Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | München, Techn. Univ., Diss., 2001. - Enth. Zeitschriftenaufsätze |
| Beschreibung: | III, 88 S. graph. Darst. |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV014158574 | ||
| 003 | DE-604 | ||
| 005 | 20020228 | ||
| 007 | t | ||
| 008 | 020220s2001 d||| m||| 00||| eng d | ||
| 016 | 7 | |a 964012596 |2 DE-101 | |
| 035 | |a (OCoLC)248600991 | ||
| 035 | |a (DE-599)BVBBV014158574 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-91 |a DE-M49 |a DE-12 |a DE-83 | ||
| 084 | |a OEK 740d |2 stub | ||
| 084 | |a VET 440d |2 stub | ||
| 084 | |a LAN 640d |2 stub | ||
| 100 | 1 | |a Hageleit, Melanie |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate |c Melanie Hageleit |
| 264 | 1 | |c 2001 | |
| 300 | |a III, 88 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a München, Techn. Univ., Diss., 2001. - Enth. Zeitschriftenaufsätze | ||
| 650 | 0 | 7 | |a Färsenmast |0 (DE-588)4153530-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Futterzusatz |0 (DE-588)4155774-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Verbraucherschutz |0 (DE-588)4117338-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Fleisch |0 (DE-588)4017469-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Quantitative Analyse |0 (DE-588)4125311-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Progestagen |0 (DE-588)4210407-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Rückstand |0 (DE-588)4124083-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Tierphysiologie |0 (DE-588)4060126-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Progestagen |0 (DE-588)4210407-5 |D s |
| 689 | 0 | 1 | |a Futterzusatz |0 (DE-588)4155774-8 |D s |
| 689 | 0 | 2 | |a Färsenmast |0 (DE-588)4153530-3 |D s |
| 689 | 0 | 3 | |a Tierphysiologie |0 (DE-588)4060126-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Progestagen |0 (DE-588)4210407-5 |D s |
| 689 | 1 | 1 | |a Futterzusatz |0 (DE-588)4155774-8 |D s |
| 689 | 1 | 2 | |a Rückstand |0 (DE-588)4124083-2 |D s |
| 689 | 1 | 3 | |a Quantitative Analyse |0 (DE-588)4125311-5 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Fleisch |0 (DE-588)4017469-4 |D s |
| 689 | 2 | 1 | |a Progestagen |0 (DE-588)4210407-5 |D s |
| 689 | 2 | 2 | |a Rückstand |0 (DE-588)4124083-2 |D s |
| 689 | 2 | 3 | |a Verbraucherschutz |0 (DE-588)4117338-7 |D s |
| 689 | 2 | |5 DE-604 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009704348&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-009704348 | |
Datensatz im Suchindex
| _version_ | 1807504162910371840 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
_
_
_
L
TABLE
OF
CONTENTS
1
ZUSAMMENFASSUNG
1
2
ABSTRACT
4
3
GENERAL
INTRODUCTION
7
3.1
CHEMICAL
DESCRIPTION
OF
MELENGESTROL
ACETATE
7
3.2 MODE
OF
PROGESTIN
ACTION
8
3.3
SUGGESTED
ANABOLIC
MECHANISM
8
3.4
LEGAL
STATUS
10
3.5
PRESENT
METHODS
FOR
MGA
DETECTION
11
4
OBJECTIVES
OF
THE
STUDY
12
5
MATERIAL
AND
METHODS
13
5.1
MATERIAL
13
5.1.1
ANIMAL
TRIAL
13
5.1.2
SAMPLE
COLLECTION
13
5.2
METHODS
14
5.2.1
DETECTION
OF
MGA
IN
EDIBLE
TISSUES
BY
GC-MS
AND
LC-MS
14
5.2.2
ENZYME
IMMUNO
ASSAY
DEVELOPMENT
FOR
MGA
DETECTION
14
5.2.3
CONTROL
OF
THE
MGA
HOMOGENEITY
IN
EXPERIMENTAL
FEEDSTUFF
PACKAGES
15
5.2.4
SCREENING
OF
MGA
IN
EDIBLE
TISSUES
15
5.2.5
DETECTION
OF
MGA,
P
4
,
LH
AND
IGF-1
IN
BLOOD
PLASMA
15
5.2.6
ER17|3
DETECTION
IN
BLOOD
PLASMA
BY
HPLC/EIA
16
5.2.7
DETECTION
OF
ESTROGEN
RESIDUES
IN
FAT
AND
MUSCLE
16
5.2.8
QUANTIFYING
OF
SPECIFIC
MRNA
EXPRESSION
BY
REAL
TIME
RT-PCR
17
6
RESULTS
AND
DISCUSSION
18
6.1
DOSE-DEPENDENT
MGA
RESIDUES
IN
EDIBLE
TISSUES
18
6.2
VALIDITY
OF
THE
PRESENT
METHODS
19
6.2.1
MELENGESTROL
ACETATE
ENZYME
IMMUNO
ASSAY
19
6.2.2
HOMOGENEITY
OF
FEEDSTUFF
PREPARATIONS
21
6.2.3
MGA
SCREENING
IN
EDIBLE
TISSUES
BY
EIA
22
II
TABLE
OF
CONTENTS
6.2.4
MGA
SCREENING
IN
BLOOD
PLASMA
23
6.2.5
E2-17P-DETERMINATION
IN
BLOOD
PLASMA
23
6.2.6
QUANTIFICATION
OF
MRNA
EXPRESSION
PATTERN
24
6.3
DOSE-DEPENDENT
PHYSIOLOGICAL
CHANGES
25
6.3.1
MGA
RESIDUES
IN
BLOOD
PLASMA
AND
PHARMACOKINETIC
25
6.3.2
ENDOGENOUS
BLOOD
PLASMA
PARAMETERS
AND
MORPHOLOGY
OF
THE
OVARIES
25
6.3.3 CHANGES
OF
MRNA
EXPRESSIONS
IN
TARGET
TISSUES
26
6.3.4
ESTROGEN
RESIDUES
IN
FAT
AND
MUSCLE
27
7
