Bioseparations science and engineering:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Oxford University Press
2003
|
| Schriftenreihe: | Topics in chemical engineering
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIX, 406 S. Ill. |
| ISBN: | 9780195123401 0195123409 |
Internformat
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| 245 | 1 | 0 | |a Bioseparations science and engineering |c Roger G. Harrison ... |
| 264 | 1 | |a New York [u.a.] |b Oxford University Press |c 2003 | |
| 300 | |a XIX, 406 S. |b Ill. | ||
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| 490 | 0 | |a Topics in chemical engineering | |
| 500 | |a Includes bibliographical references and index | ||
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| 650 | 4 | |a Biomolecules |x Separation | |
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Datensatz im Suchindex
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| adam_text | IMAGE 1
CONTENTS
PREFACE XVII
CHAPTER 1 INTRODUCTION TO BIOPRODUCTS AND BIOSEPARATIONS
1.1 INSTRUCTIONAL OBJECTIVES 3 1.2 BROAD CLASSIFICATION OF BIOPRODUCTS 3
1.3 SMALL BIOMOLECULES 4 1.3.1 PRIMARY METABOLITES 4
1.3.2 SECONDARY METABOLITES 11 1.3.3 SUMMARY OF SMALL BIOMOLECULES 12
1.4 MACROMOLECUIES: PROTEINS 14 1.4.1 PRIMARY STRUCTURE 14
1.4.2 SECONDARY STRUCTURE 14 1.4.3 TERTIARY STRUCTURE 16 EXAMPLE /.I:
EFFECT OF A REDUCING AGENT ON PROTEIN STRUCTURE AND MOBILITY 17
T.4.4 QUATERNARY STRUCTURE 18 1.4.5 PROSTHETIC GROUPS AND HYBRID
MOLECULES 18 1.4.6 FUNCTIONS AND COMMERCIAL USES OF PROTEINS 20 1.4.7
STABILITY OF PROTEINS 21 1.4.8 RECOMBINANT PROTEIN EXPRESSION 25 1.5
MACROMOLECULES: NUCLEIC ACIDS AND OLIGONUCLEOTIDES 27 1.6
MACROMOLECULES: POLYSACCHARIDES 29
1.7 PARTICULATE PRODUCTS 31 1.8 INTRODUCTION TO BIOSEPARATIONS:
ENGINEERING ANALYSIS 31 1.8.1 STAGES OF DOWNSTREAM PROCESSING 32 EXAMPLE
/.2: INITIAL SELECTION OF PURIFICATION STEPS 33
1.8.2 BASIC PRINCIPLES OF ENGINEERING ANALYSIS 34 1.8.3 PROCESS AND
PRODUCT QUALITY 35
VII
IMAGE 2
VIII CONTENTS
1.8.4 CRITERIA TUER PROCESS DEVELOPMENT 36 1.9 THE ROUTE TO MARKET 37
1.9.1 THE CHEMICAL AND APPLICATIONS RANGE OF THE BIOPRODUCT 38
1.9.2 DOCUMENTATION OF PHARMACEUTICAL BIOPRODUCTS 38 1.9.3 GLP AND CGMP
38 1.9.4 FORMULATION 39 1.10 SUMMARY 39
NOMENCLATURE 40 PROBLEMS 40 REFERENCES 41
CHAPTER 2 ANALYTICAL METHODS 43
2.1 INSTRUCTIONAL OBJECTIVES 43 2.2 SPECIFICATIONS 44 2.3 ASSAY
ATTRIBUTES 45 2.3.1 PRECISION 45
2.3.2 ACCURACY 46 2.3.3 SPECIFICITY 46 2.3.4 LINEARITY, LIMIT OF
DETECTION, AND LIMIT OF QUANTITATION 47 2.3.5 RANGE 48
