Single molecule detection in solution: methods and applications
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin
Wiley-VCH
2002
|
| Ausgabe: | 1. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 371 S. Ill., graph. Darst. |
| ISBN: | 3527403108 |
Internformat
MARC
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| 020 | |a 3527403108 |9 3-527-40310-8 | ||
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| 245 | 1 | 0 | |a Single molecule detection in solution |b methods and applications |c Ch. Zander ... (ed.) |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Berlin |b Wiley-VCH |c 2002 | |
| 300 | |a XVI, 371 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Freies Molekül - Lösung - Aufsatzsammlung | |
| 650 | 4 | |a Molecules | |
| 650 | 4 | |a Solution (Chemistry) | |
| 650 | 0 | 7 | |a Lösung |g Chemie |0 (DE-588)4036159-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Freies Molekül |0 (DE-588)4489205-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Freies Molekül |0 (DE-588)4489205-6 |D s |
| 689 | 0 | 1 | |a Lösung |g Chemie |0 (DE-588)4036159-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Zander, Christoph |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009715288&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1826205074338086912 |
|---|---|
| adam_text |
CONTENTS
OBITUARY
V
LIST
OF
CONTRIBUTORS
XIII
1
SINGLE
MOLECULE
DETECTION
IN
LIQUIDS
AND
ON
SURFACES
UNDER
AMBIENT
CONDITIONS:
INTRODUCTION
AND
HISTORICAL
OVERVIEW
1
1.1
INTRODUCTION
1
1.2
BEGINNINGS
1
1.3
DIRECTED
TRANSPORT
OF
MOLECULES:
FLUID
FLOWS,
MICROCHANNELS,
AND
MICRODROPLETS
2
1.4
CONFOCAL
DETECTION
IN
LIQUIDS
5
1.5
VIDEO
AND
CCD
WIDE
FIELD
MICROSCOPY
6
1.6
CONFOCAL
LASER
SCANNING
MICROSCOPY
ON
SURFACES
8
1.7
SPECIAL
TOPICS
10
REFERENCES
1
1
2
THEORETICAL
FOUNDATIONS
OF
SINGLE
MOLECULE
DETECTION
IN
SOLUTION
21
2.1
GENERAL
CONDITIONS
OF
SINGLE
MOLECULE
DETECTION
21
2.2
MODELING
THE
FLUORESCENCE
PHOTON
DETECTION
STATISTICS
27
2.2.1
MOLECULAR
PHOTOPHYSICS
28
2.2.2
LASER
EXCITATION
35
2.2.2.1
GAUSSIAN
OPTICS
35
2.2.2.2
NON-PARAXIAL
OPTICS
OF
FOCUSING
THROUGH
OBJECTIVES
WITH
HIGH
NA
38
2.2.3
OPTICAL
COLLECTION
EFFICIENCY
FUNCTION
43
2.2.3.1
WAVE
OPTICS
CALCULATION
43
2.2.3.2
SEMI-GEOMETRICAL
OPTICS
APPROXIMATION
47
2.2.4
MOLECULE
TRANSPORT:
DIRECTED
TRANSLATION,
FLUID
FLOW,
AND
DIFFUSION
48
2.3
DATA
EVALUATION
METHODS
50
2.3.1
BURST
SIZE
DISTRIBUTION
