Bacterial pathogenesis: a molecular approach
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Washington, DC
ASM Press
2002
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 3. Aufl. u.d.T.: Bacterial pathogenesis / Wilson, Brenda A. |
| Beschreibung: | XX, 539 S. Ill., graph. Darst. |
| ISBN: | 155581171X |
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| 245 | 1 | 0 | |a Bacterial pathogenesis |b a molecular approach |c Abigail A. Salyers and Dixie D. Whitt |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Washington, DC |b ASM Press |c 2002 | |
| 300 | |a XX, 539 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804128985621200896 |
|---|---|
| adam_text | Preface xv
Foreword xix
part i Basic Principles 1
Chapter 1
The Uneasy Truce: Never Underestimate the Power
of Bacteria 3
Why Bacteria Are Once Again in the Public Health Spotlight 3
Ancient History Takes a Toll on Today s Human Health 4
Pressing Current Issues 5
Emerging and Reemerging Infectious Diseases 6
Food Borne and Water Borne Infections 10
Modern Medicine as a Source of New Diseases 11
Microbiota Shift Diseases 11
Genomics 12
Bioterrorism 13
New Solutions, New Hope 14
New Respect for Prevention 14
Surveillance—an Early Warning System 14
Making Hospitals Safe for Patients 15
And Now for the Really Good News—You ve Got a Bacterial
Infection 15
SELECTED READINGS 16
SUMMARY OUTLINE 17
QUESTIONS 18
Chapter 2
Approaching and Studying Bacterial Diseases 19
Microbes and Disease 19
Establishing a Connection—Koch s Postulates 19
Concepts of Disease 22
vii
viii jH Contents
Measuring Infectivity and Virulence 24
Animal Models 24
Tissue Culture and Organ Culture Models 28
Good Information about the Pathology of a Disease 31
SELECTED READINGS 31
SUMMARY OUTLINE 31
QUESTIONS 33
Chapter 3 Molecular Approaches to the Diagnosis and
Characterization of Bacterial Infections 34
Seeking Insights into Virulence 34
Molecular Koch s Postulates 34
Virulence as a Complex Phenomenon 34
The Importance of Bacterial Physiology 35
Molecular Microbe Hunting 36
Role of Molecular Methods in Diagnosis 36
PCR 38
Checkerboard Hybridization 38
RAPID PCR 40
Ligase Chain Reaction 40
Ribotyping or Insertion Sequence Typing Using Restriction
Fragment Length Polymorphisms (RFLP) 41
PFGE 42
Identifying Virulence Factors Experimentally 42
Cloning, Transposon Mutagenesis, and Transcriptional
Fusions 42
Finding Genes That Are Expressed In Vivo 46
Signature Tagged Mutagenesis 48
Molecular Mania—a Boon or a Boondoggle? 48
SELECTED READINGS 50
SUMMARY OUTLINE 50
QUESTIONS 52
Chapter 4 The First Line of Defense against Infection:
Prevention and the Phagocytic Cell
Response 53
An Ounce of Prevention 53
The Human Brain—the First Line of Defense against
Infection 53
Nonspecific and Specific Defenses 54
Definitions 54
Connections between Nonspecific and Specific Defense
Systems 54
Fashion Statement 56
Epithelia 57
Defenses of Skin 57
Chemical and Physical Barriers to Bacterial
Colonization 57
Normal Microbiota 58
Defenses of the Dermis 59
When Skin Is Breached 59
Common Themes 59
Defenses of Mucosal Surfaces 60
Phagocytes and Nonspecific Cytotoxic Cells: Defenders
of Blood and Tissue 60
A Versatile Defense Force 60
Distribution of Phagocytic and Cytotoxic Cells 62
How Phagocytes Kill Bacteria 64
Just Say NO 65
Collateral Damage 65
Killing by Nonspecific Cytotoxic Cells 65
SELECTED READINGS 65
SUMMARY OUTLINE 66
QUESTIONS 68
