Meselson, Stahl, and the replication of DNA: a history of "the most beautiful experiment in biology "
"In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beau...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New Haven [u.a.]
Yale Univ. Press
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest." "This book reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment."--BOOK JACKET. |
| Beschreibung: | Includes bibliographical references (p. [449]-496) and index |
| Beschreibung: | xii, 503 p. ill. : 25 cm |
| ISBN: | 0300085400 |
Internformat
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV014384835 | ||
| 003 | DE-604 | ||
| 005 | 20111212 | ||
| 007 | t | ||
| 008 | 020603s2001 xxua||| |||| 00||| eng d | ||
| 010 | |a 2001017701 | ||
| 020 | |a 0300085400 |9 0-300-08540-0 | ||
| 035 | |a (OCoLC)45804765 | ||
| 035 | |a (DE-599)BVBBV014384835 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 044 | |a xxu |c US | ||
| 049 | |a DE-12 |a DE-83 | ||
| 050 | 0 | |a QP624 | |
| 082 | 0 | |a 572.8/6 |2 21 | |
| 084 | |a WB 2405 |0 (DE-625)147949: |2 rvk | ||
| 100 | 1 | |a Holmes, Frederic Lawrence |d 1932-2003 |e Verfasser |0 (DE-588)135802407 |4 aut | |
| 245 | 1 | 0 | |a Meselson, Stahl, and the replication of DNA |b a history of "the most beautiful experiment in biology " |c Frederic Lawrence Holmes |
| 264 | 1 | |a New Haven [u.a.] |b Yale Univ. Press |c 2001 | |
| 300 | |a xii, 503 p. |b ill. : 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references (p. [449]-496) and index | ||
| 520 | 1 | |a "In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest." "This book reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment."--BOOK JACKET. | |
| 600 | 1 | 4 | |a Meselson, Matthew |
| 600 | 1 | 4 | |a Stahl, Franklin W |
| 600 | 1 | 7 | |a Stahl, Franklin William |d 1929- |0 (DE-588)123694175 |2 gnd |9 rswk-swf |
| 600 | 1 | 7 | |a Meselson, Matthew Stanley |d 1930- |0 (DE-588)123668271 |2 gnd |9 rswk-swf |
| 648 | 7 | |a Geschichte |2 gnd |9 rswk-swf | |
| 650 | 7 | |a DNA |2 gtt | |
| 650 | 7 | |a Replicatie (biochemie) |2 gtt | |
| 650 | 4 | |a Geschichte | |
| 650 | 4 | |a DNA Replication | |
| 650 | 4 | |a DNA replication |x Experiments |x History | |
| 650 | 4 | |a Molecular Biology |x history | |
| 650 | 4 | |a Molecular biology |x Experiments |x History | |
| 650 | 0 | 7 | |a Replikation |0 (DE-588)4153174-7 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Meselson, Matthew Stanley |d 1930- |0 (DE-588)123668271 |D p |
| 689 | 0 | 1 | |a Replikation |0 (DE-588)4153174-7 |D s |
| 689 | 0 | 2 | |a Geschichte |A z |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Stahl, Franklin William |d 1929- |0 (DE-588)123694175 |D p |
| 689 | 1 | 1 | |a Replikation |0 (DE-588)4153174-7 |D s |
| 689 | 1 | 2 | |a Geschichte |A z |
| 689 | 1 | |5 DE-604 | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009848085&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-009848085 | ||
| 942 | 1 | 1 | |c 509 |e 22/bsb |f 0904 |g 73 |
Datensatz im Suchindex
| _version_ | 1804129255799390208 |
|---|---|
| adam_text | IMAGE 1
MESELSON, STAHL,
AND THE REPLICATION OF DNA A HISTORY OF
THE MOST BEAUTIFUL EXPERIMENT IN BIOLOGY
FREDERIC LAWRENCE HOLMES
YALE UNIVERSITY PRESS NEW HAVEN & LONDON
IMAGE 2
CONTENTS
PREFACE IX ACKNOWLEDGMENTS XI INTRODUCTION 1
CHAPTER ONE THE REPLICATION PROBLEM 11 CHAPTER TWO MESELSON AND STAHL 49
CHAPTER THREE TWISTS AND TURNS 75 CHAPTER FOUR CROSSING FIELDS: CHEMICAL
BONDS TO
BIOLOGICAL MUTANTS 116 CHAPTER FIVE DENSE SOLUTIONS 157 CHAPTER SIX THE
BIG MACHINE 183 CHAPTER SEVEN WORKING AT HIGH SPEED 215 CHAPTER EIGHT
THE UNSEEN BAND 272 CHAPTER NINE ONE DISCOVERY, THREE STORIES 303
CHAPTER TEN AN EXTREMELY BEAUTIFUL EXPERIMENT 319 CHAPTER ELEVEN
CENTRIFUGAL FORCES 352 CHAPTER TWELVE THE SUBUNITS OF SEMICONSERVATIVE
REPLICATION 388
CHAPTER THIRTEEN IMAGES OF AN EXPERIMENT 412 CHAPTER FOURTEEN AFTERWORD
435
ABBREVIATIONS USED IN NOTES 448 NOTES 449 INDEX 497
|
| any_adam_object | 1 |
| author | Holmes, Frederic Lawrence 1932-2003 |
| author_GND | (DE-588)135802407 |
| author_facet | Holmes, Frederic Lawrence 1932-2003 |
| author_role | aut |
| author_sort | Holmes, Frederic Lawrence 1932-2003 |
| author_variant | f l h fl flh |
| building | Verbundindex |
| bvnumber | BV014384835 |
| callnumber-first | Q - Science |
| callnumber-label | QP624 |
