The mechanisms of platelet activating factor induced alterations in lung functions:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Konstanz
Hartung-Gorre
2002
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| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Lübeck, Univ., Diss., 2001 |
| Beschreibung: | 108 S. graph. Darst. : 21 cm |
| ISBN: | 3896497774 |
Internformat
MARC
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| 100 | 1 | |a Göggel, Rolf |d 1970- |e Verfasser |0 (DE-588)123896665 |4 aut | |
| 245 | 1 | 0 | |a The mechanisms of platelet activating factor induced alterations in lung functions |c Rolf Göggel |
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| 264 | 1 | |a Konstanz |b Hartung-Gorre |c 2002 | |
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| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zugl.: Lübeck, Univ., Diss., 2001 | ||
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Datensatz im Suchindex
| _version_ | 1804129118010212352 |
|---|---|
| adam_text | Table of Contents
Table of Contents
1. Introduction 1
1.1 The lung 1
1.1.1 Morphology of the lung 1
1.1.2 Physiological parameters of the lung 2
1.1.2.1 Airway mechanics 3
1.1.2.2 Vascular mechanics 3
1.1.2.3 Smooth muscle contraction 4
1.1.2.3.1 Cytoskeletal structures involved in smooth muscle contraction 4
1.1.2.3.2 Force generation 4
1.1.2.3.3 Regulation 5
1.1.2.4 Edema formation 5
1.2 ARDS 6
1.3 PAF 7
1.3.1 PAF Metabolism 8
1.3.2 PAF signal transduction 10
1.3.2.1 PAF receptors are coupled to G proteins 10
1.3.2.2 PAF induced biochemical effects 10
1.3.3 PAF induced mediator release and receptor activation 11
1.3.4 PAF action in the lung 13
1.4 Calcium as a mediator of cell signalling 14
1.4.1 Calcium signals in endothelial cells in inflammation 14
1.4.2 Receptor induced calcium release 15
1.4.3 Store operated calcium channels (SOCs) 16
1.5Ceramide 16
1.6Caveolae 18
1.7Quinolines 19
1.8 Models to study edema formation 20
2. Aim of tin study 21
3. Material and Methods _ 22
3.1 Animals 22
3.2 Chemicals 22
3.2.1 Chemicals used in isolated perfused rat lung preparations 22
3.2.2 Other chemicals___ 24
3.2.3 Vehicles and solutes 24
3.3 Equipment 24
3.4 Methods 25
3.4.1 Isolated perfused rat lung preparation (IPL) 25
3.4.1.1 Experimental design of the perfused lung studies. 27
3.4.2 In vivo experiment with mice 27
3.4.2.1 Methodical approach 27
Table of Contents 3.4.2.2 Preparation of mice 27
3.4.2.3 Experimental design of the in vivo studies 28
3.4.3 Measurement of Ceramide levels in lung tissue 30
3.4.4 Measurement of acid sphingomyelinase activity 30
3.4.5 Determination of protein content 31
3.4.6 Measurement of thromboxane 31
3.4.7 Measurement of PGE2 31
3.4.8 Statistics 32
4. Results 33
4.1 The effects of PAF on Isolated perfused rat lungs 33
4.2 PAF induced edema formation 34
4.2.1 The cyclooxygenase dependent part of edema formation 35
4.2.1.1 PAF stimulates the release of thromboxane and PGE2 36
4.2.1.2 PGE2 induces edema formation 37
4.2.1.3 The effect of a thromboxane receptor antagonist on PGE induced edema formation. 37
4.2.1.4 The involvement of potassium channels in PGEnnduced edema formation 38
4.2.1.5 The involvement of potassium channels in PAF induced edema formation 39
4.2.2 The quinoline sensitive part of PAF induced edema formation 41
4.2.2.1 PAF and LPS induced edema formation assessed in mice in vivo 41
4.2.2.2 The effects of substances interfering with the ceramide metabolism 42
4.2.2.3 PAF induces ceramide formation in isolated perfused lungs 44
4.2.2.4 C2 Ceramide induces edema formation in isolated perfused lungs 44
4.2.2.5 The effect of an anti ceramide serum on PAF induced edema formation 45
4.2.2.6 PAF induces release of ASMase into the perfusate 46
4.2.2.7 Involvement of the mannose 6 phosphate receptor in PAF induced edema formation 47
4.2.2.8 The role of calcium in PAF induced edema formation 48
4.2.2.8.1 Intracellular calcium 48
4.2.2.8.2 Extracellular calcium 50
4.2.2.9 The involvement of myosin light chain kinase in PAF induced edema formation 51
4.2.2.10 The effect of sphingosine on PAF induced edema formation 51
4.2.3 The involvement of Rho associated kinase in PAF induced edema formation 52
4.3 The PAF induced pressor responses 53
4.3.1 ThephospholipaseA2 53
4.3.2 PGE induced pressor responses 54