2.3.6 ROBUSTNESS 48 2.4 ANALYSIS OF BIOLOGICAL ACTIVITY 49 2.4.1 ANIMAL
MODEL ASSAYS 49 2.4.2 CELL-LINE-DERIVED BIOASSAYS 49
2.4.3 IN VITRO BIOCHEMICAL ASSAYS 50 EXAMPLE 2./: COUPLED ENZYME
AS.WY!OR ALCOHOL OXIDASE 50 2.5 ANALYSIS OF PURITY 52 2.5.1
ELECTROPHORETIC ANALYSIS 52
EXAMPLE 2.2: ESTIMATION OFTHE MAXIMUM TEMPERATURE IN AN ELECTROPHORESIS
GEL 55 2.5.2 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) 67 2.5.3 MASS
SPECTROMETRY 68 2.5.4 COUPLING OF HPLC WITH MASS SPECTROMETRY 69 2.5.5
ULTRAVIOLET ABSORBANCE 69
EXAMPLE 2.3: DETERMINATION OF MOLAR AHSORPTIVITY 70 2.5.6 CHNO/AMINO
ACID ANALYSIS (AAA) 71 T:XAMPLE 2.4: CALCULATIONS BASED ON CHNO ANALYSIS
71 2.5.7 PROTEIN ASSAYS 72 2.5.8 ENZYME-LINKED IMMUNOSORBENT ASSAY 72
2.5.9 GAS CHROMATOGRAPHY 74 2.5.10 DNA HYBRIDIZATION 74 2.5.11 ICP/MS
(AA) 74 2.5.12 DRY WEIGHT 75
IMAGE 3
IX CONTENTS
2.6 MIEROBIOLOGY ASSAYS 75 2.6.1 STERILITY 75 2.6.2 BIOBURDEN 76 2.6.3
ENDOTOXIN 76 2.6.4 VIRUS AND PHAGE 76 2.7 SUMMARY 77
NOMENCLATURE 78 PROBLEMS 79 REFERENEES 81
CHAPTER 3 CELL LYSIS AND FLOCCULATION 83
3.1 INSTRUETIONAL OBJEETIVES 83 3.2 SOME ELEMENTS OF CELL STRUETURE 84
3.2.1 PROKARYOTIE CELLS 84 3.2.2 EUKARYOTIE CELLS 85 3.3 CELL LYSIS 86
3.3.1 OSMOTIE AND CHEMIEAL CELL LYSIS 86 3.3.2 MEEHANIEAL METHODS OF
LYSIS 88 3.4 FIOCEULATION 92 3.4.1 THE ELEETRIE DOUBLE LAYER 92
EXAMPLE 3.1: DEPENDENCE OF THE DEBYE RADIUS ON THE TYPE OF ELECTROLYTE
95 3.4.2 FOREES BETWEEN PARTICLES AND FIOCEULATION BY ELEETROLYTES 96
EXAMPLE 3.2: SENSITIVITY OF CRITICAL FLOCCULATION CONCENTRATION TO
TEMPERATURE AND COUNTERION CHARGE NUMBER 97 3.4.3 THE SEHULZE-HARDY RULE
98 3.4.4 FLOEEULATION RATE 98 3.4.5 POLYMERIE FLOCEULANTS 99 3.5 SUMMARY
101
NOMENELATURE 10L PROBLEMS 102 REFERENEES 103
CHAPTER 4 FILTRATION 104
4.1 INSTRUETIONAL OBJEETIVES 105 4.2 FILTRATION PRINCIPLES 105 4.2.1
CONVENTIONAL FILTRATION 106 EXAMPLE 4.1: BATCH FILTRATION 107
4.2.2 CROSSFLOW FILTRATION III EXAMPLE 4.2: CONCENTRATION POLARIZATION
IN ULTRAFILTRATION 114
IMAGE 4
X CONTENTS
4.3 FILTER MEDIA AND EQUIPMENT 117 4.3.1 CONVENTIONAL FILTRATION 117
4.3.2 CROSSFLOW FILTRATION 121 4.4 MEMBRANE FOULING 124 4.5 SCALEUP AND
DESIGN OF FILTRATION SYSTEMS 126
4.5.1 CONVENTIONAL FILTRATION 126 EXAMPLE 4.3: ROTARY VACUUM FILTRATION
126 EXAMPLE 4.4: WASHING O[A ROTARY VACUUM FILTER CAKE 128 4.5.2
CROSSFLOW FILTRATION 132
EXAMPLE 4.5: DIAFILTRATION MODE IN CROSSFLOW FILTRATION 134
4.6 SUMMARY 137 NOMENCLATURE 138 PROBLEMS 139 REFERENCES 141
CHAPTER 5 SEDIMENTATION 142
5.1 INSTRUCTIONALOBJECTIVES 142 5.2 SEDIMENTATION PRINCIPLES 143 5.2.1