| callnumber-raw | QP624 |
| callnumber-search | QP624 |
| callnumber-sort | QP 3624 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WB 2405 |
| ctrlnum | (OCoLC)45804765 (DE-599)BVBBV014384835 |
| dewey-full | 572.8/6 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8/6 |
| dewey-search | 572.8/6 |
| dewey-sort | 3572.8 16 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| era | Geschichte gnd |
| era_facet | Geschichte |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03608nam a2200613zc 4500</leader><controlfield tag="001">BV014384835</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20111212 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">020603s2001 xxua||| |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2001017701</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0300085400</subfield><subfield code="9">0-300-08540-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)45804765</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV014384835</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">xxu</subfield><subfield code="c">US</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-83</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP624</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.8/6</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WB 2405</subfield><subfield code="0">(DE-625)147949:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Holmes, Frederic Lawrence</subfield><subfield code="d">1932-2003</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)135802407</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Meselson, Stahl, and the replication of DNA</subfield><subfield code="b">a history of "the most beautiful experiment in biology "</subfield><subfield code="c">Frederic Lawrence Holmes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New Haven [u.a.]</subfield><subfield code="b">Yale Univ. Press</subfield><subfield code="c">2001</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xii, 503 p.</subfield><subfield code="b">ill. : 25 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references (p. [449]-496) and index</subfield></datafield><datafield tag="520" ind1="1" ind2=" "><subfield code="a">"In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest." "This book reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment."--BOOK JACKET.</subfield></datafield><datafield tag="600" ind1="1" ind2="4"><subfield code="a">Meselson, Matthew</subfield></datafield><datafield tag="600" ind1="1" ind2="4"><subfield code="a">Stahl, Franklin W</subfield></datafield><datafield tag="600" ind1="1" ind2="7"><subfield code="a">Stahl, Franklin William</subfield><subfield code="d">1929-</subfield><subfield code="0">(DE-588)123694175</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="600" ind1="1" ind2="7"><subfield code="a">Meselson, Matthew Stanley</subfield><subfield code="d">1930-</subfield><subfield code="0">(DE-588)123668271</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="648" ind1=" " ind2="7"><subfield code="a">Geschichte</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">DNA</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Replicatie (biochemie)</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Geschichte</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA Replication</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA replication</subfield><subfield code="x">Experiments</subfield><subfield code="x">History</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular Biology</subfield><subfield code="x">history</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular biology</subfield><subfield code="x">Experiments</subfield><subfield code="x">History</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Replikation</subfield><subfield code="0">(DE-588)4153174-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Meselson, Matthew Stanley</subfield><subfield code="d">1930-</subfield><subfield code="0">(DE-588)123668271</subfield><subfield code="D">p</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Replikation</subfield><subfield code="0">(DE-588)4153174-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Geschichte</subfield><subfield code="A">z</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Stahl, Franklin William</subfield><subfield code="d">1929-</subfield><subfield code="0">(DE-588)123694175</subfield><subfield code="D">p</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Replikation</subfield><subfield code="0">(DE-588)4153174-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">Geschichte</subfield><subfield code="A">z</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009848085&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-009848085</subfield></datafield><datafield tag="942" ind1="1" ind2="1"><subfield code="c">509</subfield><subfield code="e">22/bsb</subfield><subfield code="f">0904</subfield><subfield code="g">73</subfield></datafield></record></collection> |