Chapter 5 The First Line of Defense, Continued:
Complement, Chemokines, and
Cytokines 69
Characteristics and Roles of Complement 69
Steps in Complement Activation 71
Role of Cytokines and Chemokines in Directing the
Phagocyte Response 72
Other Activities of Cytokines 76
Stress and Resistance to Disease: Connections between
the Nervous System and the Immune System 77
The Dark Side of the Nonspecific Defenses: Septic
Shock 77
SELECTED READINGS 81
SUMMARY OUTLINE 81
QUESTIONS 83
Chapter 6 The Second Line of Defense: Antibodies and
Cytotoxic T Cells 84
Antibodies 84
Characteristics of Antibodies and Their Diverse Roles in
Preventing Infection 84
Serum Antibodies 85
Secretory Antibodies—Antibodies That Protect Mucosal
Surfaces 87
Affinity and Avidity 87
Cytotoxic T Cells 88
Production of Activated Cytotoxic T Cells and
Antibodies 88
Processing of Protein Antigens by APCs 88
Interaction between APCs and T Cells: the T Cell
Dependent Response 90
The Thl / Th2 View of Immunity Development 91
Production of Antibodies by B Cells 91
Links to Nonspecific Defenses 92
T Independent Antigens 92
Mucosal Immunity 93
Development of the Specific Response System from
Infancy to Adulthood 95
The Dark Side of the Specific Defenses— Autoimmune
Disease 95
SELECTED READINGS 96
SUMMARY OUTLINE 96
QUESTIONS 100
Chapter 7 Vaccination—an Underappreciated
Component of the Modern Medical
Armamentarium 101
Vaccines—a Major Health Care Bargain 101
The Current Vaccine Situation 101
A New Form of Child Abuse (as if We Needed
One) 103
The Success Stories 105
The Less than Success Stories 108
New Directions 111
Passive Immunization 112
SELECTED READINGS 112
SUMMARY OUTLINE 113
QUESTIONS 114
Chapter 8 Bacterial Strategies for Evading or Surviving
the Defense Systems of the Human
Body 115
Overview of Bacterial Defense Strategies 115
Colonization and Invasion of Host Surfaces 116
Penetrating Intact Skin 116
Penetrating the Mucin Layer 116
Resisting Antibacterial Peptides 117
Adherence 117
slgA Proteases 121
Iron Acquisition Mechanisms 121
Invasion and Intracellular Residence 122
Evading Complement, Phagocytes, and the Antibody
Response 123
Capsules 123
Resistance to Nitric Oxide 124
Other Strategies for Circumventing Complement and
Phagocytes 124
Surviving Phagocytosis 124
Evading the Hosf s Antibody Response 124
Contents U ix
The Opportunists 126
SELECTED READINGS 127
SUMMARY OUTLINE 128
QUESTIONS 130
Chapter 9 Bacterial Exotoxins: Important but Still a
Mystery 131
Exotoxins, Toxic Proteins Produced by Bacteria 131
Transparent Mechanisms, Mysterious Purposes 131
Characteristics and Nomenclature 132
Exotoxin Structure and Function 133
Secretion and Excretion of Exotoxins 135
Examples of Diseases Caused by Toxins 138
Diphtheria 138
Botulism and Tetanus 142
Wound Infections 145
Toxins and Shock 146
Pasteurellosis 147
SELECTED READINGS 147
SUMMARY OUTLINE 148
QUESTIONS 149
Chapter 10 Antimicrobial Compounds 150
Antimicrobial Compounds: the Safety Net of Modern
Medicine 150
Importance of Antimicrobial Compounds 150
Killing versus Inhibiting Growth 151
Antiseptics and Disinfectants 151
Mechanisms of Action 151
Resistance to Antiseptics and Disinfectants 152
Antibiotics 152
Characteristics of Antibiotics 152
The Process of Antibiotic Discovery 155
The Economics of Antibiotic Discovery 156
Mechanisms of Antibiotic Action 156
Targets of Antibiotic Action 156
Cell Wall Synthesis Inhibitors 157
Protein Synthesis Inhibitors 158
