The manufacture of medical and health products by transgenic plants:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Pr.
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 332 S. graph. Darst. |
| ISBN: | 1860942547 1860942490 |
Internformat
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| 650 | 7 | |a Transgene organismen |2 gtt | |
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| 650 | 4 | |a Biotechnology |x methods | |
| 650 | 4 | |a Genetic Engineering | |
| 650 | 4 | |a Immunologic Factors |x biosynthesis | |
| 650 | 4 | |a Materia medica, Vegetable | |
| 650 | 4 | |a Plants, Genetically Modified | |
| 650 | 4 | |a Transgenic plants | |
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Datensatz im Suchindex
| _version_ | 1804128956904898560 |
|---|---|
| adam_text | THE MANUFACTURE OG MEDICAL AND HEALTH PRODUCTS BY TRANSGENIC PLANTS ESRA
GALUN THE WEIZMANN INSTITUTE OF SCIENCE, ISRAEL EITHAN GALUN HADASSAH
UNIVERSITY HOSPITAL, ISRAEL IMPERIAL COLLEGE PRESS CONTENTS PREFACE VII
CHAPTER 1 FUNDAMENTALS OF PLANT MOLECULAR GENETICS 1 1.1. BACKGROUND:
GENES AND THEIR EXPRESSION 2 1.1.1. BASIC CONCEPTS CONCERNING GENES 2
1.1.2. IS THE LIVING WORLD MONOPHYLETIC? 3 1.1.3. GENE FLOW: PAST AND
PRESENT 4 1.2. DNA: CHEMISTRY, CODING AND RELEVANCE TO GENETIC
TRANSFORMATION 5 1.3. DNA REPLICATION 9 1.4. THE RIBONUCLEIC ACIDS
(RNAS) 15 1.4.1. THE CHEMISTRY OF RNA AND THE RNA TYPES 15 1.4.2.
TRANSCRIPTION OF DNA INTO RNA 17 1.4.3. TRANSCRIPTION BY POLYMERASE II
19 1.4.4. PROCESSING OF THE MRNA 21 1.5. TRANSLATION OF MRNA INTO
PROTEIN 28 1.5.1. INITIATION OF TRANSLATION 31 1.5.2. ELONGATION OF THE
TRANSLATED POLYPEPTIDE 32 1.5.3. TERMINATION 34 1.6. TRAFFICKING AND
MODIFICATION OF PROTEINS 34 CHAPTER 2 GENETIC TRANSFORMATION 37 2.1.
BACKGROUND ,/ * 37 2.2. MAIN CONSIDERATION OF PLANT GENETIC
TRANSFORMATION 38 XII THE MANUFACTURE OF MEDICAL AND HEALTH PRODUCTS BY
TRANSGENIC PLANTS 2.3. THE BIOLOGY OF GENETIC TRANSFORMATION MEDIATED BY
AGROBACTERIUM TUMEFACIENS 40 2.3.1. AN ABBREVIATED HISTORY 40 2.3.2. THE
ESSENCE OF A. TUMEFACIENS BIOLOGY 41 2.3.3. THE PROCESS OF INFECTION 43
2.4. THE PRACTICE OF GENETIC TRANSFORMATION MEDIATED BY AGROBACTERIUM
TUMEFACIENS 47 2.4.1. EXAMPLES OF A. TUMEFACIENS-MEDIATED TRANSFORMATION
50 2.5. GENETIC TRANSFORMATION MEDIATED BY AGROBACTERIUM RHIZOGENES 55
2.6. BIOLISTIC TRANSFORMATION 58 2.7. TRANSFORMATION OF CHLOROPLASTS 62
2.8. OTHER METHODS OF GENETIC TRANSFORMATION 65 2.9. CONSIDERATIONS
REGARDING TRANSGENE EXPRESSION 66 2.9.1. PROMOTERS 67 2.9.2. TERMINATORS
71 2.9.3. SELECTABLE MARKER GENES 72 2.9.4. REPORTER GENES 73 2.9.5.
OTHER REGULATORY ELEMENTS 74 2.10. GUIDELINES FOR GENETIC TRANSFORMATION
77 CHAPTER 3 ANTIBODIES 83 3.1. BACKGROUND ON IMMUNOLOGY 83 3.2. A BIT
OF HISTORY 84 3.3. INNATE IMMUNITY 85 3.4. ADAPTIVE IMMUNITY 86 3.4.1.
CELL TYPES DERIVED FROM THE PLURIPOTENT HEMATOPOIETIC STEM CELLS 86
3.4.2. THE PLAYGROUNDS OF THE ADAPTIVE IMMUNE SYSTEM 92 3.4.3.
INTERACTIONS IN WHICH CELLS OF THE IMMUNE SYSTEM ARE INVOLVED 94
CONTENTS XIII 3.5. PRODUCTION OF ANTIBODIES IN EXPERIMENTAL ANIMALS 96
3.5.1. POLYCLONAL ANTIBODIES 96 3.5.2. MONOCLONAL ANTIBODIES 97 3.6. AN
EPILOGUE ON THE ADAPTIVE IMMUNE SYSTEM 99 3.7. PRODUCTION OF ANTIBODY
FRAGMENTS BY TRANSGENIC PLANTS 100 3.7.1. THE CONCEPT AND THE
BIOCHEMICAL APPROACH 100 3.7.2. PRODUCTION OF F V IN BACTERIA 100 3.7.3.