CONCLUSIONS
29
8
REFERENCES
30
9
ORIGINAL
SCIENTIFIC
PUBLICATIONS
36
9.1
PUBLICATION
I
37
DETECTION
OF
MELENGESTROL
ACETATE
RESIDUES
IN
PLASMA
AND
EDIBLE
TISSUES.
9.2
PUBLICATION
II
43
A
SENSITIVE
ENZYME
IMMUNO
ASSAY
(ELA)
FOR
THE
DETERMINATION
OF
MELENGESTROL
ACETATE
(MGA)
IN
ADIPOSE
AND
MUSCLE
TISSUES.
9.3
PUBLICATION
III
51
DOSE-DEPENDENT
EFFECTS
OF
MELENGESTROL
ACETATE
(MGA)
ON
PLASMA
LEVELS
OF
ESTRADIOL,
PROGESTERONE
AND
LUTEINIZING
HORMONE
IN
CYCLING
HEIFERS
AND
INFLUENCES
ON
OESTROGEN
RESIDUES
IN
EDIBLE
TISSUES.
9.4
PUBLICATION
IV
60
VALIDITIES
OF
MRNA
QUANTIFICATION
USING
RECOMBINANT
RNA
AND
RECOMBINANT
DNA
EXTERNAL
CALIBRATION
CURVES
IN
REAL-TIME
RT-PCR.
9.5
PUBLICATION
V
69
EFFECTS
OF
SYNTHETIC
PROGESTAGENS
ON
THE
MRNA
EXPRESSION
OF
ANDROGEN
RECEPTOR,
PROGESTERONE
RECEPTOR,
ESTROGEN
RECEPTOR
A
AND
P,
INSULIN-LIKE
GROWTH
FACTOR
(IGF)-1
AND
IGF-1
RECEPTOR
IN
HEIFER
TISSUES.
10
ACKNOWLEDGEMENTS
85
11
CURRICULUM
VITAE
86
11.1
BIBLIOGRAPHY
87
11.1.1
ORIGINAL
PAPERS
87
11.1.2
PROCEEDINGS 88 |
| any_adam_object | 1 |
| author | Hageleit, Melanie |
| author_facet | Hageleit, Melanie |
| author_role | aut |
| author_sort | Hageleit, Melanie |
| author_variant | m h mh |
| building | Verbundindex |
| bvnumber | BV014158574 |
| classification_tum | OEK 740d VET 440d LAN 640d |
| ctrlnum | (OCoLC)248600991 (DE-599)BVBBV014158574 |
| discipline | Agrarwissenschaft Veterinärmedizin Ökotrophologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV014158574</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20020228</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">020220s2001 d||| m||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">964012596</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)248600991</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV014158574</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-91</subfield><subfield code="a">DE-M49</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-83</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">OEK 740d</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VET 440d</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">LAN 640d</subfield><subfield code="2">stub</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hageleit, Melanie</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate</subfield><subfield code="c">Melanie Hageleit</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2001</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">III, 88 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">München, Techn. Univ., Diss., 2001. - Enth. Zeitschriftenaufsätze</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Färsenmast</subfield><subfield code="0">(DE-588)4153530-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Futterzusatz</subfield><subfield code="0">(DE-588)4155774-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Verbraucherschutz</subfield><subfield code="0">(DE-588)4117338-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Fleisch</subfield><subfield code="0">(DE-588)4017469-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Quantitative Analyse</subfield><subfield code="0">(DE-588)4125311-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Progestagen</subfield><subfield code="0">(DE-588)4210407-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Rückstand</subfield><subfield code="0">(DE-588)4124083-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Tierphysiologie</subfield><subfield code="0">(DE-588)4060126-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Progestagen</subfield><subfield code="0">(DE-588)4210407-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Futterzusatz</subfield><subfield code="0">(DE-588)4155774-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Färsenmast</subfield><subfield code="0">(DE-588)4153530-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">Tierphysiologie</subfield><subfield code="0">(DE-588)4060126-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Progestagen</subfield><subfield code="0">(DE-588)4210407-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Futterzusatz</subfield><subfield code="0">(DE-588)4155774-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">Rückstand</subfield><subfield