Quinolones—a Class of Antibiotics That Targets DNA
Replication 161
Rifampin—an Inhibitor of RNA Synthesis 162
Trimethoprim and Sulfonamides 162
Metronidazole 162
The Newest Antibiotics 162
The Continuing Challenge 163
SELECTED READINGS 164
SUMMARY OUTLINE 165
QUESTIONS 167
x ^M Contents
Chapter 11 How Bacteria Become Resistant to
Antibiotics 168
The Dawning of Awareness 168
Mechanisms of Antibiotic Resistance 170
Overview of Resistance Mechanisms 170
Limiting Access of the Antibiotic 170
Enzymatic Inactivation of the Antibiotic 171
Active Efflux of the Antibiotic 172
Modification or Protection of the Antibiotic Target 173
Failure to Activate an Antibiotic 175
Regulation of Resistance Genes 175
Cross Resistance and Linkage 176
Antibiotic Tolerance 177
Transfer of Resistance Genes 177
Why Mutation Is Often Not the Preferred Solution 177
Plasmids 178
Transposons and Integrons 178
Conjugative Transposons 179
Will We Return to the Preantibiotic Era? 180
SELECTED READINGS 181
SUMMARY OUTLINE 182
QUESTIONS 184
part ii Specific Bacterial
Pathogens 185
Chapter 12 The Spirochetes: Borrelia burgdorferi and
Treponema pallidum 187
Lyme Disease 188
Features of B. burgdorferi 188
Morphology and Physiology 188
Borrelia Plasmids 190
The Borrelia Genome Sequence—Some Clues but Still
Many Mysteries 190
The Tick Mammal Cycle 192
Response of B. burgdorferi to Its Arthropod and
Mammalian Hosts 192
Osps 192
Leaving the Bloodstream 193
The Lyme Disease Vaccine 193
Chronic Lyme Disease 194
Variation in the Severity of the Disease—Coinfection
Confounds the Problem 194
Studying Virulence Factors of B. burgdorferi 195
Special Difficulties 195
Animal Models 195
Diagnosis and Prevention of Lyme Disease 195
Diagnosis 195
Prevention and Treatment 196
Syphilis and Lyme Disease: Two Spirochetal Diseases
with a Similar Pathology but a Different Ecology 197
Progression of Syphilis 197
Diagnosis and Treatment of Syphilis 198
Taking Stock 198
SELECTED READINGS 199
SUMMARY OUTLINE 200
QUESTIONS 201
Chapter 13 Yersinia pestis, the Cause of Plague, and Its
Relatives 202
The Rich and Terrible History of Yersinia pestis 202
Biological Warfare in the 14th Century 203
Modern Interest in Y. pestis 204
Characteristics of Y. pestis and Plague 204
Yersinia enterocolitica and Yersinia pseudotuberculosis, Food
Borne Relatives of Y. pestis 207
Yersinia Plasmids 207
Virulence Factors of V. pestis, Y. enterocolitica, and
Y. pseudotuberculosis 208
Virulence Factors Unique to Y. pestis 211
Survival in the Mammalian Body 212
Future Directions 213
SELECTED READINGS 213
SUMMARY OUTLINE 214
QUESTIONS 215
Chapter 14 Staphylococcus Species 216
The Many Types of Staphylococcal Infections 216
S.aureus 217
Coagulase Negative Staphylococci: S. epidermidis and
S. saprophyticus 217
Emerging Antibiotic Resistance, a Developing Horror
Story 218
Characteristics of Staphylococci 219
Colonization of the Human Body 219
Key Features of the Staphylococci 219
Virulence Factors of S. aureus 220
Virulence Factors 220
Virulence Factors of the Coagulase Negative
Staphylococci 227
S. epidermidis 227
S. saprophyticus 228
Future Directions 228
SELECTED READINGS 229
SUMMARY OUTLINE 229
QUESTIONS 230
Chapter 15
Group A and Group B Streptococci and
Enterococci 232
A Closer Look at Diseases Caused by Streptococci 233
The Changing Spectrum of Group A Streptococcal
Disease 233
Understanding Disease Diversity 234
Group B Streptococci and Enterococci—Emerging
