of matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1
and human chorionic gonadotropin by cytophoblastic cells: Is there regulation
by relaxin? 121
P.Mock, A. Meisser, M. Araman, C. Wuillemin, A. Campana and P. Bischof
Molecular remodelling of members of the relaxin family during primate evolution 127
T. Klonisch, C. Froehlich, F. Tetens, B. Fischer and S. Hombach Klonisch
Relaxin in the hamster 129
R. Renegar
Section 4: Reproductive Physiology of Relaxin III Ovary
Relaxin: a luteotrophic factor in the marmoset corpus luteum 139
S. Verhagen and A. Einspanier
vii
Isolation and bioactivity of relaxin from the tammar wallaby (Macropus eugenii) 145
R.A.D. Bathgate, A. Siebel, A. Claasz, M. Macris, G.W. Tregear and
L.J. Parry
Possible role of the insulin like growth factor (ICF) family for the bovine ovarian
function 147
D. Schams, B. Berisha, W. Amselgruber, M. Kosmann and R. Einspanier
Identification of consensus sequences in the rat relaxin promoter which bind
nuclear proteins 149
P. Fu, J. Gunnersen, G.W. Tregear andP.J. Roche
Section 5: Cardiovascular Physiology of Relaxin
Effects of relaxin on experimentally induced myocardial infarction. Is this hormone
a natural shield against cardiovascular disease? 153
M. Bigazzi, D. Bani and T. Bani Sacchi
Systemic relaxin administration stimulates angiogenic cytokine expression and
vessel formation in a rat myocardial infarct model 159
M. Lewis, U. Deshpande, L. Guzman, B.H. Grove, X. Huang, M.E. Erikson,
L.B. Pickford and E.N. Unemori
Is relaxin the elusive vasodilator of pregnancy? 169
K.P. Conrad, L.A. Danielson, J.N. Novak, L.J. Kerchner, R.E. Gandley,
O.D. Sherwood, RJ. Ramirez and P.A. Moalli
Reproductive hormones and blood pressure during pregnancy 177
P. Kristiansson and J.X. Wang
The effect of relaxin on vascular function in rat aorta 183
J.J. Reid, N H. Tran, G.W. Tregear andP.J. Roche
Cardiovascular phenotypes of relaxin knockout mice: Importance of gender 185
X J. Du, L. Zhao, X M. Gao and G.W. Tregear
Section 6: Physiology of Relaxin I Brain
Relaxin action on and in the brain 191
A.J.S. Summerlee andJ.D. Silvertown
viii
Neurons and neural pathways mediating the actions of circulating relaxin on the
Brain 201
M.J. McKinley, P. Burns, L. Colvill, M. Giles, P. Sinnayah, N. Sunn,
B.J. Oldfield and R.S. Weisinger
Identification of relaxin and relaxin responsive cells in the rat brain 209
T.C.D. Burazin, P.J. Davern, M.J. McKinley and G.W. Tregear
Effect of relaxin on the expression of angiotensin II receptors in the subfornical
organ of rats during pregnancy 211
A.J.S. Summerlee, R.S. Poterski and B.C. Wilson
Relaxin and relaxin receptors in brain 217
Y Y. Tan, G.W. Tregear andRJ. Summers
Section 7: Physiology of Relaxin II Male
Relaxin knockout mice demonstrate delayed growth and have underdeveloped male
reproductive tracts 221
C.S. Samuel and E.P. Amento
Relaxin expression and binding in the rat prostate 225
D.J. Hornsby, R.S. Poterski and AJ.S. Summerlee
Section 8: Preparation of Relaxin and Related Peptides
Chemical synthesis of relaxin analogues: Current status and future developments 231
G.W. Tregear, M.N. Mathieu, N.F. Dawson, K.J. Smith, A.A. Claasz,
A.B. Clippingdale andJ.D. Wade
A new synthesis of human 2 relaxin using selective bridging 237
H. Echner, F.P. Armbruster and W. Voelter
Na mono biotinylated rat relaxin: synthesis and activity 239
M.N. Mathieu, C.P. Bond, J.D. Wade, RJ. Summers and G.W. Tregear
Design, synthesis and biological activity of template assembled peptide mimetics
of rat relaxin 241
M.N. Mathieu, J.D. Wade, Y Y. Tan, RJ. Summers and G.W. Tregear