PRODUCTION OF SCF V IN PLANTS 101 3.8. PRODUCTION OF FULL-SIZE ANTIBODY
BY TRANSGENIC PLANTS 112 3.8.1. STUDIES ON THE FUNCTIONALITY OF
ANTIBODIES PRODUCED IN TRANSGENIC PLANTS 112 3.8.2. PLANTIBODIES FOR
THERAPEUTIC PURPOSES 119 3.8.3. TRANSIENT EXPRESSION OF ANTIBODY IN
TRANSGENIC PLANTS 122 CHAPTER 4 ANTIGENS 125 4.1. INTRODUCTION 125 4.2.
ANTIGENS RESULTING FROM AGROBACTERIUM -MEDIATED TRANSFORMATION 128
4.2.1. ANTIGENS FROM PATHOGENIC VIRUSES 128 4.2.2. ANTIGENS FROM
BACTERIA 143 4.2.3. PROTECTION AGAINST AUTOIMMUNITY 151 4.3. ANTIGEN
EXPRESSION BY PLANT VIRUSES 155 4.3.1. THE EARLY STUDIES 157 4.3.2. THE
USE OF COWPEA MOSAIC VIRUS 159 4.3.3. FOCUS ON HUMAN IMMUNODEFICIENCY
VIRUS (HIV) 164 4.3.4. PRODUCTION OF ANTIGENIC EPITOPES IN TOBACCO
MOSAIC VIRUS (TMV) 170 4.3.5. PLANT VIRUS EPITOPES AS ANTIGENS FOR
BACTERIAL PATHOGENS 175 XIV THE MANUFACTURE OF MEDICAL AND HEALTH
PRODUCTS BY TRANSGENIC PLANTS CHAPTER 5 THERAPEUTIC PRODUCTS UNRELATED
TO THE IMMUNE SYSTEM 183 5.1. INTRODUCTION 183 5.2. TRANSFORMATION BY
CAULIFLOWER MOSAIC VIRUS (CAMV) 183 5.3. TRANSFORMATION BY MODIFIED
TOBACCO MOSAIC VIRUS (TMV) 185 5.3.1. ANGIOTENSIN-I-CONVERTING ENZYME
INHIBITOR 185 5.3.2. ALPHA-TRICHOSANTHIN 186 5.4. TRANSFORMATION OF CELL
SUSPENSIONS 188 5.4.1. HUMAN INTERFERON 188 5.4.2. HUMAN ERYTHROPOIETIN
189 5.4.3. HUMAN INTERLEUKIN-2 AND INTERLEUKIN-4 191 5.5. AGROBACTERIUM
TUMEFACIENS -MEDIATED TRANSFORMATION 192 5.5.1. LEU-ENKEPHALIN 193
5.5.2. HUMAN SERUM ALBUMIN 194 5.5.3. CYTOCHROME P-450 196 5.5.4. HUMAN
EPIDERMAL GROWTH FACTOR 197 5.4.5. TROUT GROWTH HORMONE 198 5.5.6. RICIN
200 5.5.7. HIRUDIN 202 5.5.8. HUMAN MILK PROTEIN |3-CASEIN 205 5.5.9.
HUMAN HEMOGLOBIN 207 5.5.10. HUMAN A-LACTALBUMIN 208 5.5.11. HUMAN
LACTOFERRIN 208 5.5.12. HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING
FACTOR 211 5.5.13. HUMAN PROTEIN C 212 5.5.14. P-CAROTENE 213 5.6.
BIOLISTIC TRANSFORMATION 214 5.6.1. AVIDIN / 214 5.6.2. APROTININ 218
5.6.3. STILBENE SYNTHASE / 219 5.7. AGROBACTERIUM RHIZOGENES
TRANSFORMATION 221 CONTENTS XV 5.7.1. INDUCTION OF HAIRY ROOT CULTURES
IN MEDICINAL PLANTS WITH UNMANIPULATED A. RHIZOGENES 226 5.7.2.
INDUCTION OF HAIRY ROOT CULTURES IN MEDICINAL PLANTS WITH GENETICALLY
MANIPULATED A. RHIZOGENES 239 CHAPTER 6 GENERAL CONSIDERATIONS 245 6.1.