Human Pathogens 236
Group B Streptococci 236
Enterococcal Infections 237
Virulence Factors 237
Group A Streptococci 237
Regulation of Virulence Factors 241
Virulence Factors of Group B Streptococci 241
Enterococcus Virulence Factors 242
SELECTED READINGS 245
SUMMARY OUTLINE 245
QUESTIONS 246
Chapter 16 Pseudomonas aeruginosa and Related Species,
a Lesson in Versatility 247
A Consummate Opportunist 247
Characteristics of P. aeruginosa 248
Types of Infections 249
Virulence Factors 251
Measuring Virulence—Model Systems Raise Exciting New
Possibilities 251
Overview of the Disease Process 252
Adhesins 253
The Type III Secretion System 254
ExoS and ExoU 254
Exotoxin A 255
Elastolytic Activity 255
Other Extracellular Factors 257
Alginate Production 257
LPS Variation 259
Antibiotic Resistance 259
Future Directions 260
SELECTED READINGS 260
SUMMARY OUTLINE 261
QUESTIONS 262
Contents ^| xi
Chapter 17 Bordetella pertussis 263
Whooping Cough 263
Characteristics of the Disease 263
The Vaccine Dilemma 264
Overview of the Infection Process 264
Virulence Factors 264
Model Systems 264
Adherence 267
Toxins 268
B. pertussis and Phagocytic Cells 269
Is There a Type III Secretion System? 270
Type IV Secretion System 270
Regulation of Virulence Genes 270
Phenotypic Modulation (Transcriptional Regulation) 270
Phase Variation 272
Prevention and Treatment 272
SELECTED READINGS 272
SUMMARY OUTLINE 273
QUESTIONS 275
Chapter 18 Streptococcus pneumoniae 276
Pneumococcal Disease 276
Characteristics of S. pneumoniae 277
Progression of Pneumococcal Disease 278
Virulence Factors of S. pneumoniae 279
Animal and Cell Culture Models 279
Colonization of the Nose and Throat and Entry into the
Lung 279
Survival in the Lung 280
Ability To Evoke an Inflammatory Response 282
Interaction with the Blood Brain Barrier 283
Signature Tagged Mutagenesis 283
Antibiotic Resistance 283
Natural Transformation 284
Prevention and Treatment 285
Antibiotic Therapy 285
Vaccines 286
SELECTED READINGS 287
SUMMARY OUTLINE 288
QUESTIONS 289
Chapter 19 Tuberculosis 291
A Disease of the Past Returns To Haunt the
Future 291
Nothing Fails Like Success 292
Drug Resistance—a Worrisome New Development 292
So Soon We Forget 292
xii ^M Contents
Spread and Progression of Tuberculosis 293
Symptoms and Mode of Spread 293
Progression of the Disease 293
Latency and Persistence—Another TB Mystery 297
Mycobacterium tuberculosis and Its Unusual Cell
Wall— a Case of Fat Making for Lean and Mean 298
Treatment of TB and the Challenge Posed by Drug
Resistant Strains 298
Standard Treatment Options 298
The Emergence of Resistance 300
The W Strain—a Taste of Things To Come? 301
The Search for New Drugs 301
Diagnosis of TB 302
Virulence Factors 303
Studying Virulence Factors 303
Entry into and Survival in Phagocytes 303
Avoidance of the Activated Macrophage Response 304
Ability To Elicit a Destructive Inflammatory Response 305
Factors That Affect Host Susceptibility 305
Immunity to TB 306
BCG: a Widely Used but Controversial Vaccine 306
BCG as a Carrier for Other Vaccine Antigens 306
SELECTED READINGS 307
SUMMARY OUTLINE 307
QUESTIONS 309
Chapter 20 Legionella pneumophila and Legionnaires
Disease 311
The Dark Side of Modern Comforts: Air Conditioning
Turns Ugly 311
Legionnaires Disease 312
The Natural Host?—a Free Living Macrophage
Equivalent 312
Virulence Factors 313
Problems with Determining Legionella Virulence
Factors 313
Survival in Amoebae 314