ix
Chemical synthesis and relaxin activity of analogues of ovine insulin 3 containing
specific B chain residue replacements 243
A.A. Claasz, R A. Bathgate, N.F. Dawson, RJ. Summers, L. Otvos, Jr.,
GW. Tregear andJ.D. Wade
Chemical synthesis and biological activity of ovine insulin 3, a relaxin structural
homologue 247
N.F. Dawson, M. Macris, RJ. Summers, Y~Y. Tan, G.W. Tregear and
J.D. Wade
Solid phase synthesis of rat prorelaxin C peptides (1 73) and (76 101) 249
N.F. Dawson, Y Y. Tan, RJ. Summers, M. Macris, L. Otvos, Jr.,
G.W. Tregear and J.D. Wade
Chemical synthesis and relaxin activity of rat insulin 3 251
K.J. Smith, R.A. Bathgate, A.A. Claasz, N.F. Dawson, L. Otvos, Jr.,
G.W. Tregear and J.D. Wade
Section 9: Relaxin Bioassays
Structure activity relationships of relaxin and relaxin like factor/Insulin 3 255
Y Y. Tan, N.F. Dawson, A.R. Kompa, C. Bond, A. Claasz, J.D. Wade,
G.W. Tregear and RJ . Summers
Relaxin bioasays 261
M.E. Erikson and S H. Liu
Bioassays for relaxin and relaxin related peptides 271
Y.Y. Tan, C. Bond, J.D. Wade, G.W. Tregear andRJ. Summers
A highly sensitive homologous human relaxin ELISA 273
F.P. Armbruster, I. Maier, H J. Gron, S.M. Bailer, T. Dschietzig, K. Stangl,
H. Echner, T.H. Lippert, H. Seeger and W. Voelter
Section 10: Relaxin induced Signal Transduction
Relaxin and scaffolding proteins in signalling crosstalk 279
B.M. Sanborn, K.L. Dodge, C Y. Ku and C. Yue
Mechanism of action of relaxin in human cervix 285
L.T. Goldsmith, G. Weiss and S. Palejwala
X
Myometrial relaxant action of relaxin 291
M. Hollingsworth, S. Rudkin and S. Downing
The use of biosensor technology to search for orphan biomolecules:
towards the relaxin receptor 301
E. Nice, B. Catimel, J. Rothacker, R.A.D. Bathgate, M. Mathieu,
A.A. Claasz, G.W. Tregear and J.D. Wade
Relaxin signal transduction couples tyrosine phosphorylation to cAMP
upregulation 309
O. Bartsch, B. Bartlick andR. Ivell
Relaxin activating effect on the adenylyl cyclase and glycogen synthase in
muscles of mammals and molluscs 317
L. Kuznetsova, S. Plesneva, E. Omeljaniuk, A. Shpakov andM. Pertseva
The regulatory role of protein kinase C in insulin signal transduction via adenylyl
cyclase signalling system 321
S. Plesneva, A. Shpakov, L. Kuznetsova and M. Pertseva
Section 11: Relaxin like Factors
The relaxin like factor: from gene to physiology 327
R. Ivell, M.R. Zarreh Hoshyari Khah, R.A.D. Bathgate, M. Balvers,
P.J. Baker and P.J. O Shaughnessy
Molecular genetics of insulin3 337
S. Nef, S. Verma Kurvari, T.E. Shipman and L.F. Parada
Testicular descent in rats: a role for relaxin? 347
L.J. Parry, D.J. Hornsby, R.S. Poterski, B.C. Wilson andAJ.S. Summerlee
The relaxin like factor (Insulin3) is highly expressed in the ruminant ovary:
A putative ruminant relaxin? 349
R.A.D. Bathgate, N. Moniac, B. Bartlick, A.A. Claasz, N.F. Dawson,
Y Y. Tan, J.D. Wade, G.W. Tregear andR. Ivell
Characterization of the rat relaxin like factor/jak3 gene region 357
P.J. Roche, Z. Nasa and G. Tokhi
Relaxin like factor is differentially expressed in the normal and neoplastic human
mammary gland 359
S. Hombach Klonisch, Js Buchman, S. Sarun, B. Fischer and T. Klonisch
xi
Relaxin like factor in the human thyroid 361
T. Klonisch, S. Hombach Klonisch, B. Fischer and C. Hoang Vu
The genomics of insulin 5 363
S. Jaspers, S. Lok, C.E. Lofton Day, B.A. Haldeman, T.E. Whitmore,
K.P. Foley andD. Conklin
Section 12: Clinical Aspects of Relaxin I Matrix Remodelling
Relaxin clinical trials in systemic sclerosis 373
M.S. Erikson and E.N. Unemori