ANALYSIS
50
2.3.1.1
BURST
SIZE
DISTRIBUTION
ANALYSIS:
SINGLE
MOLECULE
TRANSITS
51
2.3.1.2
BURST
SIZE
DISTRIBUTION
ANALYSIS:
MULTIPLE
MOLECULE
TRANSITS
53
2.3.2
AUTOCORRELATION
ANALYSIS
54
2.3.3
FLUORESCENCE
INTENSITY
DISTRIBUTION
ANALYSIS
58
VIII
I
CONTENTS
2.3.4
FLUORESCENCE
DECAY
TIME
ANALYSIS
59
2.4
CONCLUSION
62
APPENDIX
2.1
POISSON
STATISTICS
OF
PHOTON
DETECTION
63
APPENDIX
2.2
SEMI-GEOMETRICAL
APPROXIMATION
OF
COLLECTION
EFFICIENCY
FUNCTION
64
APPENDIX
2.3
LIE
FILTERING
OF
RAW
DATA
65
APPENDIX
2.4
MONTE-CARLO
CALCULATION
OF
PATH
INTEGRALS
66
REFERENCES
67
3
CONCEPTUAL
BASIS
OF
FLUORESCENCE
CORRELATION
SPECTROSCOPY
AND
RELATED
TECHNIQUES
AS
TOOLS
IN
BIOSCIENCE
69
3.1
INTRODUCTION
69
3.2
HISTORICAL
OVERVIEW
OF
FLUCTUATION
ANALYSIS
AND
FCS
70
3.3
INTRODUCTION
TO
STOCHASTIC
VARIABLES
AND
PROCESSES
RELEVANT
FOR
FCS
ANALYSIS
72
3.4
DERIVATION
OF
THE
FLUORESCENCE
AUTOCORRELATION
FUNCTION
FOR
TRANSLATIONAL
DIFFUSION
75
3.5
EXPERIMENTAL
EQUIPMENT
81
3.5.1
ASPECTS
OF
THE
STANDARD
EQUIPMENT
81
3.5.2
SPECIFIC
VARIATIONS
OF
THE
EXPERIMENTAL
TECHNIQUE
84
3.6
SIGNAL-TO-NOISE
RATIO
OF
FCS
DATA
85
3.6.1
THEORETICAL
ASPECTS
OF
THE
S/N
RATIO
85
3.6.2
EXPERIMENTAL
ASPECTS
OF
THE
S/N
RATIO
87
3.7
DIFFERENT
MODALITIES
OF
FCS
88
3.7.1
CHEMICAL
REACTION
AND
TRANSLATIONAL
DIFFUSION
88
3.7.2
UNIFORM
FLOW
AND
DIFFUSION
99
3.7.3
SCANNING-FCS
AND
IMAGE
CORRELATION
SPECTROSCOPY
100
3.7.4
CROSS-CORRELATION
MODALITIES
OF
FCS
IN
THE
SPECTRAL
AND
SPATIAL
MODE
102
3.7.5
ROTATIONAL
DIFFUSION
106
3.7.6
HIGHER-ORDER
FCS
112
3.7.7
FLUORESCENCE
INTENSITY
DISTRIBUTION
ANALYSIS
114
3.8
CONCLUDING
REMARKS
117
REFERENCES
119
4
SURFACE-ENHANCED
RAMAN
SCATTERING
(SERS)
-
A
TOOL
FOR
SINGLE
MOLECULE
DETECTION
IN
SOLUTION
121
4.1
'
NORMAL
'
RAMAN
SCATTERING,
SERS
AND
SINGLE
MOLECULE
RAMAN
DETECTION
121
4.2
PHYSICS
BEHIND
THE
SERS
EFFECT
123
4.2.1
'
CHEMICAL
'
ENHANCEMENT
125
4.2.2
ELECTROMAGNETIC
FIELD
ENHANCEMENT
127
4.2.3
SERS
ENHANCEMENT
FACTORS
AND
EFFECTIVE
SERS
CROSS
SECTIONS
129
4.3
SINGLE
MOLECULE
SERS
EXPERIMENTS
133
4.3.1
SERS-ACTIVE
SUBSTRATES
133
CONTENTS
IIX
4.3.2
RAMAN
SYSTEM
AND
EXCITATION
LASERS
134
4.3.3
SINGLE
MOLECULE
RAMAN
SPECTRA
135
4.4
A
POTENTIAL
APPLICATION
OF
SINGLE
MOLECULE
RAMAN
SPECTROSCOPY
IN
DNA
SEQUENCING
138
4.5
ANTI-STOKES
SERS
-
A
TWO-PHOTON
RAMAN
PROBE
OF
SINGLE
MOLECULES
139
4.6
PROSPECTS
OF
SINGLE
MOLECULE
RAMAN
SPECTROSCOPY:
SINGLE
MOLECULE
RAMAN
SPECTROSCOPY
VS.
