Peptide-lipid interactions:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
San Diego [u.a.]
Acad. Press
2002
|
Schriftenreihe: | Current topics in membranes
52 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XXI, 583 S. Ill., graph. Darst. |
ISBN: | 0121533522 0126438714 |
Internformat
MARC
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650 | 7 | |a Interactie |2 gtt | |
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650 | 4 | |a Lipides | |
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650 | 7 | |a Membranen |2 gtt | |
650 | 7 | |a Peptiden |2 gtt | |
650 | 4 | |a Peptides | |
650 | 4 | |a Protéines membranaires | |
650 | 4 | |a Lipids | |
650 | 4 | |a Membrane Lipids | |
650 | 4 | |a Membrane Proteins | |
650 | 4 | |a Membrane lipids | |
650 | 4 | |a Membrane proteins | |
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Datensatz im Suchindex
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adam_text | Contents
Contributors xiii
Preface xvii
Previous Volumes in Series xix
PART I Biophysical Techniques for Analyzing
Peptide Lipid Interactions
CHAPTER 1 Peptide Membrane Interactions Determined
Using Site Directed Spin Labeling
DavidS. Cafiso
I. Introduction 4
II. Site Directed Spin Labeling 5
III. Membrane Interactions of Basic Peptides Derived from
Cell Signaling Motifs 12
IV. Studies Directed at Channel Forming and Other
Membrane Active Peptides 18
V. Conclusions 24
References 25
CHAPTER 2 Isothermal Titration Calorimetry for
Studying Interactions between Peptides
and Lipid Membranes
Torsten Wieprecht and Joachim Seelig
I. Introduction to Isothermal Titration Calorimetry 32
II. Measurement of the Reaction Enthalpy and the
Binding Isotherm 33
III. Binding Models for Analyzing Binding Isotherms 37
IV. Complex Membrane Binding/Membrane Perturbation
Equilibria 41
V. Thermodynamics of the Membrane Induced
Coil Helix Transition 48
VI. Thermodynamics of Peptide Binding to Curved
and Planar Membranes 52
V
vi Contents
VII. Concluding Remarks 54
References 54
CHAPTER 3 Infrared Reflection Absorption Spectroscopy
of Lipids, Peptides, and Proteins in
Aqueous Monolayers
Richard Mendelsohn and Carol R. Flach
I. Introduction 58
II. Experimental Approaches 61
III. Information from IRRAS Measurements 66
IV. IRRAS Applications to Lipid/ProteinLangmuir Films 75
V. Current State and Future Prospects for IRRAS 83
References 84
CHAPTER 4 Measuring the Depth of Amino Acid Residues
in Membrane Inserted Peptides by
Fluorescence Quenching
Erwin London and Alexey S. Ladokhin
I. Introduction 90
II. Determining Depth from Fluorescence Quenching by
Empirical Inspection of Quenching Level 90
III. Determining Depth by Parallax Analysis 91
IV. Determining Depth by Distribution Analysis 93
V. Comparing Parallax Analysis and Distribution
Analysis 97
VI. Investigating Membrane Protein Topography by Varying
Fluorophore Depth Instead of Quencher Depth 98
VII. A Cautionary Note Concerning Quenching Analysis 98
VIII. Problems That Can Affect the Accuracy of Quenching
Measurements 99
IX. Studies of Membrane Inserted Peptides by Fluorescence
Quenching 100
X. Conclusions 111
References 111
CHAPTER 5 Surface Sensitive X Ray and Neutron Scattering
Characterization of Planar Lipid Model Membranes
and Lipid/Peptide Interactions
Mathias Losche
I. Introduction 118
II. Data Inversion and Modeling in Reflectivity
Measurements 122
Contents vii
III. Characterization of Planar Lipid Model Systems 127
References 150
CHAPTER 6 Lipid Peptide Interaction Investigated by NMR
Klaus Gawrisch and Bernd W. Koenig
I. Introduction 164
II. Peptide Structure in the Membrane Bound State 165
III. Structure and Dynamics of the Lipid Matrix 176
IV. Future Directions 183
References 184
CHAPTER 7 Peptide Lipid Interactions in Supported
Monolayers and Bilayers
Lukas K. Tamm
I. Peptide Insertion into Lipid Monolayers 191
II. Supported Bilayers 194
III. ATR FTIR Spectroscopy of Peptides in Supported
Bilayers 195
IV. Analysis of Fusion Peptide Lipid Interactions 198
References 201
PART II Theoretical and Computational Analyses of
Peptide Lipid Interactions
CHAPTER 8 Free Energy Determinants of Peptide Association
with Lipid Bilayers