Relaxin decreases renal interstitial fibrosis: A novel treatment to slow the
progression of kidney disease? 383
S.L. Garber, Y. Mirochnik, C. Brecklin, L. Slobodskoy, E.N. Unemori,
B.H. Grove, J.A.L. Arruda and G. Dunea
Relaxin modulates fibrillin 2, but not fibrillin 1, gene expression by human dermal
fibroblasts 389
C.S. Samuel, L.Y. Sakai and E.P. Amento
Effect of relaxin on normal and impaired wound healing in rodents 393
X. Huang, G. Arnold, M. Lewis, L. Guzman, B.H. Grove, E.N. Unemori
and K. Szebo
The formation of amyloid fibrils by relaxin 399
C.E. MacPhee, CM. Dobson andJ.D. Wade
Section 13: Clinical Aspects of Relaxin II Joints, Breast Cancer
and Delivery
Pelvic girdle relaxation, developmental dysplasia of the hip and the hormone
relaxin are they loosely connected? 407
A.H. MacLennan
Back pain in IVF induced and spontaneous pregnancies 415
P. Kristiansson, L. Nilsson Wikmar, B. von Schoultz, K. Svdrdsudd and
H. Wramsby
Immunohistochemical detection of relaxin binding to ligaments of the thumb
and knee 421
5. Galey, J. Lubahn, D. Ivance, E. Konieczko, C. Arnold and T. Cooney
xii
Pre term delivery predicted by serum relaxin 425
/. Vogel, M. Glavind Kristensen, J. Dalby Salvig, P. Thorsen, P. Sandager
andN. Uldberg
High serum concentrations of relaxin correlate with dissemination of breast cancer 429
C. Binder, L. Binder, L. Gurlit and A. Einspanier
Relationship of serum relaxin levels to knee joint laxity in female athletes 437
C. Arnold, C. Van Bell, V. Rogers and T. Cooney
Section 14: Round Table Discussion Relaxin and the New
Millennium
Author Index 453
Subject Index 457
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| spelling | International Conference on Relaxin and Related Peptides 3 2000 Broome, Western Australia Verfasser (DE-588)1248387-4 aut Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia edited by Geoffrey W. Tregear ... [et al.] Dordrecht Kluwer Academic Publishers 2001 xxi, 460 p. ill. (some col.) : 25 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Relaxin Congresses Relaxin (DE-588)4177698-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2000 Broome Westaustralien gnd-content Relaxin (DE-588)4177698-7 s DE-604 Tregear, Geoffrey W. (DE-588)1229014799 edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009855956&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia Relaxin Congresses Relaxin (DE-588)4177698-7 gnd |
| subject_GND | (DE-588)4177698-7 (DE-588)1071861417 |
| title | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia |
| title_auth | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia |
| title_exact_search | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia |
| title_full | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia edited by Geoffrey W. Tregear ... [et al.] |
| title_fullStr | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia edited by Geoffrey W. Tregear ... [et al.] |
| title_full_unstemmed | Relaxin 2000 proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia edited by Geoffrey W. Tregear ... [et al.] |
| title_short | Relaxin 2000 |
| title_sort | relaxin 2000 proceedings of the third international conference on relaxin related peptides 22 27 october 2000 broome australia |
| title_sub | proceedings of the third International Conference on Relaxin & Related Peptides, 22-27 October 2000, Broome, Australia |
| topic | Relaxin Congresses Relaxin (DE-588)4177698-7 gnd |
| topic_facet | Relaxin Congresses Relaxin Konferenzschrift 2000 Broome Westaustralien |
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