INTRODUCTION 245 6.2. MAIN ACHIEVEMENTS 247 6.2.1. ANTIBODY FRAGMENTS
AND FULL-SIZE ANTIBODY 248 6.2.2. ANTIGENS 251 6.2.3. THERAPEUTIC
PRODUCTS THAT ARE UNRELATED TO THE IMMUNE SYSTEM 253 6.3. WHAT IS STILL
MISSING AND WHAT IS DESIRABLE IN THE FUTURE 259 6.4. SAFETY ISSUES 263
6.4.1. LABORATORY WORK AND CULTURE ROOM 263 6.4.2. SAFETY TO THE
ENVIRONMENT 264 6.4.3. SAFETY OF PRODUCTS 266 6.5. PUBLIC ACCEPTANCE 268
6.6. EPILOGUE 270 REFERENCES 273 INDEX 309
|
| any_adam_object | 1 |
| author | Galun, Esra 1927- Galun, Eithan |
| author_GND | (DE-588)133555410 |
| author_facet | Galun, Esra 1927- Galun, Eithan |
| author_role | aut aut |
| author_sort | Galun, Esra 1927- |
| author_variant | e g eg e g eg |
| building | Verbundindex |
| bvnumber | BV014091086 |
| callnumber-first | R - Medicine |
| callnumber-label | RS164 |
| callnumber-raw | RS164 SB123.57 |
| callnumber-search | RS164 SB123.57 |
| callnumber-sort | RS 3164 |
| callnumber-subject | RS - Pharmacy |
| classification_rvk | WF 9740 WG 3450 |
| classification_tum | LAN 359f LAN 220f CHE 870f |
| ctrlnum | (OCoLC)47150406 (DE-599)BVBBV014091086 |
| dewey-full | 615.32 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.32 |
| dewey-search | 615.32 |
| dewey-sort | 3615.32 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Agrarwissenschaft Chemie Pflanzenbau Medizin |
| format | Book |
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| id | DE-604.BV014091086 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:57:29Z |
| institution | BVB |
| isbn | 1860942547 1860942490 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009652873 |
| oclc_num | 47150406 |
| open_access_boolean | |
| owner | DE-M49 DE-BY-TUM DE-11 DE-188 |
| owner_facet | DE-M49 DE-BY-TUM DE-11 DE-188 |
| physical | XV, 332 S. graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Imperial College Pr. |
| record_format | marc |
| spelling | Galun, Esra 1927- Verfasser (DE-588)133555410 aut The manufacture of medical and health products by transgenic plants Esra Galun ; Eithan Galun London Imperial College Pr. 2001 XV, 332 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Geneesmiddelen gtt Planten gtt Productiewijze gtt Transgene organismen gtt Bioreactors Biotechnology methods Genetic Engineering Immunologic Factors biosynthesis Materia medica, Vegetable Plants, Genetically Modified Transgenic plants Arzneimittel (DE-588)4003115-9 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Transgene Pflanzen (DE-588)4311513-5 gnd rswk-swf Transgene Pflanzen (DE-588)4311513-5 s Arzneimittel (DE-588)4003115-9 s Herstellung (DE-588)4159653-5 s DE-604 Biotechnologie (DE-588)4069491-4 s DE-188 Galun, Eithan Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009652873&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Galun, Esra 1927- Galun, Eithan The manufacture of medical and health products by transgenic plants Geneesmiddelen gtt Planten gtt Productiewijze gtt Transgene organismen gtt Bioreactors Biotechnology methods Genetic Engineering Immunologic Factors biosynthesis Materia medica, Vegetable Plants, Genetically Modified Transgenic plants Arzneimittel (DE-588)4003115-9 gnd Biotechnologie (DE-588)4069491-4 gnd Herstellung (DE-588)4159653-5 gnd Transgene Pflanzen (DE-588)4311513-5 gnd |
| subject_GND | (DE-588)4003115-9 (DE-588)4069491-4 (DE-588)4159653-5 (DE-588)4311513-5 |
| title | The manufacture of medical and health products by transgenic plants |
| title_auth | The manufacture of medical and health products by transgenic plants |
| title_exact_search | The manufacture of medical and health products by transgenic plants |
| title_full | The manufacture of medical and health products by transgenic plants Esra Galun ; Eithan Galun |
| title_fullStr | The manufacture of medical and health products by transgenic plants Esra Galun ; Eithan Galun |
| title_full_unstemmed | The manufacture of medical and health products by transgenic plants Esra Galun ; Eithan Galun |
| title_short | The manufacture of medical and health products by transgenic plants |
| title_sort | the manufacture of medical and health products by transgenic plants |
| topic | Geneesmiddelen gtt Planten gtt Productiewijze gtt Transgene organismen gtt Bioreactors Biotechnology methods Genetic Engineering Immunologic Factors biosynthesis Materia medica, Vegetable Plants, Genetically Modified Transgenic plants Arzneimittel (DE-588)4003115-9 gnd Biotechnologie (DE-588)4069491-4 gnd Herstellung (DE-588)4159653-5 gnd Transgene Pflanzen (DE-588)4311513-5 gnd |
| topic_facet | Geneesmiddelen Planten Productiewijze Transgene organismen Bioreactors Biotechnology methods Genetic Engineering Immunologic Factors biosynthesis Materia medica, Vegetable Plants, Genetically Modified Transgenic plants Arzneimittel Biotechnologie Herstellung Transgene Pflanzen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009652873&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT galunesra themanufactureofmedicalandhealthproductsbytransgenicplants AT galuneithan themanufactureofmedicalandhealthproductsbytransgenicplants |