EQUATION OFMOTION 143 5.2.2 SENSITIVITIES 144 5.3 METHODS AND
COEFFICIENTS 146
5.3.1 EQUILIBRIUM SEDIMENTATION 146 5.3.2 SEDIMENTATION COEFFICIENT 147
EXAMPLE 5.1: APPLICATION O[THE SEDIMENTATION COEFFICIENT 147 5.3.3
EQUIVALENT TIME 148
EXAMPLE 5.2: SCALEUP BASED ON EQUIVALENT TIME 148 5.3.4 SIGMA ANALYSIS
149 5.4 PRODUCTION CENTRIFUGES: COMPARISON AND ENGINEERING ANALYSIS 149
5.4.1 TUBULAR BOWL CENTRIFUGE 150
EXAMPLE 5.3: COMPLETE RECOVERY O[BACTERIAL CELLS IN A TUBULAR BOWL
CENTRIFUGE 153 5.4.2 DISK CENTRIFUGE 153 5.5 ULTRACENTRIFUGATION 156
5.5.1 DETERMINATION OF MOLECULAR WEIGHT 156 5.6 FLOCCULATION AND
SEDIMENTATION 157 5.7 SEDIMENTATION AT LOW ACCELERATIONS 158 5.7.1
DIFFUSION, BROWNIAN MOTION 158
5.7.2 ISOTHERMAL SETTLING 159 5.7.3 CONVECTIVE MOTION AND PECLET
ANALYSIS 159 5.7.4 INCLINED SEDIMENTATION 159 5.7.5 FIELD-FLOW
FRACTIONATION 161 5.8 CENTRIFUGAL ELUTRIATION 162
IMAGE 5
XI CONTENTS
5.9 SUMMARY 162 NOMENCLATURE 164 PROBLEMS 165 REFERENCES 167
CHAPTER (, EXTRACTION 169
6.1 INSTRUCTIONAL OBJECTIVES 169 6.2 EXTRACTION PRINCIPLES 170 6.2.1
PHASE SEPARATION AND PARTITIONING EQUILIBRIA 170 6.2.2 COUNTERCURRENT
STAGE CALCULATIONS 175
EXAMPLE 6.1: SEPARATION OF A BIOPRODUCT AND AN IMPURITY BY
COUNTERCURRENT
EXAMPLE 6.2: EFFEET OF SOLVENT RATE IN COUNTERCURRENT STAGED EXTRAETION
OF EXTRACTION 179 AN ANTIBIOTIE 180 6.3 SCALEUP AND DESIGN OF EXTRACTORS
181
6.3.1 RECIPROCATING-PLATE EXTRACTION COLUMNS 182 EXAMPLE 6.3: SEALEUP OF
A RECIPROEATING-PLATE EXTRAETION COLUMN 184 6.3.2 CENTRIFUGAL EXTRACTORS
185 6.4 SUMMARY 186
NOMENCLATURE 187 PROBLEMS 188 REFERENCES 189
CHAPTER 7 LIQUID CHROMATOGRAPHY AND ADSORPTION 191
7.1 INSTRUCTIONAL OBJECTIVES 193 7.2 ADSORPTION EQUILIBRIUM 193 7.3
ADSORPTION COLUMN DYNAMICS 195 7.3.1 FIXED-BED ADSORPTION 196
EXAMPLE 7.1: DETERMINATION OFTHE MASS TRANSFER COEFFICIENTFROM
ADSORPTION BREAKTHROUGH DATA 200 7.3.2 AGITATED-BED ADSORPTION 201 7.4
CHROMATOGRAPHY COLUMN DYNAMICS 203
7.4.1 PLATE MODELS 203 7.4.2 CHROMATOGRAPHY COLUMN MASS BALANCE WITH
NEGLIGIBLE DISPERSION 204 EXAMPLE 7.2: CHROMATOGRAPHIE SEPARATION OFTWO
SOLUTES 205 EXAMPLE 7.3: CALEULATION OF THE SHOCK WAVE VELOCITY FOR A
NONLINEAR ISOTHERM 206
EXAMPLE 7.4: CALEULATION OF THE ELUTION PROFILE 207 7.4.3 DISPERSION
EFFECTS IN CHROMATOGRAPHY 209 7.4.4 GRADIENTS AND MODIFIERS 213 EXAMPLE
7.5: EQUILIBRIUM FOR A PROTEIN ANION IN THE PRESENEE OF
CHLORIDE ION 213
IMAGE 6
XII CONTENTS
7.5 ADSORBENT TYPES 215 7.5.1 SI1ICA-BASED RESINS 215 7.5.2
POLYMER-BASED RESINS 216 7.5.3 ION EXCHANGE RESINS 217 7.5.4