Regulation of Virulence Genes 315
Interaction with Mammalian Macrophages 316
Damage to the Lung 317
Prevention and Treatment 318
Legionella as a Paradigm for Intracellular
Pathogens 318
SELECTED READINGS 319
SUMMARY OUTLINE 319
QUESTIONS 321
Chapter 21 Mycoplastna pneumoniae and Chlamydia
pneumoniae 322
Lifestyles of Mycoplastna pneumoniae and Chlamydia
pneumoniae 322
Characteristics of Mycoplasma and Chlamydia
Species 325
Virulence Factors 327
M. pneumoniae 327
C. pneumoniae 328
SELECTED READINGS 329
SUMMARY OUTLINE 329
QUESTIONS 331
Chapter 22 Bacillus anihmcis, the Cause of Anthrax 332
Features of the Disease 332
Virulence Factors 333
Ability To Germinate and Survive in Macrophages 333
Toxins 334
Antiphagocytic Capsule 335
Prevention of Anthrax 335
SELECTED READINGS 336
SUMMARY OUTLINE 337
QUESTIONS 338
Chapter 23 Helicobacter pylori, a Resourceful Gastric
Pathogen 339
A Revolution in Gastroenterology 339
Good News—You re Infected! 339
The Long Road to Acceptance 340
The H. pylori Inspired Gold Rush 340
Characteristics of H. pylori 342
Morphology and Metabolism 342
Genomics 343
Virulence Factors 343
Animal Models 343
Colonization of the Stomach Mucosa 344
Eliciting an Inflammatory Response 345
LPS—Immune Mimicry 346
Type IV Secretion System 346
Prevention and Treatment 346
H. pylori Mysteries 349
SELECTED READINGS 349
SUMMARY OUTLINE 350
QUESTIONS 351
Chapter 24 Clostridium difficile and Pseudomembranous
Colitis 352
Pseudomembranous Colitis—a Disease Caused by
Antibiotics 352
Emergence of Pseudomembranous Colitis 352
Characteristics of C. difficile 353
Development and Ecology of the Disease 353
Virulence Factors 355
Toxins 355
Other Virulence Factors 358
Prevention and Treatment 359
SELECTED READINGS 360
SUMMARY OUTLINE 361
QUESTIONS 362
Chapter 25
Vibrio cholerae, the Cause of Cholera 363
Pathogenesis and Epidemiology of Cholera 363
Progression of the Disease 363
History and Distribution of Cholera Outbreaks 364
Solving the Cholera Problem 366
Virulence Factors 366
Overview 366
Colonization of the Small Intestinal Mucosa 367
Cholera Toxin 368
Other Toxins Produced by V. cholerae 373
Gene Capture—a Role for Integrons 374
The Capsule of V. cholerae O139— a Difference, but
Probably Not an Important One 374
Antibiotic Resistance 374
Transcriptional Regulation of Virulence Genes 375
The ToxR/ToxS/ToxT Regulatory System 375
Regulation in Response to Iron Levels 376
Prevention and Treatment 376
Oral Rehydration Therapy 376
The Frustrating Search for a Safe and Effective Cholera
Vaccine 377
Future Directions 377
SELECTED READINGS 378
SUMMARY OUTLINE 379
QUESTIONS 380
Chapter 26 Salmonella Species 381
Salmonella Species and Serogroups 381
Diseases Caused by Salmonella Species 382
Contents ^| xiii
S. typhimurium 382
S.typhi 383
Virulence Factors 384
Animal Models 384
Overview of the Disease Process 384
Adherence and Invasion 386
Host Factors That Affect Susceptibility to Salmonella
Infections 391
Why Is S. typhi So Invasive? 391
Acid Tolerance Response 392
Prevention and Treatment 392
Antibiotic Therapy 392
Vaccines 393
Salmonella as a Basis for Other Vaccines 393
Future Directions 394
SELECTED READINGS 394
SUMMARY OUTLINE 395
QUESTIONS 397
Chapter 27 Listeria monocytogenes, a Doubly Motile
Pathogen 398
Listeriosis 398
Characteristics of Disease Caused by Listeria
monocytogenes 398
Listeria as a Model for Studies of the Cell Mediated Immune
Response and Cytoskeleton Formation 400