Amit Kessel and Nir Ben Tal
I. Introduction 206
II. Theory 211
III. Mean Field Studies of Peptide Membrane Systems 223
IV. Open Questions 242
References 244
CHAPTER 9 Investigating Ion Channels Using
Computational Methods
Eric Jakobsson, R. Jay Mas hi, and Tsai Tien Tseng
I. Introduction 256
II. Understanding Channel Function from Structure 257
III. Understanding Channel Function from Structural
Homology 266
viii Contents
IV. Future Prospects 271
References 271
PART III Experimental Investigations of
Peptide Lipid Interactions
CHAPTER 10 The Role of Electrostatic and Nonpolar Interactions
in the Association of Peripheral Proteins
with Membranes
Diana Murray, Anna Arbuzova, Barry Honig,
and Stuart McLaughlin
I. Introduction 278
II. Electrostatic and Hydrophobic Interactions Mediate the
Membrane Association of Important Biological
Proteins 279
III. The Membrane Interaction of Simple Basic Peptides:
Theory and Experiment 282
IV. The Combination of Experimental and Theoretical
Approaches Provides a Detailed Comprehensive
Picture of the Membrane Association of Myristoylated
Proteins 289
V. Future Directions 300
References 303
CHAPTER 11 The Energetics of Peptide Lipid Interactions:
Modulation by Interfacial Dipoles and Cholesterol
Thomas J. Mclntosh, Adriana Vidal, and Sidney A. Simon
I. Introduction 310
II. Results 318
III. Discussion 327
IV. Conclusions 332
References 333
CHAPTER 12 Transmembrane a Helices
Sanjay Mall, J. Malcolm East, and Anthony G. Lee
I. Intrinsic Membrane Proteins 339
II. Effects of Intrinsic Membrane Proteins on Lipid
Bilayers 345
III. Model Transmembrane a Helices 351
IV. Biological Consequences of Hydrophobic Mismatch 363
References 365
Contents ix
CHAPTER 13 Lipidated Peptides as Tools for Understanding the
Membrane Interactions of Lipid Modified Proteins
John R. Silvius
I. Introduction 372
II. Structures of Lipid Modifications of Proteins 372
III. Chemistry of Peptide Lipidation 375
IV. Thermodynamics of Association of Lipidated Peptides
with Lipid Bilayers 377
V. Kinetics of Dissociation of Lipidated Sequences from
Bilayers: Protein Targeting by Kinetic Trapping 383
VI. Partitioning of Lipidated Peptides into Liquid Ordered
Lipid Domains 387
VII. Conclusion 389
References 390
CHAPTER 14 Experimental and Computational Studies
of the Interactions of Amphipathic Peptides
with Lipid Surfaces
Jere P. Segrest, Martin K. Jones, Vinod K. Mishra,
and G. M. Anantharamaiah
I. Introduction 398
II. Amphipathic a Helixes 398
III. Amphipathic p Strands/Sheets 415
References 430
CHAPTER 15 Interactions of pH Sensitive Peptides
and Polymers with Lipid Bilayers: Binding
and Membrane Stability
Doncho V. Zhelev and David Needham
I. Introduction 438
II. Interaction of Viral Fusion Peptides with the
Membrane 440
III. Interaction of AcE4K with Lipid Bilayer
Membranes (SOPC) 442
IV. Effect of Peptide Binding on Membrane Stability 450
V. Membrane Instability Induced by the pH Sensitive
Polymer Poly(2 Ethylacrylic Acid) (PEAA) 456
VI. Conclusion 460
References 460
x Contents
CHAPTER 16 The Hydrophobicity Threshold for Peptide
Insertion into Membranes
Charles M. Deber, Li Ping Liu, Chen Wang, Natalie K. Goto,
and Reinhart A. F Reithmeier
I. Introduction 466
II. Results 467
III. Discussion 473
IV. Conclusions 476
References 477
PART IV Specialized Topics of Biological Relevance
CHAPTER 17 Signal Sequence Function in the Mammalian
Endoplasmic Reticulum: A Biological Perspective
Christopher V. Nicchitta
I. Signal Sequences: Passage and Coronation 484
II. Signal Peptides: A Profile for Function 484
III. Signal Peptide Recognition: Where Biophysics Meets
Biology 487
IV. Yes, But What Happens at the Membrane? 492
V. Where to from Here? 494
VI. Conclusion 496
References 496
CHAPTER 18 The Process of Membrane Fusion: Nipples,
Hemifusion, Pores, and Pore Growth
Fredric S. Cohen, Ruben M. Markosyan, and Grigory B. Melikyan
I. Introduction 502
II. Structural Features and Conformational Changes of
Fusion Proteins 503
III. Hemifusion and Its Possible Role in the
Fusion Process 506
IV. The Observed Temporal Sequence of Lipid Dye Spread
and Fusion Pore Formation Depends upon Target
Membrane and the Chosen Lipid Dye 508