REVERSED-PHASE CHROMATOGRAPHY 218 7.5.5 HYDROPHOBIC INTERACTION
CHROMATOGRAPHY 218
7.5.6 AFFINITY CHROMATOGRAPHY 219 7.5.7 IMMOBILIZED METAL AFFINITY
CHROMATOGRAPHY (LMAC) 219 7.5.8 SIZE EXCLUSION CHROMATOGRAPHY 219 7.6
PARTICLE SIZE AND PRESSURE DROP IN FIXED BEDS 220
7.7 EQUIPMENT 221 7.7.1 COLUMNS 221 7.7.2 CHROMATOGRAPHY COLUMN PACKING
PROCEDURES 222 7.7.3 DETECTORS 223 7.7.4 CHROMATOGRAPHY SYSTEM FLUIDICS
223 7.8 SCALEUP 224
7.8.1 ADSORPTION 224 EXAMPLE 7.6: SCALEUP OFTHE FIXED-BEDADSORPTION OF A
PHARMACEUTICAL PMDUCT 226 7.8.2 CHROMATOGRAPHY 230
EXAMPLE 7.7: SCALEUP OF A PROTEIN CHROMATO[?RAPHY 231 EXAMPLE 7.8:
SCALEUP OF A PROTEIN CHROMATOGRAPHY USING STANDARD COLUMN SIZES 232
EXAMPLE 7. 9: SCALEUP OF ELUTION BUFFER VOLUMES IN PROTEIN
CHROMATO[?RAPHY 233
EXAMPLE 7.10: CONSIDERATION OF PRESSURE DROP IN COLUMN SCALING 233 7.9
SUMMARY 234 NOMENCLATURE 236 PROBLEMS 238
REFERENCES 241
CHAPTER 8 PRECIPITATION 243
8.1 INSTRUCTIONAL OBJECTIVES 243 8.2 PROTEIN SOLUBILITY 244 8.2.1
STRUCTURE AND SIZE 244 8.2.2 CHARGE 245
8.2.3 SOLVENT 246 EXAMPLE 8./: SALTING OUT OF A PROTEIN WITH AMMONIUM
SULFATE 249 8.3 PRECIPITATE FORMATION PHENOMENA 249 8.3.1 INITIAL MIXING
250
8.3.2 NUCLEATION 250 8.3.3 GROWTH GOVERNED BY DIFFUSION 251 EXAMPLE 8.2:
CALCULATION OF CONCENTRATION OF NUCLEI IN A PROTEIN PRECIPITATION 252
IMAGE 7
CONTENTS XIII
EXAMPLE 8.3: DIFFUSION-LIMITED GROWTH OF PARTICLES 254 8.3.4 GROWTH
GOVEMED BY FLUID MOTION 255 EXAMPLE 8.4: GROWTH OF PARTICLES LIMITED BY
FLUID MOTION 255 8.3.5 PRECIPITATE BREAKAGE 256 8.3.6 PRECIPITATE AGING
257 8.4 PARTICLE SIZE DISTRIBUTION IN A CONTINUOUS F10W STIRRED TANK
REACTOR 258
EXAMPLE 8.5: DEPENDENCE OF POPULATION DENSITY ON PARTICLE SIZE AND
RESIDENCE TIME IN A CSTR 261 8.5 METHODS OF PRECIPITATION 261 8.6 DESIGN
OF PRECIPITATION SYSTEMS 264 8 .. 7 SUMMARY 266
NOMENCLATURE 268 PROBLEMS 269 REFERENCES 271
CHAPTER 9 CRYSTALLIZATION 272
9.1 INSTRUCTIONALOBJECTIVES 273 9.2 CRYSTALLIZATION PRINCIPLES 273 9.2.1
CRYSTALS 273 9.2.2 NUCLEATION 274
9.2.3 CRYSTAL GROWTH 275 9.2.4 CRYSTAILIZATION KINETICS FROM BATCH
EXPERIMENTS 276 9.3 BATCH CRYSTALLIZERS 277 9.3.1 ANALYSIS OF DILUTION
BATCH CRYSTALLIZATION 278
EXAMPLE 9. J: BATCH CRYSTALLIZATION WITH CONSTANT RATE OF CHANGE OF
DILUENT CONCENTRATION 279 9.4 PROCESS CRYSTALLIZATION OF PROTEINS 281
9.5 CRYSTALLIZER SCALEUP AND DESIGN 282
9.5.1 EXPERIMENTAL CRYSTALLIZATION STUDIES AS A BASIS FOR SCALEUP 282
9.5.2 SCALEUP AND DESIGN CALCULATIONS 284 EXAMPLE 9.2: SCALEUP OF
CRYSTALLIZATION BASED ON CONSTANT POWER PER VOLUME 284 9.6 SUMMARY 285