SINGLE
MOLECULE
FLUORESCENCE
SPECTROSCOPY
141
REFERENCES
143
5
SINGLE
MOLECULE
DETECTION
ON
SURFACES
WITH
THE
CONFOCAL
LASER
SCANNING
MICROSCOPE
145
5.1
INTRODUCTION
145
5.2
INSTRUMENTATION
147
5.2.1
EXCITATION
SOURCES
147
5.2.2
EXCITATION
FILTER
149
5.2.3
DICHROIC
MIRROR
AND
EMISSION
FILTERS
150
5.2.4
MICROSCOPE
OBJECTIVE
AND
TUBE
LENS
151
5.2.5
PINHOLE
156
5.2.6
REFOCUSING
156
5.2.7
PHOTOELECTRIC
DETECTOR
157
5.2.8
GENERAL
LAYOUT
AND
ALIGNMENT
159
5.2.9
DATA
ACQUISITION
ELECTRONICS
162
5.2.10
SCANNING
INSTRUMENTATION
166
5.2.11
CONTROLLING
THE
OBJECTIVE-SAMPLE
SEPARATION
168
5.3
SMD
APPLICATIONS
169
5.3.1
INTENSITY
IMAGING
170
5.3.2
LIFETIME
IMAGING
173
5.3.3
TIME-WINDOWED
DETECTION:
POLARIZATION
IMAGING
175
5.3.4
RING
EXCITATION:
THREE-DIMENSIONAL
MOLECULE
ORIENTATION
179
5.4
CONCLUSION
AND
OUTLOOK
181
REFERENCES
183
6
SPECTROSCOPY
OF
INDIVIDUAL
PHOTOSYNTHETIC
PIGMENT-PROTEIN
COMPLEXES
185
6.1
INTRODUCTION
185
6.1.1
BACTERIAL
PHOTOSYNTHESIS
186
6.1.1.1
THE
LIGHT-HARVESTING
COMPLEX
II
188
6.1.2
THE
PHOTOSYNTHETIC
UNIT
OF
GREEN
PLANTS
190
6.1.2.1
PHOTOSYSTEM
II
AND
LIGHT-HARVESTING
COMPLEX
II
191
6.1.2.2
PHOTOSYSTEM
I
193
6.2
FLUORESCENCE-EXCITATION
SPECTROSCOPY
OF
INDIVIDUAL
LIGHT-HARVESTING
II
COMPLEXES
OF
RHODOPSEUDOMONAS
ACIDOPHILA
194
6.2.1
EXPERIMENTAL
194
6.2.1.1
SAMPLE
PREPARATION
194
X
I
CONTENTS
6.2.1.2
6.2.2
6.2.2.1
6.2.2.2
6.2.2.3
6.2.2.4
6.2.3
6.3
SET-UP
195
RESULTS
AND
DISCUSSION
196
LOCALIZED
VS.
DELOCALIZED
EXCITATIONS
197
EXCITON
MODEL
FOR
A
CIRCULAR
AGGREGATE
199
B800
BAND
200
B850
BAND
204
CONCLUSIONS
213
SINGLE
MOLECULE
SPECTROSCOPY
ON
THE
LIGHT-HARVESTING
COMPLEX
II
OF
HIGHER
PLANTS
214
6.3.1
6.3.2
EXPERIMENTAL
215
POLARIZATION
AND
SPECTRAL
DISTRIBUTION
OF
THE
FLUORESCENCE
EMISSION
OF
SINGLE
LHCII
MONOMERS
AND
TRIMERS
215
6.3.3
SINGLE
MOLECULE
SPECTROSCOPY
ON
PHOTOSYSTEM
I
PIGMENT-PROTEIN
COMPLEXES
223
REFERENCES
228
7
7.1
7.2
7.2.1
7.2.2
7.2.3
7.2.4
7.3
7.4
SINGLE
DYE
TRACING
FOR
ULTRASENSITIVE
MICROSCOPY
ON
LIVING
CELLS
231
INTRODUCTION
231
BASIC
PRINCIPLES
232
LOCAL
STOICHIOMETRY
234
CO-LOCALIZATION
OF
DIFFERENT
MOLECULES
234
ORIENTATION
236
LATERAL
MOBILITY
237
LIVE
CELL
IMAGING
237
OUTLOOK
242
REFERENCES
244
8
8.1
8.2
8.2.1
8.2.2
8.3
8.4
8.5
SINGLE
MOLECULE
IDENTIFICATION
IN
SOLUTION:
PRINCIPLES
AND
APPLICATIONS