Virulence Factors 400
Animal and Cell Culture Model Systems 400
Genetic System 400
Motility 400
Invasion and Cell to Cell Spread 400
LLO (My) 401
PI PLC (pic A) and PC PLC (plcB) 402
Metalloprotease 402
Actin Based Motility 402
Systemic Spread of L. monocytogenes 403
Organization and Regulation of Virulence Genes 404
Prevention and Treatment 404
SELECTED READINGS 405
SUMMARY OUTLINE 405
QUESTIONS 406
Chapter 28 Diarrheagenic Escherichk coli Strains 407
Different Types of Diarrheagenic Escherichia coli
Strains 407
Classification of Pathogenic E. coli Strains 408
Serogroup and Serotype 408
Virotype 408
xiv ^ Contents
Virulence Factors 411
ETEC Strains 411
EAggEC Strains 412
EPEC Strains 414
EHEC Strains 416
Prevention and Treatment 416
SELECTED READINGS 418
SUMMARY OUTLINE 418
QUESTIONS 420
Chapter 29
Escherichia coli Extraintestinal
Infections 422
Epidemiology of Urinary Tract Infections 422
Community Acquired Urinary Tract Infections 422
Hospital Acquired (Nosocomial) Urinary Tract
Infections 423
Virulence Factors of E. coli Strains That Cause Urinary
Tract Infections 424
Colonization of the Colon and Vagina 424
Adhesins 425
Invasion of Uroepithelial Cells 426
Toxins 427
Other Virulence Factors 427
UPEC Strains—a Paradigm for Adhesin Biogenesis 428
Organization and Regulation of Virulence Genes 429
Meningitis and Other Disseminated Infections 432
Virulence Factors Associated with Strains That Cause
Meningitis, Pneumonia, and Septicemia 433
Prevention and Treatment 433
SELECTED READINGS 434
SUMMARY OUTLINE 434
QUESTIONS 436
Chapter 30 Neisseria Species 437
The Two Pathogenic Neisseria Species 437
Types of Disease 438
Commonalities 438
Gonorrhea 438
Gonorrhea—Still a Major Public Health Problem 438
Just When We Thought We Were Seeing the Light at the
End of the Tunnel, It Turned Out To Be the Headlight of
an Oncoming Train 439
What You Don t Know Can Hurt You: Complications of
Gonorrhea 439
Meningococcal Meningitis 440
Virulence Factors 441
N. gonorrhoeae 441
How N. gonorrhoeae Evades the Host Defense
Responses 442
N. meningitidis 447
Prevention and Treatment 447
Gonorrhea 447
Meningococcal Meningitis 448
SELECTED READINGS 449
SUMMARY OUTLINE 449
QUESTIONS 451
Chapter 31 ___
Chlamydia trachomatis 452
The Hidden Epidemic 452
C. trachomatis—a Lot of Pathogenic Potential in a Very
Small Package 454
Virulence Factors 456
Special Problems Faced by Scientists Working on
Chlamydiae 456
Adherence and Invasion by EBs 456
Prevention and Treatment 458
Closing Observations 459
SELECTED READINGS 459
SUMMARY OUTLINE 459
QUESTIONS 460
appendix l Overview of Bacterial Secretion
Systems, Bacterial Adhesins and Their
Mechanisms of Assembly, and Major Bacterial
Toxins 461
A. Secretion Systems of Bacteria 461
B. Adhesins and Mechanisms of Assembly 462
C. Major Bacterial Toxins 464
APPENDIX 2 Answers to End of Chapter
Questions 467
Glossary 495
Index 525
|
| any_adam_object | 1 |
| author | Salyers, Abigail A. Whitt, Dixie D. |
| author_facet | Salyers, Abigail A. Whitt, Dixie D. |
| author_role | aut aut |
| author_sort | Salyers, Abigail A. |
| author_variant | a a s aa aas d d w dd ddw |
| building | Verbundindex |
| bvnumber | BV014116719 |
| classification_rvk | WF 5200 XD 4400 YD 2000 YD 2018 |
| classification_tum | BIO 220f MED 403f |
| ctrlnum | (OCoLC)247335907 (DE-599)BVBBV014116719 |
| dewey-full | 616.014 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.014 |
| dewey-search | 616.014 |