NOMENCLATURE 286 PROBLEMS 287 REFERENCES 288
CHAPTER 10 DRYING 290
10.1 INSTRUCTIONAL OBJECTIVES 290 10.2 DRYING PRINCIPLES 291 10.2.1
WATER IN BIOLOGICAL SOLIDS AND IN GASES 291 EXAMPLE J O. J: DRYING OF
ANTIBIOTIC CRYSTALS 294
IMAGE 8
XIV CONTENTS
10.2.2 HEAT AND MASS TRANSFER 295 EXAMPLE 10.2: CONDUCTIVE DRYING OF WET
SOLIDS IN A TRAY 296 EXAMPLE 10.3: MASS FLUX DURING THE CONSTANT RATE
DRYING PERIOD IN
EXAMPLE 10.4: TIME TO DRY NONPOROUS BIOLOGICAL SO LIDS BY CONVECTIVE
CONVECTIVE DRYING 302 DRYING 302 10.3 DRYER DESCRIPTION AND OPERATION
303
10.3.1 VACUUEM-SHELF DRYERS 303 10.3.2 BATCH VACUUM ROTARY DRYERS 304
10.3.3 FREEZE DRYERS 305 10.3.4 SPRAY DRYERS 307 10.4 SCALEUP AND DESIGN
OF DRYING SYSTEMS 308
10.4.1 VACUUM-SHELF DRYERS 308 10.4.2 BATCH VACUUM ROTARY DRYERS 308
10.4.3 FREEZE DRYERS 309 10.4.4 SPRAY DRYERS 310
EXAMPLE 10.5: SIZING OF A SPRAY DRYER 311 10.5 SUMMARY 314 NOMENCLATURE
315 PROBLEMS 315
REFERENCES 317
CHAPTER 11 BIOPROCESS DESIGN 319
11.1 INSTRUCTIONAL OBJECTIVES 319 11.2 DEFINITIONS AND BACKGROUND 320
11.3 SYNTHESIS OF BIOSEPARATION PROCESSES 322 11.3.1 PRIMARY RECOVERY
STAGES 322
11.3.2 INTERMEDIATE RECOVERY STAGES 326 11.3.3 FINAL PURIFICATION STAGES
327 11.3.4 PAIRING OF UNIT OPERATIONS IN PROCESS SYNTHESIS 328 11.4
PROCESS ANALYSIS 329
11.4.1 SPREADSHEETS 329 11.4.2 PROCESS SIMULATORS 330 11.4.3 USING A
BIOCHEMICAL PROCESS SIMULATOR 330 11.5 PROCESS ECONOMICS 334
11.5.1 CAPITAL COST ESTIMATION 334 11.5.2 OPERATING COST ESTIMATION 338
11.5.3 PROFITABILITY ANALYSIS 342 11.6 ILLUSTRATIVE EXAMPLES 343
11.6.1 CITRIC ACID PRODUCTION 343 11.6.2 HUMAN INSULIN PRODUCTION 349
11.6.3 THERAPEUTIC MONOCLONAL ANTIBODY PRODUCTION 362 11.7 SUMMARY 368
PROBLEMS 369 REFERENCES 371
IMAGE 9
XV CONTENTS
CHAPTER 12 LABORATORY EXERCISES IN BIOSEPARATIONS 373
12.1 FLOCCULANT SCREENING 373 12.1.1 BACKGROUND 373 12.1.2 OBJECTIVES
374 12.1.3 PROCEDURE 374 12.1.4 REPORT 375 12.1.5 SOME NOTES AND
PRECAUTIONS 375 12.2 CROSSFLOW FILTRATION 376
12.2.1 BACKGROUND 376 12.2.2 OBJECTIVES 376 12.2.3 PROCEDURE 376 12.2.4
REPORT 377 12.3 CENTRIFUGATION OF FLOCCULATED AND UNFLOCCULATED
PARTICULATES 377
12.3.1 BACKGROUND 378 12.3.2 OBJECTIVES 378 12.3.3 PROCEDURE 379 12.3.4
REPORT 379 12.4 AQUEOUS TWO-PHASE EXTRACTION 381
12.4.1 PHYSICAL MEASUREMENTS 381 12.4.2 PROCEDURE 382 12.4.3
CALCULATIONS AND REPORT 384 12.4.4 INVERSE LEVER RULE 385 12.5
CHROMATOGRAPHY SCALEUP 386
12.5.1 BACKGROUND 386 12.5.2 OBJECTIVES 386 12.5.3 PROCEDURE 386 12.5.4
REPORT 389 REFERENCES 391
APPENDIX TABLE OF UNITS AND CONSTANTS 392