247
INTRODUCTION
247
SMART
PROBES
253
DESIGN
AND
SPECTROSCOPIC
CHARACTERISTICS
OF
SMART
PROBES
255
EXPERIMENTS
AT
THE
SINGLE
MOLECULE
LEVEL
256
SINGLE
MOLECULE
ELECTROPHORESIS
258
SINGLE
MOLECULE
DNA
SEQUENCING
260
OUTLOOK
267
REFERENCES
270
9
9.1
9.2
9.2.1
9.2.2
9.3
9.3.1
9.3.2
STUDYING
MOLECULAR
MOTORS
ON
THE
SINGLE
MOLECULE
LEVEL
273
MOLECULAR
MOTORS
AND
SINGLE
MOLECULE
DETECTION
273
VISUALIZATION
OF
SLIDING
MOVEMENT
275
VISUALIZING
SLIDING
MOVEMENT
OF
ACTIN
FILAMENTS
275
IMMOBILIZATION
OF
PROTEIN
MOLECULES
277
IMAGING
OF
SINGLE
BIOMOLECULES
278
VISUALIZING
SINGLE
BIOMOLECULES
278
VISUALIZING
THE
TURNOVER
OF
SINGLE
ATP
MOLECULES
280
CONTENTS
I
XI
9.3.3
VISUALIZING
THE
SLIDING
MOVEMENT
OF
SINGLE
MOTOR
PROTEINS
281
9.3.4
VISUALIZING
THE
DYNAMIC
STRUCTURE
OF
PROTEINS
281
9.4
MANIPULATING
SINGLE
PROTEIN
MOLECULES
AND
MEASURING
MECHANICAL
EVENTS
GENERATED
BY
SINGLE
MOTOR
MOLECULES
282
9.4.1
MANIPULATING
KINESIN
BY
A
LASER
TRAP
AND
MEASURING
ITS
MECHANICAL
PROPERTIES
283
9.4.2
MANIPULATING
ACTIN
FILAMENT
BY
A
LASER
TRAP
284
9.4.3
MANIPULATING
AN
ACTIN
FILAMENT
BY
USING
MICRONEEDLES
AND
THE
MEASUREMENT
OF
THE
MECHANICAL
PROPERTIES
OF
ACTIN
AND
ACTOMYOSIN
286
9.4.4
MANIPULATING
MYOSIN
SI
BY
A
SCANNING
PROBE
287
9.5
SIMULTANEOUS
MEASUREMENTS
OF
MECHANICAL
AND
CHEMICAL
EVENTS
289
9.6
MOLECULAR
MACHINES
AND
SINGLE
MOLECULE
APPROACHES
291
REFERENCES
292
10
THE
CHEMISTRY
OF
A
SINGLE
ENZYME
MOLECULE
293
10.1
INTRODUCTION
293
10.2
PROTEIN
HETEROGENEITY
293
10.3
DIFFERENCES
IN
HIGHER-ORDER
PROTEIN
STRUCTURE
295
10.4
SINGLE
MOLECULE
STUDIES
OF
ALKALINE
PHOSPHATASE
296
10.5
SINGLE
MOLECULE
MICHAELIS
-
MENTEN
KINETICS
OF
CALF
INTESTINAL
ALKALINE
PHOSPHATASE
298
10.6
CONCLUSIONS
300
REFERENCES
301
11
SINGLE
MOLECULE
DETECTION
OF
SPECIFIC
NUCLEIC
ACID
SEQUENCES
303
11.1
INTRODUCTION
303
11.2
INSTRUMENTATION
FOR
SINGLE
MOLECULE
DETECTION
IN
FLOW
CAPILLARIES
304
11.2.1
APPARATUS
306
11.3
DOUBLE-LABEL
ASSAY
307
11.3.1
DETECTION
OF
LAMBDA
DNA
IN
THE
PRESENCE
OF
GENOMIC
BACKGROUND
309
11.3.2
DETECTION
OF
A
SINGLE-COPY
GENE
IN
A
TRANSFORMED
MAIZE
PLANT
309
11.3.3
DETECTION
OF
A
SPECIFIC
SEQUENCE
OF
A
PATHOGEN
313
11.3.3.1
DETECTION
OF
B.
ANTHRACIS
DNA
IN
THE
PRESENCE
OF
SALMON
SPERM
DNA
314
11.3.3.2
DETECTION
OF
B.
ANTHRACIS
DNA
IN
THE
PRESENCE
OF
B.