| id | DE-604.BV014384835 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:02:14Z |
| institution | BVB |
| isbn | 0300085400 |
| language | English |
| lccn | 2001017701 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009848085 |
| oclc_num | 45804765 |
| open_access_boolean | |
| owner | DE-12 DE-83 |
| owner_facet | DE-12 DE-83 |
| physical | xii, 503 p. ill. : 25 cm |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Yale Univ. Press |
| record_format | marc |
| spelling | Holmes, Frederic Lawrence 1932-2003 Verfasser (DE-588)135802407 aut Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " Frederic Lawrence Holmes New Haven [u.a.] Yale Univ. Press 2001 xii, 503 p. ill. : 25 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references (p. [449]-496) and index "In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest." "This book reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment."--BOOK JACKET. Meselson, Matthew Stahl, Franklin W Stahl, Franklin William 1929- (DE-588)123694175 gnd rswk-swf Meselson, Matthew Stanley 1930- (DE-588)123668271 gnd rswk-swf Geschichte gnd rswk-swf DNA gtt Replicatie (biochemie) gtt Geschichte DNA Replication DNA replication Experiments History Molecular Biology history Molecular biology Experiments History Replikation (DE-588)4153174-7 gnd rswk-swf Meselson, Matthew Stanley 1930- (DE-588)123668271 p Replikation (DE-588)4153174-7 s Geschichte z DE-604 Stahl, Franklin William 1929- (DE-588)123694175 p GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009848085&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Holmes, Frederic Lawrence 1932-2003 Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " Meselson, Matthew Stahl, Franklin W Stahl, Franklin William 1929- (DE-588)123694175 gnd Meselson, Matthew Stanley 1930- (DE-588)123668271 gnd DNA gtt Replicatie (biochemie) gtt Geschichte DNA Replication DNA replication Experiments History Molecular Biology history Molecular biology Experiments History Replikation (DE-588)4153174-7 gnd |
| subject_GND | (DE-588)123694175 (DE-588)123668271 (DE-588)4153174-7 |
| title | Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " |
| title_auth | Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " |
| title_exact_search | Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " |
| title_full | Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " Frederic Lawrence Holmes |
| title_fullStr | Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " Frederic Lawrence Holmes |
| title_full_unstemmed | Meselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology " Frederic Lawrence Holmes |
| title_short | Meselson, Stahl, and the replication of DNA |
| title_sort | meselson stahl and the replication of dna a history of the most beautiful experiment in biology |
| title_sub | a history of "the most beautiful experiment in biology " |
| topic | Meselson, Matthew Stahl, Franklin W Stahl, Franklin William 1929- (DE-588)123694175 gnd Meselson, Matthew Stanley 1930- (DE-588)123668271 gnd DNA gtt Replicatie (biochemie) gtt Geschichte DNA Replication DNA replication Experiments History Molecular Biology history Molecular biology Experiments History Replikation (DE-588)4153174-7 gnd |
| topic_facet | Meselson, Matthew Stahl, Franklin W Stahl, Franklin William 1929- Meselson, Matthew Stanley 1930- DNA Replicatie (biochemie) Geschichte DNA Replication DNA replication Experiments History Molecular Biology history Molecular biology Experiments History Replikation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009848085&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT holmesfredericlawrence meselsonstahlandthereplicationofdnaahistoryofthemostbeautifulexperimentinbiology |