The basis for gene therapy:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Springfield, Ill.
Thomas
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXV, 204 S. graph. Darst. |
| ISBN: | 0398071586 0398071594 |
Internformat
MARC
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| 100 | 1 | |a Burdette, Walter J. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The basis for gene therapy |c by Walter J. Burdette |
| 264 | 1 | |a Springfield, Ill. |b Thomas |c 2001 | |
| 300 | |a XXV, 204 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 4 | |a Gene Therapy | |
| 650 | 4 | |a Gene therapy | |
| 650 | 4 | |a Genetic engineering | |
| 650 | 4 | |a Genetics, Medical | |
| 650 | 4 | |a Medical genetics | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Molecular genetics | |
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Datensatz im Suchindex
| _version_ | 1804129124196810752 |
|---|---|
| adam_text | CONTENTS
Page
Preface vii
Introduction ix
Chronology xix
Figures xxiii
Tables xxv
Chapter
1. Setting the Stage 3
2. The Eukaryotic Cell 7
Structure of the Cell 7
The Cell Cycle 8
Apoptosis 12
3. Deoxyribonucleic Acid 16
The Structure of DNA 16
The Genetic Code 17
4. Mitochondria 21
5. Replicons 25
6. Genes 28
Structure of Genes 28
7. Gene Transfer 32
Construction of Genes 32
The Human Genome Project 32
Designer Genes 36
Gene Transfer 36
8. Genetic Engineering 38
Enzymes 38
Classification and Action of Enzymes 38
Hydrolases 39
Ligases 39
Proteins 40
The Polymerase Chain Reaction 41
Electrophoresis and Blotting 43
Electrophoresis 43
xv
xvi The Basis for Gene Therapy
Southern Blotting 45
Dot (Slot) and Colony Blotting 46
Northern Blotting 47
Western Blotting 47
9. Transcription and Translation 49
10. The Immune System 52
11. Clones 54
12. Stem Cells and Vectors 62
13. Genomic Probes ,65
Hybridization 65
Oligonucleotide Probes 66
cDNA Probes 66
Genomic DNA Probes 66
Search for Pathogenes 67
14. Clinical Genetics 71
Counseling j
Pedigree and Physical Examination 72
Follow up Discussion 72
Risks 74
15. Mutations 77
Types of Mutations .. .77
Analysis of Mutations .78
16. Selected Examples of Inherited Disease 80
Trisomy 13 80
Trisoy 18 gQ
Trisomy 21 .... gO
X .81
47,XYY 81
46, XX 82
47,xxy ;;;;;;; 82
47 xxx ¦ ¦ ¦ ¦ 82
Fragile X Syndrome 83
Achondroplasia g3
Osteogenesis Imperfecta .83
Otosclerosis go
Marfan Syndrome 84
Cystic Fibrosis 84
Carcinoma of the Breast 84
Familial Adenomatosous Polyposis (APC) 85
Contents xvii
Hereditary Nonpolyposis Colon Cancer (Lynch I and II) 85
Current Status of Hereditary Disease 85
17. Chromosomes 87
18. Oncogenes and Tumor suppressor Genes 92
RNA Retrovirus 93
Rous and Avian Oncogenes 93
DNA Viruses 94
Insertional Mutagenesis 96
Amplification of Oncogenes 96
Translocations and Tumorigenesis 98
Tumor Suppressor Genes 99
Mechanisms of Action of Oncogenes and Tumor Suppressor
Genes 102
19. Human Gene Therapy 107
Hemopoietic System 107
Diseases of Hemopoietic System 108
Metabolic Storage Diseases 109
Hemoglobin Disorders 110
Modulation of Alloreactivity in Bone marrow
Transplantation Ill
Antiangiogenesis 112
20. Vectors 116
Retroviral Vectors 116
Lentivirus Vectors 117
Foamy Virus Vectors 118
Herpes Virus Vectors 119
Adenovirus Vectors 119
Adeno Associated Virus Vectors 120
Other Viral Vectors 121
21. Use of Programmed Cell Death in Gene Therapy 123
22. The P53 Tumor Suppressor Gene 125
23. Synthetic Gene Delivery 128
24. Suicide Gene Prodrug Therapy 130
25. Immunotherapy for Cancer 132
26. Vaccines 135
27. Gene Transfers 136
Direct Gene Transfer 136
Retroviral Mediated Gene Transfer 136
Adenoviral Mediated Gene Transfer 137
xviii The Basis for Gene Therapy
Adeno Associated Viral Gene Transfer 137
Cationic Liposome Mediated Gene Transfer 137
28. Models for Gene Therapy 139
29. Gene Therapy 142
Cystic Fibrosis 142
Glaucoma 144
Mitochondrial Mutations and Human Disease 146
Duchenne and Becker Muscular Dystrophies 147
Familial Hypercholesterolemia 151
Hemoglobinopathies 154
Hemophilia 157
Lysosomal Storage Disorders 159
Severe Combined Immunodeficiency 161
Amyotrophic Lateral Sclerosis 164
Non small cell Cancer of the Lung and Others Responding
to P53 165
Postscript 167
Glossary 169
Vendors 179
Bibliography 183
World Wide Websites and Other Resources 183
Books on Genetics and Gene Transfer 185
Recent Reviews 186
Journal References 188
Index 193
|
I
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:00:09Z |
| institution | BVB |
| isbn | 0398071586 0398071594 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009761465 |
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| spelling | Burdette, Walter J. Verfasser aut The basis for gene therapy by Walter J. Burdette Springfield, Ill. Thomas 2001 XXV, 204 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Gene Therapy Gene therapy Genetic engineering Genetics, Medical Medical genetics Molecular Biology Molecular genetics Gentherapie (DE-588)4296957-8 gnd rswk-swf Gentherapie (DE-588)4296957-8 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009761465&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Burdette, Walter J. The basis for gene therapy Gene Therapy Gene therapy Genetic engineering Genetics, Medical Medical genetics Molecular Biology Molecular genetics Gentherapie (DE-588)4296957-8 gnd |
| subject_GND | (DE-588)4296957-8 |
| title | The basis for gene therapy |
| title_auth | The basis for gene therapy |
| title_exact_search | The basis for gene therapy |
| title_full | The basis for gene therapy by Walter J. Burdette |
| title_fullStr | The basis for gene therapy by Walter J. Burdette |
| title_full_unstemmed | The basis for gene therapy by Walter J. Burdette |
| title_short | The basis for gene therapy |
| title_sort | the basis for gene therapy |
| topic | Gene Therapy Gene therapy Genetic engineering Genetics, Medical Medical genetics Molecular Biology Molecular genetics Gentherapie (DE-588)4296957-8 gnd |
| topic_facet | Gene Therapy Gene therapy Genetic engineering Genetics, Medical Medical genetics Molecular Biology Molecular genetics Gentherapie |
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