GIOBIGII
DNA
314
11.4
PNA
CLAMP
PROBES
315
11.5
POLYMERASE-EXTENDED
FLUORESCENCE
REPORTERS
318
11.6
CONCLUSIONS
AND
OUTLOOK
320
REFERENCES
321
XIII
CONTENTS
12
12.1
12.2
12.2.1
12.2.2
12.2.3
12.3
12.3.1
12.3.2
12.4
12.4.1
12.4.2
12.4.3
12.4.4
12.5
SINGLE
MOLECULE
DETECTION
IN
THE
NEAR-INFRARED
323
INTRODUCTION
323
NEAR-IR
CHROMOPHORES
AND
THEIR
PHOTOPHYSICAL
PROPERTIES
327
NATIVE
NEAR-IR
DYES
327
LABELING
NEAR-IR
DYES
330
NON-COVALENT
LABELING
FLUORESCENT
PROBES
331
NEAR-INFRARED
INSTRUMENTATION
334
DIODE
LASERS
334
SINGLE
PHOTON
AVALANCHE
DIODES
336
SINGLE
MOLECULE
DETECTION
OF
NEAR-IR
DYES
IN
FLOW
STREAMS
337
TIME-GATED
DETECTION
337
SMD
USING
CONTINUOUS
WAVE
LASERS
IN
THE
NEAR-IR
340
SMD
IN
HETEROGENEOUS
ENVIRONMENTS
342
TIME-RESOLVED
DETECTION
OF
SINGLE
NEAR-IR
DYES
346
SINGLE
MOLECULE
DETECTION
IN
THE
NEAR-IR
IN
POLYMER
MICROFLUIDIC
DEVICES
352
12.5.1
DETECTION
OF
SINGLE
DNA
MOLECULES
STAINED
WITH
NEAR-IR
DYES
IN
MICROFLUIDIC
DEVICES
352
12.5.2
DETECTION
OF
SINGLE
DYE
MOLECULES
IN
THE
NEAR-IR
USING
POLYMER
MICROFLUIDIC
DEVICES
357
12.6
CONCLUSIONS
359
REFERENCES
360
NAME
INDEX
363
SUBJECT
INDEX
365 |
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV014171844 |
| callnumber-first | Q - Science |
| callnumber-label | QD96 |
| callnumber-raw | QD96.F56 |
| callnumber-search | QD96.F56 |
| callnumber-sort | QD 296 F56 |
| callnumber-subject | QD - Chemistry |
| classification_rvk | UM 3200 VG 5150 |
| ctrlnum | (OCoLC)248244736 (DE-599)BVBBV014171844 |
| dewey-full | 543.56 539.60287 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 543 - Analytical chemistry 539 - Modern physics |
| dewey-raw | 543.56 539.60287 |
| dewey-search | 543.56 539.60287 |
| dewey-sort | 3543.56 |
| dewey-tens | 540 - Chemistry and allied sciences 530 - Physics |
| discipline | Chemie / Pharmazie Physik |
| edition | 1. ed. |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV014171844 |
| illustrated | Illustrated |
| indexdate | 2025-03-10T11:07:55Z |
| institution | BVB |
| isbn | 3527403108 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009715288 |
| oclc_num | 248244736 |
| open_access_boolean | |
| owner | DE-703 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-526 DE-11 DE-188 |
| owner_facet | DE-703 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-526 DE-11 DE-188 |
| physical | XVI, 371 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Single molecule detection in solution methods and applications Ch. Zander ... (ed.) 1. ed. Berlin Wiley-VCH 2002 XVI, 371 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Freies Molekül - Lösung - Aufsatzsammlung Molecules Solution (Chemistry) Lösung Chemie (DE-588)4036159-7 gnd rswk-swf Freies Molekül (DE-588)4489205-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Freies Molekül (DE-588)4489205-6 s Lösung Chemie (DE-588)4036159-7 s DE-604 Zander, Christoph Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009715288&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Single molecule detection in solution methods and applications Freies Molekül - Lösung - Aufsatzsammlung Molecules Solution (Chemistry) Lösung Chemie (DE-588)4036159-7 gnd Freies Molekül (DE-588)4489205-6 gnd |
| subject_GND | (DE-588)4036159-7 (DE-588)4489205-6 (DE-588)4143413-4 |
| title | Single molecule detection in solution methods and applications |
| title_auth | Single molecule detection in solution methods and applications |
| title_exact_search | Single molecule detection in solution methods and applications |
| title_full | Single molecule detection in solution methods and applications Ch. Zander ... (ed.) |
| title_fullStr | Single molecule detection in solution methods and applications Ch. Zander ... (ed.) |
| title_full_unstemmed | Single molecule detection in solution methods and applications Ch. Zander ... (ed.) |
| title_short | Single molecule detection in solution |
| title_sort | single molecule detection in solution methods and applications |
| title_sub | methods and applications |
| topic | Freies Molekül - Lösung - Aufsatzsammlung Molecules Solution (Chemistry) Lösung Chemie (DE-588)4036159-7 gnd Freies Molekül (DE-588)4489205-6 gnd |
| topic_facet | Freies Molekül - Lösung - Aufsatzsammlung Molecules Solution (Chemistry) Lösung Chemie Freies Molekül Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009715288&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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