4.3.3 The role of calcium in PAF induced pressor responses 55
4.3.3.1 Intracellular calcium 55
4.3.3.2 Extracellular calcium 57
4.3.4 The involvement of phosphodiesterase V in the maintenance of vasoconstriction 60
4.3.5 The involvement of myosin light chain kinase in PAF induced pressor responses 60
4.3.6 The effect of sphingosine on PAF induced pressor responses 61
4.3.7 The involvement of Rho associated kinase in 1146619 induced pressor responses 62
4.3.8 The involvement of Rho associated kinase in PAF induced pressor responses 63
4.3.9 The effect of substances interfering with ceramide metabolism on PAF induced pressor
responses 64
5. Discussion 65
5.1 PAF induced edema formation 66
5.1.1 The cyclooxygenase sensitive part of PAF induced edema formation 66
5.1.1.1 The involvement of PLA2 in PAF induced edema formation 66
5.1.1.2 PAF induced PGE2 release 67
Table of Contents 5.1.1.3 PGE2 induces edema formation 67
5.1.1.4 The involvement of potassium channels in edema formation 68
5.1.2 Quinoline sensitive part of PAF induced edema formation 70
5.1.2.1 PAF induced edema formation mediation by ceramide 70
5.1.2.2 The role of calcium in PAF induced edema formation 74
5.1.2.3 Involvement of myosin light chain kinase and Rho associated protein kinase in PAF
induced edema formation 77
5.1.2.4 Hypothetical mechanism of PAF induced edema formation 78
5.2 PAF induced pressor responses 81
5.2.1 Thromboxane release 81
5.2.2 The role of calcium in PAF induced pressor responses 82
5.2.2.1 Intracellular calcium 82
5.2.2.2 Extracellular calcium 83
5.2.3 The role of myosin light chain and Rho associated kinase 84
5.2.4 The effects of sphingosine on pressor responses 85
5.2.6 Effects of PDE V on pressor responses 86
5.2.7 Hypothetical mechanism of PAF induced pressor responses 86
6. Summary 88
7. Deutsche Zusammenfassung 90
8. References 92
I
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:00:03Z |
| institution | BVB |
| isbn | 3896497774 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009757517 |
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| physical | 108 S. graph. Darst. : 21 cm |
| publishDate | 2002 |
| publishDateSearch | 2002 |
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| spelling | Göggel, Rolf 1970- Verfasser (DE-588)123896665 aut The mechanisms of platelet activating factor induced alterations in lung functions Rolf Göggel 1. Aufl. Konstanz Hartung-Gorre 2002 108 S. graph. Darst. : 21 cm txt rdacontent n rdamedia nc rdacarrier Zugl.: Lübeck, Univ., Diss., 2001 Platelet activating Factor (DE-588)4192717-5 gnd rswk-swf Lungenödem (DE-588)4134256-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Lungenödem (DE-588)4134256-2 s Platelet activating Factor (DE-588)4192717-5 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009757517&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Göggel, Rolf 1970- The mechanisms of platelet activating factor induced alterations in lung functions Platelet activating Factor (DE-588)4192717-5 gnd Lungenödem (DE-588)4134256-2 gnd |
| subject_GND | (DE-588)4192717-5 (DE-588)4134256-2 (DE-588)4113937-9 |
| title | The mechanisms of platelet activating factor induced alterations in lung functions |
| title_auth | The mechanisms of platelet activating factor induced alterations in lung functions |
| title_exact_search | The mechanisms of platelet activating factor induced alterations in lung functions |
| title_full | The mechanisms of platelet activating factor induced alterations in lung functions Rolf Göggel |
| title_fullStr | The mechanisms of platelet activating factor induced alterations in lung functions Rolf Göggel |
| title_full_unstemmed | The mechanisms of platelet activating factor induced alterations in lung functions Rolf Göggel |
| title_short | The mechanisms of platelet activating factor induced alterations in lung functions |
| title_sort | the mechanisms of platelet activating factor induced alterations in lung functions |
| topic | Platelet activating Factor (DE-588)4192717-5 gnd Lungenödem (DE-588)4134256-2 gnd |
| topic_facet | Platelet activating Factor Lungenödem Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009757517&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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