INDEX 395
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| discipline | Chemie / Pharmazie Chemie |
| format | Book |
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| id | DE-604.BV014371497 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:02:09Z |
| institution | BVB |
| isbn | 9780195123401 0195123409 |
| language | English |
| lccn | 2002019609 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009844782 |
| oclc_num | 48892680 |
| open_access_boolean | |
| owner | DE-703 DE-29T DE-M49 DE-BY-TUM DE-634 DE-91G DE-BY-TUM |
| owner_facet | DE-703 DE-29T DE-M49 DE-BY-TUM DE-634 DE-91G DE-BY-TUM |
| physical | XIX, 406 S. Ill. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Oxford University Press |
| record_format | marc |
| series2 | Topics in chemical engineering |
| spelling | Bioseparations science and engineering Roger G. Harrison ... New York [u.a.] Oxford University Press 2003 XIX, 406 S. Ill. txt rdacontent n rdamedia nc rdacarrier Topics in chemical engineering Includes bibliographical references and index Biochemical engineering Biomolecules Separation Trennverfahren (DE-588)4078395-9 gnd rswk-swf Biomolekül (DE-588)4135124-1 gnd rswk-swf Biomolekül (DE-588)4135124-1 s Trennverfahren (DE-588)4078395-9 s DE-604 Harrison, Roger G. Sonstige oth OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009844782&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bioseparations science and engineering Biochemical engineering Biomolecules Separation Trennverfahren (DE-588)4078395-9 gnd Biomolekül (DE-588)4135124-1 gnd |
| subject_GND | (DE-588)4078395-9 (DE-588)4135124-1 |
| title | Bioseparations science and engineering |
| title_auth | Bioseparations science and engineering |
| title_exact_search | Bioseparations science and engineering |
| title_full | Bioseparations science and engineering Roger G. Harrison ... |
| title_fullStr | Bioseparations science and engineering Roger G. Harrison ... |
| title_full_unstemmed | Bioseparations science and engineering Roger G. Harrison ... |
| title_short | Bioseparations science and engineering |
| title_sort | bioseparations science and engineering |
| topic | Biochemical engineering Biomolecules Separation Trennverfahren (DE-588)4078395-9 gnd Biomolekül (DE-588)4135124-1 gnd |
| topic_facet | Biochemical engineering Biomolecules Separation Trennverfahren Biomolekül |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009844782&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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