code="0">(DE-588)4124083-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="3"><subfield code="a">Quantitative Analyse</subfield><subfield code="0">(DE-588)4125311-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Fleisch</subfield><subfield code="0">(DE-588)4017469-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="1"><subfield code="a">Progestagen</subfield><subfield code="0">(DE-588)4210407-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="2"><subfield code="a">Rückstand</subfield><subfield code="0">(DE-588)4124083-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="3"><subfield code="a">Verbraucherschutz</subfield><subfield code="0">(DE-588)4117338-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009704348&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-009704348</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV014158574 |
| illustrated | Illustrated |
| indexdate | 2024-08-16T01:04:54Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009704348 |
| oclc_num | 248600991 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-M49 DE-BY-TUM DE-12 DE-83 |
| owner_facet | DE-91 DE-BY-TUM DE-M49 DE-BY-TUM DE-12 DE-83 |
| physical | III, 88 S. graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| record_format | marc |
| spelling | Hageleit, Melanie Verfasser aut Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate Melanie Hageleit 2001 III, 88 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2001. - Enth. Zeitschriftenaufsätze Färsenmast (DE-588)4153530-3 gnd rswk-swf Futterzusatz (DE-588)4155774-8 gnd rswk-swf Verbraucherschutz (DE-588)4117338-7 gnd rswk-swf Fleisch (DE-588)4017469-4 gnd rswk-swf Quantitative Analyse (DE-588)4125311-5 gnd rswk-swf Progestagen (DE-588)4210407-5 gnd rswk-swf Rückstand (DE-588)4124083-2 gnd rswk-swf Tierphysiologie (DE-588)4060126-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Progestagen (DE-588)4210407-5 s Futterzusatz (DE-588)4155774-8 s Färsenmast (DE-588)4153530-3 s Tierphysiologie (DE-588)4060126-2 s DE-604 Rückstand (DE-588)4124083-2 s Quantitative Analyse (DE-588)4125311-5 s Fleisch (DE-588)4017469-4 s Verbraucherschutz (DE-588)4117338-7 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009704348&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hageleit, Melanie Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate Färsenmast (DE-588)4153530-3 gnd Futterzusatz (DE-588)4155774-8 gnd Verbraucherschutz (DE-588)4117338-7 gnd Fleisch (DE-588)4017469-4 gnd Quantitative Analyse (DE-588)4125311-5 gnd Progestagen (DE-588)4210407-5 gnd Rückstand (DE-588)4124083-2 gnd Tierphysiologie (DE-588)4060126-2 gnd |
| subject_GND | (DE-588)4153530-3 (DE-588)4155774-8 (DE-588)4117338-7 (DE-588)4017469-4 (DE-588)4125311-5 (DE-588)4210407-5 (DE-588)4124083-2 (DE-588)4060126-2 (DE-588)4113937-9 |
| title | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate |
| title_auth | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate |
| title_exact_search | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate |
| title_full | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate Melanie Hageleit |
| title_fullStr | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate Melanie Hageleit |
| title_full_unstemmed | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate Melanie Hageleit |
| title_short | Analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate |
| title_sort | analytical developments for residue monitoring and characterization of the anabolic action of melengestrol acetate |
| topic | Färsenmast (DE-588)4153530-3 gnd Futterzusatz (DE-588)4155774-8 gnd Verbraucherschutz (DE-588)4117338-7 gnd Fleisch (DE-588)4017469-4 gnd Quantitative Analyse (DE-588)4125311-5 gnd Progestagen (DE-588)4210407-5 gnd Rückstand (DE-588)4124083-2 gnd Tierphysiologie (DE-588)4060126-2 gnd |
| topic_facet | Färsenmast Futterzusatz Verbraucherschutz Fleisch Quantitative Analyse Progestagen Rückstand Tierphysiologie Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009704348&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hageleitmelanie analyticaldevelopmentsforresiduemonitoringandcharacterizationoftheanabolicactionofmelengestrolacetate |