| dewey-sort | 3616.014 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 2. ed. |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV014116719 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:57:57Z |
| institution | BVB |
| isbn | 155581171X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009672335 |
| oclc_num | 247335907 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-355 DE-BY-UBR DE-11 DE-188 DE-578 |
| owner_facet | DE-M49 DE-BY-TUM DE-355 DE-BY-UBR DE-11 DE-188 DE-578 |
| physical | XX, 539 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | ASM Press |
| record_format | marc |
| spelling | Salyers, Abigail A. Verfasser aut Bacterial pathogenesis a molecular approach Abigail A. Salyers and Dixie D. Whitt 2. ed. Washington, DC ASM Press 2002 XX, 539 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier 3. Aufl. u.d.T.: Bacterial pathogenesis / Wilson, Brenda A. Pathogenese (DE-588)4115512-9 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Pathogene Bakterien (DE-588)4173543-2 gnd rswk-swf Bakterien (DE-588)4004296-0 gnd rswk-swf Pathogenität (DE-588)4205990-2 gnd rswk-swf Bakterielle Infektion (DE-588)4004301-0 gnd rswk-swf Virulenz (DE-588)4129834-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bakterien (DE-588)4004296-0 s Pathogenese (DE-588)4115512-9 s DE-604 Pathogene Bakterien (DE-588)4173543-2 s Molekularbiologie (DE-588)4039983-7 s Bakterielle Infektion (DE-588)4004301-0 s Virulenz (DE-588)4129834-2 s 1\p DE-604 Pathogenität (DE-588)4205990-2 s 2\p DE-604 Whitt, Dixie D. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009672335&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Salyers, Abigail A. Whitt, Dixie D. Bacterial pathogenesis a molecular approach Pathogenese (DE-588)4115512-9 gnd Molekularbiologie (DE-588)4039983-7 gnd Pathogene Bakterien (DE-588)4173543-2 gnd Bakterien (DE-588)4004296-0 gnd Pathogenität (DE-588)4205990-2 gnd Bakterielle Infektion (DE-588)4004301-0 gnd Virulenz (DE-588)4129834-2 gnd |
| subject_GND | (DE-588)4115512-9 (DE-588)4039983-7 (DE-588)4173543-2 (DE-588)4004296-0 (DE-588)4205990-2 (DE-588)4004301-0 (DE-588)4129834-2 (DE-588)4143413-4 |
| title | Bacterial pathogenesis a molecular approach |
| title_auth | Bacterial pathogenesis a molecular approach |
| title_exact_search | Bacterial pathogenesis a molecular approach |
| title_full | Bacterial pathogenesis a molecular approach Abigail A. Salyers and Dixie D. Whitt |
| title_fullStr | Bacterial pathogenesis a molecular approach Abigail A. Salyers and Dixie D. Whitt |
| title_full_unstemmed | Bacterial pathogenesis a molecular approach Abigail A. Salyers and Dixie D. Whitt |
| title_short | Bacterial pathogenesis |
| title_sort | bacterial pathogenesis a molecular approach |
| title_sub | a molecular approach |
| topic | Pathogenese (DE-588)4115512-9 gnd Molekularbiologie (DE-588)4039983-7 gnd Pathogene Bakterien (DE-588)4173543-2 gnd Bakterien (DE-588)4004296-0 gnd Pathogenität (DE-588)4205990-2 gnd Bakterielle Infektion (DE-588)4004301-0 gnd Virulenz (DE-588)4129834-2 gnd |
| topic_facet | Pathogenese Molekularbiologie Pathogene Bakterien Bakterien Pathogenität Bakterielle Infektion Virulenz Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009672335&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT salyersabigaila bacterialpathogenesisamolecularapproach AT whittdixied bacterialpathogenesisamolecularapproach |