V. The Dependence of Fusion on Spontaneous Curvature
of Lipid Monolayers 510
VI. An Ectodomain of HA Anchored to a Membrane Can Yield
Fusion or End State Hemifusion 514
VII. Fusion Does Not Require a Precise Amino Acid Sequence
of the TM Domain 515
Contents xi
VIII. Capturing Candidates of Transitional Hemifusion 515
IX. The Role of Fusion Proteins in Hemifusion and Pore
Formation 517
X. The Effects of Lipid Composition on Pore Flickering
and Growth 518
XI. Energy and Shape Considerations in Pore Growth 522
XII. Outlook 524
References 524
CHAPTER 19 PrenylationofCaaX Type Proteins: Basic Principles
through Clinical Applications
Herbert I. Hurwitz and Patrick J. Casey
I. Introduction 532
II. Enzymology of the CaaX Prenyltransferases: FTase and
GGTase I 534
III. Development of FTase Inhibitors as Anticancer
Agents 540
IV. Clinical Results from Evaluation of FTIs as Antitumor
Agents 544
V. Summary and Conclusions 545
References 546
CHAPTER 20 Peptides as Probes of Protein Protein Interactions
Involved in Neurotransmitter Release
Thomas Kuner, Hiroshi Tokumaru, and George J. Augustine
I. Introduction 552
II. Peptide Design 554
III. Characterization of Peptide Activity on Protein Protein
Interactions 562
IV. Functional Analysis of Peptides in a Presynaptic
Terminal 564
V. Summary and Outlook 567
References 568
Index 571
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genre_facet | Aufsatzsammlung |
id | DE-604.BV014238686 |
illustrated | Illustrated |
indexdate | 2024-07-09T19:00:09Z |
institution | BVB |
isbn | 0121533522 0126438714 |
language | English |
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physical | XXI, 583 S. Ill., graph. Darst. |
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spelling | Peptide-lipid interactions ed. by Sidney A. Simon ... Peptide lipid interactions San Diego [u.a.] Acad. Press 2002 XXI, 583 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 52 Interactie gtt Lipiden gtt Lipides Lipides membranaires Membranen gtt Peptiden gtt Peptides Protéines membranaires Lipids Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Peptide (DE-588)4045125-2 gnd rswk-swf Lipidmembran (DE-588)4167790-0 gnd rswk-swf Wechselwirkung (DE-588)4064937-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Peptide (DE-588)4045125-2 s Lipidmembran (DE-588)4167790-0 s Wechselwirkung (DE-588)4064937-4 s DE-604 Simon, Sidney A. Sonstige oth Current topics in membranes 52 (DE-604)BV036839511 52 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009761979&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Peptide-lipid interactions Current topics in membranes Interactie gtt Lipiden gtt Lipides Lipides membranaires Membranen gtt Peptiden gtt Peptides Protéines membranaires Lipids Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Peptide (DE-588)4045125-2 gnd Lipidmembran (DE-588)4167790-0 gnd Wechselwirkung (DE-588)4064937-4 gnd |
subject_GND | (DE-588)4045125-2 (DE-588)4167790-0 (DE-588)4064937-4 (DE-588)4143413-4 |
title | Peptide-lipid interactions |
title_alt | Peptide lipid interactions |
title_auth | Peptide-lipid interactions |
title_exact_search | Peptide-lipid interactions |
title_full | Peptide-lipid interactions ed. by Sidney A. Simon ... |
title_fullStr | Peptide-lipid interactions ed. by Sidney A. Simon ... |
title_full_unstemmed | Peptide-lipid interactions ed. by Sidney A. Simon ... |
title_short | Peptide-lipid interactions |
title_sort | peptide lipid interactions |
topic | Interactie gtt Lipiden gtt Lipides Lipides membranaires Membranen gtt Peptiden gtt Peptides Protéines membranaires Lipids Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Peptide (DE-588)4045125-2 gnd Lipidmembran (DE-588)4167790-0 gnd Wechselwirkung (DE-588)4064937-4 gnd |
topic_facet | Interactie Lipiden Lipides Lipides membranaires Membranen Peptiden Peptides Protéines membranaires Lipids Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Peptide Lipidmembran Wechselwirkung Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009761979&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV036839511 |
work_keys_str_mv | AT simonsidneya peptidelipidinteractions |